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Mechanismen epithelialer Homöostase - Dr. Rust

Grafik: Katja Rust

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Using the Drosophila follicle stem cell lineage, we do investigate mechanisms of epithelial homeostasis with single cell transcriptomics and high resolution live imaging approaches. Current projects in the lab include:

  • The use of single cell RNA-sequencing approaches to investigate signaling pathway functions in early epithelial development
  • The investigation of epithelial tumorigenesis and associated cancer cachexia
  • The analysis of non-occluding functions of septate junction proteins in epithelial development
Grafik: Katja Rust

Publications

Holtwick, V., Schubert, A., & Rust, K. (2024). Distinct non-occluding functions of septate junction components in signaling pathway regulation and cell polarity during epithelial development. In bioRxiv. https://doi.org/10.1101/2024.09.06.611635 

Hirschhäuser, A., Molitor, D., Salinas, G., Großhans, J., Rust, K., & Bogdan, S. (2023). Single-cell transcriptomics identifies new blood cell populations in Drosophila released at the onset of metamorphosis. Development . https://doi.org/10.1242/dev.201767

Lehne, F., Pokrant, T., Parbin, S., Salinas, G., Großhans, J., Rust, K., Faix, J., & Bogdan, S. (2022). Calcium bursts allow rapid reorganization of EFhD2/Swip-1 cross-linked actin networks in epithelial wound closure. Nature Communications, 13(1), 2492. https://doi.org/10.1038/s41467-022-30167-0.

Li, H., Janssens, J., De Waegeneer, M., Kolluru, S. S., Davie, K., Gardeux, V., Saelens, W., David, F. P. A., Brbić, M., Spanier, K., Leskovec, J., McLaughlin, C. N., Xie, Q., Jones, R. C., Brueckner, K., Shim, J., Tattikota, S. G., Schnorrer, F., Rust, K., … Zinzen, R. P. (2022). Fly Cell Atlas: A single-nucleus transcriptomic atlas of the adult fruit fly. Science, 375(6584), eabk2432. https://doi.org/10.1126/science.abk2432.

Rust, K., and Wodarz, A. Transcriptional Control of Apical-Basal Polarity Regulators. Int J Mol Sci. 2021 Nov 15;22(22):12340. https://doi.org/10.3390/ijms222212340

Rust, K., Byrnes, L. E., Yu, K. S., Park, J. S., Sneddon, J. B., Tward, A. D., & Nystul, T. G. (2020). A single-cell atlas and lineage analysis of the adult Drosophila ovary. Nature Communications, 11(1), 5628. https://doi.org/10.1038/s41467-020-19361-0.

Rust, K., & Nystul, T. (2020). Signal transduction in the early Drosophila follicle stem cell lineage. Current Opinion in Insect Science, 37, 39–48. https://doi.org/10.1016/j.cois.2019.11.005.

Rust, K., Tiwari, M.D., Mishra, V.K., Grawe, F., and Wodarz, A*. Myc and the Tip60 chromatin remodeling complex control neuroblast maintenance and polarity in Drosophila. EMBO J. 2018 Aug 15;37(16):e98659. https://doi.org/10.15252/embj.201798659.

 

Contact:
Dr. Katja Rust
Molecular Cellphysiology
Emil-Mannkopff-Str. 2
35037 Marburg
katja.rust@uni-marburg.de