Functional imaging
Our research focuses on studying neural network activity through the use of imaging and neurophysiological techniques. We employ various functional imaging methods, such as functional magnetic resonance imaging, positron emission tomography, and electroencephalography, to investigate the spatio-temporal properties of neural networks. From a scientific standpoint, we are particularly interested in how different imaging techniques and new acquisition methods can provide complementary information about brain activity. We are also examining how the functional interaction of different brain areas is altered by various diseases or specific forms of therapy, such as deep brain stimulation. Our primary focus is on identifying the underlying pathophysiological mechanisms of different movement disorders, such as Parkinson's disease and essential tremor, and exploring the functional correlates of specific motor and non-motor symptoms. Our work has potential clinical and translational applications, including the multimodal description of pathologically altered network activity and the investigation of modifiability by individual therapies. We hope our research will lead to the development of more effective therapeutic interventions for movement disorders.
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Connectivity of the rhinencephalon in iPD-patients Investigation of the connectivity pattern of the olfactory brain in patients with idiopathic Parkinson's disease
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fPET-based metabolic connectivity and cognition in Parkinson's disease patients Changes in functional connectivity in the brain of Parkinson's disease patients with cognitive impairment
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ET-EEG EEG study of the underlying sensorimotor network in essential tremor and how expectancy affects it
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ET-fMRI Connectivity- and sensor-based optimisation of stimulation parameters in patients with essential tremor and deep brain stimulation
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ET-Eye Investigation of oculomotor dysfunction in essential tremor and its neurophysiological basis
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fPET_DBS Effects of functional connectivity of activated tissue volumes on clinical outcome of deep brain stimulation in Parkinson's disease
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fPET_NMS Investigation of the metabolic networks responsible for the clinical outcome of deep brain stimulation using dynamic FDG-fPET
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Resting-state EEG in DBS-patients Effects of Deep Brain Stimulation on resting metabolism in people with Parkinson's disease
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Resting-state functional PET Effects of Parkinson's disease on the brain metabolism
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Molecular connectivity of dopamine neurons Molecular connectivity of dopamine neurons in the nigrostriatal system
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tVNS-PD Influence of transcutaneous vagal nerve stimulation on non-motor symptoms in Parkinson's disease