Welcome to the homepage of the Diederich lab

Research Subjects:

Computer-aided drug design (CADD)
Preparative organic chemistry
Synthesis of novel inhibitors/modulators for kinases (Pim-1, PKA), transporters (NTCP, ASBT SOAT), nuclear receptors (PPARβ/δ), GPCRs and viral targets like matrix proteins (VP40 of Ebola virus) and proteases (NS2B-NS3 of Dengue virus)
Proteolysis targeting chimeras (PROTACs) technology
Temporary covalent fragment-based drug design (TCFBDD)
In vitro assays, recombinant gene expression, protein production and purification
X-Ray protein crystallography