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Publikationen

2024

Bernhard FP, Schütte S, Heidenblut M, Oehme M, Rinné S & Decher N. (2024).
A novel KCNC3 gene variant in the voltage-dependent Kv3.3 channel in an atypical form of SCA13 with dominant central vertigo.
Front. Cell. Neurosci. 18:1441257.

*Neelsen LC, *Riel EB, *Rinné S, Schmid F-R, Jürs BC, Bedoya M, Langer JP, Eymsh B, Kiper AK, Cordeiro S, ^#Decher N, ^#Baukrowitz T & ^#Schewe M. (2024).
Ion occupancy of the selectivity filter controls opening of a cytoplasmic gate in the K_2P channel TALK-2.
Nature commun. 15: 7545. *shared first authors. #shared last and corresponding authors.

Rinné S, Schick F, Vowinkel K, Schütte S, Krasel C, Kauferstein S, Schäfer MK-H, Kiper AK, Müller T & ^#Decher N. (2024).
Potassium channel TASK-5 forms functional heterodimers with TASK-1 and TASK-3 to break its silence.
Nature Commun. 15: 7548. *shared first authors. ^#corresponding author.

Kiper AK, Wegner S, Kadala A, Rinné S, Schütte S, Winter Z, Bertoune MAR, Touska F, Matschke V, Wrobel E, Streit A-K, Lang F, Schmidt C, Schulze-Bahr E, Schäfer MK-H, Voelkl J, Seebohm G, Zimmermann K & Decher N. (2024).
KCNQ1 is an essential mediator of the sex-dependent perception of moderate cold temperatures.
Proc. Natl. Acad. Sci. USA 121: e2322475121.

Rinné S, Kiper AK, Jacob R, Ortiz-Bonnin B, Schindler RFR, Fischer S, Komadowski M, De Martino E, Schäfer MK-H, Cornelius T, Fabritz L, Helker CSM, Brand T & Decher N. (2024).
Popeye-domain-containing proteins modulate the voltage-gated cardiac sodium channel Nav1.5.
iScience. 27: 109696.

Zhang Y, Shaabani S, Vowinkel K, Trombetta-Lima M, Sabogal-Guáqueta AM, Chen T, Hoekstra J, Lembeck J, Decher N, Dömling A & Dolga AM. (2024).
Novel SK channel positive modulators prevent ferroptosis and excitotoxicity in neuronal cells.
Biomed. Pharmacother. 171: 116163.
2023

Schreiber JA, Derksen A, Goerges G, Schütte S, Sörgel J, Kiper AK, Strutz-Seebohm N, Ruck T, Meuth SG, Decher N & Seebohm G. (2023).
Cloxyquin activates hTRESK by allosteric modulation of the selectivity filter.
Commun. Biol. 6: 745.

Fender H, Walter K, Kiper AK, Plačkić J, Kisko TM, Braun MD, Schwarting RKW, Rohrbach S, Wöhr M, Decher N & Kockskämper J. (2023).
Calcium handling remodeling underlies impaired sympathetic stress response in ventricular myocardium from CACNA1C haploinsufficient rats.
Int. J. Mol. Sci. 24: 9795.

Labbaf A, Dellin M, Komadowski M, Chetkovich D, Decher N, Pape H-C, Seebohm G, Budde T & Zobeiri M. (2023).
Characterization of Kv1.2-mediated outward current in TRIP8b-deficient mice.
Biol.Chem. 404: 291-302.

Vera-Zambrano A, Baena-Nuevo M, Rinné S, Villegas-Esguevillas M, Barreira B, Telli G, de Benito-Bueno A, Antonio Blázquez J, Climent B, Pérez-Vizcaino F, Valenzuela C, Decher N, Gonzalez T & Cogolludo A. (2023).
Sigma-1 receptor modulation fine-tunes Kv1.5 channels and impacts pulmonary vascular function.
Pharmacol. Res. 189: 106684.

*Rinné S, *Oertli A, Nagel C, Tomsits P, Jenewein T, Kääb S, Kauferstein S, Loewe A, ^‡Beckmann BM &^‡,#Decher N. (2023).
Functional characterization of a spectrum of novel Romano-Ward Syndrome KCNQ1 variants.
Int. J. Mol. Sci. 24: 1350. *shared first authors. ^‡shared senior authors. ^#corresponding author.

Swan A, Schindler R, Savarese M, Mayer I, Rinné S, Bleser F, Schaenzer A, Hahn A, Sabatelli M, Perna F, Chapman K, Pfuhl M, Spivey A, Decher N, Udd B, Tasca G & Brand T. (2023).
Differential effects of mutations of POPDC proteins on heteromeric interaction and membrane trafficking.
Acta Neuropathol. Commun. 11: 4.
2022

*Rinné S, *Stallmeyer B, Pingerra A, Netter MF, Matschke LA, Dittmann S, Kirchhefer U, Neudorf U, Opp J, Striessnig J, ^#Decher N & ^#Schulze-Bahr ESB. (2022).
Whole exome sequencing identifies a heterozygous mutation in the Cav1.3 gene CACNA1D in familial sinus node dysfunction and focal idiopathic epilepsy.
Int. J. Mol. Sci. 23: 14215. *Shared first authors. ^#Shared last and corresponding authors

*Arévalo B, *Bedoya M, *Kiper AK, Vergara F, Ramirez D, Mazola Y, Bustos D, Zúñiga R, Cikutovic R, Cayo A, Rinné S, Ramírez-Apan MT, Sepúlveda F, Cerda O, Lopez-Collazo E, ^#Decher N, ^#Zúñiga L, ^#Gutierrez M & ^#González W. (2022).
Selective TASK-1 inhibitor with a defined structure-activity relationship reduces cancer cell proliferation and viability.
J. Med. Chem. 65: 15014-15027. *shared first authors. ^#Shared corresponding authors

Baldwin T, Li Y, Marsden A, Rinné S, Carbajal AG, Schindler R, Zhang M, Garcia M, Venna V, Decher N, Brand T & Dessauer CW. (2022).
POPDC1 scaffolds a complex of adenylyl cyclase 9 and the potassium channel TREK-1 in heart.
EMBO Reports. 23: e55208.

*Kummer S, *Rinné S, Seemann G, Bachmann N, Timothy K, Thornton PS, Pillekamp F, Mayatepek E, Bergmann C, Meissner T & Decher N^#. (2022).
Hyperinsulinemic hypoglycemia associated with a Cav1.2 variant with mixed gain- and loss-of-function effects.
Int. J. Mol. Sci. 23: 8097. *shared first authors. ^#corresponding author.

Mazola Y, Márquez-Montesinos JCE, Ramírez D, Zúñiga L, Decher N, Ravens U, Yarov-Yarovoy V & González W. (2022).
Common structural pattern for flecainide binding in atrial-selective Kv1.5 and Nav1.5 channels: a computational approach.
Pharmaceutics. 14: 1356.

Schreiber JA, Möller M, Zaydman M, Zhao L, Beller Z, Becker S, Ritter N, Hou P, Shi J, Silva J, Wrobel E, Strutz-Seebohm N, Decher N, Schmitt N, Meuth SG, Düfer M, Wünsch B, Cui J & Seebohm G. (2022).
A benzodiazepine activator locks Kv7.1 channels open by electro-mechanical uncoupling.
Communications Biology. 5: 301.

Valdés-Jiménez A, Jiménez-González D, Reyes-Parada M, Rinné S, Kiper AK, Decher N, González W & Núñez-Vivanco G. (2022).
A new strategy for multitarget drug discovery/repositioning through the identification of similar 3D amino acid patterns among proteins structures: the case of tafluprost and its effects on cardiac ion channels.
Frontiers in Pharmacology.13: 855792.

Matschke LA, Komadowski MA, Stöhr A, Lee B, Henrich MT, Griesbach M, Rinné S, Geibl FF, Chiu W-H, Koprich JB, Brotchie JM, Kiper AK, Dolga AM, Oertel WH & Decher N. (2022).
Enhanced firing of locus coeruleus neurons and SK channel dysfunction are conserved in distinct models of prodromal Parkinson’s disease.
Scientific Reports. 1 2: 3180.

Wiedmann F, Beyersdorf C, Zhou X-B, Kraft M, Paasche A, Jávorszky N, Rinné S, Sutanto H, Büscher A, Foerster KI, Blank A, El-Battrawy I, Li X, Lang S, Tochtermann U, Kremer J, Arif R, Karck M, Decher N, van Loon G, Akin I, Borggrefe M, Kallenberger S, Heijman J, Haefeli WE, Katus HA & Schmidt C. (2022).
Treatment of atrial fibrillation with doxapram: TASK‑1 potassium channel inhibition as a novel pharmacological strategy.
Card. Res. 118: 1728-1741.
2021
Ramírez D, Mejía-Gutiérrez M, Insuasty B, Rinné S, Kiper AK, Platzk M, Müller T, Decher N, Quiroga J, De-la-Torre P & González W. (2021).
5-(indol-2-yl)pyrazolo[3,4-b]pyridines as a new family of TASK-3 Channel Blockers: a Pharmacophore-based Regioselective Synthesis.
Molecules. 26: 3897.

*Kiper AK, *Bedoya M, *Stalke S, *Marzian S, Ramírez D, Cruz Adl, Peraza DA, Vera-Zambrano A, Márquez Montesinos JCE, Arévalo Ramos BA, Rinné S, Gonzalez T, Valenzuela C, Gonzalez W & ^#Decher N. (2021).
Identification of a critical binding site for local anesthetics in the side pockets of Kv1 channels.
Br. J. Pharmacol. 178: 3034-3048. *shared first authors. ^#corresponding author.^*,#Decher N, *Rinné S, Bedoya M, González W & Kiper AK. (2021).
Molecular pharmacology of K_2P potassium channels.
Cell. Physiol. Biochem. 55: 87-107. Invited Review. *shared first author. ^#corresponding author.

*Oertli A, *Rinné S, Moss KR, Kääb S, Seemann G, Beckmann BM & Decher N. (2021).
Molecular mechanism of autosomal recessive long QT-syndrome 1 without deafness.
Int. J. Mol. Sci. 22:1112.*shared first author.

Wiedmann F, Rinné S, Donner B, Decher N, Katus HA & Schmidt C. (2021).
Mechanosensitive TREK-1 two-pore-domain potassium (K_2P) channels in the cardiovascular system.
Prog. Biophys. Mol. Biol. 159:126-135.
2020

*Endres D, *Decher N, Röhr I, Vowinkel K, Domschke K, Komlosi K, Tzschach A, Gläser B, Schiele M, Runge K, Süß P, Schuchardt F, Nickel K, Stallmeyer B, Rinné S, Schulze-Bahr E & Tebartz van Elst L. (2020).
New Cav1.2 Channelopathy with high-functioning autism, affective disorder, severe dental enamel defects, a short QT interval, and a novel CACNA1C loss-of-function mutation.
Int. J. Mol. Sci. 21: 8611. *shared first author.

Erlenhardt N, Kletke O, Wohlfarth F, Komadowski MA, Clasen L, Makimoto H, Rinné S, Kelm M, Jungen C, Decher N, Meyer C & Klöcker N. (2020).
Disease-associated HCN4 V759I variant is not sufficient to impair cardiac pacemaking.
Pflügers Archive. 472: 1733-1742.

Rinné S, Ortiz-Bonnin B, Stallmeyer B, Kiper AK, Fortmüller L, Schindler RFR, Herbort-Brand U, Kabir NS, Dittmann S, Friedrich C, Zumhagen S, Gualandi F, Selvatici R, Rapezzi C, Arbustini E, Ferlini A, Fabritz L, Schulze-Bahr E, Brand T & *Decher N. (2020).
POPDC2 a novel susceptibility gene for conduction disorders.
J. Mol. Cell Cardiol. 145: 74-83. *corresponding author.

^#Rödström KEJ, ^#Kiper AK, Zhang W, Rinné S, Pike ACW, Goldstein M, Conrad LJ, Delbeck M, Hahn MG, Meier H, Platzk M, Quigley A, Speedman D, Shrestha L, Mukhopadhyay SMM, Burgess-Brown NA, Tucker SJ, Mueller T, *Decher N & *Carpenter EP. (2020).
A lower X-gate in TASK channels traps inhibitors within the vestibule.
Nature 582: 443-447.*Shared senior and corresponding authors.^#Shared first author.

Bustos D, Bedoya M, Ramirez D, Concha G, Zúñiga L, Decher N, Hernandez EW, Sepúlveda FV, Martinez L & González W. (2020).
Elucidating the structural basis of the intracellular pH sensing mechanism of TASK-2 K_2P channel.
Int. J. Mol. Sci. 21: 532.
2019

Ganjam G, Bolte K, Matschke L, Neitemeier S, Dolga A, Höllerhage M, Hoeglinger G, Adamczyk A, Decher N, Oertel W & Culmsee C. (2019).
Mitochondrial damage by alpha synuclein causes cell death in human dopaminergic neurons.
Cell. Death. Dis. 10: 865.

Vissing J, Johnson K, Töpf A, Nafissi S, Díaz-Manera J, French VM, Schindler RF, Sarathchandra P, Løkken N, Rinné S, Freund M, Decher N, Müller T, Duno M, Krag T, Brand T & Straub V. (2019).
POPDC3 gene variants associate with a new form of limb girdle muscular dystrophy.
Ann. Neurol. 86: 832-843.

Ramírez D, Concha G, Arévalo B, Prent-Peñaloza L, Zúñiga L, Kiper AK, Rinné S, Reyes-Parada M, Decher N, González W & Caballero J. (2019).
Discovery of novel TASK-3 channel blockers using a pharmacophore-based virtual screening.
Int. J. Mol. Sci. 20: 4014.

Bedoya M, Rinné S, Kiper AK, Decher N, González W & Ramírez D. (2019).
TASK Channels Pharmacology: New Challenges in Drug Design.
J. Med. Chem. 62: 10044-10058.

Ramírez D*, Bedoya M, Kiper AK, Rinné S, Morales-Navarro S, Hernández-Rodríguez EW, Sepúlveda FV, Decher N* & González W*. (2019).
Structure/activity analysis of TASK-3 channel antagonists based on a 5,6,7,8 tetrahydropyrido[4,3-d]pyrimidine.
Int. J. Mol. Sci. 20: 2252. *shared corresponding author.

Wiedmann F, Kiper AK, Bedoya M, Ratte A, Rinné S, Kraft M, Waibel M, Anad P, Wenzel W, Gonzalez W, Katus HA, Decher N* & Constanze Schmidt*. (2019).
Identification of the A293 (AVE1231) binding site in the cardiac two-pore domain potassium channel TASK-1: a common low affinity antiarrhythmic drug binding site.
Cell. Physiol. Biochem. 52: 1223-1235. *shared senior and corresponding author.

Rinné S, Kiper AK, Vowinkel KS, Ramírez D, Schewe M, Bedoya M, Aser D, Gensler I, Netter MF, Stansfeld PJ, Baukrowitz T, González W & *Decher N. (2019).
The molecular basis for an allosteric inhibition of K⁺-flux gating in K_2P channels.
eLIFE. 8: e39476. *corresponding author.

Schewe M, Sun H, Mert Ü, Mackenzie A, Pike ACW, Schulz F, Constantin C, Vowinkel KS, Conrad LJ, Kiper AK, Gonzalez W, Musinszki M, Tegtmeier M, Pryde DC, Belabed H, Nazare M, de Groot BL, Decher N, Fakler B, Carpenter EP, Tucker SJ & Baukrowitz T. (2019).
A pharmacological master key mechanism that unlocks the selectivity filter gate in K⁺ channels.
Science. 363: 875-880.

Key J, Mueller A-K, Gispert S, Matschke L, Wittig I, Corti O, Münch C, *Decher N & *Auburger G. (2019).
Ubiquitylome profiling of Parkin-null brain reveals dysregulation of calcium homeostasis factors ATP1A2, Hippocalcin and GNA11, reflected by altered firing of noradrenergic neurons.
Neurobiol. Dis. 127: 114-130. *shared corresponding authors.

Kuß J, Stallmeyer B, Hain E, Goldstein M, Rinné S, Pees C, Zumhagen S, Seebohm G, Decher N, Pott L, Kienitz M-C & Schulze-Bahr E. (2019).
Familial sinus node disease caused by a gain of GIRK channel function.
Circ. Genom. Precis. Med. 12: e002238.
2018

Soufi M, Ruppert V, Rinné S, Mueller T, Kurt B, Pilz G, Maieron A, Dodel R, Decher N & Schaefer JR. (2018).
Increased KCNJ18 promoter activity as a mechanism in atypical normokalemic periodic paralysis.
Neurol. Genet. 4: e274.

Möller M, Silbernagel N, Wrobel E, Stallmayer B, Amedonu E, Rinné S,  Peischard S, Meuth SG, Wünsch B, Strutz-Seebohm N, Decher N, Schulze-Bahr E &  Seebohm G. (2018).
In vitro analyses of novel HCN4 gene mutations.
Cell. Physiol. Biochem. 49: 1197-1207.

Silbernagel N, Walecki M,  Schäfer MK-H, Kessler M, Zobeiri M, Rinné S, Kiper AK, Komadowski MA, Vowinkel KS, Wemhöner K, Fortmüller L, Schewe M, Dolga AM, Scekic‑Zahirovic J, Matschke LA, Culmsee C, Baukrowitz T, Monassier L, Ullrich ND, Dupuis L, Just S, Budde T, Fabritz L & *Decher N. (2018).
The VAMP-associated protein VAPB is required for cardiac and neuronal pacemaker channel function.
FASEB J. 32: 6159-6173. *corresponding author.

Pott A, Bock S, Berger IM, Frese K, Dahme T, Kessler M, Rinné S, Decher N, Just S & Rottbauer W. (2018).
Mutation of the Na⁺/K⁺-ATPase Atp1a1a.1 causes QT interval prolongation and bradycardia in zebrafish.
J. Mol. Cell. Cardiol.  120: 42–52.

Henrich MT, Geibl FF, Lee B, Chiu W-H, Koprich JB, Brotchie JM, Timmermann L, Decher N, ^§Matschke LA & ^§Oertel WH. (2018).
A53T-α-synuclein overexpression in murine locus coeruleus induces Parkinson's disease-like pathology in neurons and glia.
Acta. Neuropathol. Commun. 6: 39. ^§shared last authors.

*Matschke LA, Rinné S, Snutch TP, Oertel WH, Dolga AM & *Decher N. (2018).
Calcium-activated SK potassium channels are key modulators of the pacemaker frequency in locus coeruleus neurons.
Mol. Cell. Neuroci. 88: 330–341.*corresponding authors.
2017

Rinné S, Kiper AK, Schmidt C, Ortiz-Bonnin B, Zwiener S, Seebohm G & *Decher N. (2017).
Stress-Kinase Regulation of TASK-1 and TASK-3.
Cell. Physiol. Biochem.  44: 1024-1037. *corresponding author.

Leist M, Rinné S, Datunashvili M, Aissaoui A, Pape H-C, Decher N, Meuth SG & Budde T. (2017).
Acetylcholine-dependent upregulation of TASK-1 channels in thalamic interneurons by a smooth muscle-like signalling pathway.
J. Physiol.  595: 5875-5893.

see also Perspectives by Kim D. (2017). Endocytosis: another pathway in receptor-Gq-TASK signalling.

*Decher N, Kiper AK & Rinné S. (2017).
Stretch-activated potassium currents in the heart: focus on TREK-1 and arrhythmias.
Prog. Biophys. Mol. Biol. 130: 223-232. Invited Review.  *corresponding author

Ramirez D, Arévalo B, Martínez G, Rinné S, Sepúlveda F, *Decher N & *González W. (2017).
Side fenestrations provide an `anchor´ for a stable binding of A1899 to the pore of TASK-1 potassium channels.
Mol. Pharm. 14: 2197-2208. *corresponding authors

Honrath B, Matschke L, Meyer T, Magerhans L, Perocchi F, Ganjam GK, Zischka H, Krasel C, Gerding A, Bakker BM, Bünemann M, Strack S, Decher N,  Culmsee C & Dolga A. (2017).
SK2 channels regulate mitochondrial respiration and mitochondrial Ca2+ uptake.
Cell. Death Differ.  24: 761-773.

*Decher N, Ortiz-Bonnin B, Friedrich C, Schewe M, Kiper AK, Rinné S, Seemann G, Peyronnet R, Zumhagen S, Bustos D, Kockskämper J, Kohl P, Just S, González W, Baukrowitz T, Stallmeyer B & Schulze-Bahr E. (2017).
Sodium permeable and `hypersensitive´ TREK-1 channels cause ventricular tachycardia.
EMBO Mol. Med. 9: 403-414. *corresponding author.

see also Editorial by Goldstein SA. (2017). Sodium leak through K_2P potassium channels and cardiac arrhythmia, an emerging theme

Stallmeyer B, Kuß J, Kotthoff S, Zumhagen S, Vowinkel K, Rinné S, Matschke LA, Friedrich C, Schulze-Bahr E, Rust S, Seebohm G, Decher N & Schulze-Bahr E. (2017).
A mutation in the G-protein gene GNB2 causes familial sinus node and atrioventricular conduction dysfunction.
Circ. Res. 120: e33-e44.
2016

Ortiz-Bonnin B, Rinné S, Moss R, Streit AK, Scharf M, Richter K, Stöber A, Pfeufer A, Seemann G, Kääb S, Beckmann BM & *Decher N. (2016).
Electrophysiological characterization of a large set of novel variants in the SCN5A-gene: Identification of novel LQTS3 und BrS mutations.
Pflügers Archiv. 468: 1375-1387. *corresponding author.

Goldstein M, Rinné S, Kiper AK, Ramírez D, Netter MF, Bustos D, Ortiz-Bonnin B, González W & *Decher N. (2016).
Functional mutagenesis screens reveal the `cap structure´ formation in disulfide-bridge free TASK channels.
Sci. Rep. 6: 19492. *corresponding author.

Schindler RFR, Scotton C, Zhang J, Passarelli C, Ortiz-Bonnin B, Simrick S, Schwerte T, Poon K-L, Fang M, Rinné S, Froese A, Nikolaev VO, Grunert C, Müller T, Tasca G, Sarathchandra P, Drago F, Dallapiccola B, Rapezzi C, Arbustini E, Di Raimo FR, Neri M, Selvatici R, Gualandi F, Fattori F, Pietrangelo A, Li W, Jiang H, Xu X, Bertini E, Decher N, Wang J, Brand T & Ferlini A. (2016).
POPDC1^S201F causes muscular dystrophy and arrhythmia by affecting protein trafficking.
J. Clin. Invest. 126: 239-253.
2015

Wemhöner K, Kanyshkova T, Silbernagel N, Fernandez-Orth J, Bittner S, Kiper AK, Rinné S, Netter MF, Meuth SG, Budde T & *Decher N. (2015).
An N-terminal deletion variant of HCN1 in the epileptic WAG/Rij strain modulates HCN current densities.
Front. Mol. Neurosci. 8: 63.*corresponding author.

Matschke LA, Bertoune M, Röper J, Snutch TP, Oertel WH, Rinné S & *Decher N. (2015).
A concerted action of L- and T-type Ca²⁺ channels regulates locus coeruleus pacemaking.
Mol. Cell. Neurosci. 68:293-302. *corresponding author.

Rinné S, Kiper AK, Schlichthörl G, Dittmann S, Netter MF, Limberg SH, Silbernagel N, Zuzarte M, Moosdorf R, Wulf H, Schulze-Bahr E, Rolfes C & *Decher N. (2015).
TASK-1 and TASK-3 may form heterodimers in human atrial cardiomyocytes.
J. Mol. Cell. Cardiol. 81: 71-80. *corresponding author.

Wemhöner K, Friedrich C, Stallmeyer B, Coffey AJ, Grace A, Zumhagen S, Seebohm G, Ortiz-Bonnin B, Rinné S, Sachse FB, Schulze-Bahr E & *Decher N. (2015).
Gain-of-function mutations in the calcium channel CACNA1C (Cav1.2) cause non-syndromic long-QT but not Timothy syndrome.
J. Mol. Cell. Cardiol. 80: 186-195. *corresponding author.

Kiper AK, Rinné S, Rolfes C, Ramírez D, Seebohm G, Netter MF, González W & *Decher N. (2015).
Kv1.5 blockers preferentially inhibit TASK-1 channels: TASK-1 as a target against atrial fibrillation and obstructive sleep apnea?
Pflügers Arch. 467: 1081-1090. *corresponding author.

*Decher N, Kiper AK, Rolfes C, Schulze-Bahr E & Rinné S. (2015).
The role of acid-sensitive two-pore domain potassium channels in cardiac electrophysiology: focus on arrhythmias.
Pflügers Arch. 467: 1055-1067. Invited Review. *corresponding author.

Bista P, Pawlowski M, Cerina M, Ehling P, Leist M, Meuth P, Aissaoui A, Borsotto M, Heurteaux C, Decher N, Pape HP, Oliver D, Meuth SG & Budde T. (2015).
Differential phospholipase C-dependent modulation of TWIK-related acid-sensitive K⁺ (TASK) and TWIK-related K⁺ (TREK) channels in rat thalamocortical relay neurons.
J. Physiol. 593: 127-144.
2014

Streit AK, Matschke LA, Dolga AM, Rinné S & *Decher N. (2014).
RNA editing in the central cavity as a mechanism to regulate surface expression of the voltage-gated potassium channel Kv1.1.
J. Biol. Chem. 289: 26762-26771. *corresponding author

^§Friedrich C, ^§Rinné S, Zumhagen S, Kiper AK, Silbernagel N, Netter MF, Stallmeyer B, Schulze-Bahr E & *Decher N. (2014).
Gain-of-function mutation in TASK-4 channels and severe cardiac conduction disorder.
EMBO Mol. Med. 6: 937-951. §shared first authors, *corresponding author

Sanchez-Padilla J, Guzman JN, Ilijic E, Kondapalli J, Galtieri DJ, Yang B, Schieber S, Oertel W, Wokosin D, Schumacker P & Surmeier DJ. (2014).
Mitochondrial oxidant stress in locus coeruleus is regulated by activity and nitric oxide synthase.
Nature Neurosci. 17: 832-840.

Renigunta V, Fischer T, Zuzarte M, Kling S, Zou X, Siebert K, Limberg M, Rinné S, Decher N, Schlichthörl G & Daut J. (2014).
Co-operative endocytosis of the endosomal SNARE protein syntaxin-8 and the potassium channel TASK-1.
Mol. Biol. Cell. 25: 1877-1891.

Munoz C, Pakladok T, Almilaji A, Elvira B, Decher N, Shumilina E & Lang F. (2014).
Up-Regulation of Kir2.1 (KCNJ2) by the Serum & Glucocorticoid Inducible SGK3.
Cell. Physiol. Biochem. 33: 491-500.

*Rinné S, Renigunta V, Schlichthörl G, Zuzarte M, Bittner S, Meuth SG, Decher N, Daut J & *Preisig-Müller R. (2014).
A splice variant of the two-pore domain potassium channel TREK-1 with only one pore domain reduces the surface expression of full-length TREK-1 channels.
Pflügers Arch. 466: 1559-1570. *corresponding authors
2013

Marzian S, Stansfeld PJ, Rapedius M, Rinné S, Nematian-Ardestani E, Abbruzzese JL, Steinmeyer K, Sansom MSP, Sanguinetti MC, Baukrowitz T & *Decher N. (2013).
Side pockets provide the basis for a new mechanism of Kv channel–specific inhibition.
Nature Chem. Biol. 9: 507-513. *corresponding author

see also Editorial by Wulff, H. & Yarov-Yarovoy, V. (2013). Channels: Sticking to nooks and crannies.

Limberg M, Zumhagen S, Netter MF, Coffey AJ, Grace A, Rogers J, Böckelmann D, Rinné S, Stallmeyer B, ^*,^§Decher N & ^§Schulze-Bahr E. (2013).
Non dominant-negative KCNJ2 gene mutations leading to Andersen-Tawil syndrome with an isolated cardiac phenotype.
Basic Res. Cardiol. 108: 353. *corresponding author, ^§shared senior authors

Ulm C, Saffarzadeh M, Mahavadi P, Müller S, Prem G, Saboor F, Simon P, Middendorff R, Geyer H, Henneke I, Bayer N, Rinné S, Lütteke T, Böttcher-Friebertshäuser E, Gerardy-Schahn R, Schwarzer D, Mühlenhoff M, Preissner KT, Günther A, Geyer R & Galuska SP. (2013).
Soluble Polysialylated NCAM: A Novel Player of the Innate Immune System in the Lung.
Cell. Mol. Life Sci. 70: 3695-3708.

Dolga A, Netter MF, Perocchi F, Doti N, Meissner L, Tobaben S, Grohm J, Zischka H, Plesnila N, Decher N & Culmsee C. (2013).
Mitochondrial small conductance SK2 channels prevent glutamate-induced oxytosis and mitochondrial dysfunction.
J. Biol. Chem. 88: 10792-10804.

*Decher N, Netter MF & Streit AK. (2013).
Putative impact of RNA editing on drug discovery.
Chem. Biol. Drug Des. 81: 13-21. Invited Review. Cover picture. *corresponding author

see also Commentary by Selwood, DL. (2013). Beyond the Hundred Dollar Genome – Drug Discovery Futures

Schiekel J, Lindner M, Hetzel A, Wemhöner K, Renigunta V, Schlichthörl G, Decher N, Oliver D & Daut J. (2013).
Inhibition of the potassium channel TASK-1 in rat cardiac muscle by endothelin-1 is mediated by phospholipase C.
Cardiovasc. Res. 97: 97-105.

see also Editorial by Mubagwa, K. (2013). Signalling between G-protein-coupled receptors and TASK-1 channels.
2012

Netter MF, Zuzarte M, Schlichthörl G, Klöcker N & *Decher N. (2012).
The HCN4 channel mutation D553N associated with bradycardia has a C-linker mediated gating defect.
Cell. Physiol. Biochem. 30: 1227-1240. *corresponding author

Wemhöner K, Silbernagel N, Marzian S, Netter MF, Rinné S, Stansfeld PJ & *Decher N. (2012).
A leucine zipper motif essential for gating of hyperpolarization-activated channels.
J. Biol. Chem. 287: 40150-40160. *corresponding author

Froese A, Breher SS, Waldeyer C, Schindler RF, Nikolaev VO, Rinné S, Wischmeyer E, Schlueter J, Becher J, Simrick S, Vauti F, Kuhtz J, Meister P, Kreissl S, Torlopp A, Liebig SK, Laakmann S, Müller TD, Neumann J, Stieber J, Ludwig A, Maier SK, Decher N, Arnold HH, Kirchhof P, Fabritz L & Brand T (2012).
Popeye domain containing proteins are essential for stress-mediated modulation of cardiac pacemaking in mice.
J. Clin. Invest. 122: 1119-30.

see also Editorial by Boukens, BJ & Christoffels VM. (2012). Popeye proteins: muscle for the aging sinus node.

Seebohm G, Strutz-Seebohm N, Ursu ON, Preisig-Müller R, Zuzarte M, Hill EV, Kienitz MC, Bendahhou S, Fauler M, Tapken D, Decher N, Collins A, Jurkat-Rott K, Steinmeyer K, Lehmann-Horn F, Daut J, Tavaré JM, Pott L, Bloch W & Lang F. (2012).
Altered stress stimulation of inward rectifier potassium channels in Andersen-Tawil syndrome.
FASEB J. 26: 513-522.
2011

Limberg SH, Netter MF, Rolfes C, Rinné S, Schlichthörl G, Zuzarte M, Vassiliou T, Moosdorf R, Wulf H, Daut J, Sachse FB & *Decher N. (2011).
TASK-1 channels may modulate action potential duration of human atrial cardiomyocytes.
Cell. Physiol. Biochem. 28: 613-624.*corresponding author

Streit AK & *Decher N. (2011).
A-to-I RNA editing modulates the pharmacology of neuronal ion channels and receptors.
Biochemistry (Moscow) 76: 890-899. Invited Review. *corresponding author

*Decher N, Wemhöner K, Rinné S, Netter MF, Zuzarte M, Aller MI, Kaufmann SG, Li XT, Meuth SG, Daut J, Sachse FB & Maier SK. (2011).
Knock-out of the potassium channel TASK-1 leads to a prolonged QT interval and a disturbed QRS complex.
Cell. Physiol. Biochem. 28: 77-86. *corresponding author

Piechotta PL, Rapedius M, Stansfeld PJ, Bollepalli MK, Erhlich G, Andres-Enguix I, Fritzenschaft H, Decher N, Sansom MS, Tucker SJ & Baukrowitz T. (2011).
The pore structure and gating mechanism of K_2P channels.
EMBO J. 30: 3607-3619.

Streit AK, Derst C, Wegner S, Heinemann U, Zahn RK & *Decher N. (2011).
RNA editing of Kv1.1 channels may account for reduced ictogenic potential of 4-aminopyridine in chronic epileptic rats.
Epilepsia 52: 645-648. *corresponding author

Streit AK, Netter MF, Kempf F, Walecki M, Rinné S, Bollepalli MK, Preisig-Müller R, Renigunta V, Daut J, Baukrowitz T, Sansom MS, Stansfeld PJ & *Decher N. (2011).
A specific two-pore domain potassium channel blocker defines the structure of the TASK-1 open pore.
J. Biol. Chem. 286: 13977-13984. *corresponding author

Renigunta A, Renigunta V, Saritas T, Decher N, Mutig K & Waldegger S. (2011).
Tamm-Horsfall glycoprotein interacts with renal outer medullary potassium channel ROMK2 and regulates its function.
J. Biol. Chem. 286: 2224-2235.
2010

*Decher N, Streit AK, Rapedius M, Netter MF, Marzian S, Ehling P, Schlichthörl G, Craan T, Renigunta V, Köhler A, Dodel RC, Navarro-Polanco RA, Preisig-Müller R, Klebe G, Budde T, Baukrowitz T & Daut J. (2010).
RNA editing modulates the binding of drugs and highly unsaturated fatty acids to the open pore of Kv potassium channels.
EMBO J. 29: 2101-2113. *corresponding author

see also Editorial by Horn, R. & Reenan, R. (2010). Channels get in an HUFA: RNA editing gets them out of a jam.

Moreno-Galindo EG, Barrio-Echavarría GF, Vásquez JC, Decher N, Sachse FB, Tristani-Firouzi M, Sánchez-Chapula JA & Navarro-Polanco RA. (2010).
Molecular basis for a high-potency open-channel block of Kv1.5 channel by the endocannabinoid anandamide.
Mol. Pharmacol. 77: 751-758.

Gao YD, Hanley PJ, Rinné S, Zuzarte M & Daut J. (2010)
Calcium-activated K⁺ channel (KCa3.1) activity during Ca²⁺ store depletion and store-operated Ca²⁺ entry in human macrophages.
Cell Calcium 48: 19-27.
2008

*Decher N, Gonzalez T, Streit AK, Sachse F, Renigunta V, Soom M, Heineman SH, Daut J & Sanguinetti MC. (2008).
Structural determinants of Kvß1 induced channel inactivation: a PIP₂ modulated hairpin.
EMBO J. 27: 3164-3174. *corresponding author

Arechiga IA, Barrio-Echavarria G, Rodriguez-Menchaca A, Moreno-Galindo E, Decher N, Tristani-Firouzi M, Sanchez-Chapula J, Navarro-Polanco R. (2008)
Kv1.5 Open Channel Block by Antiarrhythmic Drug Disopyramide: Molecular Determinants of Block.
J. Pharmacol. Sci. 108: 49-55.
2007

Arias C, Guizy M, David M, Marzian S, Gonzalez T, Decher N & Valenzuela C. (2007).
Kvbeta1.3 Reduces the Degree of Stereoselective Bupivacaine Block of Kv1.5 Channels.
Anesthesiology 107: 641-651.

*Decher N, Renigunta V, Zuzarte M, Soom M, Heinemann S, Timothy K, Keating M, Daut J, Sanguinetti M, Splawski I.(2007).
Impaired Interaction between the slide helix and the C-terminus of Kir2.1: A novel mechanism of Andersen syndrome
Cardiovasc. Res. 75: 748-757. *corresponding author.

Putzke C, Wemhöner K, Sachse F, Rinné S, Schlichthörl G, Li XT, Jaé L, Eckhardt I, Wischmeyer E, Wulf H, Preisig-Müller R, Daut J & Decher N. (2007).
The acid-sensitive potassium channel TASK-1 in rat cardiac muscle
Cardiovasc. Res. 75: 59-68.

see also Editorial by Charpentier, F. (2007). Understanding the cardiac role of K2P channels: A new TASK for electrophysiologists.

Strutz-Seebohm N, Gutcher I, Decher N, Steinmeyer K, Lang F & Seebohm G. (2007).
Comparison of potent Kv1.5 potassium channel inhibitors reveals the molecular basis for blocking kinetics and bindung mode.
Cell. Physiol. Biochem. 20: 791-800.
2006

Decher N, Kumar P, Gonzalez T, Pirard B & Sanguinetti MC. (2006).
Binding site of a novel Kv1.5 blocker: a "foot in the door" against atrial fibrillation.
Mol. Pharmacol. 70: 1204-1211.
2005

Decher N, Kumar P, Gonzalez T, Renigunta V & Sanguinetti MC. (2005).
Structural basis for competition between drug binding and Kvbeta 1.3 accessory subunit-induced N-type inactivation of Kv1.5 channels.
Mol. Pharmacol. 68: 995-1005.

Splawski I, Timothy KW, Decher N, Kumar P, Sachse FB, Beggs AH, Sanguinetti MC & Keating MT. (2005).
Severe arrhythmia disorder caused by cardiac L-type calcium channel mutations.
Proc. Natl. Acad. Sci. USA 102: 8089-8096.
2004

Splawski I, Timothy KW, Sharpe LM, Decher N, Kumar P, Bloise R, Napolitano C, Schwartz PJ, Joseph RM, Condouris K, Tager-Flusberg H, Priori SG, Sanguinetti MC & Keating MT. (2004).
CaV1.2 calcium channel dysfunction causes a multisystem disorder including arrhythmia and autism.
Cell 119: 19-31.

*Decher N, Barth AS, Gonzalez T, Steinmeyer K & Sanguinetti MC. (2004).
Novel KChIP2 isoforms increase functional diversity of transient outward potassium currents.
J. Physiol. 557:761-72. *corresponding author.

Best L, Yates AP, Decher N, Steinmeyer K & Nilius B. (2004).
Inhibition of glucose-induced electrical activity in rat pancreatic beta-cells by DCPIB, a selective inhibitor of volume-sensitive anion currents.
Eur. J. Pharmacol. 489: 13-19.

Decher N, Chen J & Sanguinetti MC. (2004).
Voltage-dependent gating of HCN pacemaker channels: Molecular coupling between the S4-S5 and C-linkers.
J. Biol. Chem. 279: 13859-13865.

*Decher N, Pirard B, Bundis F, Peukert S, Baringhaus KH, Busch AE, Steinmeyer K & Sanguinetti MC. (2004).
Molecular basis for block of Kv1.5 channels: Conservation of drug binding sites among voltage-gated K⁺ channels.
J. Biol. Chem. 279: 394-400. *corresponding author
2003

*Decher N, Bundis F, Vajna R & Steinmeyer K. (2003).
KCNE2 modulates current amplitudes and activation kinetics of HCN4: influence of KCNE family members on HCN4 currents.
Pflügers Arch. 446: 633-640. *corresponding author

*Scherer CR, *Lerche C, *Decher N, Dennis AT, Maier P, Ficker E, Pinto YM, Busch AE, Wollnik B & Steinmeyer K. (2002).
The antihistamine fexofenadine does not affect I_Kr currents in a case report of drug-induced cardiac arrhythmia.
Br. J. Pharmacol. 137: 892-900. *shared first authors.
2001

Decher N, Lang HJ, Nilius B, Brüggemann A, Busch AE & Steinmeyer K. (2001).
DCPIB is a novel selective blocker of ICl,swell and prevents swelling-induced shortening of guinea pig atrial action potential duration.
Br. J. Pharmacol. 134: 1467-1479.

Decher N, Uyguner O, Scherer CR, Karaman B, Yüksel-Apak M, Busch AE, Steinmeyer K & Wollnik B. (2001).
hKChIP2 is a functional modifier of hKv4.3 potassium channels: Cloning and expression of a short hKChIP2 splice variant.
Cardiovasc. Res. 52: 255-264.

Decher N, Maier M, Dittrich W, Gassenhuber J, Brüggemann A, Busch AE & Steinmeyer K. (2001).
Characterization of TASK-4, a novel member of the pH-sensitive, two-pore domain potassium channel family.
FEBS Letters. 492: 84-89