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Research profile

The common research goal of the working groups is the development of new therapeutics in the field of bacterially caused infectious diseases. The expertise and methodological approaches include:

• the development of new efficient synthesis methods of molecular libraries, which are provided as test substances for drug screening;
• methods for ligand "fishing" from complex natural substance libraries;
• organic chemical syntheses of chemotherapeutic agents against pathogenic bacteria and fungi;
• the development of small ligands that inhibit or modulate protein function by combining protein crystallography, protein/ligand functional studies, molecular modelling and structure-based design and chemical synthesis of ligands;
• Evaluation of natural ribozymes, RNA/protein complexes and protein enzymes of RNA metabolism as drug targets as well as the application and further development of RNA technologies (antisense, aptamers, RNA interference);
• Physicochemical characterisation of macromolecule/ligand interactions and development of biosensory methods.