Hauptinhalt
Publikationen
Das Gerätezentrum Massenspektrometrie und Elementanalytik beteiligt sich intensiv an Forschungsprojekten diverser Arbeitsgruppen, ist eine Core-Facility des LOEWE-Zentrums für Synthetische Mikrobiologie (Synmikro) und mit Z-Projekten in den SFBs 987 (Mikrobiologie) und 1021 (Virologie) vertreten. Das spiegelt sich in zahlreichen Publikationsbeteiligungen wider:
2020 (2), 2019 (8), 2018 (5), 2017 (8), 2016 (5), 2015 (4), 2014 (3), 2013 (6), 2012 (6), 2011 (8), 2010 (6), 2009 (4), 2008 (3), 2007 (4), 2006 (8), 2005 (3), 2004 (7), 2003 (2), 2002 (5), 2001 (1), 2000 (1)
2020
98) Noncoding RNA MaIL1 is an integral component of the TLR4-TRIF pathway. Aznaourova M, Janga H, Sefried S, Kaufmann A, Dorna J, Volkers SM, Georg P, Lechner M, Hoppe J, Dökel S, Schmerer N, Gruber AD, Linne U, Bauer S, Sander LE, Schmeck B, Schulte LN. Proc Natl Acad Sci U S A. 2020 Apr 21;117(16):9042-9053. doi: 10.1073/pnas.1920393117
2019
97) Exploiting Substrate Promiscuity of Ectoine Hydroxylase for Regio- and Stereoselective Modification of Homoectoine. Czech L, Wilcken S, Czech O, Linne U, Brauner J, Smits SHJ, Galinski EA, Bremer E. Front Microbiol. 2019 Nov 27;10:2745. doi: 10.3389/fmicb.2019.02745
96) Using a marine microalga as a chassis for polyethylene terephthalate (PET) degradation. Moog D, Schmitt J, Senger J, Zarzycki J, Rexer KH, Linne U, Erb T, Maier UG. Microb Cell Fact. 2019 Oct 10;18(1):171. doi: 10.1186/s12934-019-1220-z
95) The DNA repair protein SHPRH is a nucleosome-stimulated ATPase and a nucleosome-E3 ubiquitin ligase. Brühl J, Trautwein J, Schäfer A, Linne U, Bouazoune K. Epigenetics Chromatin. 2019 Aug 21;12(1):52. doi: 10.1186/s13072-019-0294-5
94) Conditional Singlet Oxygen Generation through a Bioorthogonal DNA-targeted Tetrazine Reaction. Linden G, Zhang L, Pieck F, Linne U, Kosenkov D, Tonner R, Vázquez O. Angew Chem Int Ed Engl. 2019 Sep 9;58(37):12868-12873. doi: 10.1002/anie.201907093
93) Structural changes within the bifunctional cryptochrome/photolyase CraCRY upon blue light excitation. Franz-Badur S, Penner A, Straß S, von Horsten S, Linne U, Essen LO. Sci Rep. 2019 Jul 9;9(1):9896. doi: 10.1038/s41598-019-45885-7
92) Biochemical characterization of the Helicobacter pylori bactofilin-homolog HP1542. Holtrup S, Heimerl T, Linne U, Altegoer F, Noll F, Waidner B. PLoS One. 2019 Jun 24;14(6):e0218474. doi: 10.1371/journal.pone.0218474
91) Elucidation of substrate specificities of decorating enzymes involved in mannosylerythritol lipid production by cross-species complementation. Deinzer HT, Linne U, Xie X, Bölker M, Sandrock B. Fungal Genet Biol. 2019 Sep;130:91-97. doi: 10.1016/j.fgb.2019.05.003
90) Phosphoproteome Analysis of Cells Infected with Adapted and Nonadapted Influenza A Virus Reveals Novel Pro- and Antiviral Signaling Networks. Weber A, Dam S, Saul VV, Kuznetsova I, Müller C, Fritz-Wolf K, Becker K, Linne U, Gu H, Stokes MP, Pleschka S, Kracht M, Schmitz ML. J Virol. 2019 Jun 14;93(13):e00528-19. doi: 10.1128/JVI.00528-19
2018
89) Light-Driven Domain Mechanics of a Minimal Phytochrome Photosensory Module Studied by EPR.
Assafa TE, Anders K, Linne U, Essen LO, Bordignon E. Structure. 2018 Aug 28. pii: S0969-2126(18)30291-0. doi: 10.1016/j.str.2018.08.003.
88) Investigation of the Biosynthesis of the Lasso Peptide Chaxapeptin Using an E. coli-Based Production System.
Martin-Gómez H, Linne U, Albericio F, Tulla-Puche J, Hegemann JD. J Nat Prod. 2018 Sep 28;81(9):2050-2056. doi: 10.1021/acs.jnatprod.8b00392.
87) FliS/flagellin/FliW heterotrimer couples type III secretion and flagellin homeostasis.
Altegoer F, Mukherjee S, Steinchen W, Bedrunka P, Linne U, Kearns DB, Bange G. Sci Rep. 2018 Aug 1;8(1):11552. doi: 10.1038/s41598-018-29884-8.
86) Hinge-Type Dimerization of Proteins by a Tetracysteine Peptide of High Pairing Specificity.
Schrimpf A, Hempel F, Li A, Linne U, Maier UG, Reetz MT, Geyer A. Biochemistry. 2018 Jul 3;57(26):3658-3664. doi: 10.1021/acs.biochem.8b00475.
85) An sRNA and Cold Shock Protein Homolog-Based Feedforward Loop Post-transcriptionally Controls Cell Cycle Master Regulator CtrA.
Robledo M, Schlüter JP, Loehr LO, Linne U, Albaum SP, Jiménez-Zurdo JI, Becker A. Front Microbiol. 2018 Apr 24;9:763. doi: 10.3389/fmicb.2018.00763.
2017
84) Minimal and RNA-free RNase P in Aquifex aeolicus.
Nickel AI, Wäber NB, Gößringer M, Lechner M, Linne U, Toth U, Rossmanith W, Hartmann RK. Proc Natl Acad Sci U S A. 2017 Oct 17;114(42):11121-11126. doi: 10.1073/pnas.1707862114.
83) Sensing of Alzheimer's Disease and Multiple Sclerosis Using Nano-Bio Interfaces.
Hajipour MJ, Ghasemi F, Aghaverdi H, Raoufi M, Linne U, Atyabi F, Nabipour I, Azhdarzadeh M, Derakhshankhah H, Lotfabadi A, Bargahi A, Alekhamis Z, Aghaie A, Hashemi E, Tafakhori A, Aghamollaii V, Mashhadi MM, Sheibani S, Vali H, Mahmoudi M.
J Alzheimers Dis. 2017;59(4):1187-1202. doi: 10.3233/JAD-160206.
82) The RxLR Motif of the Host Targeting Effector AVR3a of Phytophthora infestans Is Cleaved before Secretion.
Wawra S, Trusch F, Matena A, Apostolakis K, Linne U, Zhukov I, Stanek J, Koźmiński W, Davidson I, Secombes CJ, Bayer P, van West P.
Plant Cell. 2017 Jun;29(6):1184-1195. doi: 10.1105/tpc.16.00552.
81) Requirement of the RNA-binding protein SmpB during intracellular growth of Listeria monocytogenes.
Mraheil MA, Frantz R, Teubner L, Wendt H, Linne U, Wingerath J, Wirth T, Chakraborty T.
Int J Med Microbiol. 2017 Apr;307(3):166-173. doi: 10.1016/j.ijmm.2017.01.007.
80) Eight at one stroke - a synthetic tetra-disulfide peptide epitope.
Schrimpf A, Linne U, Geyer A.
Org Biomol Chem. 2017 Mar 22;15(12):2512-2521. doi: 10.1039/c6ob02746f.
79) Regulation of Polyhydroxybutyrate Accumulation in Sinorhizobium meliloti by the Trans-Encoded Small RNA MmgR.
Lagares A Jr, Borella GC, Linne U, Becker A, Valverde C.
J Bacteriol. 2017 Mar 28;199(8). pii: e00776-16. doi: 10.1128/JB.00776-16.
78) A False-Positive Screening Hit in Fragment-Based Lead Discovery: Watch out for the Red Herring.
Cramer J, Schiebel J, Wulsdorf T, Grohe K, Najbauer EE, Ehrmann FR, Radeva N, Zitzer N, Linne U, Linser R, Heine A, Klebe G.
Angew Chem Int Ed Engl. 2017 Feb 6;56(7):1908-1913. doi: 10.1002/anie.201609824.
77) Comprehensive and Systematic Analysis of the Immunocompatibility of Polyelectrolyte Capsules.
Zyuzin MV, Díez P, Goldsmith M, Carregal-Romero S, Teodosio C, Rejman J, Feliu N, Escudero A, Almendral MJ, Linne U, Peer D, Fuentes M, Parak WJ.
Bioconjug Chem. 2017 Feb 15;28(2):556-564. doi: 10.1021/acs.bioconjchem.6b00657.
2016
76) The B1 Protein Guides the Biosynthesis of a Lasso Peptide.
Zhu S, Fage CD, Hegemann JD, Mielcarek A, Yan D, Linne U, Marahiel MA.
Sci Rep. 2016 Oct 18;6:35604. doi: 10.1038/srep35604.
75) Mapping light-driven conformational changes within the photosensory module of plant phytochrome B.
von Horsten S, Straß S, Hellwig N, Gruth V, Klasen R, Mielcarek A, Linne U, Morgner N, Essen LO.
Sci Rep. 2016 Oct 3;6:34366. doi: 10.1038/srep34366.
74) Structure and Mechanism of the Sphingopyxin I Lasso Peptide Isopeptidase.
Fage CD, Hegemann JD, Nebel AJ, Steinbach RM, Zhu S, Linne U, Harms K, Bange G, Marahiel MA.
Angew Chem Int Ed Engl. 2016 Oct 4;55(41):12717-21. doi: 10.1002/anie.201605232.
73) Crystal Structure of Bacillus subtilis Cysteine Desulfurase SufS and Its Dynamic Interaction with Frataxin and Scaffold Protein SufU.
Blauenburg B, Mielcarek A, Altegoer F, Fage CD, Linne U, Bange G, Marahiel MA.
PLoS One. 2016 Jul 6;11(7):e0158749. doi: 10.1371/journal.pone.0158749.
72) Insights into the Unique Phosphorylation of the Lasso Peptide Paeninodin.
Zhu S, Hegemann JD, Fage CD, Zimmermann M, Xie X, Linne U, Marahiel MA.
J Biol Chem. 2016 Jun 24;291(26):13662-78. doi: 10.1074/jbc.M116.722108.
2015
71) Catalytic mechanism and allosteric regulation of an oligomeric (p)ppGpp synthetase by an alarmone.
Steinchen W, Schuhmacher JS, Altegoer F, Fage CD, Srinivasan V, Linne U, Marahiel MA, Bange G.
Proc Natl Acad Sci U S A. 2015 Oct 27;112(43):13348-53. doi: 10.1073/pnas.1505271112.
70) Isolation of Extracellular Polymeric Substances from Biofilms of the Thermoacidophilic Archaeon Sulfolobus acidocaldarius.
Jachlewski S, Jachlewski WD, Linne U, Bräsen C, Wingender J, Siebers B.
Front Bioeng Biotechnol. 2015 Aug 27;3:123.
69) NOX1 supports the metabolic remodeling of HepG2 cells.
Bertram K, Valcu CM, Weitnauer M, Linne U, Görlach A.
PLoS One. 2015 Mar 25;10(3):e0122002.
68) MinD-like ATPase FlhG effects location and number of bacterial flagella during C-ring assembly.
Schuhmacher JS, Rossmann F, Dempwolff F, Knauer C, Altegoer F, Steinchen W, Dörrich AK, Klingl A, Stephan M, Linne U, Thormann KM, Bange G.
Proc Natl Acad Sci U S A. 2015 Mar 10;112(10):3092-7.
2014
67) Functional reconstitution of mitochondrial Fe/S cluster synthesis on Isu1 reveals the involvement of ferredoxin.
Webert H, Freibert SA, Gallo A, Heidenreich T, Linne U, Amlacher S, Hurt E, Mühlenhoff U, Banci L, Lill R.
Nat Commun. 2014 Oct 31;5:5013.
66) C7-prenylation of tryptophanyl and O-prenylation of tyrosyl residues in dipeptides by an Aspergillus terreus prenyltransferase.
Wunsch C, Zou HX, Linne U, Li SM.
Appl Microbiol Biotechnol. 2014 Aug 16.
65) Peroxisomes contribute to biosynthesis of extracellular glycolipids in fungi.
Freitag J, Ast J, Linne U, Stehlik T, Martorana D, Bölker M, Sandrock B.
Mol Microbiol. 2014 Jul;93(1):24-36. doi: 10.1111/mmi.12642. Epub 2014 Jun 3.
2013
64) Structural characterization of the heterobactin siderophores from Rhodococcus erythropolis PR4 and elucidation of their biosynthetic machinery.
Bosello M, Zeyadi M, Kraas FI, Linne U, Xie X, Marahiel MA.
J Nat Prod. 2013 Dec 27;76(12):2282-90. doi: 10.1021/np4006579. Epub 2013 Nov 26.
63) GAPDH: the missing link between glycolysis and mitochondrial oxidative phosphorylation?
Ramzan R, Weber P, Linne U, Vogt S.
Biochem Soc Trans. 2013 Oct;41(5):1294-7.
62) Temperature: the "ignored" factor at the NanoBio interface.
Mahmoudi M, Abdelmonem AM, Behzadi S, Clement JH, Dutz S, Ejtehadi MR, Hartmann R, Kantner K, Linne U, Maffre P, Metzler S, Moghadam MK, Pfeiffer C, Rezaei M, Ruiz-Lozano P, Serpooshan V, Shokrgozar MA, Nienhaus GU, Parak WJ.
ACS Nano. 2013 Aug 27;7(8):6555-62.
61) Covalent inhibition of SUMO and ubiquitin-specific cysteine proteases by an in situ thiol-alkyne addition.
Sommer S, Weikart ND, Linne U, Mootz HD.
Bioorg Med Chem. 2013 May 1;21(9):2511-7
60) Two [4Fe-4S] Clusters Containing Radical SAM Enzyme SkfB Catalyze Thioether Bond Formation during the Maturation of the Sporulation Killing Factor.
Flühe L, Burghaus O, Wieckowski BM, Giessen TW, Linne U, Marahiel MA.
J Am Chem Soc. 2013 Jan 23;135(3):959-62.
59) Two-Photon-Induced Selective Decarboxylation of Aspartic Acids D85 and D212 in Bacteriorhodopsin.
Imhof M, Rhinow D, Linne U, Hampp N.
J Phys Chem Lett. 2012 Oct 18;3(20):2991-4. doi: 10.1021/jz301292n.
2012
58) Isolation, structure elucidation, and biosynthesis of an unusual hydroxamic acid ester-containing siderophore from Actinosynnema mirum.
Giessen TW, Franke KB, Knappe TA, Kraas FI, Bosello M, Xie X, Linne U, Marahiel MA.
J Nat Prod. 2012 May 25;75(5):905-14.
57) Determination of peptide topology through time-resolved double-resonance under electron capture dissociation conditions.
Pérot-Taillandier M, Zirah S, Rebuffat S, Linne U, Marahiel MA, Cole RB, Tabet JC, Afonso C.
Anal Chem. 2012 Jun 5;84(11):4957-64.
56) The radical SAM enzyme AlbA catalyzes thioether bond formation in subtilosin A.
Flühe L, Knappe TA, Gattner MJ, Schäfer A, Burghaus O, Linne U, Marahiel MA.
Nat Chem Biol. 2012 Feb 26;8(4):350-7.
55) Biosynthesis of the iron-guanylylpyridinol cofactor of [Fe]-hydrogenase in methanogenic archaea as elucidated by stable-isotope labeling.
Schick M, Xie X, Ataka K, Kahnt J, Linne U, Shima S.
J Am Chem Soc. 2012 Feb 15;134(6):3271-80.
54) Doped semimetal clusters: ternary, intermetalloid anions [Ln@Sn7Bi7]4- and [Ln@Sn4Bi9]4- (Ln = La, Ce) with adjustable magnetic properties.
Lips F, Hołyńska M, Clérac R, Linne U, Schellenberg I, Pöttgen R, Weigend F, Dehnen S.
J Am Chem Soc. 2012 Jan 18;134(2):1181-91.
53) Evidence for acyl-iron ligation in the active site of [Fe]-hydrogenase provided by mass spectrometry and infrared spectroscopy.
Shima S, Schick M, Kahnt J, Ataka K, Steinbach K, Linne U.
Dalton Trans. 2012 Jan 21;41(3):767-71.
2011
52) Microalgae as bioreactors for bioplastic production.
Hempel F, Bozarth AS, Lindenkamp N, Klingl A, Zauner S, Linne U, Steinbüchel A, Maier UG.
Microb Cell Fact. 2011 Oct 17;10:81.
51) Beta hydroxylation of glycolipids from Ustilago maydis and Pseudozyma flocculosa by an NADPH-dependent β-hydroxylase.
Teichmann B, Lefebvre F, Labbé C, Bölker M, Linne U, Bélanger RR.
Appl Environ Microbiol. 2011 Nov;77(21):7823-9.
50) Chemical engineering of Mycobacterium tuberculosis dodecin hybrids.
Vinzenz X, Grosse W, Linne U, Meissner B, Essen LO.
Chem Commun (Camb). 2011 Oct 21;47(39):11071-3.
49) Introducing lasso peptides as molecular scaffolds for drug design: engineering of an integrin antagonist.
Knappe TA, Manzenrieder F, Mas-Moruno C, Linne U, Sasse F, Kessler H, Xie X, Marahiel MA.
Angew Chem Int Ed Engl. 2011 Sep 5;50(37):8714-7.
48) Stereo- and regioselective azide/alkyne cycloadditions in carbonic anhydrase II via tethering, monitored by crystallography and mass spectrometry.
Wischeler JS, Sun D, Sandner NU, Linne U, Heine A, Koert U, Klebe G.
Chemistry. 2011 May 16;17(21):5842-51.
47) Topoisomer differentiation of molecular knots by FTICR MS: lessons from class II lasso peptides.
Zirah S, Afonso C, Linne U, Knappe TA, Marahiel MA, Rebuffat S, Tabet JC.
J Am Soc Mass Spectrom. 2011 Mar;22(3):467-79.
46) Biosynthesis of the siderophore rhodochelin requires the coordinated expression of three independent gene clusters in Rhodococcus jostii RHA1.
Bosello M, Robbel L, Linne U, Xie X, Marahiel MA.
J Am Chem Soc. 2011 Mar 30;133(12):4587-95.
45) Identification of a biosynthesis gene cluster for flocculosin a cellobiose lipid produced by the biocontrol agent Pseudozyma flocculosa.
Teichmann B, Labbé C, Lefebvre F, Bölker M, Linne U, Bélanger RR.
Mol Microbiol. 2011 Mar;79(6):1483-95.
2010
44) Simultaneous C7- and N1-prenylation of cyclo-L-Trp-L-Trp catalyzed by a prenyltransferase from Aspergillus oryzae.
Zou HX, Xie XL, Linne U, Zheng XD, Li SM.
Org Biomol Chem. 2010 Jun 28;8(13):3037-44.
43) Bacterial translation elongation factor EF-Tu interacts and colocalizes with actin-like MreB protein.
Defeu Soufo HJ, Reimold C, Linne U, Knust T, Gescher J, Graumann PL.
Proc Natl Acad Sci U S A. 2010 Feb 16;107(7):3163-8.
42) Elucidation of the complete ferrichrome A biosynthetic pathway in Ustilago maydis.
Winterberg B, Uhlmann S, Linne U, Lessing F, Marahiel MA, Eichhorn H, Kahmann R, Schirawski J.
Mol Microbiol. 2010 Mar;75(5):1260-71.
41) Erythrochelin--a hydroxamate-type siderophore predicted from the genome of Saccharopolyspora erythraea.
Robbel L, Knappe TA, Linne U, Xie X, Marahiel MA.
FEBS J. 2010 Feb;277(3):663-76.
40) ATP-dependent carboxylation of acetophenone by a novel type of carboxylase.
Jobst B, Schühle K, Linne U, Heider J.
J Bacteriol. 2010 Mar;192(5):1387-94.
39) The glucagon receptor antagonist BI-32169 constitutes a new class of lasso peptides.
Knappe TA, Linne U, Xie X, Marahiel MA.
FEBS Lett. 2010 Feb 19;584(4):785-9.
2009
39) Insights into the biosynthesis and stability of the lasso peptide capistruin.
Knappe TA, Linne U, Robbel L, Marahiel MA.
Chem Biol. 2009 Dec 24;16(12):1290-8.
37) Photoreduction of the folate cofactor in members of the photolyase family.
Moldt J, Pokorny R, Orth C, Linne U, Geisselbrecht Y, Marahiel MA, Essen LO, Batschauer A.
J Biol Chem. 2009 Aug 7;284(32):21670-83. Epub 2009 Jun 16.
36) On the function and structure of synthetically modified porins.
Reitz S, Cebi M, Reiss P, Studnik G, Linne U, Koert U, Essen LO.
Angew Chem Int Ed Engl. 2009;48(26):4853-7.
35) Physical-chemical plant-derived signals induce differentiation in Ustilago maydis.
Mendoza-Mendoza A, Berndt P, Djamei A, Weise C, Linne U, Marahiel M, Vranes M, Kämper J, Kahmann R.
Mol Microbiol. 2009 Feb;71(4):895-911. Epub 2008 Dec 23.
2008
34) Role of DptE and DptF in the lipidation reaction of daptomycin.
Wittmann M, Linne U, Pohlmann V, Marahiel MA.
FEBS J. 2008 Nov;275(21):5343-54.
33) Isolation and structural characterization of capistruin, a lasso peptide predicted from the genome sequence of Burkholderia thailandensis E264.
Knappe TA, Linne U, Zirah S, Rebuffat S, Xie X, Marahiel MA.
J Am Chem Soc. 2008 Aug 27;130(34):11446-54. Epub 2008 Aug 1.
32) Harnessing the chemical activation inherent to carrier protein-bound thioesters for the characterization of lipopeptide fatty acid tailoring enzymes.
Kopp F, Linne U, Oberthür M, Marahiel MA.
J Am Chem Soc. 2008 Feb 27;130(8):2656-66. Epub 2008 Feb 1.
2007
31) A biosynthetic gene cluster for a secreted cellobiose lipid with antifungal activity from Ustilago maydis.
Teichmann B, Linne U, Hewald S, Marahiel MA, Bölker M.
Mol Microbiol. 2007 Oct;66(2):525-33. Epub 2007 Sep 10.
30) Detection of nonribosomal peptide synthetase genes in Xylaria sp. BCC1067 and cloning of XyNRPSA.
Paungmoung P, Punya J, Pongpattanakitshote S, Jeamton W, Vichisoonthonkul T, Bhumiratana S, Tanticharoen M, Linne U, Marahiel MA, Cheevadhanarak S.
FEMS Microbiol Lett. 2007 Sep;274(2):260-8. Epub 2007 Jul 9.
29) Use of biotin derivatives to probe conformational changes in proteins.
Azim-Zadeh O, Hillebrecht A, Linne U, Marahiel MA, Klebe G, Lingelbach K, Nyalwidhe J.
J Biol Chem. 2007 Jul 27;282(30):21609-17. Epub 2007 Jun 1.
28) Aminoacyl-coenzyme A synthesis catalyzed by adenylation domains.
Linne U, Schäfer A, Stubbs MT, Marahiel MA.
FEBS Lett. 2007 Mar 6;581(5):905-10. Epub 2007 Feb 7.
2006
27) Impact of epimerization domains on the intermodular transfer of enzyme-bound intermediates in nonribosomal peptide synthesis.
Stein DB, Linne U, Hahn M, Marahiel MA.
Chembiochem. 2006 Nov;7(11):1807-14.
26) In vivo biocombinatorial synthesis of lipopeptides by COM domain-mediated reprogramming of the surfactin biosynthetic complex.
Chiocchini C, Linne U, Stachelhaus T.
Chem Biol. 2006 Aug;13(8):899-908.
25) Rational design of bacitracin A derivatives by incorporating natural product derived heterocycles.
Wagner B, Schumann D, Linne U, Koert U, Marahiel MA.
J Am Chem Soc. 2006 Aug 16;128(32):10513-20.
24) Ferri-bacillibactin uptake and hydrolysis in Bacillus subtilis.
Miethke M, Klotz O, Linne U, May JJ, Beckering CL, Marahiel MA.
Mol Microbiol. 2006 Sep;61(6):1413-27. Epub 2006 Aug 3.
23) Identification of a gene cluster for biosynthesis of mannosylerythritol lipids in the basidiomycetous fungus Ustilago maydis.
Hewald S, Linne U, Scherer M, Marahiel MA, Kämper J, Bölker M.
Appl Environ Microbiol. 2006 Aug;72(8):5469-77.
22) Ligation of a synthetic peptide to the N terminus of a recombinant protein using semisynthetic protein trans-splicing.
Ludwig C, Pfeiff M, Linne U, Mootz HD.
Angew Chem Int Ed Engl. 2006 Aug 4;45(31):5218-21.
21) Formylation domain: an essential modifying enzyme for the nonribosomal biosynthesis of linear gramicidin.
Schoenafinger G, Schracke N, Linne U, Marahiel MA.
J Am Chem Soc. 2006 Jun 14;128(23):7406-7.
20) PNA-based reagents for the direct and site-specific synthesis of thymine dimer lesions in genomic DNA.
Pieck JC, Kuch D, Grolle F, Linne U, Haas C, Carell T.
J Am Chem Soc. 2006 Feb 8;128(5):1404-5.
2005
19) Utility of epimerization domains for the redesign of nonribosomal peptide synthetases.
Stein DB, Linne U, Marahiel MA.
FEBS J. 2005 Sep;272(17):4506-20.
18) Fluorescence resonance energy transfer as a probe of peptide cyclization catalyzed by nonribosomal thioesterase domains.
Grünewald J, Kopp F, Mahlert C, Linne U, Sieber SA, Marahiel MA.
Chem Biol. 2005 Aug;12(8):873-81.
17) Synthesis of linear gramicidin requires the cooperation of two independent reductases.
Schracke N, Linne U, Mahlert C, Marahiel MA.
Biochemistry. 2005 Jun 14;44(23):8507-13.
2004
16) Synthesis and derivatization of daptomycin: a chemoenzymatic route to acidic lipopeptide antibiotics.
Grünewald J, Sieber SA, Mahlert C, Linne U, Marahiel MA.
J Am Chem Soc. 2004 Dec 29;126(51):17025-31.
15) RNA is more UV resistant than DNA: the formation of UV-induced DNA lesions is strongly sequence and conformation dependent.
Kundu LM, Linne U, Marahiel M, Carell T.
Chemistry. 2004 Nov 5;10(22):5697-705.
14) Relative binding affinities of molecular capsules investigated by ESI-mass spectrometry.
Zadmard R, Kraft A, Schrader T, Linne U.
Chemistry. 2004 Sep 6;10(17):4233-9.
13) Prevention of Alzheimer's disease-associated Abeta aggregation by rationally designed nonpeptidic beta-sheet ligands.
Rzepecki P, Nagel-Steger L, Feuerstein S, Linne U, Molt O, Zadmard R, Aschermann K, Wehner M, Schrader T, Riesner D.
J Biol Chem. 2004 Nov 12;279(46):47497-505. Epub 2004 Aug 20.
12) Reactions catalyzed by mature and recombinant nonribosomal peptide synthetases.
Linne U, Marahiel MA.
Methods Enzymol. 2004;388:293-315.
11) Mutational analysis of a type II thioesterase associated with nonribosomal peptide synthesis.
Linne U, Schwarzer D, Schroeder GN, Marahiel MA.
Eur J Biochem. 2004 Apr;271(8):1536-45.
10) The linear pentadecapeptide gramicidin is assembled by four multimodular nonribosomal peptide synthetases that comprise 16 modules with 56 catalytic domains.
Kessler N, Schuhmann H, Morneweg S, Linne U, Marahiel MA.
J Biol Chem. 2004 Feb 27;279(9):7413-9. Epub 2003 Dec 11.
2003
9) The two main DNA lesions 8-Oxo-7,8-dihydroguanine and 2,6-diamino-5-formamido-4-hydroxypyrimidine exhibit strongly different pairing properties.
Ober M, Linne U, Gierlich J, Carell T.
Angew Chem Int Ed Engl. 2003 Oct 20;42(40):4947-51.
8) Systematic and quantitative analysis of protein-protein recognition between nonribosomal peptide synthetases investigated in the tyrocidine biosynthetic template.
Linne U, Stein DB, Mootz HD, Marahiel MA.
Biochemistry. 2003 May 6;42(17):5114-24.
2002
7) Regeneration of misprimed nonribosomal peptide synthetases by type II thioesterases.
Schwarzer D, Mootz HD, Linne U, Marahiel MA.
Proc Natl Acad Sci U S A. 2002 Oct 29;99(22):14083-8. Epub 2002 Oct 16.
6) Evidence for a monomeric structure of nonribosomal Peptide synthetases.
Sieber SA, Linne U, Hillson NJ, Roche E, Walsh CT, Marahiel MA.
Chem Biol. 2002 Sep;9(9):997-1008.
5) Decreasing the ring size of a cyclic nonribosomal peptide antibiotic by in-frame module deletion in the biosynthetic genes.
Mootz HD, Kessler N, Linne U, Eppelmann K, Schwarzer D, Marahiel MA.
J Am Chem Soc. 2002 Sep 18;124(37):10980-1.
4) Timing of epimerization and condensation reactions in nonribosomal peptide assembly lines: kinetic analysis of phenylalanine activating elongation modules of tyrocidine synthetase B.
Luo L, Kohli RM, Onishi M, Linne U, Marahiel MA, Walsh CT.
Biochemistry. 2002 Jul 23;41(29):9184-96.
3) Mutational analysis of the C-domain in nonribosomal peptide synthesis.
Bergendahl V, Linne U, Marahiel MA.
Eur J Biochem. 2002 Jan;269(2):620-9.
2001
2) Portability of epimerization domain and role of peptidyl carrier protein on epimerization activity in nonribosomal peptide synthetases.
Linne U, Doekel S, Marahiel MA.
Biochemistry. 2001 Dec 25;40(51):15824-34.
2000
1) Control of directionality in nonribosomal peptide synthesis: role of the condensation domain in preventing misinitiation and timing of epimerization.
Linne U, Marahiel MA.
Biochemistry. 2000 Aug 29;39(34):10439-47.