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Publikationen

2024

Glucocorticoids induce a maladaptive epithelial stress response to aggravate acute kidney injury. Zhou L, Torres Pereiro M, Li Y, Derigs M, Kuenne C, Hielscher T, Huang W, Kränzlin B, Tian G, Kobayashi K, Lu GHN, Roedl K, Schmidt C, Günther S, Looso M, Huber J, Xu Y, Wiech T, Sperhake JP, Wichmann D, Gröne HJ, Worzfeld T.
Sci Transl Med 2024, 16,eadk5005: doi:10.1126/scitranslmed.adk5005.

A Survey on End-of-Life Contemplation Among Patients on Dialysis.
Russwurm M, Rabaev A, Hoyer JD, Haas CS, Volberg C, Russ P.
Kid Int Rep 2024 ,Oct;9(10):2981-2987: doi.org/10.1016/j.ekir.2024.07.035.

Optimizing Skin Surface Metabolomics: A Comprehensive Evaluation of Sampling Methods, Extraction Solvents, and Analytical Techniques.
Chen H, Chen Y, Zhou Y, Cao S, Lu J, Han L, Worzfeld T, Krutmann J, Wang J, Xia J.
J Invest Dermatol. 2024 Sep 19:S0022-202X(24)02105-5. doi: 10.1016/j.jid.2024.08.027.

Western lifestyle, metaflammation and the cell of origin of colon cancer.
Verhagen MP, Schmitt M, Fodde R.
Nat Rev Gastroenterol Hepatol. 2024 Sep;21(9):603-604. doi: 10.1038/s41575-024-00964-7.

Secretome Analysis Using Affinity Proteomics and Immunoassays: A Focus on Tumor Biology.
Beutgen VM, Shinkevich V, Pörschke J, Meena C, Steitz AM, Pogge von Strandmann E, Graumann J, Gómez-Serrano M.
Mol Cell Proteomics. 2024 Aug 13;23(9):100830. doi: 10.1016/j.mcpro.2024.100830.

Histopathology of congestive nephropathy: a case description and literature review.
Husain-Syed F, Rangaswami J, Núñez J, Skrzypek S, Jux C, Gröne HJ, Birk HW.
ESC Heart Fail. 2024 Aug;11(4):2395-2398. doi: 10.1002/ehf2.14760.

Non-stem cell lineages as an alternative origin of intestinal tumorigenesis in the context of inflammation.
Verhagen MP, Joosten R, Schmitt M, Välimäki N, Sacchetti A, Rajamäki K, Choi J, Procopio P, Silva S, van der Steen B, van den Bosch TPP, Seinstra D, de Vries AC, Doukas M, Augenlicht LH, Aaltonen LA, Fodde R.
Nat Genet. 2024 Jul;56(7):1456-1467. doi: 10.1038/s41588-024-01801-y .

Characterization of recombinant factor IX fusion proteins enabling subcutaneous administration.
Schön K, Pestel S, Riedesel J, Seyfert-Brandt W, Claar P, Herzog E, Rezvani-Sharif A, Ponnuswamy P, Nolte MW.
J Thromb Haemost. 2024 Jul 15:S1538-7836(24)00424-0. doi: 10.1016/j.jtha.2024.07.007. Epub ahead of print.

Long term renal outcome of Cryopyrin-associated periodic syndrome (CAPS) under anti-Interleukin-1 therapy.
Russwurm M, Johannsen S, Kortus-Götze B, Haas CS.
Sci Rep. 2024 Jul 18;14(1):16595. doi: 10.1038/s41598-024-67380-4

Inhibition of the glucocorticoid receptor attenuates proteinuric kidney diseases in multiple species.
Stamellou E, Agrawal S, Siegerist F, Buse M, Kuppe C, Lange T, Buhl EM, Alam J, Strieder T, Boor P, Ostendorf T, Gröne HJ, Floege J, Smoyer WE, Endlich N, Moeller MJ.
Nephrol Dial Transplant. 2024 Jun 28;39(7):1181-1193. doi: 10.1093/ndt/gfad254.

ANCA Kidney Risk Score Performance in a German Cohort of Patients with Histologically Confirmed ANCA-Associated Renal Vasculitis.
Scurt FG, Hirschfeld V, Ganz MJ, Herzog C, Mertens PR, Gröne HJ, Chatzikyrkou C.
Kidney360. 2024 Jun 1;5(6):886-894. doi: 10.34067/KID.0000000000000459.

Reciprocal crosstalk between Th17 and mesothelial cells promotes metastasis-associated adhesion of ovarian cancer cells.
Neuhaus F, Lieber S, Shinkevich V, Steitz AM, Raifer H, Roth K, Finkernagel F, Worzfeld T, Burchert A, Keber C, Teply-Szymanski J, Nist A, Stiewe T, Reinartz S, Beutgen VM, Graumann J, Pauck K, Garn H, Gaida M, Müller R, Huber M.
Clin Transl Med. 2024 Apr;14(4):e1604. doi: 10.1002/ctm2.1604. Erratum in: Clin Transl Med. 2024 Jun;14(6):e1729. doi: 10.1002/ctm2.

Immune tolerance and the prevention of autoimmune diseases essentially depend on thymic tissue homeostasis.
Shirafkan F, Hensel L, Rattay K.
Front Immunol. 2024 Mar 20;15:1339714. doi: 10.3389/fimmu.2024.1339714.

Ehf and Fezf2 regulate late medullary thymic epithelial cell and thymic tuft cell development.
Lammers S, Barrera V, Brennecke P, Miller C, Yoon J, Balolong J, Anderson MS, Ho Sui S, Steinmetz LM, von Andrian UH, Rattay K.
Front Immunol. 2024 Feb 14;14:1277365. doi: 10.3389/fimmu.2023.1277365.
2023

TRAIL-dependent apoptosis of peritoneal mesothelial cells by NK cells promotes ovarian cancer invasion.
Steitz AM, Schröder C, Knuth I, Keber CU, Sommerfeld L, Finkernagel F, Jansen JM, Wagner U, Müller-Brüsselbach S, Worzfeld T, Huber M, Beutgen VM, Graumann J, Pogge von Strandmann E, Müller R, Reinartz S.
iScience. 2023 Nov 7;26(12):108401. doi: 10.1016/j.isci.2023.108401.

The complex pathology of diabetic nephropathy in humans.
Kriz W, Löwen J, Gröne HJ.
Nephrol Dial Transplant. 2023 Sep 29;38(10):2109-2119. doi: 10.1093/ndt/gfad052

Nanobody inhibitors of Plexin-B1 identify allostery in plexin-semaphorin interactions and signaling.
Cowan R, Trokter M, Oleksy A, Fedorova M, Sawmynaden K, Worzfeld T, Offermanns S, Matthews D, Carr MD, Hall G.
J Biol Chem. 2023 Jun;299(6):104740. doi: 10.1016/j.jbc.2023.104740.

Kidney Biopsy Findings in Patients with SARS-CoV-2 Infection or After COVID-19 Vaccination.
de Las Mercedes Noriega M, Husain-Syed F, Wulf S, Csala B, Krebs CF, Jabs WJ, Zipfel PF, Gröne HJ, Wiech T; CoV-Kidney Investigators.
Clin J Am Soc Nephrol. 2023 May 1;18(5):613-625. doi: 10.2215/CJN.0000000000000106.

The SHDRA syndrome-associated gene TMEM260 encodes a protein-specific O-mannosyltransferase.
Larsen ISB, Povolo L, Zhou L, Tian W, Mygind KJ, Hintze J, Jiang C, Hartill V, Prescott K, Johnson CA, Mullegama SV, McConkie-Rosell A, McDonald M, Hansen L, Vakhrushev SY, Schjoldager KT, Clausen H, Worzfeld T, Joshi HJ, Halim A.
Proc Natl Acad Sci U S A. 2023 May 23;120(21):e2302584120. doi: 10.1073/pnas.2302584120.

The Role of Viral Infections in the Onset of Autoimmune Diseases.
Sundaresan B, Shirafkan F, Ripperger K, Rattay K.
Viruses. 2023 Mar 18;15(3):782. doi: 10.3390/v15030782.

Pathogenicity of Human Anti-PLA 2 R1 Antibodies in Minipigs: A Pilot Study.
Reinhard L, Wiech T, Reitmeier A, Lassé M, Machalitza M, Heumann A, Ferru N, Loreth D, Schröder ML, Hutzfeldt A, Stahl FR, Peine S, Gröne HJ, Meyer-Schwesinger C, Rinschen MM, Stahl RAK, Hoxha E.
J Am Soc Nephrol. 2023 Mar 1;34(3):369-373. doi: 10.1681/ASN.0000000000000068.

Plexin-B1 Mutation Drives Metastasis in Prostate Cancer Mouse Models.
Shorning B, Trent N, Griffiths DF, Worzfeld T, Offermanns S, Smalley MJ, Williamson M.
Cancer Res Commun.2023 Mar 16;3(3):444-458. doi: 10.1158/2767-9764.

DNA methylation biomarkers for noninvasive detection of triple-negative breast cancer using liquid biopsy.
Manoochehri M, Borhani N, Gerhäuser C, Assenov Y, Schönung M, Hielscher T, Christensen BC, Lee MK, Gröne HJ, Lipka DB, Brüning T, Brauch H, Ko YD, Hamann U.
Int J Cancer. 2023 Mar 1;152(5):1025-1035. doi: 10.1002/ijc.34337
2022

Colon tumour cell death causes mTOR dependence by paracrine P2X4 stimulation.
Schmitt M, Ceteci F, Gupta J, Pesic M, Böttger TW, Nicolas AM, Kennel KB, Engel E, Schewe M, Callak Kirisözü A, Petrocelli V, Dabiri Y, Varga J, Ramakrishnan M, Karimova M, Ablasser A, Sato T, Arkan MC, de Sauvage FJ, Greten FR.
Nature. 2022 Dec;612(7939):347-353. doi: 10.1038/s41586-022-05426-1.

An antagonistic monoclonal anti-Plexin-B1 antibody exerts therapeutic effects in mouse models of postmenopausal osteoporosis and multiple sclerosis.
Vogler M, Oleksy A, Schulze S, Fedorova M, Kojonazarov B, Nijjar S, Patel S, Jossi S, Sawmynaden K, Henry M, Brown R, Matthews D, Offermanns S, Worzfeld T.
J Biol Chem. 2022 15;102265. doi: 10.1016/j.jbc.2022.102265

A semaphorin-plexin-Rasal1 signaling pathway inhibits gastrin expression and protects against peptic ulcers.
Xu R, Höß C, Swiercz J.M, Brandt D.T, Lutz V, Petersen N, Li R, Zhao D, Oleksy A, Creigh-Pulatmen T, Trokter M, Fedorova M, Atzberger A, Strandby R.B, Olsen A.A, Achiam M.P, Matthews D, Huber M, Gröne H.J, Offermanns S, Worzfeld T.
Sci Transl Med. 2022, 20;14(654):eabf1922. doi: 10.1126/scitranslmed.abf1922.

A Prospective Multicenter Trial to Evaluate Urinary Metabolomics for Non-invasive Detection of Renal Allograft Rejection (PARASOL): Study Protocol and Patient Recruitment.
Banas MC, Böhmig GA, Viklicky O, Rostaing LP, Jouve T, Guirado L, Facundo C, Bestard O, Gröne HJ, Kobayashi K, Hanzal V, Putz FJ, Zecher D, Bergler T, Neumann S, Rothe V, Schwäble Santamaria AG, Schiffer E, Banas B.
Front Med (Lausanne) 2022, 8:780585. doi:10.3389/fmed.2021.780585.

Diverse molecular causes of unsolved autosomal dominant tubulointerstitial kidney diseases.
Wopperer FJ, Knaup KX, Stanzick KJ, Schneider K, Jobst-Schwan T, Ekici AB, Uebe S, Wenzel A, Schliep S, Schürfeld C, Seitz R, Bernhardt W, Gödel M, Wiesener A, Popp B, Stark KJ, Gröne HJ, Friedrich B, Weiß M, Basic-Jukic N, Schiffer M, Schröppel B, Huettel B, Beck BB; Genomics England Research Consortium, Sayer JA, Ziegler C, Büttner-Herold M, Amann K, Heid IM, Reis A, Pasutto F, Wiesener MS.
Kidney Int. 2022, 26:S0085-2538(22)00384-2. doi: 10.1016/j.kint.2022.04.031.

Sphingosine 1-Phosphate Receptor 5 (S1P5) Knockout Ameliorates Adenine-Induced Nephropathy.
Eckes T, Patyna S, Koch A, Oftring A, Gauer S, Obermüller N, Schwalm S, Schaefer L, Chun J, Gröne HJ, Pfeilschifter J.
Int J Mol Sci. 2022 2;23(7):3952. doi: 10.3390/ijms23073952.

Wnt signaling is boosted during intestinal regeneration by a CD44-positive feedback loop.
Romina J Walter, Steffen J Sonnentag, Leonel Munoz-Sagredo, Melanie Merkel, Ludovic Richert, Felix Bunert, Yvonne M Heneka, Thomas Loustau, Michael Hodder, Rachel A Ridgway, Owen J Sansom, Yves Mely, Ulrich Rothbauer, Mark Schmitt, Véronique Orian-Rousseau.
Cell Death Dis. 2022 21;13(2):168. doi: 10.1038/s41419-022-04607-0. PMID: 35190527.2021
2021

Specialized transendothelial dendritic cells mediate thymic T-cell selection against blood-borne macromolecules
Vollmann EH, Rattay K, Barreiro O, Thiriot A, Fuhlbrigge RA, Vrbanac V, Kim KW, Jung S, Tager AM, Andrian UH
Nat Commun 2021, 28;12(1):6230. doi: 10.1038/s41467-021-26446-x

Bone marrow sinusoidal endothelium controls terminal erythroid differentiation and reticulocyte maturation
Heil J, Olsavszky V, Busch K, Klapproth K, de la Torre C, Sticht C, Sandorski K, Hoffmann J, Schönhaber H, Zierow J, Winkler M, Schmid CD, Staniczek T, Daniels DE, Frayne J, Metzgeroth G, Nowak D, Schneider S, Neumaier M, Weyer V, Groden C, Gröne HJ, Richter K, Mogler C, Taketo MM, Schledzewski K, Géraud C, Goerdt S, Koch PS.
Nat Commun 2021, 12(1):6963. doi: 10.1038/s41467-021-27161-3.

Blockade of Glycosphingolipid Synthesis Inhibits Cell Cycle and Spheroid Growth of Colon Cancer Cells In Vitro and Experimental Colon Cancer Incidence In Vivo
Jennemann R, Volz M, Bestvater F, Schmidt C, Richter K, Kaden S, Müthing J, Gröne HJ, Sandhoff R.
Int J Mol Sci 2021, 22(19):10539. doi: 10.3390/ijms221910539.

Complement catalyzing glomerular diseases
Peter F Zipfel PF, Wiech T, Gröne HJ, Skerka C.
Cell Tissue Res 2021, 385(2):355-370. doi: 10.1007/s00441-021-03485-w.

Measurement of urinary Dickkopf-3 uncovered silent progressive kidney injury in patients with chronic obstructive pulmonary disease
Schunk SJ, Beisswenger C, Ritzmann F, Herr C, Wagner M, Triem S, Hütter G, Schmit D, Zewinger S, Sarakpi T, Honecker A, Mahadevan P, Boor P, Wagenpfeil S, Jörres R, Watz H, Welte T, Vogelmeier CF, Gröne HJ, Fliser D, Speer T, Bals R
Kidney Int 2021, 100(5):1081-1091. doi: 10.1016/j.kint.2021.06.029.

Congestive nephropathy: a neglected entity? Proposal for diagnostic criteria and future perspectives
Husain-Syed F, Gröne HJ, Assmus B, Bauer P, Gall H, Seeger W, Ghofrani A, Ronco C, Birk HW
ESC Heart Fail 2021, 8(1):183-203 doi: 10.1002/ehf2.13118.

Pathomorphological sequence of nephron loss in diabetic nephropathy.
Löwen J, Gröne EF, Groß-Weißmann ML, Bestvater F, Gröne HJ, Kriz W.
Am J Physiol Renal Physiol 2021, 321(5):F600-F616. doi: 10.1152/ajprenal.00669.2020

Characterization of a L136P mutation in Formin-like 2 (FMNL2) from a patient with chronic inflammatory bowel disease.
Trefzer R, Elpeleg O, Gabrusskaya T, Stepensky P, Mor-Shaked H, Grosse R, Brandt DT.
PLoS One 2021, 16(5):e0252428. https://doi.org/10.1371/journal.pone.0252428

A Hundred-Year Researching History on the Low Ionic Strength in Red Blood Cells: Literature Review
Fuhrmann GF, Netter KJ.
J Biomed Res Environ Sci 2021, 2(3):139-168. doi:10.37871/jbres1204

Mechanochemical control of epidermal stem cell divisions by B-plexins.
Jiang C, Javed A, Kaiser L, Nava MM, Xu R, Brandt DT, Zhao D, Mayer B, Fernández-Baldovinos J, Zhou L, Höß C, Sawmynaden K, Oleksy A, Matthews D, Weinstein LS, Hahn H, Gröne HJ, Graumann P, Niessen CM, Offermanns S, Wickström SA, Worzfeld T.
Nat Commun 2021, 12(1):1308. https://doi.org/10.1038/s41467-021-21513-9

TTL-expression modulates epithelial morphogenesis.
Müller M, Ringer K, Hub F, Kamm K, Worzfeld T, Jacob R.
Front Cell Dev Biol 2021. https://doi.org/10.3389/fcell.2021.635723

Glycolipid-dependent and lectin-driven transcytosis in mouse enterocytes.
Ivashenka A, Wunder C, Chambon V, Sandhoff R, Jennemann R, Dransart E, Podsypanina K, Lombard B, Loew D, Lamaze C, Poirier F, Gröne HJ, Johannes L, Shafaq-Zadah M.
Commun Biol 2021, 4(1):173. https://doi.org/10.1038/s42003-021-01693-2

CaM Kinase II-δ Is Required for Diabetic Hyperglycemia and Retinopathy but Not Nephropathy.
Chen J, Fleming T, Katz S, Dewenter M, Hofmann K, Saadatmand A, Kronlage M, Werner MP, Pokrandt B, Schreiter F, Lin J, Katz D, Morgenstern J, Elwakiel A, Sinn P, Gröne HJ, Hammes HP, Nawroth PP, Isermann B, Sticht C, Brügger B, Katus HA, Hagenmueller M, Backs J.
Diabetes 2021, 70(2):616-626. https://doi.org/10.2337/db19-0659
2020

Congestive nephropathy: a neglected entity? Proposal for diagnostic criteria and future perspectives.
Husain-Syed F, Gröne HJ, Assmus B, Bauer P, Gall H, Seeger W, Ghofrani A, Ronco C, Birk HW.
ESC Heart Fail 2020, 8(1):183-203. https://doi.org/10.1002/ehf2.13118

The Kinetics of Glucose Transport in Human Red Blood Cells Depend on Their Metabolic State.
Günter Fred Fuhrmann
J Biomed Res Environ Sci. 2020, 1(7): 334-342. doi: 10.37871/jbres1164

Development of a New Macrophage-Specific TRAP Mouse (Mac TRAP) and Definition of the Renal Macrophage Translational Signature.
Hofmeister A, Thomaßen MC, Markert S, Marquardt A, Preußner M, Rußwurm M, Schermuly RT, Steinhoff U, Gröne HJ, Hoyer J, Humphreys BD, Grgic I.
Sci Rep 2020, 10:7519. https://doi.org/10.1038/s41598-020-63514-6

Endothelial Notch Signaling Controls Insulin Transport in Muscle.
Hasan SS, Jabs M, Taylor J, Wiedmann L, Leibing T, Nordström V, Federico G, Roma LP, Carlein C, Wolff G, Ekim-Üstünel B, Brune M, Moll I, Tetzlaff F, Gröne HJ, Fleming T, Géraud C, Herzig S, Nawroth PP, Fischer A.
EMBO Mol Med 2020, 12:e09271. https://doi.org/10.15252/emmm.201809271

Gangliosides Modulate Insulin Secretion by Pancreatic Beta-Cells Under Glucose Stress.
Jennemann R, Kaden S, Volz M, Nordström V, Herzer S, Sandhoff R, Gröne HJ.
Glycobiology 2020, cwaa022. https://doi.org/10.1093/glycob/cwaa02

TRPC1 Regulates the Activity of a Voltage-Dependent Nonselective Cation Current in Hippocampal CA1 Neurons.
Kepura F, Braun E, Dietrich A, Plant TD.
Cells 2020, 9:459. https://doi.org/10.3390/cells9020459
2019

Multi-platform Affinity Proteomics Identify Proteins Linked to Metastasis and Immune Suppression in Ovarian Cancer Plasma.
Graumann J, Finkernagel F, Reinartz S, Stief T, Brödje D, Renz H, Jansen JM, Wagner U, Worzfeld T, Pogge von Strandmann E, Müller R.
Front Oncol 2019, 9:1150. https://doi.org/10.3389/fonc.2019.01150

Bacterial Immunogenic α-galactosylceramide Identified in the Murine Large Intestine: Dependency on Diet and Inflammation.
von Gerichten J, Lamprecht D, Opálka L, Soulard D, Marsching C, Pilz R, Sencio V, Herzer S, Galy B, Nordström V, Hopf C, Gröne HJ, Trottein F, Sandhoff R.
J Lipid Res 2019, 60(11):1892-1904. https://doi.org/10.1194/jlr.RA119000236

Dual-platform affinity proteomics identifies links between the recurrence of ovarian carcinoma and proteins released into the tumor microenvironment.
Finkernagel F, Reinartz S, Schuldner M, Malz A, Jansen JM, Wagner U, Worzfeld T, Graumann J, von Strandmann EP, Müller R.
Theranostics 2019, 9(22):6601-6617. https://doi.org/10.7150/thno.37549

The impact of Semaphorin 4C/Plexin-B2 signaling on fear memory via remodeling of neuronal and synaptic morphology.
Simonetti M, Paldy E, Njoo C, Bali KK, Worzfeld T, Pitzer C, Kuner T, Offermanns S, Mauceri D, Kuner R.
Mol Psychiatry 2019. https://doi.org/10.1038/s41380-019-0491-4

O-GlcNAcylation of Histone Deacetylase 4 Protects the Diabetic Heart From Failure.
Kronlage M, Dewenter M, Grosso J, Fleming T, Oehl U, Lehmann LH, Falcão-Pires I, Leite-Moreira AF, Volk N, Gröne HJ, Müller OJ, Sickmann A, Katus HA, Backs J.
Circulation 2019, 140(7):580-594. https://doi.org/10.1161/CIRCULATIONAHA.117.031942

Herniation of the Tuft With Outgrowth of Vessels Through the Glomerular Entrance in Diabetic Nephropathy Damages the Juxtaglomerular Apparatus.
Löwen J, Gröne E, Gröne HJ, Kriz W.
Am J Physiol Renal Physiol 2019, 317(2):F399-F410. https://doi.org/10.1152/ajprenal.00617.2018

Renal Globotriaosylceramide Facilitates Tubular Albumin Absorption and Its Inhibition Protects Against Acute Kidney Injury.
Morace I, Pilz R, Federico G, Jennemann R, Krunic D, Nordström V, von Gerichten J, Marsching C, Schießl IM, Müthing J, Wunder C, Johannes L, Sandhoff R, Gröne HJ.
Kidney Int 2019, 96(2):327-341. https://doi.org/10.1016/j.kint.2019.02.010

Cell type-selective pathways and clinical associations of lysophosphatidic acid biosynthesis and signaling in the ovarian cancer microenvironment.
Reinartz S, Lieber S, Pesek J, Brandt DT, Asafova A, Finkernagel F, Watzer B, Nockher WA, Nist A, Stiewe T, Jansen JM, Wagner U, Konzer A, Graumann J, Grosse R, Worzfeld T, Müller-Brüsselbach S, Müller R.
Mol Oncol 2019, 13(2):185-201. https://doi.org/10.1002/1878-0261.12396
2018

A Rac1-FMNL2 signaling module affects cell-cell contact formation independent of Cdc42 and membrane protrusions.
Grobe H, Wüstenhagen A, Baarlink C, Grosse R, Grikscheit K.
PLoS One 2018, 13(3):e0194716. https://doi.org/10.1371/journal.pone.0194716

Mitochondrial rescue prevents glutathione peroxidase-dependent ferroptosis.
Jelinek A, Heyder L, Daude M, Plessner M, Krippner S, Grosse R, Diederich WE, Culmsee C.
Free Radic Biol Med 2018, 117:45-57. https://doi.org/10.1016/j.freeradbiomed.2018.01.019

Prognosis of ovarian cancer is associated with effector memory CD8+ T cell accumulation in ascites, CXCL9 levels and activation-triggered signal transduction in T cells.
Lieber S, Reinartz S, Raifer H, Finkernagel F, Dreyer T, Bronger H, Jansen JM, Wagner U, Worzfeld T, Müller R, Huber M.
Oncoimmunology 2018, 7(5):e1424672. https://doi.org/10.1080/2162402X.2018.1424672

Proteotranscriptomics Reveal Signaling Networks in the Ovarian Cancer Microenvironment.
Worzfeld T, Finkernagel F, Reinartz S, Konzer A, Adhikary T, Nist A, Stiewe T, Wagner U, Looso M, Graumann J, Müller R.
Mol Cell Proteomics 2018, 17(2):270-289. https://doi.org/10.1074/mcp.RA117.000400

Dynamizing nuclear actin filaments.
Plessner M, Grosse R.
Curr Opin Cell Biol 2018, 56:1-6. https://doi.org/10.1016/j.ceb.2018.08.005

Interplay of cell-cell contacts and RhoA/MRTF-A signaling regulates cardiomyocyte identity.
Dorn T, Kornherr J, Parrotta EI, Zawada D, Ayetey H, Santamaria G, Iop L, Mastantuono E, Sinnecker D, Goedel A, Dirschinger RJ, My I, Laue S, Bozoglu T, Baarlink C, Ziegler T, Graf E, Hinkel R, Cuda G, Kääb S, Grace AA, Grosse R, Kupatt C, Meitinger T, Smith AG, Laugwitz KL, Moretti A.
EMBO J 2018, 37(12). https://doi.org/10.15252/embj.201798133
2017

Actin visualization at a glance.
Melak M, Plessner M, Grosse R.
J Cell Sci. 2017 Feb 1;130(3):525-530. doi: 10.1242/jcs.189068. Epub 2017 Jan 12. Review. Erratum in: J Cell Sci. 2017 May 1;130(9):1688.
PMID:28082420

A reverse signaling pathway downstream of Sema4A controls cell migration via Scrib.
Sun T, Yang L, Kaur H, Pestel J, Looso M, Nolte H, Krasel C, Heil D, Krishnan RK, Santoni MJ, Borg JP, Bünemann M, Offermanns S, Swiercz JM, Worzfeld T.
J Cell Biol. 2017 Jan 2;216(1):199-215. doi: 10.1083/jcb.201602002.
PMID:28007914

The Unique Molecular and Cellular Microenvironment of Ovarian Cancer.
Worzfeld T, Pogge von Strandmann E, Huber M, Adhikary T, Wagner U, Reinartz S, Müller R.
Front Oncol. 2017 Feb 22;7:24. doi: 10.3389/fonc.2017.00024. Review.
PMID:28275576

Report: MRTF transcription and Ezrin-dependent plasma membrane blebbing are required for entotic invasion.
Soto Hinojosa L, Holst M, Baarlink C, Grosse R.
J Cell Biol. 2017 DOI: 10.1083/jcb.201702010 | Published August 3, 2017

A Tri-part Protein Complementation System Using Antibody-Small Peptide Fusions Enables Homogeneous Immunoassays.
Dixon AS, Kim SJ, Baumgartner BK, Krippner S, Owen SC.
Scientific Reports, 7:8186, Doi:10.1038/s41598-017-07569-y. published online 15. August 2017

Semaphorin 4C Plexin-B2 signaling in peripheral sensory neurons is pronociceptive in a model of inflammatory pain.
Paldy E, Simonetti M, Worzfeld T, Bali KK, Vicuña L, Offermanns S, Kuner R.
Nat Commun. 2017 Aug 2;8(1):176. doi: 10.1038/s41467-017-00341-w.

Immunosuppression in Honeybee Queens by the Neonicotinoids Thiacloprid and Clothianidin
Brandt A, Grikscheit K, Siede R, Grosse R, Meixner MD, Büchler R.
Scientific Reports, 7:4673/DOI:1k0.1038/s41598-017-04734-1

A transient pool of nuclear F-actin at mitotic exit controls chromatin organization.
Baarlink C, Plessner M, Sherrard A, Morita K, Misu S, Virant D, Kleinschnitz EM, Harniman R, Alibhat D, Baumeister S, Miyamoto K, Endesfelder U, Kaidi A, Grosse R.
Nature Cell Biology        DOI: 10.1038/ncb3641
2016

Formins at the Junction
Grikscheit K, Grosse R.
Trends Biochem Sci, 2016 Feb;41(2):148-159. Review

SCAI promotes DNA double-strand break repair in distinct chromosomal contexts
Kring Hansen R, Mund A, Lund Poulsen S, Sandoval M, Klement K, Tsouroula K, Tollenaere M A X, Mäschle M, Soria R, Offermanns S, Worzfeld T, Grosse R, Brandt D T, Rozell B, Mann M, Cole F, Soutoglou E, Goodarzi A A, Daniel J A, Mailand N, Bekker-Jensen S.
Nature Cell Biology, 2016; 18(12), 1357-1366.

Semaphorins and Plexins in Kidney Disease
Xia J, Worzfeld T.
Nephron. 2016;132(2):93-100.

Apicobasal polarity of brain endothelial cells.
Worzfeld T, Schwaninger M.
J Cereb Blood Flow Metab. 2016 Feb;36(2):340-362.

Mutant p53 promotes tumor progression and metastasis by the endoplasmic reticulum UDPase ENTPD5
Vogiatzi F, Brandt DT, Schneikert J, Fuchs J, Grikscheit K, Wanzel M, Pavlakis E, Charles JP, Timofeev O, Nist A, Mernberger M, Kantelhardt EJ, Siebolts U, Bartel F, Jacob R, Rath A, Moll R, Grosse R, Stiewe T.
Proc Natl Acad Sci USA. 2016 Dec 27;113(52):E8433-E8442.
2015

Formin-like 2 Promotes β1-Integrin Trafficking and Invasive Motility Downstream of PKCα.
Wang Y, Arjonen A, Pouwels J, Ta H, Pausch P, Bange G, Engel U, Pan X, FacklerOT, Ivaska J, Grosse R.
Dev Cell. 2015 Aug 24;34(4):475-483. pii: S1534-5807(15)00422-0. doi: 10.1016/j.devcel.2015.06.015.

Extracellular signaling cues for nuclear actin polymerization.
Plessner M, Grosse R.
Eur J Cell Biol. 2015 Jun 1. pii: S0171-9335(15)00055-2. doi: 10.1016/j.ejcb.2015.05.009.

Junctional actin assembly is mediated by Formin-like 2 downstream of Rac1.
Grikscheit K, Frank T, Wang Y, Grosse R.
J Cell Biol. 2015 May 11;209(3):367-76. doi: 10.1083/jcb.201412015.

Nuclear F-actin formation and reorganization upon cell spreading.
Plessner M, Melak M, Chinchilla P, Baarlink C, Grosse R.
J. Biol Chem. 2015 May 1;290(18):11209-16. doi: 10.1074/jbc.M114.627166.

LOV is all we need.
Grosse R.
Nat Rev Mol Cell Biol. 2015 Apr;16(4):206. doi: 10.1038/nrm3950.

Semaphorin-Plexin Signaling Controls Mitotic Spindle Orientation during Epithelial Morphogenesis and Repair.
Xia, J., Swiercz, J.M., Bañón-Rodríguez, I., Matković, I., Federico, G., Sun, T., Franz, T., Brakebusch, C.H., Kumanogoh, A., Friedel, R.H., Martín-Belmonte, F., Gröne, H.J., Offermanns, S., Worzfeld, T. (2015).
Dev. Cell 33, 299-313.

RanBP3 Regulates Melanoma Cell Proliferation via Selective Control of Nuclear Export.
Pathria G, Garg B, Wagner C, Garg K, Gschaider M, Jallili A, Wagner SN
J Invest Dermatol 2015 Oct 8 doi: 10.1038/jid.2015.401.

Filamin A interacts with the coactivator MKL1 to promote the activity of the transcription factor SRF and cell migration.
Kircher P, Hermanns C, Nossek M, Drexler MK, Grosse R, Fischer M, Sarikas A, Penkava J, Lewis T, Prywes R, Gudermann T, Muehlich S.
Sci Signal. 2015 Nov 10;8(402):ra112. doi: 10.1126/scisignal.aad2959.
2014

Pharmacological Inhibition of Actin Assembly to Target Tumor Cell Motility.
Nürnberg A, Kollmannsperger A, Grosse R.
Rev Physiol Biochem Pharmacol. 2013 Nov 6.
Published 2014

G-protein-coupled receptor signaling and polarized actin dynamics drive cell-in-cell invasion.
Purvanov V, Holst M, Khan J, Baarlink C, Grosse R.
Elife. 2014 Jun 20;3. doi: 10.7554/eLife.02786.

Formin' actin in the nucleus.
Baarlink C, Grosse R.
Nucleus. 2014 Jan-Feb;5(1):15-20.

Dynamics of Gαq-protein-p63RhoGEF interaction and its regulation by RGS2.
Bodmann EL, Rinne A, Brandt D, Lutz S, Wieland T, Grosse R, Bünemann M.
Biochem J. 2014 Feb 15;458(1):131-40.

Specific Phosphorylations Transmit Signals from Leukocyte ß2- to ß1-Ingegrins and Regulate Adhesion.
Uotila LM, Jahan F, Soto Hinojosa L, Melandry E, Grönholm M, Gahmberg CG.
J Bio Chem doi: 10.1074/jbc.M114.588111

TRPs in mechanosensing and volume regulation.
Plant TD.
Handb Exp Pharmacol. 2014;223:743-66. doi: 10.1007/978-3-319-05161-1_2.

Genetic dissection of plexin signaling in vivo.
Worzfeld T*, Swiercz JM, Sentürk A, Genz B, Korostylev A, Deng S, Xia J, Hoshino M, Epstein JA, Chan AM, Vollmar B, Acker-Palmer A, Kuner R, Offermanns S.
Proc. Natl. Acad. Sci. USA 111:2194-2199 (2014)
* corresponding author

Semaphorins and plexins as therapeutic targets.
Worzfeld T, Offermanns S.
Nat Rev Drug Discov. 2014 Aug;13(8):603-21.