Research group Prof. Dr. Shu-Ming Li

Successful doctoral defence in 2024: Sina Stierle, Daniel Janzen, Andreas Martin, Zhengxi Zhang, Jenny Zhou, Marlies Peter, Zhanghai Li, Yu Dai
Crosstalk of multiple pathways in Penicillium crustosum. Organic Letters, 26, DOI: 10.1021/acs.orglett.4c03698
Alkyl and hydride migrations in sesquiterpenoid biosynthesis. Organic Letters, 26, DOI: 10.1021/acs.orglett.4c0235
Structural basis of cytochrome P450 enzymes for intramolecular coupling and nucleobase transfer. ChemCatChem, 16, DOI: 10.1002/cctc.202400105
Poster prizes for Marlies Peter and Jenny Zhou at the International PhD Student & Postdoc Meeting 2024 in Marburg

Summary on cytochrome P450 enzymes as nucleobase transferases. Methods Enzymol., vol 693, 2023, DOI: 10.1016/bs.mie.2023.09.012
Biosynthesis of p-terphenyls in fungi. Org. Lett. 2023, DOI: 10.1021/acs.orglett.3c02234
Flavin-catalyzed oxidative indole ring opening of indole diterpenes and oxygen incorporation from solvent water. Org. Lett. 2023, DOI: 10.1021/acs.orglett.3c01320

A berberine bridge enzyme-like protein catalyzes an oxidative lactonization between two hydroxyl groups. Org. Lett. 2022, 24, 6072–6077, DOI: 10.1021/acs.orglett.2c02438
Widely distributed bifunctional cytochrome P450 enzymes for both intramolecular C-C bond formation in cYY and its coupling with guanine and hypoxanthine. Angew.Chem.Intern.Ed. 2022, 61, e202200377.
A bifunctional nonreducing polyketide synthase from Penicillium crustosum. Org. Lett. 2022, 24, 462–466.
Two different oxidases install exo-double bonds at the diketopiperazine ring. ACS Catal. 2022, 12, 648–654. Pressemitteilung der Universität Marburg, Highlighted in Hot off the Press in Nat. Prod. Rep. 2022
Cytochrome P450-mediated meta hydroxylation at a monoalkylated benzene ring. Org. Lett. 2022, 24, 262–267.

Promotionspreis (doctoral prize) of the Philipps-University 2021 for Dr. Jie Fan. Congratulations!
Summary on prenylated chalcones from plants. Nat. Prod. Rep. 2021,
Specific and stereoselective ring expansion in the biosynthesis of oxepinamides. Org. Lett. 2021, 23, 2024-2028. Highlighted in Hot off the Press in Nat. Prod. Rep. 2021.
Cyclodipeptide synthase-associated cytochrome P450 enyzmes. Appl. Microbiol. Biotechnol. 2021, 105, 2277–2285.
Systematic summary on fungal benzene carbaldehydes. Nat. Prod. Rep. 2021, 38, 240-263.

PHOENIX Pharmaceutics Science Award 2020 for Prof. Li and his team, Pressemitteilung der Universität Marburg
Phenethyl derivative formation in Aspergillus ustus. Org. Lett. 2020, 22, 7837. Highlighted in Hot off the Press in Nat. Prod. Rep. 2020.
Elucidation of the first oxepinamide biosynthetic pathway in fungi. Nature Commun. 2020,11, 4914
Two new cyclodipeptide dimerases from Saccharopolyspora antimicrobica. ChemComm 2020, 56, 11042–11045. Highlighted in Hot off the Press in Nat. Prod. Rep. 2020.
Accumulation of an isocoumarin in an Aspergillus nidulans strain carrying a polyketide synthase gene and its modification by host enzymes, Org. Biomol. Chem. 2020, 18, 4946-4948. Highlighted in Hot off the Press in Nat. Prod. Rep. 2020.
Biosynthesis of the prenylated salicylaldehyde flavoglaucin provides an example for a highly programmed machinery in natural product biosynthesis, Org. Lett. 2020, 22, 2256
ortho-Quinone methide as highly reactive coupling reagent with diverse natural products, J. Org. Chem, 2020, 85, 1298
Conversion of a 5ß-carboxylmethyl acyltetronate to a 5a-methyl derivative by consecutive oxidation and reduction, Org. Lett. 2020, 22, 88. Highlighted in Hot off the Press in Nat. Prod. Rep. 2020.

Coupling of hypoxanthin with cyclodipeptides catalyzed by cytochrome P450 enzymes, Org. Lett. 2019, 21, 9104
Two cytochrome P450 enzymes catalyze new dimerization patterns of tryptophan–containing cyclodipeptides, Org. Lett. 2019, 21,7094
Small but effective: Two similar five gene-clusters of about 4 kbps from two Streptomyces strains are responsible for the biosynthesis of guanitryptmycins, Angew. Chem. Intern. Ed. 2019, 58, 11534, Highlighted in Hot off the Press in Nat. Prod. Rep. 2019, Pressemitteilung der Universität Marburg
A fungus of deep-sea sediment as a potential host for gene expression, ACS Chem. Biol. 2019, 14, 1227
Non-enzymatic 1,4-Michael Additions in the formation of fungal metabolites, J. Am. Chem. Soc. 2019, 141, 4225, Pressemitteilung der Universität Marburg
Domain recombination of nonribosomal peptide synthetase (NRPS)-like enzymes in Saccharomyces cerevisiae, Org. Lett. 2019, 21, 498

Increasing structural diversity of geranylated cyclic dipeptides by site-directed mutagenesis of the available dimethylallyl transferases, Org. Lett. 2018, 20, 7201
Hydroxylation and double bond migration within a dimethylallyl moiety, ACS Chem. Biol. 2018, 13, 2949
A bacterial cytochrome P450 enzyme functions as a guaninyl transferase of cyclodipeptides, Org. Lett. 2018, 20, 4921

Gem-diprenylation by one fungal prenyltransferase, Org. Lett. 2017, 19, 388
One prenyltransferase catalyzes at least three prenylation steps, Org. Lett. 2017, 19, 5928
Spontaneous formation of prenylated β-carbolines after tryptophan prenylation in Saccharomyces cerevisiae, ACS Syn. Biol. 2017, 6, 1056
Very high promiscuity of an aromatic prenyltransferase, Nature Chem. Biol. 2017, 13, 226

Prenyltransferases as key enzymes in primary and secondary metabolism as well as in the chemoenzymatic synthesis, Appl. Microbiol. Biotechn. 2015, 99, 7379; Appl. Microbiol. Biotechn. 2015, 99, 7399

Stereospecific formation of cis-configured prenylated pyrroloindoline diketopiperazines, Chem. Biol. 2013, 20, 1492

Acceptance of unnatural allyl donors by DMATS prenyltransferases, Org. Lett. 2012, 14, 4882; Org. Lett. 2013, 15, 3062; Org. Lett. 2013, 15, 5834

Ergot alkaloids as important natural products, Nat. Prod. Rep. 2011, 28, 496
Fumitremorgin-type alkaloids, J. Antibiot. 2011, 64, 45

The first crystal structure of tryptophan-containing cyclic dipeptide prenyltransferases, J. Am. Chem. Soc. 2010, 132, 17849
Fungal prenylated indole derivatives as important natural products, Nat. Prod. Rep. 2010, 27, 57

PHOENIX Pharmaceutics Science Award 2009 for Ole Rigbers and Shu-Ming Li, Pressemitteilung der Universität Marburg
The first crystal structure of the fungal DMATS prenyltransferases, Proc. Natl. Acad. Sci. USA 2009, 106, 14309