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Publikationen Ulrich Steinhoff

Lauscher JC, Gröne J, Dullat S, Hotz B, Ritz JP, Steinhoff U, Buhr HJ and A. Visekruna (2009). Association between activation of atypical NF-kappaB1 p105 signaling pathway and nuclear beta-catenin accumulation in colorectal carcinoma. Mol. Carcinog. 49: 1219

Visekruna A, Huber M, Hellhund A, Bothur E, Reinhard K, Bollig N, Schmidt N, Joeris T, Lohoff M and U. Steinhoff (2010) c-Rel is crucial for the induction of Foxp3 (+) regulatory CD4(+) T cells but not T(H)17 cells. Eur. J. Immunol. 40: 671- 6

Schmidt, N., Gonzales, E., Visekruna A., Kühl, A., Loddenkemper C., Mollenkopf H., Kaufmann, SHE Steinhoff, U., and T. Joeris (2010). Targeting the proteasome: Partial inhibition of the proteasome by bortezomib or deletion of the immunosubunit LMP7 attenuates experimental colitis. Gut 59: 896-906

Heimesaat MM, Nogai A, Bereswill S, Plickert R, Fischer A, Loddenkemper C, Steinhoff U, Tchaptchet S, Thiel E, Freudenberg MA, Göbel UB, Uharek L. (2010). MyD88/TLR9 mediated immunopathology and gut microbiota dynamics in a novel murine model of intestinal graft-versus-host disease. Gut 59:1079-87

Neves P, Lampropoulou V, Calderon-Gomez E, Roch T, Stervbo U, Shen P, Kühl A, Loddenkemper C, Haury M, Nedospasov S, Kaufmann SHE, Steinhoff U, Calado D and Fillatreau S (2010). MyD88-signalling in B cells suppresses protective immunity during Salmonella typhimurium infection. Immunity, 33:777-90

Reinhard K, Huber M, Weber C, Hellhund A, Toboldt A, Abass E, Casper B, Joeris T, Herr C, Bals R, Steinhoff U, Lohoff M and Visekruna A. (2011) c-Rel promotes type 1 and type 17 immune responses during Leishmania major infection. Eur. J. Immunol, 41:1388-98.

Lawrenz M, Visekruna A, Kühl A, Schmidt N, Kaufmann SHE and Steinhoff U (2012). Genetic and pharmacological targeting of TPL-2 kinase ameliorates experimental colitis: a potential target for the treatment of Crohn´s disease? Mucosal Immunol. 2: 129-139

Visekruna A, Volkov A and Steinhoff U. (2012). A Key Role for NF-kB transcription factor c-Rel in T Lymphocyte differentiation and effector functions 2012). Clin. Devel. Immunol., 2012:239368. Epub 2012 Mar 6.

Joeris T, Visekruna A, Schmidt N, Krienke P and U. Steinhoff (2012). LMP7 dependent regulation of the proteasome system in infection and inflammation. PLoS One 7(6):e39827

Struck D, Franck I, Enders S, Schmidt C, Stallmach A, Steinhoff U, Heimesaat M and O Liesenfeld (2012). Treatment with interleukin-18 binding protein prevents Toxoplasma gondii-induced small intestinal pathology. European Journal of Microbiology and Immunology 3: 249–257

Volkov A, Hagner S, Löser S, Alnahas S, Raifer H, Hellhund A, Garn H and U Steinhoff (2013). ?5i Subunit Deficiency of the Immunoproteasome Leads to Reduced Th2 Response in OVA Induced Acute Asthma. PLoSOne 4;8(4):e60565; doi: 10.1371/journal.pone.0060565

Abass E, Bollig N, Reinhard K, Camara B, Mansour D, Visekruna A, Lohoff M and U Steinhoff (2013). rKLO8, a novel Leishmania donovani - derived recombinant immunodominant protein for sensitive detection of visceral leishmaniasis in Sudan. PloS Negl Trop Dis. 18;7:e2322; doi: 10.1371/journal.pntd.0002322

Mittrücker HW, Seidel D, Bland P W, Zarzycka A, Kaufmann SHE, Visekruna A and U Steinhoff (2014). Reduced innate and enhanced adaptive immunity against Listeria monocytogenes infection in germfree mice. Eur. J. Immunol., 44:1710-5

Yun Y, Srinivas G, Kuenzel S, Linnenbrink M , Alnahas S, Bruce K, Steinhoff U, Baines J F and U. Schaible (2014). Environmentally determined differences in the murine lung microbiota and their relation to alveolar architecture. PLoS One. 3;9(12):e113466. doi: 10.1371/journal.pone.0113466

Visekruna A, Linnerz T, Martinic V, Vachharajani N, Hartmann S, Harb H, Joeris T, Pfefferle P, Hofer J M and U. Steinhoff (2015). Transcription factor c-Rel plays a crucial role in driving anti-CD40-mediated innate colitis. Mucosal Immunol, 8:307-15

Abass E, Martinkovic F, Semiao-Santos SJ, Sundar S, Walden P, Piarroux R, el Harith A, Lohoff M and U. Steinhoff (2015). Heterogeneity of Leishmania Donovani parasites complicates diagnosis of visceral Leishmaniasis: Comparison of different serological tests in three endemic regions. Plos One 3;10:e0116408. doi: 10.1371

Evita B, Raifer H, Haftmann C, Stittrich A-B, Brüstle A, Brenner D, Bollig N, Bieringer M, Kang CH, Reinhard K, Camara B, Huber M,Visekruna A, Steinhoff U, Repenning A, Bauer U-M, Sexl V, Radbruch A, Sparwasser T, Mashreghi M-F, Mak TW and M Lohoff (2015). Antigen receptor mediated depletion of FOXP3 in induced regulatory T lymphocytes via PTPN2 and FOXO1. Nature communication,13;6:8576

Di Marco Barros R, Roberts NA, Dart RJ, Vantourout P, Jandke A, Nussbaumer O, Deban L, Cipolat S, Hart R, Iannitto ML, Laing A, Spencer-Dene B, East P, Gibbons D, Irving PM, Pereira P, Steinhoff U, Hayday A. (2016). Epithelia Use Butyrophilin-like Molecules to Shape Organ-Specific ?? T Cell Compartments. Cell 22:203-218.

Krebs CF, Paust HJ, Krohn S, Koyro T, Brix SR, Riedel JH, Bartsch P, Wiech T, Meyer-Schwesinger C, Huang J, Fischer N, Busch P, Mittrücker HW, Steinhoff U, Stockinger B, Perez LG, Wenzel UO, Janneck M, Steinmetz OM, Gagliani N, Stahl RA, Huber S, Turner JE, Panzer U. (2016). Autoimmune Renal Disease is Exacerbated by S1P-Receptor-1-Dependent Intestinal TH17 Cell Migration to the Kidney. Immunity 45:1078-1092

Martínez Abad LP, Almeida CS, Mattos AM, Mendonça AC, Alves MJ, Pinheiro AC, Porrozzi R, Abass E, Steinhoff U, Teixeira HC (2017). Diagnostic Accuracy of rKLO8 versus rK26 ELISAs for Screening of Canine Visceral Leishmaniasis. Acta Trop. 166:133-138. doi: 10.1016

Vachharajani N, Joeris T, Harmann S, Luu M, Koniarczyk K, Pantazis G, Hofer MJ, Steinhoff U and Visekruna A (2017). Selective targeting of immunoproteasome subunit LMP7 prevents inflammation-driven carcinogenesis. Oncotarget, 31:50447-50459. doi: 10.18632

Kespohl M, Vachharajani N, Luu M, Harb H, Pautz S, Wolff S, Sillner N, Walker A, Schmitt-Kopplin P, Boettger T, Renz H, Offermanns S, Steinhoff U, Visekruna A. (2017). The microbial metabolite butyrate induces expression of Th1-assocoated factors in CD4+ T cells. Front. Immunol. 28;8:1036. doi: 10.3389/fimmu.2017.01036

Alnahas S, Hagner-Benesch S, Raifer H, Kilic A, Gasteiger G, Mutters, R, Hellhund A, Prinz I, Visekruna A, Garn H and Steinhoff U (2017). IL-17 and TNF-? are key mediators of Moraxella catarrhalis triggered exacerbation of allergic airway inflammation. Frontiers in Immunology, 14; doi: 10.3389/fimmu.2017.01562

Robak O, Heimesaat M, Kruglov A, Prepens S, Ninnemann J, Reppe K, Suter M, Kirschning CJ, Buer J, Hornef MW, Schnare M, Schneider P, Witzenrath M, Bereswill S, Steinhoff U, Suttorp N, Sander LE, Chaput C and Opitz B. (2018). Antibiotic treatment-induced secondary IgA deficiency enhances susceptibility to Pseudomonas aeruginosa pneumonia. J. Clin. Invest, 128(8):3535-3545.

Luu M, Pautz S, Kohl V, Singh R, Romero R, Lucas S, Hofmann J, Raifer H, Vachharajani N, Carrascosa LC, Lamp B, Nist A, Stiewe T, Shaul Y, Adhikary T, Zaiss MM, Lauth M, Steinhoff U, Visekruna A (2019). The short-chain fatty acid pentanoate suppresses autoimmunity by modulating the metabolic-epigenetic crosstalk in lymphocytes. Nat. Comm., 15 (1): doi: 10.1038/s41467-019-08711-2.

Visekruna A, Hartmann S, Sillke YR., Glauben R, Fischer F, Raifer H, Mollenkopf H, Bertrams W, Schmeck B, Klein M, Pagenstecher A, Lohoff M, Jacob R, Pabst O, Bland PW, Luu M, Romero R, Siegmund B, Rajalingam K, and U Steinhoff (2019). Intestinal development and homeostasis require activation and apoptosis of diet-reactive T cells. . Clin. Invest., 130:1972-1983.

Reviews (peer reviewed)

Garn H, Bahn S, Baune BT, Binder EB, Bisgaard H, Chatila TA, Chavakis T, Culmsee C, Dannlowski U, Gay S, Gern J, Haahtela T, Kircher T, Müller-Ladner U, Neurath MF, Preissner KT, Reinhardt C, Rook G, Russell S, Schmeck B, Stappenbeck T, Steinhoff U, van Os J, Weiss S, Zemlin M, Renz H (2016). Current concepts in chronic inflammatory diseases: Interactions between microbes, cellular metabolism, and inflammation. J Allergy Clin Immunol. 138: 47-56

Luu M, Steinhoff U, Visekruna A (2017). Functional heterogeneity of gut-resident regulatory T cells. Clin Transl Immunology. 9:e156. doi: 10.1038