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Publications Giulia Treccani
2024
Editorial: Toward an understanding of neurodevelopmental disorders: novel insights from molecular, behavioural and neuroinflammatory mechanisms
Luca Pangrazzi, Giovanni Provenzano, Giulia Treccani, Luigi Balasco. Front Psychiatry. 2024 Jun 24:15:1444783.doi: 10.3389/fpsyt.2024.1444783.eCollection 2024. PMID:38979502
2023
NG2-glia: rising stars in stress-related mental disorders?
Poggi G, Wennström M, Müller MB, Treccani G. Mol Psychiatry. 2023 Feb;28(2):518-520. doi: 10.1038/s41380-022-01838-7. Epub 2022 Oct 24. PMID: 36280754
2022
Analysis of hyperforin (St. John's wort) action at TRPC6 channel leads to the development of a new class of antidepressant drugs.
El Hamdaoui Y, Zheng F, Fritz N, Ye L, Tran MA, Schwickert K, Schirmeister T, Braeuning A, Lichtstein D, Hellmich UA, Weikert D, Heinrich M, Treccani G, Schäfer MKE, Nowak G, Nürnberg B, Alzheimer C, Müller CP, Friedland K. Mol Psychiatry.2022 Dec;27(12):5070-5085.doi: 10.1038/s41380-022-01804-3. Epub 2022 Oct 12. PMID: 36224261
Chronic Social stress disrupts the intracellular redistribution of brain hexokinase 3 induced by shifts in peripheral glucose levels.
van der Kooij, Rojas-Charry L, Givehchi M, Wolf C, Bueno D, Arndt S, Tenzer S, Mattioni L, Treccani G, Hasch A, Schmeisser MJ, Vianello C, Giacomello M, Methner A. J Mol Med (Berl). 2022 Oct; 100(10):1441-1453. doi: 10.1007/s00109-022-02235-x. Epub 2022 Aug 9. PMID: 35942566
2021
Longitudinal CSF proteome profiling in mice to uncover the acute and sustained mechanisms of action of rapid acting antidepressant (2R, 6R)-hydroxynorketamine (HNK).
van der Kooij MA, Rojas-Charry L, Givehchi M, Wolf C, Bueno D, Arndt S, Tenzer S, Mattioni L, Treccani G, Hasch A, Schmeisser MJ, Vianello C, Giacomello M, Methner A. J Mol Med (Berl). 2022 Oct;100(10):1441-1453. doi: 10.1007/s00109-022-02235-x. Epub 2022 Aug 9. PMID: 35943566
Early life adversity targets the transcriptional signature of hippocampal NG2+ glia and affects voltage gated sodium (Nav) channels properties.
Treccani G, Yigit H, Lingner T, Schleuβner V, Mey F, van der Kooij MA, Wennström M, Herzog DP, Linke M, Fricke M, Schmeisser MJ, Wegener G, Mittmann T, Trotter J, Müller MB. Neurobiol Stress. 2021 May 14;15:100338. doi: 10.1016/j.ynstr.2021.100338. eCollection 2021 Nov. PMID: 34095364
Early onset of depression and treatment outcome in patients with major depressive disorder.
Herzog DP, Wagner S, Engelmann J, Treccani G, Dreimüller N, Müller MB, Tadic A, Murck H, Lieb K. J Psychiatr Res. 2021 Jul;139:150-158. doi: 10.1016/j.jpsychires.2021.05.048. Epub 2021 May 23. PMID: 34058654
The Kynurenine Pathway Is Upregulated by Methyl-deficient Diet and Changes Are Averted by Probiotics.
Tillmann S, Awwad HM, MacPherson CW, Happ DF, Treccani G, Geisel J, Tompkins TA, Ueland PM, Wegener G, Obeid R. Mol Nutr Food Res. 2021 May;65(9):e2100078. doi: 10.1002/mnfr.202100078. Epub 2021 Mar 24. PMID: 33686786
A distinct transcriptional signature of antidepressant response in hippocampal dentate gyrus granule cells.
Herzog DP, Pascual Cuadrado D, Treccani G, Jene T, Opitz V, Hasch A, Lutz B, Lieb K, Sillaber I, van der Kooij MA, Tiwari VK, Müller MB. Transl Psychiatry. 2021 Jan 5;11(1):4. doi: 10.1038/s41398-020-01136-2. PMID: 33414410
Hippocampal NG2+ pericytes in chronically stressed rats and depressed patients: a quantitative study.
Treccani G, Schlegelmilch AL, Schultz N, Herzog DP, Bessa JM, Sotiropoulos I, Müller MB, Wennström M. Stress. 2021 May;24(3):353-358. doi: 10.1080/10253890.2020.1781083. Epub 2020 Jun 24. PMID: 32546032
2020
Structural Plasticity and Molecular Markers in Hippocampus of Male Rats after Acute Stress.
Chen F, Polsinelli B, Nava N, Treccani G, Elfving B, Müller HK, Musazzi L, Popoli M, Nyengaard JR, Wegener G. Neuroscience. 2020 Jul 1;438:100-115. doi: 10.1016/j.neuroscience.2020.05.001. Epub 2020 May 12. PMID: 32407976
Sexually Dimorphic Behavioral Profile in a Transgenic Model Enabling Targeted Recombination in Active Neurons in Response to Ketamine and (2R,6R)-Hydroxynorketamine Administration.
Herzog DP, Mellema RM, Remmers F, Lutz B, Müller MB, Treccani G. Int J Mol Sci. 2020 Mar 20;21(6):2142. doi: 10.3390/ijms21062142. PMID: 32244978
2019
Chronic mild stress induces anhedonic behavior and changes in glutamate release, BDNF trafficking and dendrite morphology only in stress vulnerable rats. The rapid restorative action of ketamine.
Tornese P, Sala N, Bonini D, Bonifacino T, La Via L, Milanese M, Treccani G, Seguini M, Ieraci A, Mingardi J, Nyengaard JR, Calza S, Bonanno G, Wegener G, Barbon A, Popoli M, Musazzi L. Neurobiol Stress. 2019 Apr 2;10:100160. doi: 10.1016/j.ynstr.2019.100160. eCollection 2019 Feb. PMID: 31193464
S-Ketamine Reverses Hippocampal Dendritic Spine Deficits in Flinders Sensitive Line Rats Within 1 h of Administration.
Treccani G, Ardalan M, Chen F, Musazzi L, Popoli M, Wegener G, Nyengaard JR, Müller HK. Mol Neurobiol. 2019 Nov;56(11):7368-7379. doi: 10.1007/s12035-019-1613-3. Epub 2019 Apr 29. PMID: 31037646
Acute Inescapable Stress Rapidly Increases Synaptic Energy Metabolism in Prefrontal Cortex and Alters Working Memory Performance.
Musazzi L, Sala N, Tornese P, Gallivanone F, Belloli S, Conte A, Di Grigoli G, Chen F, Ikinci A, Treccani G, Bazzini C, Castiglioni I, Nyengaard JR, Wegener G, Moresco RM, Popoli M. Cereb Cortex. 2019 Dec 17;29(12):4948-4957. doi: 10.1093/cercor/bhz034. PMID: 30877789
Decoding the Mechanism of Action of Rapid-Acting Antidepressant Treatment Strategies: Does Gender Matter?
Herzog DP, Wegener G, Lieb K, Müller MB, Treccani G. Int J Mol Sci. 2019 Feb 22;20(4):949. doi: 10.3390/ijms20040949. PMID: 30813226
From Structure to Behavior: Circuit Specificity of Stress-Induced Synaptic Plasticity in the Basolateral Amygdala Projection Neurons.
Treccani G. Biol Psychiatry. 2019 Feb 1;85(3):e7-e9. doi: 10.1016/j.biopsych.2018.11.017. PMID: 30621860
2018
Chronic social stress-induced hyperglycemia in mice couples individual stress susceptibility to impaired spatial memory.
van der Kooij MA, Jene T, Treccani G, Miederer I, Hasch A, Voelxen N, Walenta S, Müller MB. Proc Natl Acad Sci U S A. 2018 Oct 23;115(43):E10187-E10196. doi: 10.1073/pnas.1804412115. Epub 2018 Oct 9. PMID: 30301805
Expression and glucocorticoid-dependent regulation of the stress-inducible protein DRR1 in the mouse adult brain.
Masana M, Westerholz S, Kretzschmar A, Treccani G, Liebl C, Santarelli S, Dournes C, Popoli M, Schmidt MV, Rein T, Müller MB. Brain Struct Funct. 2018 Dec;223(9):4039-4052. doi: 10.1007/s00429-018-1737-7. Epub 2018 Aug 18. PMID: 30121783
Probiotics Affect One-Carbon Metabolites and Catecholamines in a Genetic Rat Model of Depression.
Tillmann S, Awwad HM, Eskelund AR, Treccani G, Geisel J, Wegener G, Obeid R. Mol Nutr Food Res. 2018 Apr;62(7):e1701070. doi: 10.1002/mnfr.201701070. Epub 2018 Mar 13. PMID: 29453804
2017
Temporal Dynamics of Acute Stress-Induced Dendritic Remodeling in Medial Prefrontal Cortex and the Protective Effect of Desipramine.
Nava N, Treccani G, Alabsi A, Kaastrup Mueller H, Elfving B, Popoli M, Wegener G, Nyengaard JR. Cereb Cortex. 2017 Jan 1;27(1):694-705. doi: 10.1093/cercor/bhv254. PMID: 26523035
The expression of plasticity-related genes in an acute model of stress is modulated by chronic desipramine in a time-dependent manner within medial prefrontal cortex.
Nava N, Treccani G, Müller HK, Popoli M, Wegener G, Elfving B. Eur Neuropsychopharmacol. 2017 Jan;27(1):19-28. doi: 10.1016/j.euroneuro.2016.11.010. Epub 2016 Nov 24. PMID: 27890541
2016
Differential expression of postsynaptic NMDA and AMPA receptor subunits in the hippocampus and prefrontal cortex of the flinders sensitive line rat model of depression.
Treccani G, Gaarn du Jardin K, Wegener G, Müller HK. Synapse. 2016 Nov;70(11):471-4. doi: 10.1002/syn.21918. Epub 2016 Jun 21. PMID: 27262028
2015
Functional and structural remodeling of glutamate synapses in prefrontal and frontal cortex induced by behavioral stress.
Musazzi L, Treccani G, Popoli M. Front Psychiatry. 2015 Apr 27;6:60. doi: 10.3389/fpsyt.2015.00060. eCollection 2015. PMID: 25964763
2014
Chronic desipramine prevents acute stress-induced reorganization of medial prefrontal cortex architecture by blocking glutamate vesicle accumulation and excitatory synapse increase.
Nava N, Treccani G, Liebenberg N, Chen F, Popoli M, Wegener G, Nyengaard JR. Int J Neuropsychopharmacol. 2014 Dec 13;18(3):pyu085. doi: 10.1093/ijnp/pyu085. PMID: 25522419
Time-dependent activation of MAPK/Erk1/2 and Akt/GSK3 cascades: modulation by agomelatine.
Musazzi L, Seguini M, Mallei A, Treccani G, Pelizzari M, Tornese P, Racagni G, Tardito D. BMC Neurosci. 2014 Oct 21;15:119. doi: 10.1186/s12868-014-0119-1. PMID: 25332063
Acute stress rapidly increases the readily releasable pool of glutamate vesicles in prefrontal and frontal cortex through non-genomic action of corticosterone. Treccani G, Musazzi L, Perego C, Milanese M, Nava N, Bonifacino T, Lamanna J, Malgaroli A, Drago F, Racagni G, Nyengaard JR, Wegener G, Bonanno G, Popoli M. Mol Psychiatry. 2014 Apr;19(4):401. doi: 10.1038/mp.2014.20. PMID: 24658610
Stress and corticosterone increase the readily releasable pool of glutamate vesicles in synaptic terminals of prefrontal and frontal cortex.
Treccani G, Musazzi L, Perego C, Milanese M, Nava N, Bonifacino T, Lamanna J, Malgaroli A, Drago F, Racagni G, Nyengaard JR, Wegener G, Bonanno G, Popoli M. Mol Psychiatry. 2014 Apr;19(4):433-43. doi: 10.1038/mp.2014.5. Epub 2014 Feb 18. PMID: 24535456
2013
Chronic treatment with agomelatine or venlafaxine reduces depolarization-evoked glutamate release from hippocampal synaptosomes.
Milanese M, Tardito D, Musazzi L, Treccani G, Mallei A, Bonifacino T, Gabriel C, Mocaer E, Racagni G, Popoli M, Bonanno G. BMC Neurosci. 2013 Jul 29;14:75. doi: 10.1186/1471-2202-14-75. PMID: 23895555
The action of antidepressants on the glutamate system: regulation of glutamate release and glutamate receptors.
Musazzi L, Treccani G, Mallei A, Popoli M. Biol Psychiatry. 2013 Jun 15;73(12):1180-8. doi: 10.1016/j.biopsych.2012.11.009. Epub 2012 Dec 28. PMID: 23273725
2012
Glutamate hypothesis of depression and its consequences for antidepressant treatments.
Musazzi L, Treccani G, Popoli M. Expert Rev Neurother. 2012 Oct;12(10):1169-72. doi: 10.1586/ern.12.96. PMID: 23082730
Towards a glutamate hypothesis of depression: an emerging frontier of neuropsychopharmacology for mood disorders.
Sanacora G, Treccani G, Popoli M. Neuropharmacology. 2012 Jan;62(1):63-77. doi: 10.1016/j.neuropharm.2011.07.036. Epub 2011 Aug 3. PMID: 21827775