Hauptinhalt

tRNA-Prozessierung - RNase P

• Mechanismus der Katalyse
• Evolution von RNA-basierten und Protein-Allein-Enzymen
• Antibiotische Hemmung von RNase P-Enzymen

Aktuelle Publikationen

Schwarz TS, Wäber NB, Feyh R, Weidenbach K, Schmitz RA, Marchfelder A, Hartmann RK (2019) Homologs of Aquifex aeolicus protein-only RNase P are not the major RNase P activities in the archaea Haloferax volcanii and Methanosarcina mazei. IUBMB Life 71(8):1109-1116

Nickel AI, Wäber NB, Gößringer M, Lechner M, Linne U, Toth U, Rossmanith W, Hartmann RK (2017) Minimal and RNA-free RNase P in Aquifex aeolicus. Proc Natl Acad Sci U S A. 114(42):11121-11126

Gößringer M, Lechner M, Brillante N, Weber C, Rossmanith W, Hartmann RK (2017) Protein-only RNase P function in Escherichia coli: viability, processing defects and differences between PRORP isoenzymes. Nucleic Acids Res. 45(12):7441-7454.

Kooperationspartner

Prof. W. Rossmanith, Wien; Prof. A. Marchfelder, Ulm; Prof. W. Diederich/Prof. M. Schlitzer/Prof. K. Reuter (Marburg)

Funding

DFG

Ansprechpartner

M. Gößringer, R.K. Hartmann