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Publikationen

2024

Enhanced photodynamic therapy of curcumin using biodegradable PLGA coated mesoporous silica nanoparticles
MU Amin, S Ali, KH Engelhardt, U Nasrullah, E Preis, J Schaefer, ...
European Journal of Pharmaceutics and Biopharmaceutics, 114503

An innovative approach to detect circulating tumor cells
V Roschenko, D Schorr, M Wojcik, MU Amin, U Bakowsky, E Preis
Colloids and Surfaces B: Biointerfaces 241, 114059

In Vitro Photoselective Gene Transfection of Hepatocellular Carcinoma Cells with Hypericin Lipopolyplexes
H Shah, S Schlüter, MU Amin, A Abu Dayyih, KH Engelhardt, ...
ACS Applied Materials & Interfaces

Ameliorative Delivery of Docetaxel and Curcumin using PEG Decorated Lipomers: A Cutting-Edge In-Vitro/In-Vivo Appraisal
I Tariq, H Hassan, S Ali, SA Raza, PA Shah, MY Ali, Z Tariq, U Bakowsky
Journal of Drug Delivery Science and Technology, 105814

Overexpression of ACVRL1 inhibits the tube formation ability of HMEC-1 endothelial cells
JR Rusche, L Xiang-Tischhauser, M Bette, BA Stuck, U Bakowsky, ...
Laryngo-Rhino-Otologie 103 (S 02)

In vitro and in ovo photodynamic efficacy of nebulized curcumin-loaded tetraether lipid liposomes prepared by DC as stable drug delivery system
L Bender, E Preis, KH Engelhardt, MU Amin, AM Ayoub, D Librizzi, ...
European Journal of Pharmaceutical Sciences 196, 106748
https://pubmed.ncbi.nlm.nih.gov/38744595/

Evaluating the photodynamic efficacy of nebulized curcumin-loaded liposomes prepared by thin-film hydration and dual centrifugation: In vitro and in ovo studies
L Bender, AM Ayoub, J Schulze, MU Amin, D Librizzi, KH Engelhardt, ...
Biomaterials Advances 159, 213823

Assessment of Imaging Flow Cytometry for the Simultaneous Discrimination of Protein Particles and Silicone Oil Droplets in Biologicals
I Fawaz, SH Schaz, P Garidel, U Bakowsky, M Blech
Journal of Pharmaceutical Innovation 19 (2), 11

Photodynamic Therapy: A Rising Star in Pharmaceutical Applications
E Preis, U Bakowsky
Pharmaceutics 16 (8), 1072

2023

Recent Innovations of Mesoporous Silica Nanoparticles Combined with Photodynamic Therapy for Improving Cancer Treatment
DS Nady, A Hassan, MU Amin, U Bakowsky, SA Fahmy
Pharmaceutics 16 (1), 14

EVALUATION OF PHOTODYNAMIC EFFICIENCY OF NEBULIZED LIPOSOMES IN VITRO AND IN OVO
L Bender, D Librizzi, J Schaefer, U Bakowsky
JOURNAL OF AEROSOL MEDICINE AND PULMONARY DRUG DELIVERY 36 (6), A11-A11

Modern Photodynamic Glioblastoma Therapy Using Curcumin-or Parietin-Loaded Lipid Nanoparticles in a CAM Model Study
J Schulze, L Schöne, AM Ayoub, D Librizzi, MU Amin, K Engelhardt, ...
ACS Applied Bio Materials 6 (12), 5502-5514

Solid Lipid Nanoparticles Containing Dopamine and Grape Seed Extract: Freeze-Drying with Cryoprotection as a Formulation Strategy to Achieve Nasal Powders
E De Giglio, U Bakowsky, K Engelhardt, A Caponio, M La Pietra, ...
Molecules 28 (23), 7706

Langmuir Monolayer Stabilization Characteristics on Tetraether Lipids at the Air-Water Interface with Variance in Dispersion Time
S Vidawati, U Bakowsky, U Rothe, N Safira P
Novel Aspects on Chemistry and Biochemistry 8, 182-191

Recent advances in brain delivery of synthetic and natural nano therapeutics: Reviving hope for Alzheimer's disease patients
DS Nady, U Bakowsky, SA Fahmy
Journal of Drug Delivery Science and Technology, 105047

Lipid-Coated Polymeric Nanoparticles for the Photodynamic Therapy of Head and Neck Squamous Cell Carcinomas
V Roschenko, AM Ayoub, K Engelhardt, J Schäfer, MU Amin, E Preis, ...
Pharmaceutics 15 (10), 2412

RNAi-Mediated Knockdown of Cottontail Rabbit Papillomavirus Oncogenes Using Low-Toxicity Lipopolyplexes as a Paradigm to Treat Papillomavirus-Associated Cancers
U Ali, M Bette, G Ambreen, SR Pinnapireddy, I Tariq, A Marquardt, ...
Pharmaceutics 15 (10), 2379

Photoactive Parietin-loaded nanocarriers as an efficient therapeutic platform against triple-negative breast cancer
AM Ayoub, MS Atya, AM Abdelsalam, J Schulze, MU Amin, K Engelhardt, ...
International journal of pharmaceutics 643, 123217

Generation of a Syngeneic Heterozygous ACVRL1(wt/mut) Knockout iPS Cell Line for the In Vitro Study of HHT2-Associated Angiogenesis
L Xiang-Tischhauser, M Bette, JR Rusche, K Roth, N Kasahara, BA Stuck, ...
Cells 12 (12), 1600

How to xenograft cancer cells on the chorioallantoic membrane of a fertilized hen’s egg and its visualization by PET/CT and MRI
J Schulze, D Librizzi, L Bender, J Jedelská, BH Yousefi, J Schaefer, ...
ACS applied bio materials 6 (6), 2435-2445

Co-Delivery of Ylang Ylang Oil of Cananga odorata and Oxaliplatin Using Intelligent pH-Sensitive Lipid-Based Nanovesicles for the Effective Treatment of Triple …
NK Sedky, NM Abdel-Kader, MY Issa, MMM Abdelhady, SN Shamma, ...
International Journal of Molecular Sciences 24 (9), 8392

Generation of an ACVRL1 knockout iPS cell line for the in vitro study of HHT type 2 associated angiogenesis
R Mandic, M Bette, RJ Rusche, AB Stuck, U Bakowsky, B Greber, ...
Laryngo-Rhino-Otologie 102 (S 02)

RNAi knockdown of ACVRL1 in the endothelial cell line HMEC-1 mimics disturbances in angiogenesis as observed in patients with hereditary hemorrhagic telangiectasia (HHT) type 2
JR Rusche, L Xiang-Tischhauser, M Bette, BA Stuck, U Bakowsky, ...
Laryngo-Rhino-Otologie 102 (S 02)

Visualization and Characterization of Liposomes by Atomic Force Microscopy
K Engelhardt, E Preis, U Bakowsky
Liposomes: Methods and Protocols, 253-263

Magnetic Thermosensitive Liposomes Loaded with Doxorubicin
M Alawak, AA Dayyih, I Awak, B Gutberlet, K Engelhardt, U Bakowsky
Liposomes: Methods and Protocols, 103-119

Behaviour of Monolayers Tetraether Lipids Caldarchaeol-PO4 on the Modification of the Solid Surface-supported Wafer Silicon to Amino-silanised: Comparison of Analysis Studies …
S Vidawati, U Bakowsky, U Rothe
Research Aspects in Chemical and Materials Sciences 6, 136-147

Photothermally Controlled Drug Release of Poly(d,l-lactide) Nanofibers Loaded with Indocyanine Green and Curcumin for Efficient Antimicrobial Photodynamic …
B Gutberlet, E Preis, V Roschenko, U Bakowsky
Pharmaceutics 15 (2), 327

2022

Co-delivery of carbonic anhydrase IX inhibitor and doxorubicin as a promising approach to address hypoxia-induced chemoresistance
MU Amin, S Ali, MY Ali, DC Fuhrmann, I Tariq, BS Seitz, E Preis, J Brüßler, ...
Drug Delivery 29 (1), 2072-2085

Thermosensitive liposomes encapsulating nedaplatin and picoplatin demonstrate enhanced cytotoxicity against breast cancer cells
SA Fahmy, E Preis, AA Dayyih, M Alawak, HM El-Said Azzazy, ...
ACS omega 7 (46), 42115-42125

Highly stable liposomes based on Tetraether lipids as a promising and versatile drug delivery system
A Hemetsberger, E Preis, K Engelhardt, B Gutberlet, F Runkel, ...
Materials 15 (19), 6995

Thermoresponsive liposomes for photo-triggered release of hypericin cyclodextrin inclusion complex for efficient antimicrobial photodynamic therapy
AA Dayyih, B Gutberlet, E Preis, KH Engelhardt, MU Amin, ...
ACS Applied Materials & Interfaces 14 (28), 31525-31540

Investigating 3R in vivo approaches for bio‐distribution and efficacy evaluation of nucleic acid nanocarriers: studies on peptide‐mimicking ionizable lipid
J Giselbrecht, SR Pinnapireddy, F Alioglu, H Sami, D Sedding, F Erdmann, ...
Small 18 (18), 2107768

Photodynamic and antiangiogenic activities of parietin liposomes in triple negative breast cancer
AM Ayoub, MU Amin, G Ambreen, AA Dayyih, AM Abdelsalam, ...
Biomaterials advances 134, 112543

Cucumber-derived exosome-like vesicles and plantcrystals for improved dermal drug delivery
AM Abraham, S Wiemann, G Ambreen, J Zhou, K Engelhardt, J Brüßler, ...
Pharmaceutics 14 (3), 476

PEGylated chitosan nanoparticles encapsulating ascorbic acid and oxaliplatin exhibit dramatic apoptotic effects against breast cancer cells
SA Fahmy, A Ramzy, AA Mandour, S Nasr, A Abdelnaser, U Bakowsky, ...
Pharmaceutics 14 (2), 407

RNA-Cholesterol Nanoparticles Function as Potent Immune Activators via TLR7 and TLR8
HL Obermann, II Lederbogen, J Steele, J Dorna, LE Sander, K Engelhardt, ...
Frontiers in Immunology 12, 658895

Stability Monomolecular Properties of Archaeal Tetraether Lipids Layers onto Solid Substrates
S Vidawati, U Bakowsky
Advances in Biological Chemistry 12 (1), 29-37

Liposome‐Encapsulated Bioactive Guttiferone E Exhibits Anti‐Inflammatory Effect in Lipopolysaccharide‐Stimulated MH‐S Macrophages and Cytotoxicity against Human Cancer Cells
JP Dzoyem, SR Pinnapireddy, H Fouotsa, J Brüßler, F Runkel, ...
Mediators of Inflammation 2022 (1), 8886087

2021

The role of long non-coding RNAs (lncRNAs) in female oriented cancers
Naz F, Tariq I, Ali S, Somaida A, Preis E, Bakowsky U
Cancers 13 (23), 6102 doi: 10.3390/cancers13236102

Thermosensitive liposomes encapsulating hypericin: Characterization and photodynamic efficiency
Dayyih AA, Alawak M, Ayoub AM, Amin MU, Dayyih WA, Engelhardt KH, Duse L, Preis E, Brüßler J, Bakowsky U
International journal of pharmaceutics 609, 121195 doi: 10.1016/j.ijpharm.2021.121195

In Ovo Testing Method for Inhalants on a Chorio-Allantoic Membrane
Schulze J, Lehmann J, Agel S, Amin UM, Schaefer J, Bakowsky U
ACS applied bio materials 4 (11), 7764-7768 doi: 10.1021/acsabm.1c01016

Surface tailored zein as a novel delivery system for hypericin: Application in photodynamic therapy
Abdelsalam AM, Somaida A, Ambreen G, Ayoub AM, Tariq I, Engelhardt KH, Garidel P, Fawaz I, Amin MU, Wojcik M, Bakowsky U
Materials Science and Engineering: C 129, 112420 doi: 10.1016/j.msec.2021.112420

Chitosan-Coated PLGA Nanoparticles Loaded with Peganum harmala Alkaloids with Promising Antibacterial and Wound Healing Activities
Azzazy HMES, Fahmy SA, Mahdy NK, Meselhy MR, Bakowsky U 
Nanomaterials 11 (9), 2438 doi: 10.3390/nano11092438

Ultrasound-responsive smart drug delivery system of lipid coated mesoporous silica nanoparticles
Amin MU, Ali S, Tariq I, Ali MY, Pinnapreddy SR, Preis E, Woelk C, Harvey R, Hause G, Brüßler J, Bakowsky U
Pharmaceutics 13 (9), 1396 doi: 10.3390/pharmaceutics13091396

Surface-tailored zein nanoparticles: strategies and applications
Abdelsalam AM, Somaida A, Ayoub AM, Alsharif FM, Preis E, Wojcik M, Bakowsky U
Pharmaceutics 13 (9), 1354 doi: 10.3390/pharmaceutics13091354

Improvement of pulmonary photodynamic therapy: nebulisation of curcumin-loaded tetraether liposomes
Lehmann J, Agel MR, Engelhardt KH, Pinnapireddy SR, Agel S, Duse L, Preis E, Wojcik M, Bakowsky U

Pharmaceutics 13 (8), 1243 doi: 10.3390/pharmaceutics13081243

Enhanced efficacy and drug delivery with lipid coated mesoporous silica nanoparticles in cancer therapy.
Amin MU, Ali S, Ali MY, Tariq I, Nasrullah U, Pinnapreddy SR, Wölk C, Bakowsky U, Brüßler J
Eur J Pharm Biopharm. 2021 Aug;165:31-40. doi: 10.1016/j.ejpb.2021.04.020.

The chorioallantoic membrane as a bio-barrier model for the evaluation of nanoscale drug delivery systems for tumour therapy.
Preis E, Schulze J, Gutberlet B, Pinnapireddy SR, Jedelská J, Bakowsky U
Adv Drug Deliv Rev. 2021 Jul;174:317-336. doi: 10.1016/j.addr.2021.04.022.

Green Synthesis of Platinum and Palladium Nanoparticles Using Peganum harmala L. Seed Alkaloids: Biological and Computational Studies.
Fahmy SA, Fawzy IM, Saleh BM, Issa MY, Bakowsky U, Azzazy HME
Nanomaterials (Basel). 2021 Apr 9;11(4):965. doi: 10.3390/nano11040965.

Lipoparticles for Synergistic Chemo-Photodynamic Therapy to Ovarian Carcinoma Cells: In vitro and in vivo Assessments.
Ali S, Amin MU, Tariq I, Sohail MF, Ali MY, Preis E, Ambreen G, Pinnapireddy SR, Jedelská J, Schäfer J, Bakowsky U.
Int J Nanomedicine. 2021 Feb 11;16:951-976. doi: 10.2147/IJN.S285950. 

ADAM 8 as a novel target for doxorubicin delivery to TNBC cells using magnetic thermosensitive liposomes.
Alawak M, Abu Dayyih A, Mahmoud G, Tariq I, Duse L, Goergen N, Engelhardt K, Reddy Pinnapireddy S, Jedelská J, Awak M, König AM, Brüßler J, Bartsch JW, Bakowsky U.
Eur J Pharm Biopharm. 2021 Jan;158:390-400. doi: 10.1016/j.ejpb.2020.12.012.

2020

Host-Guest Complexation of Oxaliplatin and Para-Sulfonatocalix[n]Arenes for Potential Use in Cancer Therapy.
Fahmy SA, Ponte F, Fawzy IM, Sicilia E, Bakowsky U, Azzazy HME.
Molecules. 2020 Dec 14;25(24):5926. doi: 10.3390/molecules25245926.

Lipodendriplexes mediated enhanced gene delivery: a cellular to pre-clinical investigation.
Tariq I, Ali MY, Sohail MF, Amin MU, Ali S, Bukhari NI, Raza A, Pinnapireddy SR, Schäfer J, Bakowsky U.
Sci Rep. 2020 Dec 8;10(1):21446. doi: 10.1038/s41598-020-78123-6.

Particle Detection and Characterization for Biopharmaceutical Applications: Current Principles of Established and Alternative Techniques.
Gross-Rother J, Blech M, Preis E, Bakowsky U, Garidel P.
Pharmaceutics. 2020 Nov 19;12(11):1112. doi: 10.3390/pharmaceutics12111112.

Sensitivity of Papilloma Virus-Associated Cell Lines to Photodynamic Therapy with Curcumin-Loaded Liposomes.
Ambreen G, Duse L, Tariq I, Ali U, Ali S, Pinnapireddy SR, Bette M, Bakowsky U, Mandic R.
Cancers (Basel). 2020 Nov 5;12(11):3278. doi: 10.3390/cancers12113278.

Potent Cytotoxicity of Four Cameroonian Plant Extracts on Different Cancer Cell Lines.
Somaida A, Tariq I, Ambreen G, Abdelsalam AM, Ayoub AM, Wojcik M, Dzoyem JP, Bakowsky U.
Pharmaceuticals (Basel). 2020 Oct 31;13(11):357. doi: 10.3390/ph13110357.

Platinum Nanoparticles: Green Synthesis and Biomedical Applications.
Fahmy SA, Preis E, Bakowsky U, Azzazy HME.
Molecules. 2020 Oct 28;25(21):4981. doi: 10.3390/molecules25214981.

Downregulation of MDR 1 gene contributes to tyrosine kinase inhibitor induce apoptosis and reduction in tumor metastasis: A gravity to space investigation.
Tariq I, Ali MY, Janga H, Ali S, Amin MU, Ambreen G, Ali U, Pinnapireddy SR, Schäfer J, Schulte LN, Bakowsky U.
Int J Pharm. 2020 Dec 15;591:119993. doi: 10.1016/j.ijpharm.2020.119993. 

Photodynamic inactivation of circulating tumor cells: An innovative approach against metastatic cancer.
Raschpichler M, Preis E, Pinnapireddy SR, Baghdan E, Pourasghar M, Schneider M, Bakowsky U.
Eur J Pharm Biopharm. 2020 Dec;157:38-46. doi: 10.1016/j.ejpb.2020.10.003.

Development and Characterization of Ultrasound Activated Lipopolyplexes for Enhanced Transfection by Low Frequency Ultrasound in In Vitro Tumor Model.
Shah H, Tariq I, Engelhardt K, Bakowsky U, Pinnapireddy SR.
Macromol Biosci. 2020 Dec;20(12):e2000173. doi: 10.1002/mabi.202000173. 

Efficient Transfection of Large Plasmids Encoding HIV-1 into Human Cells-A High Potential Transfection System Based on a Peptide Mimicking Cationic Lipid.
Janich C, Ivanusic D, Giselbrecht J, Janich E, Pinnapireddy SR, Hause G, Bakowsky U, Langner A, Wölk C.
Pharmaceutics. 2020 Aug 25;12(9):805. doi: 10.3390/pharmaceutics12090805.

Palladium Nanoparticles Fabricated by Green Chemistry: Promising Chemotherapeutic, Antioxidant and Antimicrobial Agents.
Fahmy SA, Preis E, Bakowsky U, Azzazy HME.
Materials (Basel). 2020 Aug 19;13(17):3661. doi: 10.3390/ma13173661.

Evaluation of digital image analysis as a supportive tool for the stratification of head and neck vascular anomalies.
Ehrenreich J, Bette M, Schmidt A, Roeßler M, Bakowsky U, Geisthoff UW, Stuck BA, Mandic R.
Eur Arch Otorhinolaryngol. 2020 Oct;277(10):2893-2906. doi: 10.1007/s00405-020-06097-2. 

Magnetic resonance activatable thermosensitive liposomes for controlled doxorubicin delivery.
Alawak M, Mahmoud G, Dayyih AA, Duse L, Pinnapireddy SR, Engelhardt K, Awak I, Wölk C, König AM, Brüßler J, Bakowsky U.
Mater Sci Eng C Mater Biol Appl. 2020 Oct;115:111116. doi: 10.1016/j.msec.2020.111116. 

Biocompatible indocyanine green loaded PLA nanofibers for in situ antimicrobial photodynamic therapy.
Preis E, Anders T, Širc J, Hobzova R, Cocarta AI, Bakowsky U, Jedelská J.
Mater Sci Eng C Mater Biol Appl. 2020 Oct;115:111068. doi: 10.1016/j.msec.2020.111068.

Establishment of a Synthetic In Vitro Lung Surfactant Model for Particle Interaction Studies on a Langmuir Film Balance.
Schüer JJ, Arndt A, Wölk C, Pinnapireddy SR, Bakowsky U.
Langmuir. 2020 May 5;36(17):4808-4819. doi: 10.1021/acs.langmuir.9b03712.

Wavelength dependent photo-cytotoxicity to ovarian carcinoma cells using temoporfin loaded tetraether liposomes as efficient drug delivery system.
Ali S, Amin MU, Ali MY, Tariq I, Pinnapireddy SR, Duse L, Goergen N, Wölk C, Hause G, Jedelská J, Schäfer J, Bakowsky U.
Eur J Pharm Biopharm. 2020 May;150:50-65. doi: 10.1016/j.ejpb.2020.03.008.

Contact-Triggered Lipofection from Multilayer Films Designed as Surfaces for in Situ Transfection Strategies in Tissue Engineering.
Husteden C, Doberenz F, Goergen N, Pinnapireddy SR, Janich C, Langner A, Syrowatka F, Repanas A, Erdmann F, Jedelská J, Bakowsky U, Groth T, Wölk C.
ACS Appl Mater Interfaces. 2020 Feb 26;12(8):8963-8977. doi: 10.1021/acsami.9b18968.

Comparison of Tanaka lipid mixture with natural surfactant Alveofact to study nanoparticle interactions on Langmuir film balance.
Schüer JJ, Wölk C, Bakowsky U, Pinnapireddy SR.
Colloids Surf B Biointerfaces. 2020 Apr;188:110750. doi: 10.1016/j.colsurfb.2019.110750.

2019

A triple chain polycationic peptide-mimicking amphiphile - efficient DNA-transfer without co-lipids.
Pinnapireddy SR , Giselbrecht J , Strehlow B , Janich C , Husteden C , Meister A , Loppnow H , Sedding D , Erdmann F , Hause G , Brezesinski G , Groth T , Langner A , Bakowsky U , Wölk C .
Biomater Sci. 2019 Dec 17;8(1):232-249. doi: 10.1039/c9bm01093a.

Targeted ErbB3 cancer therapy: A synergistic approach to effectively combat cancer.
Ali MY, Tariq I, Ali S, Amin MU, Engelhardt K, Pinnapireddy SR, Duse L, Schäfer J, Bakowsky U.
Int J Pharm. 2020 Feb 15;575:118961. doi: 10.1016/j.ijpharm.2019.118961.

Selective anti-ErbB3 aptamer modified sorafenib microparticles: In vitro and in vivo toxicity assessment.
Ali MY, Tariq I, Farhan Sohail M, Amin MU, Ali S, Pinnapireddy SR, Ali A, Schäfer J, Bakowsky U.
Eur J Pharm Biopharm. 2019 Dec;145:42-53. doi: 10.1016/j.ejpb.2019.10.003.

Nucleic acid carrier composed of a branched fatty acid lysine conjugate-Interaction studies with blood components.
Giselbrecht J, Wiedemann S, Reddy Pinnapireddy S, Goergen N, Loppnow H, Sedding D, Erdmann F, Bakowsky U, Hause G, Lúcio M, Langner A, Wölk C.
Colloids Surf B Biointerfaces. 2019 Dec 1;184:110547. doi: 10.1016/j.colsurfb.2019.110547.

Hypericin inclusion complexes encapsulated in liposomes for antimicrobial photodynamic therapy.
Plenagl N, Seitz BS, Duse L, Pinnapireddy SR, Jedelska J, Brüßler J, Bakowsky U.
Int J Pharm. 2019 Oct 30;570:118666. doi: 10.1016/j.ijpharm.2019.118666.

Spray dried curcumin loaded nanoparticles for antimicrobial photodynamic therapy.
Preis E, Baghdan E, Agel MR, Anders T, Pourasghar M, Schneider M, Bakowsky U.
Eur J Pharm Biopharm. 2019 Sep;142:531-539. doi: 10.1016/j.ejpb.2019.07.023.

The Use of Artificial Gel Forming Bolalipids as Novel Formulations in Antimicrobial and Antifungal Therapy.
Goergen N, Wojcik M, Drescher S, Pinnapireddy SR, Brüßler J, Bakowsky U, Jedelská J.
Pharmaceutics. 2019 Jul 1;11(7):307. doi: 10.3390/pharmaceutics11070307.

Hydrogel implants for transscleral drug delivery for retinoblastoma treatment.
Cocarta AI, Hobzova R, Sirc J, Cerna T, Hrabeta J, Svojgr K, Pochop P, Kodetova M, Jedelska J, Bakowsky U, Uhlik J.
Mater Sci Eng C Mater Biol Appl. 2019 Oct;103:109799. doi: 10.1016/j.msec.2019.109799.

Synergistic effects of ultrasound and photodynamic therapy leading to biofilm eradication on polyurethane catheter surfaces modified with hypericin nanoformulations.
Vögeling H, Plenagl N, Seitz BS, Duse L, Pinnapireddy SR, Dayyoub E, Jedelska J, Brüßler J, Bakowsky U.
Mater Sci Eng C Mater Biol Appl. 2019 Oct;103:109749. doi: 10.1016/j.msec.2019.109749. 

Photodynamic therapy - hypericin tetraether liposome conjugates and their antitumor and antiangiogenic activity.
Plenagl N, Duse L, Seitz BS, Goergen N, Pinnapireddy SR, Jedelska J, Brüßler J, Bakowsky U.
Drug Deliv. 2019 Dec;26(1):23-33. doi: 10.1080/10717544.2018.1531954.

Chemotherapy Based on Supramolecular Chemistry: A Promising Strategy in Cancer Therapy.
Fahmy SA, Brüßler J, Alawak M, El-Sayed MMH, Bakowsky U, Shoeib T.
Pharmaceutics. 2019 Jun 20;11(6). pii: E292. doi: 10.3390/pharmaceutics11060292. 

Photodynamic Therapy of Ovarian Carcinoma Cells with Curcumin-Loaded Biodegradable Polymeric Nanoparticles.
Duse L, Agel MR, Pinnapireddy SR, Schäfer J, Selo MA, Ehrhardt C, Bakowsky U.
Pharmaceutics. 2019 Jun 15;11(6). pii: E282. doi: 10.3390/pharmaceutics11060282.

Curcumin loaded nanoparticles as efficient photoactive formulations against gram-positive and gram-negative bacteria.
Agel MR, Baghdan E, Pinnapireddy SR, Lehmann J, Schäfer J, Bakowsky U.
Colloids Surf B Biointerfaces. 2019 Jun 1;178:460-468. doi: 10.1016/j.colsurfb.2019.03.027. 

Nano spray dried antibacterial coatings for dental implants.
Baghdan E, Raschpichler M, Lutfi W, Pinnapireddy SR, Pourasghar M, Schäfer J, Schneider M, Bakowsky U.
Eur J Pharm Biopharm. 2019 Jun;139:59-67. doi: 10.1016/j.ejpb.2019.03.003.

Poly(d,l-lactide)/polyethylene glycol micro/nanofiber mats as paclitaxel-eluting carriers: preparation and characterization of fibers, in vitro drug release, antiangiogenic activity and tumor recurrence prevention.
Hobzova R, Hampejsova Z, Cerna T, Hrabeta J, Venclikova K, Jedelska J, Bakowsky U, Bosakova Z, Lhotka M, Vaculin S, Franek M, Steinhart M, Kovarova J, Michalek J, Sirc J.Mater Sci Eng C Mater Biol Appl. 2019 May;98:982-993. doi: 10.1016/j.msec.2019.01.046. 

Development of inhalable curcumin loaded Nano-in-Microparticles for bronchoscopic photodynamic therapy.
Baghdan E, Duse L, Schüer JJ, Pinnapireddy SR, Pourasghar M, Schäfer J, Schneider M, Bakowsky U.
Eur J Pharm Sci. 2019 Apr 30;132:63-71. doi: 10.1016/j.ejps.2019.02.025.

ortho-Fluoroazobenzene derivatives as DNA intercalators for photocontrol of DNA and nucleosome binding by visible light.
Heinrich B, Bouazoune K, Wojcik M, Bakowsky U, Vázquez O.
Org Biomol Chem. 2019 Feb 13;17(7):1827-1833. doi: 10.1039/c8ob02343c.

In situ intravenous photodynamic therapy for the systemic eradication of blood stream infections.
Raschpichler M, Agel MR, Pinnapireddy SR, Duse L, Baghdan E, Schäfer J, Bakowsky U.
Photochem Photobiol Sci. 2019 Feb 13;18(2):304-308. doi: 10.1039/c8pp00267c.

Lipodendriplexes: A promising nanocarrier for enhanced gene delivery with minimal cytotoxicity.
Tariq I, Pinnapireddy SR, Duse L, Ali MY, Ali S, Amin MU, Goergen N, Jedelská J, Schäfer J, Bakowsky U.
Eur J Pharm Biopharm. 2019 Feb;135:72-82. doi: 10.1016/j.ejpb.2018.12.013. 

Glycosylated Artificial Virus-Like Hybrid Vectors for Advanced Gene Delivery.
Pinnapireddy SR, Raafat El Assy M, Schlote P, Bakowsky U.
Polymers (Basel). 2019 Feb 1;11(2). pii: E243. doi: 10.3390/polym11020243.

Nanoenabled Bioseparations: Current Developments and Future Prospects.
Fahmy SA, Alawak M, Brüßler J, Bakowsky U, El Sayed MMH.
Biomed Res Int. 2019 Jan 29;2019:4983291. doi: 10.1155/2019/4983291.

2018

Nanoscaled ultrasound contrast agents for enhanced sonothrombolysis.
Brüßler J, Strehlow B, Becker A, Schubert R, Schümmelfeder J, Nimsky C, Bakowsky U.
Colloids Surf B Biointerfaces. 2018 Dec 1;172:728-733. doi: 10.1016/j.colsurfb.2018.09.037.

Stabilized tetraether lipids based particles guided prophyrins photodynamic therapy.
Mahmoud G, Jedelská J, Omar SM, Strehlow B, Schneider M, Bakowsky U.
Drug Deliv. 2018 Nov;25(1):1526-1536. doi: 10.1080/10717544.2018.1482970.

Virome Analysis Reveals No Association of Head and Neck Vascular Anomalies with an Active Viral Infection.
Franke N, Bette M, Marquardt A, Briese T, Lipkin WI, Kurz C, Ehrenreich J, Mack E, Baying B, Beneš V, Rodepeter FR, Neff A, Teymoortash A, Eivazi B, Geisthoff U, Stuck BA, Bakowsky U, Mandic R.
In Vivo. 2018 Nov-Dec;32(6):1323-1331. doi: 10.21873/invivo.11382.

Evaluation of a ureteral catheter coating by means of a BioEncrustation in vitro model.
Frant M, Dayyoub E, Bakowsky U, Liefeith K.
Int J Pharm. 2018 Jul 30;546(1-2):86-96. doi: 10.1016/j.ijpharm.2018.04.023.

The application of STEP-technology® for particle and protein dispersion detection studies in biopharmaceutical research.
Gross-Rother J, Herrmann N, Blech M, Pinnapireddy SR, Garidel P, Bakowsky U.
Int J Pharm. 2018 May 30;543(1-2):257-268. doi: 10.1016/j.ijpharm.2018.03.050. 

Low level LED photodynamic therapy using curcumin loaded tetraether liposomes.
Duse L, Pinnapireddy SR, Strehlow B, Jedelská J, Bakowsky U.
Eur J Pharm Biopharm. 2018 May;126:233-241. doi: 10.1016/j.ejpb.2017.10.005. 

Overcoming the polycation dilemma - Explorative studies to characterise the efficiency and biocompatibility of newly designed lipofection reagents.
Giselbrecht J, Janich C, Pinnapireddy SR, Hause G, Bakowsky U, Wölk C, Langner A.
Int J Pharm. 2018 Apr 25;541(1-2):81-92. doi: 10.1016/j.ijpharm.2018.02.029.

Resuspendable Powders of Lyophilized Chalcogen Particles with Activity against Microorganisms.
Griffin S, Sarfraz M, Hartmann SF, Pinnapireddy SR, Nasim MJ, Bakowsky U, Keck CM, Jacob C.
Antioxidants (Basel). 2018 Jan 27;7(2). pii: E23. doi: 10.3390/antiox7020023.

Lipid coated chitosan-DNA nanoparticles for enhanced gene delivery.
Baghdan E, Pinnapireddy SR, Strehlow B, Engelhardt KH, Schäfer J, Bakowsky U.
Int J Pharm. 2018 Jan 15;535(1-2):473-479. doi: 10.1016/j.ijpharm.2017.11.045. 

2017

Photo-responsive tetraether lipids based vesicles for prophyrin mediated vascular targeting and direct phototherapy.
Mahmoud G, Jedelská J, Strehlow B, Omar S, Schneider M, Bakowsky U.
Colloids Surf B Biointerfaces. 2017 Nov 1;159:720-728. doi: 10.1016/j.colsurfb.2017.08.049.

Antibacterial and anti-encrustation biodegradable polymer coating for urinary catheter.
Dayyoub E, Frant M, Pinnapireddy SR, Liefeith K, Bakowsky U.
Int J Pharm. 2017 Oct 5;531(1):205-214. doi: 10.1016/j.ijpharm.2017.08.072.

Interaction of DNA with Cationic Lipid Mixtures-Investigation at Langmuir Lipid Monolayers.
Janich C, Hädicke A, Bakowsky U, Brezesinski G, Wölk C.
Langmuir. 2017 Oct 3;33(39):10172-10183. doi: 10.1021/acs.langmuir.7b02014. 

Malonic acid based cationic lipids - The way to highly efficient DNA-carriers.
Wölk C, Janich C, Bakowsky U, Langner A, Brezesinski G.
Adv Colloid Interface Sci. 2017 Oct;248:20-34. doi: 10.1016/j.cis.2017.08.003. 

Aspherical, Nanostructured Microparticles for Targeted Gene Delivery to Alveolar Macrophages.
Möhwald M, Pinnapireddy SR, Wonnenberg B, Pourasghar M, Jurisic M, Jung A, Fink-Straube C, Tschernig T, Bakowsky U, Schneider M.
Adv Healthc Mater. 2017 Oct;6(20). doi: 10.1002/adhm.201700478.

Composite liposome-PEI/nucleic acid lipopolyplexes for safe and efficient gene delivery and gene knockdown.
Pinnapireddy SR, Duse L, Strehlow B, Schäfer J, Bakowsky U.
Colloids Surf B Biointerfaces. 2017 Oct 1;158:93-101. doi: 10.1016/j.colsurfb.2017.06.022.

Evaluation of liposomal carnosine in adjuvant arthritis.
Slovák L, Poništ S, Fedorova T, Logvinenko A, Levacheva I, Samsonova O, Bakowsky U, Pašková Ľ, Čavojský T, Tsiklauri L, Bauerová K.
Gen Physiol Biophys. 2017 Oct;36(4):471-479. doi: 10.4149/gpb_2017014.

Fast therapeutic DNA internalization - A high potential transfection system based on a peptide mimicking cationic lipid.
Janich C, Pinnapireddy SR, Erdmann F, Groth T, Langner A, Bakowsky U, Wölk C.
Eur J Pharm Biopharm. 2017 Sep;118:38-47. doi: 10.1016/j.ejpb.2016.12.007. 

Development of expanded polytetrafluoroethylene cardiovascular graft platform based on immobilization of poly lactic-co-glycolic acid nanoparticles using a wet chemical modification technique.
Al Meslmani BM, Mahmoud GF, Bakowsky U.
Int J Pharm. 2017 Aug 30;529(1-2):238-244. doi: 10.1016/j.ijpharm.2017.06.091.

Real-time, label-free monitoring of cell viability based on cell adhesion measurements with an atomic force microscope.
Yang F, Riedel R, Del Pino P, Pelaz B, Said AH, Soliman M, Pinnapireddy SR, Feliu N, Parak WJ, Bakowsky U, Hampp N.
J Nanobiotechnology. 2017 Mar 22;15(1):23. doi: 10.1186/s12951-017-0256-7.

Transfection Studies with Colloidal Systems Containing Highly Purified Bipolar Tetraether Lipids from Sulfolobus acidocaldarius.
Engelhardt KH, Pinnapireddy SR, Baghdan E, Jedelská J, Bakowsky U.
Archaea. 2017 Jan 23;2017:8047149. doi: 10.1155/2017/8047149. 

Liposome-polyethylenimine complexes (DPPC-PEI lipopolyplexes) for therapeutic siRNA delivery in vivo.
Ewe A, Panchal O, Pinnapireddy SR, Bakowsky U, Przybylski S, Temme A, Aigner A.
Nanomedicine. 2017 Jan;13(1):209-218. doi: 10.1016/j.nano.2016.08.005. 

Anti-inflammatory and anti-nociceptive activities of African medicinal spices and vegetables
Dzoyem JP, McGaw LJ, Kuete V, Bakowsky U.
Medicinal Spices and Vegetables from Africa. 2017, 239-70

Cytotoxicity  of secondary metabolites from dracaena viridiflora Engl & Krause and their semisythetic analogues.
Teponno RB., Dzoyem JP, Nono RN, Kauhl U, Sandjo LP, Tapondjou LA, Bakowsky U, Opatz T.
Rec. Nat. Prod. Jan 2017, Vol. 11 (5); 421-30

2016

Fast therapeutic DNA internalization - A high potential transfection system based on a peptide mimicking cationic lipid.
Janich C, Pinnapireddy SR, Erdmann F, Groth T, Langner A, Bakowsky U, Wölk C.
Eur J Pharm Biopharm. Dec 2016: doi: 10.1016/j.ejpb.2016.12.007

Structures of malonic acid diamide/phospholipid composites and their lipoplexes
Janich C, Taßler S, Meister A, Hause G, Schäfer J, Bakowsky U, Brezesinski G, Wölk C.
Soft Matter. July 2016, Vol. 12 (27); 5854-66

 Nanoparticle Tracking Analysis of Particle Size and Concentration Detection in Suspensions of Polymer and Protein Samples: Influence of Experimental and Data Evaluation Parameters
Gross J, Sayle S, Karow AR, Bakowsky U, Garidel P.
Eur J Pharm Biopharm. July 2016, Vol. 104; 30-41

Covalent immobilization of lysozyme onto woven and knitted crimped polyethylene terephtalate grafts to minimize the adhesion of broad spectrum pathogens.
Al Meslmani B, Mahmoud GF, Leichtweiß T., Strehlow B, Sommer FO, Lohoff MD, Bakowsky U.
Mat Sci Eng: C. 2016, Available online: 25 August 2015; 78-87

2015

 Thrombin-inhibiting anticoagulant liposomes: development and characterization.
Endreas W, Brueßler J, Vornicescu D, Keusgen M, Bakowsky U, Steinmetzer T.
Chem Med Chem: Published online Dec 14, 2015; DOI: 10.1002/

Investigation of binary lipid mixtures of a three-chain cationic lipid with phospholipids suitable for gene delivery
Wölk C, Janich C, Meister A, Drescher S, Langner A, Brezesinski G, Bakowsky U.
Bioconjugate Chem. 2015 Oct 26; DOI: 10.1021

Bipolar tetraether lipids derived from thermoacidophilic archaeon Sulfolobus acidocaldarius for membrane stabilization of chlorin e6 based liposomes for photodynamic therapy
Mahmoud GF, Jedelská J, Strehlow B, Bakowsky U.
Eur J Pharm Biopharm. 2015; Available online 1 May 2015

Multifunctional network-structured film coating for woven and knitted polyethylene terephtalate against cardiovascular graft-associated infections
Al Meslmani B, Mahmoud GF, Sommer FO, Lohoff MD, Bakowsky U.
Int J Pharm. 2015 May 1; 270-276

 2014

Optimized thermosensitive liposomes for selective doxorubicin delivery: formulation development, quality analysis and bioactivity proof
Levacheva I, Samsonova O, Tazina E, Beck-Broichsitter M, Levachev S, Strehlow B, Baryshnikova M, Oborotova N, Baryshnikov A, Bakowsky U.
Colloids Surf B Biointerfaces. 2014 Sep 1;121:248-56 

Development of thrombus-resistant and cell compatible crimped polyethylene terephthalate cardiovascular grafts using surface co-immobilized heparin and collagen
Al Meslmani B, Mahmoud G, Strehlow B, Mohr E, Leichtweiß T, Bakowsky U.
Mater Sci Eng C Mater Biol Appl. 2014 Oct 1;43:538-46. doi: 10.1016

A chiral, low-cytotoxic [ni15]-wheel complex
Muche S, Levacheva I, Samsonova O, Pham L, Christou G, Bakowsky U, Hołyńska M.
Inorg Chem. 2014 Jul 21;53(14):7642-9

Quantification of nanoparticle uptake into hair follicles in pig ear and human forearm
Raber AS, Mittal A, Schäfer J, Bakowsky U, Reichrath J, Vogt T, Schaefer UF, Hansen S, Lehr CM.
J Control Release. 2014 Apr 10;179:25-32

Storage stability of optimal liposome-polyethylenimine complexes (lipopolyplexes) for DNA or siRNA delivery
Ewe A, Schaper A, Barnert S, Schubert R, Temme A, Bakowsky U, Aigner A.
Acta Biomater. 2014 Mar 1. pii: S1742-7061(14)00089-0

Correlation of structure and echogenicity of nanoscaled ultrasound contrast agents in vitro
Brüßler J, Marxer E, Becker A, Schubert R, Schümmelfeder J, Nimsky C, Bakowsky U.
Colloids Surf B Biointerfaces. 2014 Feb 28;117C:206-215 

2013

 A chorioallantoic membrane model for the determination of anti-angiogenic effects of imatinib
Özcetin A, Aigner A, Bakowsky U.
Eur J Pharm Biopharm. 2013 Nov;85(3 Pt A):711-5

The chorioallantoic membrane assay is a promising ex vivo model system for the study of vascular anomalies
Jedelská J, Strehlow B, Bakowsky U, Aigner A, Höbel S, Bette M, Roessler M, Franke N, Teymoortash A, Werner JA, Eivazi B, Mandic R.
In Vivo. 2013 Nov-Dec;27(6):701-5

Nanostructured medical device coatings based on self-assembled poly(lactic-co-glycolic acid) nanoparticles
Dayyoub E, Hobler C, Nonnweiler P, Keusgen M, Bakowsky U.
Mater Sci Eng C Mater Biol Appl. 2013 Jul 1;33(5):3018-24

Epidermal growth factor-induced modulation of cytokeratin expression levels influences the morphological phenotype of head and neck squamous cell carcinoma cells
Makarova G, Bette M, Schmidt A, Jacob R, Cai C, Rodepeter F, Betz T, Sitterberg J, Bakowsky U, Moll R, Neff A, Sesterhenn A, Teymoortash A, Ocker M, Werner JA, Mandic R.
Cell Tissue Res. 2013 Jan;351(1):59-72 

2012

Targeted delivery of transferrin-conjugated liposomes to an orthotopic model of lung cancer in nude rats
Gaspar MM, Radomska A, Gobbo OL, Bakowsky U, Radomski MW, Ehrhardt C.
J Aerosol Med Pulm Drug Deliv. 2012 Dec;25(6):310-8

Contrast-enhanced ultrasound ventriculography
Becker A, Kuhnt D, Bakowsky U, Nimsky C.
Neurosurgery. 2012 Dec;71(2 Suppl Operative):ons296-301

Biophysical and biological investigation of DNA nano-complexes with a non-toxic, biodegradable amine-modified hyperbranched polyester
Reul R, Nguyen J, Biela A, Marxer E, Bakowsky U, Klebe G, Kissel T.
Int J Pharm. 2012 Oct 15;436(1-2):97-105

Impact of lyoprotectants for the stabilization of biodegradable nanoparticles on the performance of air-jet, ultrasonic, and vibrating-mesh nebulizers
Beck-Broichsitter M, Kleimann P, Schmehl T, Betz T, Bakowsky U, Kissel T, Seeger W.
Eur J Pharm Biopharm. 2012 Oct;82(2):272-80

PEI-complexed LNA antiseeds as miRNA inhibitors
Thomas M, Lange-Grünweller K, Dayyoub E, Bakowsky U, Weirauch U, Aigner A, Hartmann RK, Grünweller A.
RNA Biol. 2012 Aug;9(8):1088-98

Atomic force microscopy and analytical ultracentrifugation for probing nanomaterial protein interactions
Schaefer J, Schulze C, Marxer EE, Schaefer UF, Wohlleben W, Bakowsky U, Lehr CM.
ACS Nano. 2012 Jun 26;6(6):4603-14

Highly potent inhibitors of proprotein convertase furin as potential drugs for treatment of infectious diseases
Becker GL, Lu Y, Hardes K, Strehlow B, Levesque C, Lindberg I, Sandvig K, Bakowsky U, Day R, Garten W, Steinmetzer T.
J Biol Chem. 2012 Jun 22;287(26):21992-2003

In vitro and in vivo characterisation of PEG-lipid-based micellar complexes of salmon calcitonin for pulmonary delivery
Baginski L, Gobbo OL, Tewes F, Salomon JJ, Healy AM, Bakowsky U, Ehrhardt C.
Pharm Res. 2012 Jun;29(6):1425-34

Predicting protein instability in sustained protein delivery systems using spectral-phase interference
Seidel N, Sitterberg J, Vornholt W, Bakowsky U, Keusgen M, Kissel T.
Biomaterials. 2012 Feb;33(6):1929-38

Investigations into the fate of inhaled salmon calcitonin at the respiratory epithelial barrier
Baginski L, Tewes F, Buckley ST, Healy AM, Bakowsky U, Ehrhardt C.
Pharm Res. 2012 Jan;29(1):332-41 

2011

A novel nanoscaled ultrasound contrast agent for specific targeting to the sites of inflammation
Bakowsky U, Marxer E, Schaefer J, Bendas G, Schuemmelfeder J.
Ultrasound in Medicine & Biology. 2011 Aug; 37(8):S 107

Determination of success of transcoronary ablation of septum hypertrophy in patients with hypertrophic obstructive cardiomyopathy by perfusion echocardiography    Schuemmelfeder J, Gietzen F, Hamid S, Bakowsky U.
Ultrasound in Medicine & Biology. 2011 Aug; 37 (8): S 110

Plaque characterization in the carotid artery by ultrasound contrast agents
Schuemmelfeder J, Hamid S, Grieser A, Bakowsky U.
Ultrasound in Medicine & Biology. 2011 Aug; 37 (8): S 156

Methotrexate-loaded chitosan- and glycol chitosan-based nanoparticles: a promising strategy for the administration of the anticancer drug to brain tumors
Trapani A, Denora N, Iacobellis G, Sitterberg J, Bakowsky U, Kissel T.
AAPS PharmSciTech. 2011 Dec;12(4):1302-11

Stability of monomolecular films of archaebacterial tetraether lipids on silicon wafers: a comparison of physisorbed and chemisorbed monolayers
Vidawati S, Sitterberg J, Rothe U, Bakowsky U.
Colloids Surf B Biointerfaces. 2011 Oct 15;87(2):209-16

Biophysical investigation of pulmonary surfactant surface properties upon contact with polymeric nanoparticles in vitro
Beck-Broichsitter M, Ruppert C, Schmehl T, Guenther A, Betz T, Bakowsky U, Seeger W, Kissel T, Gessler T.
Nanomedicine. 2011 Jun;7(3):341-50

Ultrasound active nanoscaled lipid formulations for thrombus lysis
Becker A, Marxer E, Brüssler J, Hoormann AS, Kuhnt D, Bakowsky U, Nimsky C.
Eur J Pharm Biopharm. 2011 Apr;77(3):424-9

Development and characterization of new nanoscaled ultrasound active lipid dispersions as contrast agents
Marxer EE, Brüssler J, Becker A, Schümmelfeder J, Schubert R, Nimsky C, Bakowsky U.
Eur J Pharm Biopharm. 2011 Apr;77(3):430-7

Reverse transcription polymerase chain reaction (RT-PCR) analysis of proteolytic enzymes in cultures of human respiratory epithelial cells
Baginski L, Tachon G, Falson F, Patton JS, Bakowsky U, Ehrhardt C.
J Aerosol Med Pulm Drug Deliv. 2011 Apr;24(2):89-101

Model membrane approaches to determine the role of calcium for the antimicrobial activity of friulimicin
Reder-Christ K, Falkenstein-Paul H, Klocek G, Al-Kaddah S, Bakowsky U, Bendas G.
Int J Antimicrob Agents. 2011 Mar;37(3):256-60

2010

Liposome-polyethylenimine complexes for enhanced DNA and siRNA delivery
Schäfer J, Höbel S, Bakowsky U, Aigner A.
Biomaterials. 2010 Sep;31(26):6892-900

AFM and ellipsometric studies on LB films of natural asymmetric and symmetric bolaamphiphilic archaebacterial tetraether lipids on silicon wafers
Vidawati S, Sitterberg J, Bakowsky U, Rothe U.
Colloids Surf B Biointerfaces. 2010 Jul 1;78(2):303-9

Archaebacterial tetraetherlipid liposomes
Ozcetin A, Mutlu S, Bakowsky U.
Methods Mol Biol. 2010;605:87-96

Preparation, characterization and in silico modeling of biodegradable nanoparticles containing cyclosporine A and coenzyme Q10
Ankola DD, Durbin EW, Buxton GA, Schäfer J, Bakowsky U, Kumar MN.
Nanotechnology. 2010 Feb 10;21(6):065104

Atomic force microscopy for the characterization of proteoliposomes
Sitterberg J, Gaspar MM, Ehrhardt C, Bakowsky U.
Methods Mol Biol. 2010;606:351-61

2009

Utilising atomic force microscopy for the characterisation of nanoscale drug delivery systems
Sitterberg J, Ozcetin A, Ehrhardt C, Bakowsky U.
Eur J Pharm Biopharm. 2010 Jan;74(1):

Triazine dendrimers as nonviral gene delivery systems: effects of molecular structure on biological activity
Merkel OM, Mintzer MA, Sitterberg J, Bakowsky U, Simanek EE, Kissel T.
Bioconjug Chem. 2009 Sep;20(9):1799-806

Nanocomposites of lung surfactant and biodegradable cationic nanoparticles improve transfection efficiency to lung cells
Nguyen J, Reul R, Betz T, Dayyoub E, Schmehl T, Gessler T, Bakowsky U, Seeger W, Kissel T.
J Control Release. 2009 Nov 16;140(1):47-54

The potential of glycol chitosan nanoparticles as carrier for low water soluble drugs
Trapani A, Sitterberg J, Bakowsky U, Kissel T.
Int J Pharm. 2009 Jun 22;375(1-2):97-106

Stabilization of aerosolizable nano-carriers by freeze-drying
Packhaeuser CB, Lahnstein K, Sitterberg J, Schmehl T, Gessler T, Bakowsky U, Seeger W, Kissel T.
Pharm Res. 2009 Jan;26(1):129-38

2008

Effects of cell-penetrating peptides and pegylation on transfection efficiency of polyethylenimine in mouse lungs
Nguyen J, Xie X, Neu M, Dumitrascu R, Reul R, Sitterberg J, Bakowsky U, Schermuly R, Fink L, Schmehl T, Gessler T, Seeger W, Kissel T.
J Gene Med. 2008 Nov;10(11):1236-46

Polyethylenimine PEI F25-LMW allows the long-term storage of frozen complexes as fully active reagents in siRNA-mediated gene targeting and DNA delivery
Höbel S, Prinz R, Malek A, Urban-Klein B, Sitterberg J, Bakowsky U, Czubayko F, Aigner A.
Eur J Pharm Biopharm. 2008 Sep;70(1):29-41

Gene delivery using chitosan, trimethyl chitosan or polyethylenglycol-graft-trimethyl chitosan block copolymers: establishment of structure-activity relationships in vitro
Germershaus O, Mao S, Sitterberg J, Bakowsky U, Kissel T.
J Control Release. 2008 Jan 22;125(2):145-54

Charged nanoparticles as protein delivery systems: a feasibility study using lysozyme as model protein
Cai C, Bakowsky U, Rytting E, Schaper AK, Kissel T.
Eur J Pharm Biopharm. 2008 May;69(1):31-42

Adhesion characteristics and stability assessment of lectin-modified liposomes for site-specific drug delivery
Bakowsky H, Richter T, Kneuer C, Hoekstra D, Rothe U, Bendas G, Ehrhardt C, Bakowsky U.
Biochim Biophys Acta. 2008 Jan;1778(1):242-9

Inhaled liposomes - current strategies and future challenges
Gaspar MM, Bakowsky U, Ehrhardt C.
J. Biomed. Nanotechnol. 2008 Sep; 4(3): 245-257

A new drug vehicle - lipid coated biodegradable nanoparticles
Schaefer J, Sitterberg J, Ehrhardt C, Ravi Kumar MNV, Bakowsky U.
Adv Sci Technol. 2008 Sep; 57: 148-153

New antibacterial, antiadhesive films based on self assemblies of modified tetraetherlipids
Dayyoub E, Sitterberg J, Rothe U, Bakowsky U.
Adv Sci Technol. 2008 Sep; 57: 188-194

 2007

Peroral delivery of insulin using chitosan derivatives: a comparative study of polyelectrolyte nanocomplexes and nanoparticles
Jintapattanakit A, Junyaprasert VB, Mao S, Sitterberg J, Bakowsky U, Kissel T.
Int J Pharm. 2007 Sep 5;342(1-2):240-9

Poly(vinyl alcohol)-graft-poly(lactide-co-glycolide) nanoparticles for local delivery of paclitaxel for restenosis treatment
Westedt U, Kalinowski M, Wittmar M, Merdan T, Unger F, Fuchs J, Schäller S, Bakowsky U, Kissel T.
J Control Release. 2007 May 14;119(1):41-51

The role of lipid II in membrane binding of and pore formation by nisin analyzed by two combined biosensor techniques
Christ K, Wiedemann I, Bakowsky U, Sahl HG, Bendas G.
Biochim Biophys Acta. 2007 Mar;1768(3):694-704

Iloprost-containing liposomes for aerosol application in pulmonary arterial hypertension: formulation aspects and stability
Kleemann E, Schmehl T, Gessler T, Bakowsky U, Kissel T, Seeger W.
Pharm Res. 2007 Feb;24(2):277-87

Conformational change of membrane proteins leads to shape changes of red blood cells
Betz T, Bakowsky U, Müller MR, Lehr CM, Bernhardt I.
Bioelectrochemistry. 2007 Jan;70(1):122-6

Understanding nanoscale drug delivery systems
Bakowsky U, Sitterberg J.
Glatt Int. Times. 2007, 23: 19-23 

2006

Stabilized nanocarriers for plasmids based upon cross-linked poly(ethylene imine)
Neu M, Sitterberg J, Bakowsky U, Kissel T.
Biomacromolecules. 2006 Dec;7(12):3428-38

Selectins--potential pharmacological targets?
Kneuer C, Ehrhardt C, Radomski MW, Bakowsky U.
Drug Discov Today. 2006 Nov;11(21-22):1034-40

Effect of PEGylation on the stability of liposomes during nebulisation and in lung surfactant
Anabousi S, Kleemann E, Bakowsky U, Kissel T, Schmehl T, Gessler T, Seeger W, Lehr CM, Ehrhardt C.
J Nanosci Nanotechnol. 2006 Sep-Oct;6(9-10):3010-6

The influence of physicochemical parameters on the efficacy of non-viral DNA transfection complexes: a comparative study
Kneuer C, Ehrhardt C, Bakowsky H, Kumar MN, Oberle V, Lehr CM, Hoekstra D, Bakowsky U.
J Nanosci Nanotechnol. 2006 Sep-Oct;6(9-10):2776-82

Influence of polyethylene glycol chain length on the physicochemical and biological properties of poly(ethylene imine)-graft-poly(ethylene glycol) block copolymer/SiRNA polyplexes
Mao S, Neu M, Germershaus O, Merkel O, Sitterberg J, Bakowsky U, Kissel T.
Bioconjug Chem. 2006 Sep-Oct;17(5):1209-18

Trastuzumab-polyethylenimine-polyethylene glycol conjugates for targeting Her2-expressing tumors
Germershaus O, Merdan T, Bakowsky U, Behe M, Kissel T.
Bioconjug Chem. 2006 Sep-Oct;17(5):1190-9

In vitro assessment of transferrin-conjugated liposomes as drug delivery systems for inhalation therapy of lung cancer
Anabousi S, Bakowsky U, Schneider M, Huwer H, Lehr CM, Ehrhardt C.
Eur J Pharm Sci. 2006 Dec;29(5):367-74

RNA interference-mediated gene silencing of pleiotrophin through polyethylenimine-complexed small interfering RNAs in vivo exerts antitumoral effects in glioblastoma xenografts
Grzelinski M, Urban-Klein B, Martens T, Lamszus K, Bakowsky U, Höbel S, Czubayko F, Aigner A.
Hum Gene Ther. 2006 Jul;17(7):751-66

Synthesis of a polymer skeleton at the inner leaflet of liposomal membranes: polymerization of membrane-adsorbed pH-sensitive monomers
Gutmayer D, Thomann R, Bakowsky U, Schubert R.
Biomacromolecules. 2006 May;7(5):1422-8

A low molecular weight fraction of polyethylenimine (PEI) displays increased transfection efficiency of DNA and siRNA in fresh or lyophilized complexes
Werth S, Urban-Klein B, Dai L, Höbel S, Grzelinski M, Bakowsky U, Czubayko F, Aigner A.
J Control Release. 2006 May 15;112(2):257-70

Self-assembled polyelectrolyte nanocomplexes between chitosan derivatives and insulin
Mao S, Bakowsky U, Jintapattanakit A, Kissel T.
J Pharm Sci. 2006 May;95(5):1035-48

The in vitro stability of air-filled polybutylcyanoacrylate microparticles
Olbrich C, Hauff P, Scholle F, Schmidt W, Bakowsky U, Briel A, Schirner M.
Biomaterials. 2006 Jul;27(19):3549-59

Lessons learned from clustering of fluorinated glycolipids on selectin ligand function in cell rolling
Schumacher G, Bakowsky U, Gege C, Schmidt RR, Rothe U, Bendas G.
Biochemistry. 2006 Mar 7;45(9):2894-903

DNA nano-carriers from biodegradable cationic branched polyesters are formed by a modified solvent displacement method
Oster CG, Wittmar M, Bakowsky U, Kissel T.
J Control Release. 2006 Apr 10;111(3):371-81

Design of estradiol loaded PLGA nanoparticulate formulations: a potential oral delivery system for hormone therapy
Hariharan S, Bhardwaj V, Bala I, Sitterberg J, Bakowsky U, Ravi Kumar MN.
Pharm Res. 2006 Jan;23(1):184-95

2005

Preparation and characterization of chitosan and trimethyl-chitosan-modified poly-(epsilon-caprolactone) nanoparticles as DNA carriers
Haas J, Ravi Kumar MN, Borchard G, Bakowsky U, Lehr CM.
AAPS PharmSciTech. 2005 Aug 10;6(1):E22-30

PEGylation of poly(ethylene imine) affects stability of complexes with plasmid DNA under in vivo conditions in a dose-dependent manner after intravenous injection into mice
Merdan T, Kunath K, Petersen H, Bakowsky U, Voigt KH, Kopecek J, Kissel T.
Bioconjug Chem. 2005 Jul-Aug;16(4):785-92

Assessing transferrin modification of liposomes by atomic force microscopy and transmission electron microscopy
Anabousi S, Laue M, Lehr CM, Bakowsky U, Ehrhardt C.
Eur J Pharm Biopharm. 2005 Jul;60(2):295-303

In vitro cell response to a polymer surface micropatterned by laser interference lithography
Yu F, Mücklich F, Li P, Shen H, Mathur S, Lehr CM, Bakowsky U.
Biomacromolecules. 2005 May-Jun;6(3):1160-7

Nonbilayer phase of lipoplex-membrane mixture determines endosomal escape of genetic cargo and transfection efficiency
Zuhorn IS, Bakowsky U, Polushkin E, Visser WH, Stuart MC, Engberts JB, Hoekstra D.
Mol Ther. 2005 May;11(5):801-10

Salbutamol is actively absorbed across human bronchial epithelial cell layers
Ehrhardt C, Kneuer C, Bies C, Lehr CM, Kim KJ, Bakowsky U.
Pulm Pharmacol Ther. 2005;18(3):165-70

Laser interference lithography as a new and efficient technique for micropatterning of biopolymer surface
Yu F, Li P, Shen H, Mathur S, Lehr CM, Bakowsky U, Mücklich F.
Biomaterials. 2005 May;26(15):2307-12

2004

Cationic poly(lactide-co-glycolide) nanoparticles as efficient in vivo gene transfection agents
Kumar MN, Mohapatra SS, Kong X, Jena PK, Bakowsky U, Lehr CM.
J Nanosci Nanotechnol. 2004 Nov;4(8):990-4

Self-assembling nanocomplexes from insulin and water-soluble branched polyesters, poly[(vinyl-3-(diethylamino)- propylcarbamate-co-(vinyl acetate)-co-(vinyl alcohol)]-graft- poly(L-lactic acid): a novel carrier for     transmucosal delivery of peptides
Simon M, Wittmar M, Bakowsky U, Kissel T.
Bioconjug Chem. 2004 Jul-Aug;15(4):841-9

Cationic silica nanoparticles as gene carriers: synthesis, characterization and transfection efficiency in vitro and in vivo
Ravi Kumar MN, Sameti M, Mohapatra SS, Kong X, Lockey RF, Bakowsky U, Lindenblatt G, Schmidt H, Lehr CM.
J Nanosci Nanotechnol. 2004 Sep;4(7):876-81

Transfection with different colloidal systems: comparison of solid lipid nanoparticles and liposomes
Tabatt K, Kneuer C, Sameti M, Olbrich C, Müller RH, Lehr CM, Bakowsky U.
J Control Release. 2004 Jun 18;97(2):321-32

Selectins-an emerging target for drug delivery
Ehrhardt C, Kneuer C, Bakowsky U.
Adv Drug Deliv Rev. 2004 Mar 3;56(4):527-49

Preparation and characterization of cationic PLGA nanospheres as DNA carriers
Ravi Kumar MN, Bakowsky U, Lehr CM.
Biomaterials. 2004 May;25(10):1771-7

2003

Lipoplex assembly visualized by atomic force microscopy
Oberle V, Bakowsky U, Hoekstra D.
Methods Enzymol. 2003;373:281-97

Laser ablation patterning by interference induces directional cell growth
Li P, Bakowsky U, Yu F, Loehbach C, Muecklich F, Lehr CM.
IEEE Trans Nanobioscience. 2003 Sep;2(3):138-45

Stabilisation by freeze-drying of cationically modified silica nanoparticles for gene delivery
Sameti M, Bohr G, Ravi Kumar MN, Kneuer C, Bakowsky U, Nacken M, Schmidt H, Lehr CM.
Int J Pharm. 2003 Nov 6;266(1-2):51-60

Pegylated polyethylenimine-Fab' antibody fragment conjugates for targeted gene delivery to human ovarian carcinoma cells
Merdan T, Callahan J, Petersen H, Kunath K, Bakowsky U, Kopecková P, Kissel T, Kopecek J.
Bioconjug Chem. 2003 Sep-Oct;14(5):989-96

2002

Phase behavior of cationic amphiphiles and their mixtures with helper lipid influences lipoplex shape, DNA translocation, and transfection efficiency
Zuhorn IS, Oberle V, Visser WH, Engberts JB, Bakowsky U, Polushkin E, Hoekstra D.
Biophys J. 2002 Oct;83(4):2096-108

Phospholipid species act as modulators in p97/p47-mediated fusion of Golgi membranes
Pécheur EI, Martin I, Maier O, Bakowsky U, Ruysschaert JM, Hoekstra D.
Biochemistry. 2002 Aug 6;41(31):9813-23

Interference of serum with lipoplex-cell interaction: modulation of intracellular processing
Zuhorn IS, Visser WH, Bakowsky U, Engberts JB, Hoekstra D.
Biochim Biophys Acta. 2002 Feb 18;1560(1-2):25-36

Cooperation between lateral ligand mobility and accessibility for receptor recognition in selectin-induced cell rolling
Bakowsky U, Schumacher G, Gege C, Schmidt RR, Rothe U, Bendas G.
Biochemistry. 2002 Apr 9;41(14):4704-12

2001

Cationic solid-lipid nanoparticles can efficiently bind and transfect plasmid DNA
Olbrich C, Bakowsky U, Lehr CM, Müller RH, Kneuer C.
J Control Release. 2001 Dec 13;77(3):345-55

2000

A nonviral DNA delivery system based on surface modified silica-nanoparticles can efficiently transfect cells in vitro
Kneuer C, Sameti M, Bakowsky U, Schiestel T, Schirra H, Schmidt H, Lehr CM.
Bioconjug Chem. 2000 Nov-Dec;11(6):926-32

Lipoplex formation under equilibrium conditions reveals a three-step mechanism
Oberle V, Bakowsky U, Zuhorn IS, Hoekstra D.
Biophys J. 2000 Sep;79(3):1447-54

Monomolecular organization of the main tetraether lipid from Thermoplasma acidophilum at the water-air interface
Bakowsky U, Rothe U, Antonopoulos E, Martini T, Henkel L, Freisleben HJ.
Chem Phys Lipids. 2000 Mar;105(1):31-42

1999

Investigation of the orientation of purple membrane sheets in Langmuir-Blodgett films by a quartz crystal microbalance
Lu T, Rothe U, Liebau M, Schaffer H, Hufnagel P, Bakowsky U.
IUBMB Life. 1999 Nov;48(5):549-56

Targetability of novel immunoliposomes prepared by a new antibody conjugation technique
Bendas G, Krause A, Bakowsky U, Vogel J, Rothe U.
Int J Pharm. 1999 Apr 20;181(1):79-93

1998

The role of glycolipids in mediating cell adhesion: a flow chamber study
Vogel J, Bendas G, Bakowsky U, Hummel G, Schmidt RR, Kettmann U, Rothe U.
Biochim Biophys Acta. 1998 Jul 17;1372(2):205-15