Hauptinhalt
Publications Carsten Culmsee
Selected Publications
2024
Günther M, Schnierle P, Rose T, Schlegel J, Boonen G, Drewe J, Muñoz E, Fiebich BL, Culmsee C. AMPK-activation by Cimicifuga racemosa extract Ze 450 is associated with metabolic effects and cellular resilience against age-related pathologies in different tissue cell types. Pharmaceutics. 2024 16(3):393. doi: 10.3390/pharmaceutics16030393
Porth J, Ajouri J, Kleinlein M, Höcker M, Elke G, Meybohm P, Culmsee C, Muellenach RM. [Application and control of intravenous fluids in German intensive care units: a national survey among critical care physicians]. (In German) Anaesthesiologie 2024 73(2):85-92. doi: 10.1007/s00101-024-01379-4.
2023
Günther M, Dabare S, Fuchs J, Gunesch S, Hofmann J, Decker M, Culmsee C. Flavonoid-phenolic acid hybrids are potent inhibitors of ferroptosis via attenuation of mitochondrial impairment. Antioxidants 2023 13(1):44. doi: 10.3390/antiox13010044.
Uzuegbunam BC, Rummel C, Librizzi D, Culmsee C, Hooshyar Yousefi B. Radiotracers for imaging of inflammatory biomarkers TSPO and COX-2 in the brain and in the periphery. Int J Mol Sci. 2023 24(24):17419. doi: 10.3390/ijms242417419.
Hernandez J, Schäffer J, Herden C, Pflieger FJ, Reiche S, Körber S, Kitagawa H, Welter J, Michels S, Culmsee C, Bier J, Sommer N, Kang JX, Mayer K, Hecker M, Rummel C. n-3 Polyunsaturated Fatty Acids Modulate LPS-Induced ARDS and the Lung-Brain Axis of Communication in Wild-Type versus Fat-1 Mice Genetically Modified for Leukotriene B4 Receptor 1 or Chemerin Receptor 23 Knockout. Int J Mol Sci. 2023 Aug 31;24(17):13524. doi: 10.3390/ijms241713524.
Schindler F, Schinkoethe T, Mahner S, Kolben T, Wuerstlein R, Culmsee C, Harbeck N, Eggersmann TK. Clinical relevance of potential self-medication drug interactions in antineoplastic and immune-modulating therapy among online pharmacy customers. Ther Adv Drug Safety 2023 Aug 24;14:20420986231188845. doi: 10.1177/20420986231188845. eCollection 2023.
Merkel M, Goebel B, Boll M, Adhikari A, Maurer V, Steinhilber D, Culmsee C. Mitochondrial reactive oxygen species formation determines ACSL4/LPCAT2-mediated ferroptosis. Antioxidants 2023 12(8):1590. doi: 10.3390/antiox12081590
Chen T, Majernikova N, Marmolejo-Garza A, Trombetta-Lima M, Sabogal-Guaqueta AM, Zhang Y, Ten Kate R, Zuidema M, Mulder PPMFA, den Dunnen W, Gosens R, Verpoorte E, Culmsee C, Eisel ULM, Dolga AM. Mitochondrial transplantation rescues neuronal cells from ferroptosis. Free Radic Biol Med. 2023 208:62-72. doi: 10.1016/j.freeradbiomed.2023
Han W, Meißner EM, Neunteibl S, Günther M, Kahnt J, Dolga AM, Xie C, Plesnila N, Zhu C, Blomgren K, Culmsee C. Dying transplanted neural stem cells mediate survival bystander effects in the injured brain. Cell Death Dis. 2023 14(3):173. doi 10.1038/s41419-023-05698-z.
Correction: Cell Death Dis. 2023 14(3):203
Locatelli G, Marques-Ferreira F, Katsoulas A, Kalaitzaki V, Krueger M, Ingold-Heppner B, Walthert S, Sankowski R, Prazeres da Costa O, Dolga A, Huber M, Gold M, Culmsee C, Waisman A, Bechmann I, Milchevskaya V, Prinz M, Tresch A, Becher B, Buch T. IGF1R expression by adult oligodendrocytes is not required in the steady-state but supports neuroinflammation. Glia 2022 71(3):616-632. doi: 10.1002/glia.24299
2022
Drewe J, Boonen G, Culmsee C. Treat more than heat - New therapeutic implications of Cimicifuga racemosa through AMPK-dependent metabolic effects. Phytomedicine 2022 100:154060. doi: 10.1016/j.phymed.2022.154060
Ramzan R, Dolga AM, Michels S, Weber P, Culmsee C, Rastan AJ, Vogt S. Cytochrome c oxidase inhibition by ATP decreases mitochondrial ROS production. Cells 2022 11(6):992. doi: 10.3390/cells11060992
Bredehöft J, Dolga AM, Honrath B, Wache S, Mazurek S, Culmsee C, Schoemaker RG, Gerstberger R, Roth J, Rummel C. SK-Channel activation alters peripheral metabolic pathways in mice, but not lipopolysaccharide-induced fever or inflammation. J Inflame Res. 2022 15:509-531. doi: 10.2147/JIR.S338812
2021
Zhao K, Schäfer A, Zhang Z, Elsässer K, Culmsee C, Zhong L, Pagenstecher A, Rimsky C, Bartsch JW. Inhibition of carbonic anhydrase 2 overcomes temozolomide resistance in glioblastoma cells. Int J Mol Sci. 2021 23(1):157. doi: 10.3390/ijms23010157
Hoffmann L, Waclawczyk MS, Tang S, Hanschmann EM, Gellert M, Rust MB, Culmsee C. Cofilin oxidation links oxidative distress to mitochondrial demise and neuronal cell death. Cell Death Dis. 2021 12(11):953. doi: 10.1038/s41419-021-04242-1
Rabenau M, Dillberger B, Günther M, Krippner S, Butterweck V, Boonen G, Drewe J, Eckert GP, Culmsee C. Cimicifuga racemosa extract Ze 450 re-balances energy metabolism and promotes longevity. Antioxidants (Basel) 2021 10(9):1432.
doi: 10.3390/antiox10091432
Wehn AC, Khalin I, Duering M, Hellal F, Culmsee C, Vandenabeele P, Plesnila N, Terpolilli NA. RIPK1 or RIPK3 deletion prevents progressive neuronal cell death and improves memory function after traumatic brain injury. Acta Neuropathol Commun. 2021 9(1):138. doi: 10.1186/s40478-021-01236-0
Russo L, Mascanzoni F, Farina B, Dolga AM, Monti A, Caporale A, Culmsee C, Fattorusso R, Ruvo M, Doti N. Design, Optimization, and structural characterization of an apoptosis-inducing factor peptide targeting human cyclophilin A to inhibit apoptosis inducing factor-mediated cell death. J Med Chem 2021 64(15):11445-11459. doi: 10.1021/acs.jmedchem.1c00777
Hinder L, Pfaff AL, Emmerich RE, Michels S, Schlitzer M, Culmsee C. Characterization of novel diphenylamine compounds as ferroptosis inhibitors. J Pharmacol Exp Ther 2021 378(2):184-196. doi: 10.1124/jpet.121.000534
Wilkaniec A, Lenkiewicz AM, Babiec L, Murawska E, Jesko HM, Cieslik M, Culmsee C, Adamczyk A. Exogenous alpha-synuclein evoked parkin downregulation promotes mitochondrial dysfunction in neuronal cells. Implications for Parkinson's Disease pathology. Front Aging Neurosci 2021 24:13:591475. doi:10.3389/fnagi.2021.591475
Kepser LJ, Khudayberdiev S, Hinojosa LS, Macchi C, Ruscica M, Marcello E, Culmsee C, Grosse R, Rust MB. Cyclase-associated protein 2 (CAP2) controls MRTF-A localization and SRF activity in mouse embryonic fibroblasts. Sci Rep 2021 26:11(1):4789. doi: 10.1038/s41598-021-84213-w
2020
Clemente LP, Rabenau M, Tang S, Stanka J, Cors E, Stroh J, Culmsee C, von Karstedt S. Dynasore blocks ferroptosis through combined modulation of iron uptake and inhibition of mitochondrial respiration. Cells 2020 9:9(10):E2259. doi: 10.3390/cells9102259
Schindler E, Hohmann C, Culmsee C. Medication review by community pharmacists for type 2 diabetes patients in routine care: results of the DIATHEM-study. Front Pharmacol. 2020 12;11:01176. doi: 10.3389/fpharm.2020.01176
Krabbendam IE, Honrath B, Dilberger B, Iannetti EF, Branicky RS, Meyer T, Evers B, Dekker FJ, Koopman WJH, Beyrath J, Bano D, Schmidt M, Bakker BM, Hekimi S, Culmsee C, Eckert GP, Dolga AM. SK channel-mediated metabolic escape to glycolysis inhibits ferroptosis and supports stress resistance in C. elegans. Cell Death Dis. 2020 11(4):263. doi: 10.1038/s41419-020-2458-4
Richter M, Vidovic N, Biber K, Dolga A, Culmsee C, Dodel R. The neuroprotective role of microglial cells against amyloid beta-mediated toxicity in organotypic hippocampal slice cultures. Brain Pathol. 2020 30(3):589-602. doi: 10.1111/bpa.12807
Krabbendam IE, Honrath B, Bothof L, Silva-Pavez E, Huerta H, Peñaranda Fajardo NM, Dekker F, Schmidt M, Culmsee C, César Cárdenas J, Kruyt F, Dolga AM. SK channel activation potentiates auranofin-induced cell death in glio- and neuroblastoma cells. Biochem Pharmacol. 2020 171:113714. doi: 10.1016/j.bcp.2019.113714
2019
Frommer KW, Hasseli R, Schäffler A, Lange U, Rehart S, Steinmeyer J, Rickert M, Sarter K, Zaiss MM, Culmsee C, Ganjam G, Michels S, Müller-Ladner U, Neumann E. Free fatty acids in bone pathophysiology of rheumatic diseases. Front Immunol. 2019 10:2757. doi: 10.3389/fimmu.2019.02757
Ganjam GK, Bolte K, Matschke LA, Neitemeier S, Dolga AM, Höllerhage M, Höglinger GU, Adamczyk A, Decher N, Oertel WH, Culmsee C. Mitochondrial damage by alpha-synuclein causes cell death in human dopaminergic neurons. Cell Death Dis. 2019 10(11):865. doi: 10.1038/s41419-019-2091-2
Michels S, Dolga AM, Braun MD, Kisko TM, Sungur AÖ, Witt SH, Rietschel M, Dempfle A, Wöhr M, Schwarting RKW, Culmsee C. Interaction of the psychiatric risk gene Cacna1c with post-weaning social isolation or environmental enrichment does not affect brain mitochondrial bioenergetics in rats. Front Cell Neurosci. 2019 13:483. doi: 10.3389/fncel.2019.00483
Panahpour H, Terpolilli NA, Schaffert D, Culmsee C, Plesnila N. Central application of Aliskiren, a renin inhibitor, improves outcome after experimental stroke independent of its blood pressure lowering effect. Front Neurol 2019 10:942. doi: 10.3389/fneur.2019.00942
Kessemeier N, Meyn D, Hoeckel M, Reitze J, Culmsee C, Tryba M. A new approach on assessing clinical pharmacists' impact on prescribing errors in a surgical intensive care unit. Int J Clin Pharm. 2019 41(5):1184-1192. doi: 10.1007/s11096-019-00874-8
Hoffmann L, Rust MB, Culmsee C. Actin(g) on mitochondria - a role for cofilin1 in neuronal cell death pathways. Biol Chem. 2019 400(9):108-1097. doi: 10.1515/hsz-2019-0120
Li K, Li T, Wang Y, Xu Y, Zhag S, Culmsee C, Wang X, Zhu C. Sex differences in neonatal mouse brain injury after hypoxia-ischemia and adaptaquin treatment. J Neurochem 2019 150(6):759-775. doi: 10.1111/jnc.14790
Ramzan R, Michels S, Weber P, Rhiel A, Irqsusi M, Rastan AJ, Culmsee C, Vogt S. Protamine sulfate induces mitochondrial hyperpolarization and a subsequent increase in reactive oxygen species production. J Pharmacol Exp Ther. 2019 370(2):308-317. doi: 10.1124/jpet.119.257725.
Rabenau M, Unger M, Drewe J, Culmsee C. Metabolic switch induced by Cimicifuga racemosa extract prevents mitochondrial damage and oxidative cell death. Phytomedicine. 2019; 52: 107-116. doi: 10.1016/j.phymed.2018.09.177
Wilkaniec A, Lenkiewicz AM, Czapski GA, Jęśko HM, Hilgier W, Brodzik R, Gąssowska-Dobrowolska M, Culmsee C, Adamczyk A. Extracellular Alpha-Synuclein Oligomers Induce Parkin S-Nitrosylation: Relevance to Sporadic Parkinson's Disease Etiopathology. Mol Neurobiol. 2019; 56:125-140. doi: 10.1007/s12035-018-1082-0
Culmsee C, Michels S, Scheu S, Arolt V, Dannlowski U, Alferink J. Mitochondria, microglia and the immune system – how are they linked in affective disorders? Frontiers Psychiatry. 2019; 9:739. doi: 10.3389/fpsyt.2018.00739
Wu Y, Song J, Wang Y, Wang X, Culmsee C, Zhu C. The potential role of ferroptosis in neonatal brain injury. Frontiers in Neuroscience. 2019; 13:115. doi: 10.3389/fnins.2019.00115
Kircher T, Wöhr M, Nenadic I, Schwarting R, Schratt G, Alferink J, Culmsee C, Garn H, Hahn T, Müller-Myhsok B, Dempfle A, Hahmann M, Jansen A, Pfefferle P, Renz H, Rietschel M, Witt SH, Nöthen M, Krug A, Dannlowski U. Neurobiology of the major psychoses: a translational perspective on brain structure and function-the FOR2107 consortium. Eur Arch Psychiatry Clin Neurosci. 2019; 269(8):949-962. doi: 10.1007/s00406-018-0943-x
2018
Kisko TM, Braun MD, Michels S, Witt SH, Rietschel M, Culmsee C, Schwarting RKW, Wöhr M. Sex-dependent effects of Cacna1c haploinsufficiency on juvenile social play behavior and pro-social 50-kHz ultrasonic communication in rats. Genes Brain Behav. 2018; 27:e12552. doi: 10.1111/gbb.12552
Rabenau M, Unger M, Drewe J, Culmsee C. Effects of Cimicifuga racemosa extract Ze450 on mitochondria in models of oxidative stress in neuronal cells. Data Brief. 2018; 21:1872-1879. doi: 10.1016/j.dib.2018.10.092
Ganjam GK, Terpolilli NA, Diemert S, Eisenbach I, Hoffmann L, Reuther C, Herden C, Roth J, Plesnila N, Culmsee C. Cylindromatosis mediates neuronal cell death in vitro and in vivo. Cell Death Differ. 2018; 25:1394-1407. doi: 10.1038/s41418-017-0046-7
Kisko TM, Braun MD, Michels S, Witt SH, Rietschel M, Culmsee C, Schwarting RKW, Wöhr M. Cacna1c haploinsufficiency leads to pro-social 50-kHz ultrasonic communication deficits in rats. Dis Model Mech. 2018; 11(6):dmm034116. doi: 10.1242/dmm.034116
Silbernagel N, Walecki M, Schäfer MK, Kessler M, Zobeiri M, Rinné S, Kiper AK, Komadowski MA, Vowinkel KS, Wemhöner K, Fortmüller L, Schewe M, Dolga AM, Scekic-Zahirovic J, Matschke LA, Culmsee C, Baukrowitz T, Monassier L, Ullrich ND, Dupuis L, Just S, Budde T, Fabritz L, Decher N. The VAMP-associated protein VAPB is required for cardiac and neuronal pacemaker channel function. FASEB J. 2018; 32(11):6159-6173. doi: 10.1096/fj.201800246R
Michels S, Wöhr M, Schwarting RK, Culmsee C. Psychiatric risk gene Cacna1c determines mitochondrial resilience against oxidative stress in neurons. Cell Death Dis. 2018; 9:645. doi: 10.1038/s41419-018-0676-9
Honrath B, Krabbendam IE, IJsebaart C, Pegoretti V, Bendridi N, Rieusset J, Schmidt M, Culmsee C, Dolga AM. SK channel activation is neuroprotective in conditions of enhanced ER-mitochondrial coupling. Cell Death Dis. 2018; 9:593. doi: 10.1038/s41419-018-0590-1
Michels S, Ganjam GK, Martins H, Schratt GM, Wöhr M, Schwarting RKW, Culmsee C. Downregulation of the psychiatric susceptibility gene Cacna1c promotes mitochondrial resilience to oxidative stress in neuronal cells. Cell Death Dis. 2018; 4:54. doi: 10.1038/s41420-018-0061-6
Jelinek A, Heyder L, Daude M, Plessner M, Krippner S, Grosse R, Diederich WE, Culmsee C. Mitochondrial rescue prevents glutathione peroxidase-dependent ferroptosis. Free Radic Biol Med. 2018; 117:45-57. doi: 10.1016/j.freeradbiomed.2018.01.019
Connolly NMC, Theurey P, Adam-Vizi V, Bazan NG, Bernardi P, Bolaños JP, Culmsee C, Dawson VL, Deshmukh M, Duchen MR, Düssmann H, Fiskum G, Galindo MF, Hardingham GE, Hardwick JM, Jekabsons MB, Jonas EA, Jordán J, Lipton SA, Manfredi G, Mattson MP, McLaughlin B, Methner A, Murphy AN, Murphy MP, Nicholls DG, Polster BM, Pozzan T, Rizzuto R, Satrústegui J, Slack RS, Swanson RA, Swerdlow RH, Will Y, Ying Z, Joselin A, Gioran A, Moreira Pinho C, Watters O, Salvucci M, Llorente-Folch I, Park DS, Bano D, Ankarcrona M, Pizzo P, Prehn JHM. Guidelines on experimental methods to assess mitochondrial dysfunction in cellular models of neurodegenerative diseases. Cell Death Differ. 2018; 25:542-572. doi: 10.1038/s41418-017-0020-4
Honrath B, Culmsee C, Dolga AM. One protein, different cell fate: the differential outcome of depleting GRP75 during oxidative stress in neurons. Cell Death Dis. 2018; 9:32. doi: 10.1038/s41419-017-0148-7
Krabbendam IE, Honrath B, Culmsee C, Dolga AM. Mitochondrial Ca2+-activated K+ channels and their role in cell life and death pathways. Cell Calcium. 2018; 69:101-111. doi: 10.1016/j.ceca.2017.07.005
Plesnila N, Culmsee C. Involvement of apoptosis-inducing factor (AIF) in neuronal cell death following cerebral ischemia. In: Fujikawa D. (eds) Acute Neuronal Injury. The Role of Excitotoxic Programmed Cell Death Mechanisms, 2nd Edition. Springer Cham 2018; pp. 103–113. ISBN: 978-3-319-77495-4. doi: https://doi.org/10.1007/978-3-319-77495-4_6
2017
Müller-Rebstein S, Trenkwalder C, Ebentheuer J, Oertel WH, Culmsee C, Höglinger GU. Drug safety analysis in a real-life cohort of Parkinson's disease patients with polypharmacy. CNS Drugs. 2017; 31:1093-1102. doi: 10.1007/s40263-017-0478-0
Honrath B, Metz I, Bendridi N, Rieusset J, Culmsee C, Dolga AM. Glucose-regulated protein 75 determines ER-mitochondrial coupling and sensitivity to oxidative stress in neuronal cells. Cell Death Dis. 2017; 3:17076. doi: 10.1038/cddiscovery.2017.76
Rehklau K, Hoffmann L, Gurniak CB, Ott M, Witke W, Scorrano L, Culmsee C, Rust MB. Cofilin1-dependent actin dynamics control DRP1-mediated mitochondrial fission. Cell Death Dis. 2017; 8(10):e3063. doi: 10.108/cddis.2017.448
Honrath B, Krabbendam IE, Culmsee C, Dolga AM. Small conductance Ca(2+)-activated K(+) channels in the plasma membrane, mitochondria and the ER: Pharmacology and implications in neuronal diseases. Neurochem Int. 2017; 109:13-23. doi: 10.1016/j.neuint.2017.05.005
Müller-Rebstein S, Trenkwalder C, Oertel WH, Culmsee C, Eckermann G, Höglinger GU. [Pharmacotherapy of Parkinson's disease : Aspects of drug safety]. Nervenarzt. 2017; 88:888-894. doi: 10.1007/s00115-017-0345-8
Zhou K, Xie C, Wickström M, Dolga AM, Zhang Y, Li T, Xu Y, Culmsee C, Kogner P, Zhu C, Blomgren K. Lithium protects hippocampal progenitors, cognitive performance and hypothalamus-pituitary function after irradiation to the juvenile rat brain. Oncotarget 2017; 8:34111-34127. doi: 10.18632/oncotarget.16292
Niu X, Brahmbhatt H, Mergenthaler P, Zhang Z, Sang J, Daude M, Ehlert FGR, Diederich WE, Wong E, Zhu W, Pogmore J, Nandy JP, Satyanarayana M, Jimmidi RK, Arya P, Leber B, Lin J, Culmsee C, Yi J, Andrews DW. A Small-Molecule Inhibitor of Bax and Bak Oligomerization Prevents Genotoxic Cell Death and Promotes Neuroprotection. Cell Chem Biol. 2017; 24:493-506.e5. doi: 10.1016/j.chembiol.2017.03.011
Neitemeier S, Jelinek A, Laino V, Hoffmann L, Eisenbach I, Eying R, Ganjam GK, Dolga AM, Oppermann S, Culmsee C. BID links ferroptosis to mitochondrial cell death pathways. Redox Biol. 2017; 12:558-570.doi: 10.1016/j.redox.2017.03.007
Honrath B, Matschke L, Meyer T, Magerhans L, Perocchi F, Ganjam GK, Zischka H, Krasel C, Gerding A, Bakker BM, Bünemann M, Strack S, Decher N, Culmsee C, Dolga AM. SK2 channels regulate mitochondrial respiration and mitochondrial Ca(2+) uptake. Cell Death Differ. 2017; 24:761-773. doi: 10.1038/cdd.2017.2
2016
Garn H, Bahn S, Baune BT, Binder EB, Bisgaard H, Chatila TA, Chavakis T, Culmsee C, Dannlowski U, Gay S, Gern J, Haahtela T, Kircher T, Müller-Ladner U, Neurath MF, Preissner KT, Reinhardt C, Rook G, Russell S, Schmeck B, Stappenbeck T, Steinhoff U, van Os J, Weiss S, Zemlin M, Renz H (2016) Current concepts in chronic inflammatory diseases: interactions between microbes, cellular metabolism, and inflammation. J Allergy Clin Immunol 138(1):47-56
Neitemeier S, Dolga AM, Honrath B, Karuppagounder SS, Alim I, Ratan RR, Culmsee C (2016) Inhibition of HIF-prolyl-4-hydroxylases prevents mitochondrial impairment and cell death in a model of neuronal oxytosis. Cell Death Dis 7:e2214
Karuppagounder SS, Alim I, Khim SJ, Bourassa MW, Sleiman SF, John R, Thinnes CC, Yeh TL, Demetriades M, Neitemeier S, Cruz D, Gazaryan I, Killilea DW, Morgenstern L, Xi G, Keep RF, Schallert T, Tappero RV, Zhong J, Cho S, Maxfield FR, Holman TR, Culmsee C, Fong GH, Su Y, Ming GL, Song H, Cave JW, Schofield CJ, Colbourne F, Coppola G, Ratan RR. Therapeutic targeting of oxygen-sensing prolyl hydroxylases abrogates ATF4-dependent neuronal death and improves outcomes after brain hemorrhage in several rodent models. Sci Transl Med. 2016 Mar 2;8(328):328ra29.
Richter M, Vidovic N, Honrath B, Mahavidi P, Dodel R, Dolga AM, Culmsee C (2015) Activation of SK2 channels preserves ER Ca(2+) homeostasis and protects against ER stress-induced cell death. Cell Death Differ 23(5):814-27
2015
Dong F, Eibach M, Bartsch JW, Dolga AM, Schlomann U, Conrad C, Schieber S, Schilling O, Biniossek ML, Culmsee C, Strik H, Koller G, Carl B, Nimsky C (2015) The metalloprotease-disintegrin ADAM8 contributes to temozolomide chemoresistance and enhanced invasiveness of human glioblastoma cells. Neuro Oncol 17(11):1474-85
Benzler J, Ganjam GK, Pretz D, Oelkrug R, Koch CE, Legler K, Stöhr S, Culmsee C, Williams LM, Tups A (2015) Central inhibition of IKKbeta/NF-kappaB signaling attenuates high-fat diet-induced obesity and glucose intolerance. Diabetes 64(6):2015-27
Richter M, Nickel C, Apel L, Kaas A, Dodel R, Culmsee C, Dolga AM (2015) SK channel activation modulates mitochondrial respiration and attenuates neuronal HT-22 cell damage induced by H2O2. Neurochem Int 81:63-75
2014
Neitemeier S, Ganjam GK, Diemert S, Culmsee C (2014) Pifithrin-alpha provides neuroprotective effects at the level of mitochondria independently of p53 inhibition. Apoptosis 19(12):1665-77
Gold M, Dolga AM, Koepke J, Mengel D, Culmsee C, Dodel R, Koczulla AR, Bach JP (2014) alpha1-Antitrypsin modulates microglial-mediated neuroinflammation and protects microglial cells from amyloid-beta-induced toxicity. J Neuroinflammation 11:165
Reuther C, Ganjam GK, Dolga AM, Culmsee C (2014) The serine protease inhibitor TLCK attenuates intrinsic death pathways in neurons upstream of mitochondrial demise. Apoptosis 19(11):1545-58
Barho MT, Oppermann S, Schrader FC, Degenhardt I, Elsässer K, Wegscheid-Gerlach C, Culmsee C, Schlitzer M (2014) N-acyl-derivatives of 4-pheoxyaniline as neuroprotective agents. ChemMedChem 9(10):2260-73
Oppermann S, Schrader FC, Elsässer K, Dolga AM, Kraus AL, Doti N, Wegscheid-Gerlach C, Schlitzer M, Culmsee C (2014) Novel N-phenyl-substituted thiazolidinediones protect neural cells against glutamate- and tBid-induced toxicity. J Pharmacol Exp Ther 350(2):273-89
Höllerhage M, Goebel JN, de Andrade A, Hildebrandt T, Dolga A, Culmsee C, Oertel WH, Hengerer B, Höglinger GU (2014) Trifluoperazine rescues human dopaminergic cells from wild-type alpha-synuclein-induced toxicity. Neurobiol Aging 35(7):1700-11
Dolga AM, de Andrade A, Meissner L, Knaus HG, Höllerhage M, Christophersen P, Zischka H, Plesnila N, Höglinger GU, Culmsee C (2014) Subcellular expression and neuroprotective effects of SK channels in human dopaminergic neurons. Cell Death Dis 5:e999
Doti N, Reuther C, Scognamiglio PL, Dolga AM, Plesnila N, Ruvo M, Culmsee C (2014) Inhibition of the AIF/CypA complex protects against intrinisic death pathways induced by oxidative stress. Cell Death Dis 5:e993
2013
Ganjam GK, Benzler J, Pinkenburg O, Boucsein A, Stöhr S, Steger J, Culmsee C, Barrett P, Tups A (2013) Overexpression of suppressor of cytokine signaling 3 in the arcuate nucleus of juvenile Phodopus sungorus alters seasonal body weight changes. J Comp Physiol B 183(8): 1101-11
White A, Culmsee C, Beart P (2013) Oxidative stress and neurodegeneration. Neurochem Int 62(5):521
Dolga AM, Netter MG, Perocchi F, Doti N, Meissner L, Tobaben S, Grohm J, Zischka H, Plesnila N, Decher N, Culmsee C (2013) Mitochondrial small conductance SK2 channels prevent glutamate-induced oxytosis and mitochondrial dysfunction. J Biol Chem 288(15):10792-804
2012
Dolga Am, Culmsee C (2012) Protective roles for potassium SK/K(Ca)2 channels in microglia and neurons. Front Pharmacol 3:196 Free PMC article
Dolga AM, Letsche T, Gold M, Doti N, Bacher M, Chiamvimonvat N, Dodel R, Culmsee C (2012) Activation of KCNN3/SK3/K(Ca)2.3 channels attenuates enhanced calcium influx and inflammatory cytokine production in activated microglia. Glia 60(12): 2050-64
Oxler EM, Dolga A, Culmsee C (2012) AIF depletion provides neuroprotection through a preconditioning effect. Apoptosis 17(10):1027-38
Grohm J, Kim SW, Mamrak U, Tobaben S, Cassidy-Stone A, Nunnari J, Plesnila N, Culmsee C (2012) Inhibition of Drp1 provides neuroprotection in vitro and in vivo. Cell Death Differ 19(9):1446-58
Diemert S, Dolga AM, Tobaben S, Grohm J, Pfeifer S, Öxler E, Culmsee C (2012) Impedance measurement for real time detection of neuronal cell death. J Neurosci Methods 203(1):69-77
2011
Tobaben S, Grohm J, Seiler A, Conrad M, Plesnila N, Culmsee C (2011) Bid-mediated mitochondrial damage is a key mechnism in glutamate-induced oxidative stress and AIF-dependent cell death in immortalized HT-22 hippocampal neurons. Cell Death and Differentiation 18(2):282-292 [Epub 2010 Aug. 6]
Dolga AM, Terpolilli N, Kepura F, Nijholt IM, Knaus H-G, D’Orsi B, Prehn JHM, Eisel ULM, Plant T, Plesnila N, Culmsee C (2011) KCa2 channels activation prevents [Ca2+]i deregulation and reduces neuronal death following glutamate toxicity and cerebral ischemia. Cell Death Dis. 2, e:147
Dolga AM, Culmsee C, de Lau L, Winter Y, Oertel WH, Luiten PG, Eisel UL (2011) Statins - increasing or reducing the risk of Parkinson's disease? Exp Neurol. 228(1): 1-4 [Epub 2010 Nov. 24]
Nijboer CH, Heijnen CJ, van der Kooij MA, Zijlstra J, van Velthoven CT, Culmsee C, van Bel F, Hagberg H, Kavelaars A (2011) Targeting the p53 pathway to protect the neonatal ischemic brain. Ann Neurol. 2011 Aug;70(2):255-64.
2010
Hangen E, De Zio D, Bordi M, Zhu C, Dessen P, Caffin F, Lachkar S, Perfettini JL, Lazar V, Benard J, Fimia GM, Piacentini M, Harper F, Pierron G, Vicencio JM, Bénit P, de Andrade A, Höglinger G, Culmsee C, Rustin P, Blomgren K, Cecconi F, Kroemer G, Modjtahedi N (2010) A brain-specific isoform of mitochondrial apoptosis-inducing factor: AIF2.Cell Death Differ. 17(7):1155-66 [Epub 2010 Jan 29.]
Grohm J, Plesnila N, Culmsee C (2010) Bid mediates fission, membrane permeabilization and peri-nuclear accumulation of mitochondria as a prerequisite for oxidative neuronal cell death. Brain Behav Immun. 24(5):831-8 [Epub 2009 Dec. 2]
2009
Cardoso AL, Costa P, de Almeida LP, Simões S, Plesnila N, Culmsee C, Wagner E, de Lima MC (2009) Tf-lipoplex-mediated c-jun silencing improves neuronal survival following excitotoxic damage in vivo. J Control Release. 2010 Mar 19;142(3):392-403
Culmsee C (2009) Targeting beta2-adrenoceptors for neuroprotection after cerebral ischemia: is inhibition or stimulation best? Anesth Analg. 2009 Jan;108(1):3-5.
2008
Slemmer JE, Zhu C, Landshamer S, Trabold R, Grohm J, Ardeshiri A, Wagner E, Sweeney MI, Blomgren K, Culmsee C, Weber JT, Plesnila N (2008) Causal role of apoptosis-inducing factor for neuronal cell death following traumatic brain injury. Am J Pathol. 2008 Dec;173(6):1795-805.
Cardoso AL, Simões S, de Almeida LP, Plesnila N, Pedroso de Lima MC, Wagner E, Culmsee C (2008) Tf-lipoplexes for neuronal siRNA delivery: a promising system to mediate gene silencing in the CNS. J Control Release. 2008 Dec 8;132(2):113-23.
Seiler A, Schneider M, Förster H, Roth S, Wirth EK, Culmsee C, Plesnila N, Kremmer E, Rådmark O, Wurst W, Bornkamm GW, Schweizer U, Conrad M (2008) Glutathione peroxidase 4 senses and translates oxidative stress into 12/15-lipoxygenase dependent- and AIF-mediated cell death. Cell Metab. 2008 Sep;8(3):237-48.
Beck H, Semisch M, Culmsee C, Plesnila N, Hatzopoulos AK (2008) Egr-1 regulates expression of the glial scar component phosphacan in astrocytes after experimental stroke. Am J Pathol. 2008 Jul;173(1):77-92.
Landshamer S, Hoehn M, Barth N, Duvezin-Caubert S, Schwake G, Tobaben S, Kazhdan I, Becattini B, Zahler S, Vollmar A, Pellecchia M, Reichert A, Plesnila N, Wagner E, Culmsee C (2008) Bid-induced release of AIF from mitochondria causes immediated neuronal cell death. Cell Death Differ. 2008 Oct;15(10):1553-63
2007
Gaedtke L, Thoenes L, Culmsee C, Mayer B, Wagner E (2007) Proteomic analysis reveals differences in spheroid versus monolayer cultures of low passage colon cancer cells. J Proteome Res. 6(11):4111-4118
Culmsee C, Junker V, Thal S, Kremers W, Schneider H, Plesnila N, Krieglstein J (2007) Enantio-selective effects of clenbuterol in cultured neurons and astrocytes, and in a mouse model of cerebral ischemia. Eur J Pharm. 575(1-3):57-65
Plesnila N, von Baumgarten L, Retiounskaia M, Engel D, Ardeshiri A, Zimmermann R, Hofmann F, Landshamer S, Wagner E, Culmsee C (2007). Delayed neuronal death after brain trauma involves p53-dependent inhibition of NF-kB transcriptional activity. Cell Death Diff., 14: 1529-1541. PubMed / Reprint request
Tarcha PJ, Pelisek J,Merdan t,Waters J, Cheung K, v Gersdorff K, Culmsee C, Wagner E (2007) Synthesis and Characterization of Chemically Condensed Oligoethyleneimine Containing Beta-Aminopropionamide Linkages for siRNA Delivery. Biomaterials 28: 3731-40. PubMed / Reprint request
Isele NB, Lee HS, Landshamer S, Straube A, Padovan CS, Plesnila N, Culmsee C (2007) Bone marrow stromal cells mediate protection through stimulation of PI3-K/Akt and MAPK signaling in neurons. NeurochemInt. 50: 243-250. PubMed / Reprint request
Ameri K, Hammond EM, Culmsee C, Raida M, Katschinski DM, Wenger RH, Wagner E, Davis RJ, Hai T, Denko N, Harris AL (2007) Induction of activating transcription factor 3 by anoxia is independent of p53 and the hypoxic HIF signalling pathway. Oncogene. 26: 284-289. PubMed / Reprint request
Henn IH, Bouman L, Schlehe JS, Schlierf A, Schramm JE, Wegener E, Nakaso K, Culmsee C, Berninger B, Krappmann D, Tatzelt J, Winklhofer KF (2007) Parkin mediates neuroprotection through activation of IKK/NF-kB signalling. J. Neuroscience 27: 1868-1878. PubMed / Reprint request
Zhu C, Wang X, Huang Z, Qiu L, Xu F, Vahsen N, Nilsson M, Eriksson PS, Hagberg H, Culmsee C, Plesnila N, Kroemer G, Blomgren K. (2007) Apoptosis-inducing factor is a major contributor to neuronal loss induced by neonatal cerebral hypoxia-ischemia. Cell Death Differ. 14: 775-784. PubMed / Reprint request
Cardoso AL, Simões S, Almeida LP, Pelisek J., Culmsee C, Wagner E, Pedroso de Lima MC (2007) siRNA delivery by Transferrin associated Lipoplexes: a non-viral strategy to mediate gene silencing. J Gene Med 9: 170-183. PubMed / Reprint request
Culmsee C, Krieglstein J. (2007) Ischaemic brain damage after stroke: new insights into efficient therapeutic strategies. International Symposium on Neurodegeneration and Neuroprotection. EMBO Rep. 8, 129 – 133. PubMed / Reprint request
2006
Culmsee C, Gasser E, Hansen S, Tonn JC, Wagner E, Goldbrunner R (2006) Effects of Raf-1 siRNA on human microvascular endothelial cells: A potential therapeutic strategy for inhibition of tumor angiogenesis. Brain Res 1125: 147-154. PubMed / Reprint request
Becattini B, Culmsee C, Leone M, Zhai D, Zhang X, Crowell KJ, Rega MF, Landshamer S, Reed JC, Plesnila N, Pellecchia M (2006) Structure-activity relationships by interligand NOE-based design and synthesis of antiapoptotic compounds targeting Bid. Proc Natl Acad Sci U S A. 103: 12602-12606. PubMed / Reprint request
Culmsee C, Plesnila N (2006) Targeting Bid to prevent programmed cell death in neurons. Biochem Soc Trans 34: 1334-1340. PubMed / Reprint request
Culmsee C, Landshamer S (2006) Molecular insights into mechanisms of the cell death program: role in the progression of neurodegenerative disorders. CurrAlzheimer Res 3: 269-283. PubMed / Reprint request
Culmsee C, Krieglstein J (2006) Emerging pharmacotherapeutic strategies for the treatment of ischemic stroke. Drug Discovery Today.Therapeutic strategies. 621-628.
2005
Culmsee C, Zhu C, Landshamer S, Becattini B, Wagner E, Pellecchia M, Blomgren K, Plesnila N (2005) Apoptosis-inducing factor triggered by poly(ADP-ribose) polymerase and Bid mediates neuronal cell death after oxygen-glucose deprivation and focal cerebral ischemia. J Neurosci. 25:10262-10272. PubMed / Reprint request
Culmsee C, Gerling N, Landshamer S, Rickerts B, Duchstein HJ, Umezawa K, Klumpp S, Krieglstein J (2005) Nitric oxide donors induce neurotrophin-like survival signaling and protect neurons against apoptosis. Mol Pharmacol. 68:1006-1017. PubMed / Reprint request
Culmsee C, Krieglstein J (2005). Mechanisms of neuronal degeneration after ischemic stroke – emerging targets for novel therapeutic strategies. Drug Discovery Today.Disease Mechanisms. 2:463-470.
Culmsee C, Mattson MP (2005) The role of p53 in neuronal apoptosis. BiochemBiophys Res Com. 331:761-777. PubMed / Reprint request
2004
Culmsee C, Junker V, Kremers W, Thal S, Plesnila N, Krieglstein J (2004) Combination therapy in ischemic stroke. Synergistic neuroprotective effects of memantine and clenbuterol. Stroke, 35:1197-1202. PubMed / Reprint request
Plesnila N, Zhu C, Culmsee C, Gröger M, Moskowitz MA, Blomgren K (2004) Nuclear Translocation of Apoptosis-Inducing Factor (AIF) after Focal Cerebral Ischemia. J Cereb Blood Flow Metab, 24:458-466. PubMed / Reprint request
Zhu Y, Culmsee C, Klumpp S, Krieglstein J (2004) Activation of NF-kB through PI3K/Akt and MAPK/Erk1,2 signaling contributes to the neuroprotective effect of TGFß1 in hippocampal neurons. Neuroscience 123:897-906. PubMed / Reprint request
Gerling N, Culmsee C, Klumpp S, Krieglstein J (2004) The tyrosine phosphatase inhibitor orthovanadate mimics NGF-induced neuroprotective signaling in rat hippocampal neurons. NeurochemInt, 44:505-520. PubMed / Reprint request
Boeckle S, v. Gersdorff K, V.d. Piepen S, Culmsee C, Wagner E, Ogris M (2004) Purification of polyethyleneimine polyplexes highlights the role of free polycation in gene transfer. J Gene Med 6:1102-1111. PubMed / Reprint request
2003
Culmsee C, Siewe J, Junker V, Retiounskaia m, Schwarz S, Camandola S, El-Metainy S, Behnke H, Mattson MP, Krieglstein J (2003) Reciprocal inhibition of p53 and NF-kappa B transcriptional activities determines cell survival or death in neurons. J Neuroscience, 18:8586-8595. PubMed / Reprint request
2002
Culmsee C, Junker V, Gerling N, Lehmann M, Nikolova-Karakashian M, Prehn JHM, Mattson MP, Krieglstein J (2002) NGF-induced neuroprotection in hippocampal neurons requires the common neurotrophin receptor p75NTR. Neuroscience, 115:1089-1108. PubMed / Reprint request
Zhu Y, Yang GY, Ahlemeyer B, Pang L, Che XM, Culmsee C, Klumpp S, Krieglstein J (2002) Transforming growth factor-beta 1 increases bad phosphorylation and protects neurons against damage. J Neurosci 22:3898-3909. PubMed / Reprint request
Zhu X, Yu QS, Cutler R, Culmsee C, Holloway HW, Mattson MP, Greig NH. (2002) Design and synthesis of novel p53 inhibitors as neuroprotective agents. J Med Chem 45:5090-5097. PubMed / Reprint request
Van Ess PJ, Pedersen WA, Culmsee C, Mattson MP, Blouin RA (2002) Elevated hepatic and depressed renal cytochrome P450 activity in the Tg2576 transgenic mouse model of Alzheimer's disease. J Neurochem 80:571-578. PubMed / Reprint request
Junker V, Becker A, Hühne R, Zembatov M, Ravati A, Culmsee C, Krieglstein J (2002) Stimulation of ß-adrenoceptors activates astrocytes and provides neuroprotection. EurJ Pharm 446:25-36. PubMed / Reprint request
Chan SL, Culmsee C, Haughey N, Klapper W, Mattson MP (2002) Presinilin-1 mutations sensitize neurons to DNA-damage-induced death by a mechanism involving perturbed calcium homeostasis and activation of calpains and caspase-12. NeurobiolDis, 11:2-19. PubMed / Reprint request
Bui TN, König, HG, Culmsee C, Bauerbach E, Poppe M, Krieglstein J, Prehn JHM (2002) p75 neurotrophin receptor is required for constitutive and NGF survival signalling in PC12 cells and rat hippocampal neurons. J Neurochem 81:594-605. PubMed / Reprint request
Stumm R, Rummel, J, Junker V, Culmsee C, Pfeiffer M, Krieglstein J, Höllt V, Schulz S (2002) A dual role for the SDF-1/CXCR4 chemokine receptor system in adult brain: isoform selective regulation of SDF-1 expression and cerebral leukocyte recruitment after focal ischemia. J Neurosci 22:5865-5878. PubMed / Reprint request
2001
Culmsee C, Zhu Y, Krieglstein J, Mattson MP (2001) Evidence for the involvement of Par-4 in ischemic cell death. J Cereb Blood Flow Metab 21:334-343.
Culmsee C, Zhu X, Yu Q, Chan SL, Camandola S, Guo Z, Greig N, Mattson MP (2001) A synthetic inhibitor of p53 protects neurons in the brain against ischemic and excitotoxic injury. J Neurochem 77:220-228.
Culmsee C, Bondada S, Mattson MP (2001) Hippocampal neurons of mice deficient in DNA-dependent protein kinase exhibit increased vulnerability to DNA damage, oxidative stress and excitotoxicity. Brain Res Mol Brain Res 87:257-262.
Culmsee C, Monnig J, Kemp B, Mattson MP (2001) Evidence that AMP activated protein kinase protects against metabolic, excitotoxic and oxidative insults in embryonic hippocampal neurons. J Mol Neurosci 17:45-58.
Stumm R, Culmsee C, Schafer MK, Krieglstein J, Weihe E (2001) Adaptive plasticity in tachykinin and tachykinin receptor expression after focal cerebral ischemia is differentially linked to gabaergic and glutamatergic cerebrocortical circuits and cerebrovenular endothelium. J Neurosci 21:798-811.
Zhu Y, Culmsee C, Roth-Eichhorn S, Krieglstein J (2001) ß2-Adrenoceptor stimulation enhances latent TGF-ß1 binding protein-1 and TGF-ß1 expression in rat hippocampus after transient forebrain ischemia. Neuroscience 107:593-602.
2000
Fu W, Killen M, Culmsee C, Dhar S, Pandita TK, Mattson MP (2000) The catalytic subunit of telomerase protects developing brain neurons against apoptosis. J Mol Neurosci, 14:3-15.
Kruman II, Culmsee C, Chan S, Kruman Y, Penix L, Mattson MP (2000) Homocysteine induces apoptosis and accelerates oxidative and excitotoxic damage in hippocampal neurons. J Neurosci 20:6920-6926.
Schaper C, Zhu Y, Kouklei M, Culmsee C, Krieglstein J (2000) Stimulation of 5-HT(1A) receptors reduces apoptosis after transient forebrain ischemia in the rat. Brain Res 883:41-50.
Zhu Y, Roth-Eichhorn S, Braun N, Culmsee C, Rami A, Krieglstein J (2000) The expression of transforming growth factor-beta1 (TGF-beta1) in hippocampal neurons: a temporary upregulated protein level after transient forebrain ischemia in the rat. Brain Res 866:286-298.
Pedersen WA, McCullers D, Culmsee C, Haughey NJ, Kasarskis E, Herman JP, Mattson MP (2000) Neuroprotective effects of corticotropin releasing hormone against amyloid-beta peptide toxicity in experimental models of Alzheimer’s disease. NeurobiolDis 8:492-503.
Mattson MP, Culmsee C, Yu ZF, Camandola S (2000) Roles of NF-kB in neuronal survival and plasticity. J Neurochem, 74:443-456.
Mattson MP, Culmsee C, Yu ZF (2000) Apoptosis and anti-apoptotic mechanisms in stroke. Cell Tiss Research, 301:173-187.
1999
Culmsee C, Pedersen WA, Ziegler D, Herman J, Mattson MP (1999) Aberrant stress response associated with severe hypoglycemia in a transgenic mouse model of Alzheimer’s disease. J Mol Neurosci, 13: 159-165.
Culmsee C, Vedder H, Ravati A, Junker V, Otto D, Ahlemeyer B, Krieg JC, Krieglstein J (1999) Neuroprotection by estrogens in a mouse model of focal cerebral ischemia and in cultured neurons: Evidence for a receptor independent antioxidative mechanism. J Cereb Blood Flow Metab, 19:1263-1269.
Culmsee C, Semkova I, Krieglstein J (1999) NGF mediates the neuroprotective effect of the b2-adrenoceptor agonist clenbuterol in vitro and in vivo: Evidence from a NGF-antisense study. NeurochemInt, 35: 47-57.
Culmsee C, Stumm R K, Schaefer MKH, Weihe E, Krieglstein J (1999) Clenbuterol induces growth factor mRNA, activates astrocytes, and protects rat brain tissue against ischemic damage. EurJ Pharmacol, 379: 33-45.
Ravati A, Junker V, Kouklei M, Ahlemeyer B, Culmsee C, Krieglstein J (1999) Enalapril and moexipril protect from free radical-induced neuronal damage in vitro and reduce ischemic brain injury in mice and rats. EurJ Pharmacol 373: 21-33.
Zhu Y, Prehn JHM, Culmsee C, Krieglstein J (1999) The b2-adrenoceptor agonist clenbuterol modulates bcl-2, bcl-xl and bax protein expression following transient forebrain ischemia. Neuroscience 90: 1255-1263.
Mattson MP, Pedersen WA, Duan W, Culmsee C, Camandola S. (1999) Cellular and molecular mechanisms underlying perturbed energy metabolism and neuronal degeneration in Alzheimer's and Parkinson's diseases. Ann N Y Acad Sci, 893:154-75.
1998
Culmsee C, Junker V, Wolz P, Semkova I, Krieglstein J (1998) Lubeluzole protects hippocampal neurons from excitotoxicity in vitro and reduces brain damage caused by ischemia. Eur J Pharmacol, 342: 193-201.
Braun N, Zhu Y, Culmsee C, Krieglstein J, Zimmermann H (1998) Upregulation of the enzyme chain hydrolizing extracellular ATP following transient forebrain ischemia in the rat. J Neurosci, 18: 4891-4900.
Zhu Y, Culmsee C, Semkova I, Krieglstein J (1998) Stimulation of b2-adrenoceptors inhibits apoptosis in rat brain after transient forebrain ischemia. J Cereb Blood Flow Metab, 18: 1032-1039.