Clostridium sporogenes-derived metabolites protect mice against colonic inflammation. Krause FF, Mangold KI, Ruppert AL, Leister H, Hellhund-Zingel A, Lopez Krol A, Pesek J, Watzer B, Winterberg S, Raifer H, Binder K, Kinscherf R, Walker A, Nockher WA, Taudte RV, Bertrams W, Schmeck B, Kühl AA, Siegmund B, Romero R, Luu M, Göttig S, Bekeredjian-Ding I, Steinhoff U, Schütz B, Visekruna A. Gut Microbes 2024; 16(1). https://doi.org/10.1080/19490976.2024.2412669 A Novel Approach for Glioblastoma Treatment by Combining Apoptosis Inducers (TMZ, MTX, and Cytarabine) with E.V.A. (Eltanexor, Venetoclax, and A1210477) Inhibiting XPO1, Bcl-2, and Mcl-1. Zhao K, Braun M, Meyer L, Otte K, Raifer H, Helmprobst F, Möschl V, Pagenstecher A, Urban H, Ronellenfitsch MW, Steinbach JP, Pesek J,Watzer B, Nockher WA, Taudte RV, Neubauer A, Nimsky C, Bartsch JW, Rusch T. Cells 2024; 13(7), 632. https://doi.org/10.3390/cells13070632
Prostacyclin Released by Cancer-Associated Fibroblasts Promotes Immunosuppressive and Pro-Metastatic Macrophage Polarization in the Ovarian Cancer Microenvironment. Sommerfeld L, Knuth I, Finkernagel F, Pesek J, Nockher WA, Jansen JM, Wagner U, Nist A, Stiewe T, Müller-Brüsselbach S, Müller R, Reinartz S. Cancers 2022, 14(24), 6154. https://doi.org/10.3390/cancers14246154
Arachidonic acid, a clinically adverse mediator in the ovarian cancer microenvironment, impairs JAK-STAT signaling in macrophages by perturbing lipid raft structures. Hammoud MK, Dietze R, Pesek J, Finkernagel F, Unger A, Bieringer T, Nist A, Stiewe T, Bhagwat AM, Nockher WA, Reinartz S, Müller-Brüsselbach S, Graumann J and Müller R. Mol Oncol. 2022 Sep; 16 (17): 3146-3166. https://doi.org/10.1002/1878-0261.13221
An anti-inflammatory eicosanoid switch mediates the suppression of type-2 inflammation by helminth larval products. de Los Reyes Jiménez M, Lechner A, Alessandrini F, Bohnacker S, Schindela S, Trompette A, Haimerl P, Thomas D, Henkel F, Mourão A, Geerlof A, da Costa CP, Chaker AM, Brüne B, Nüsing R, Jakobsson PJ, Nockher WA, Feige MJ, Haslbeck M, Ohnmacht C, Marsland BJ, Voehringer D, Harris NL, Schmidt-Weber CB, Esser-von Bieren J. Sci Transl Med. 2020 Apr 22;12(540).
α-Linolenic Acid-Rich Diet Influences Microbiota Composition and Villus Morphology of the Mouse Small Intestine. Todorov H, Kollar B, Bayer F, Brandão I, Mann A, Mohr J, Pontarollo G, Formes H, Stauber R, Kittner JM, Endres K, Watzer B, Nockher WA, Sommer F, Gerber S, Reinhardt C. Nutrients. 2020 Mar 11;12(3). pii: E732. doi: 10.3390/nu12030732.
Overexpression of cyclooxygenase-2 in adipocytes reduces fat accumulation in inguinal white adipose tissue and hepatic steatosis in high-fat fed mice. Banhos Danneskiold-Samsøe N, Sonne SB, Larsen JM, Hansen AN, Fjære E, Isidor MS, Petersen S, Henningsen J, Severi I, Sartini L, Schober Y, Wolf J, Nockher WA, Wolfrum C, Cinti S, Sina C, Hansen JB, Madsen L, Brix S, Kristiansen K. Sci Rep. 2019 Jun 20;9(1):8979. doi: 10.1038/s41598-019-45062-w.
Cell type-selective pathways and clinical associations of lysophosphatidic acid biosynthesis and signaling in the ovarian cancer microenvironment. Reinartz S, Lieber S, Pesek J, Brandt DT, Asafova A, Finkernagel F, Watzer B, Nockher WA, Nist A, Stiewe T, Jansen JM, Wagner U, Konzer A, Graumann J, Grosse R, Worzfeld T, Müller-Brüsselbach S, Müller R. Mol Oncol. 2019 Feb;13(2):185-201. doi: 10.1002/1878-0261.12396. Epub 2018 Nov 15.
Determination of red blood cell fatty acid profiles: Rapid and high-confident analysis by chemical ionization-gas chromatography-tandem mass spectrometry. Schober Y, Wahl HG, Renz H, Nockher WA. J Chromatogr B Analyt Technol Biomed Life Sci. 2017 Jan 1;1040:1-7. doi: 10.1016/j.jchromb.2016.11.019. Epub 2016 Nov 13.
A transcriptome-based global map of signaling pathways in the ovarian cancer microenvironment associated with clinical outcome. Reinartz S, Finkernagel F, Adhikary T, Rohnalter V, Schumann T, Schober Y, Nockher WA, Nist A, Stiewe T, Jansen JM, Wagner U, Müller-Brüsselbach S, Müller R. Genome Biol. 2016 May 23;17(1):108. doi: 10.1186/s13059-016-0956-6.
Plasma Uromodulin Correlates With Kidney Function and Identifies Early Stages in Chronic Kidney Disease Patients. Steubl D, Block M, Herbst V, Nockher WA, Schlumberger W, Satanovskij R, Angermann S, Hasenau AL, Stecher L, Heemann U, Renders L, Scherberich J. Medicine (Baltimore). 2016 Mar;95(10):e3011. doi: 10.1097/MD.0000000000003011.
Design and Synthesis of Highly Active Peroxisome Proliferator-Activated Receptor (PPAR) β/δ Inverse Agonists with Prolonged Cellular Activity. Toth PM, Lieber S, Scheer FM, Schumann T, Schober Y, Nockher WA, Adhikary T, Müller-Brüsselbach S, Müller R, Diederich WE. ChemMedChem. 2016 Mar 4;11(5):488-96. doi: 10.1002/cmdc.201500594. Epub 2016 Feb 11.
ω-3 fatty acids contribute to the asthma-protective effect of unprocessed cow's milk. Brick T, Schober Y, Böcking C, Pekkanen J, Genuneit J, Loss G, Dalphin JC, Riedler J, Lauener R, Nockher WA, Renz H, Vaarala O, Braun-Fahrländer C, von Mutius E, Ege MJ, Pfefferle PI; PASTURE study group. J Allergy Clin Immunol. 2016 Jun;137(6):1699-1706.e13. doi: 10.1016/j.jaci.2015.10.042. Epub 2016 Jan 12.
Deregulation of PPARβ/δ target genes in tumor-associated macrophages by fatty acid ligands in the ovarian cancer microenvironment. Schumann T, Adhikary T, Wortmann A, Finkernagel F, Lieber S, Schnitzer E, Legrand N, Schober Y, Nockher WA, Toth PM, Diederich WE, Nist A, Stiewe T, Wagner U, Reinartz S, Müller-Brüsselbach S, Müller R. Oncotarget. 2015 May 30;6(15):13416-33.
[Metastasized renal cell carcinoma. Measurement of plasma levels of the tyrosine kinase inhibitors sunitinib, sorafenib and pazopanib]. Keil C, Götze L, Olbert P, Hofmann R, Nockher WA, Hegele A. Urologe A. 2015 Jun;54(6):811-8. doi: 10.1007/s00120-014-3711-1.
Nilotinib is more potent than imatinib for treating plexiform neurofibroma in vitro and in vivo. Wei J, Freytag M, Schober Y, Nockher WA, Mautner VF, Friedrich RE, Manley PW, Kluwe L, Kurtz A. PLoS One. 2014 Oct 23;9(10):e107760. doi: 10.1371/journal.pone.0107760. eCollection 2014.
Development and clinical application of a LC-MS/MS method for simultaneous determination of various tyrosine kinase inhibitors in human plasma. Götze L, Hegele A, Metzelder SK, Renz H, Nockher WA. Clin Chim Acta. 2012 Jan 18;413(1-2):143-9. doi: 10.1016/j.cca.2011.09.012. Epub 2011 Sep 16.
Clostridium sporogenes-derived metabolites protect mice against colonic inflammation. Krause FF, Mangold KI, Ruppert AL, Leister H, Hellhund-Zingel A, Lopez Krol A, Pesek J, Watzer B, Winterberg S, Raifer H, Binder K, Kinscherf R, Walker A, Nockher WA, Taudte RV, Bertrams W, Schmeck B, Kühl AA, Siegmund B, Romero R, Luu M, Göttig S, Bekeredjian-Ding I, Steinhoff U, Schütz B, Visekruna A. Gut Microbes 2024; 16(1). https://doi.org/10.1080/19490976.2024.2412669
A Novel Approach for Glioblastoma Treatment by Combining Apoptosis Inducers (TMZ, MTX, and Cytarabine) with E.V.A. (Eltanexor, Venetoclax, and A1210477) Inhibiting XPO1, Bcl-2, and Mcl-1. Zhao K, Braun M, Meyer L, Otte K, Raifer H, Helmprobst F, Möschl V, Pagenstecher A, Urban H, Ronellenfitsch MW, Steinbach JP, Pesek J, Watzer B, Nockher WA, Taudte RV, Neubauer A, Nimsky C, Bartsch JW, Rusch T. Cells. 2024; 13(7), 632. https://doi.org/10.3390/cells13070632
Immunometabolic Profiling of Chronic Subdural Hematoma through Untargeted Mass Spectrometry Analysis: Preliminary Findings of a Novel Approach. Kipele M, Buchfelder M, Taudte RV, Stadlbauer A, Kinfe T, Bozhkov Y. Diagnostics. 2023; 13(21):3345. https://doi.org/10.3390/diagnostics13213345
L-arginine metabolism inhibits arthritis and inflammatory bone loss. Cao S, Li Y, Song R, Meng X, Fuchs M, Liang C, Kachler K, Meng X, Wen J, Schlötzer-Schrehardt U, Taudte V, Gessner A, Kunz M, Schleicher U, Zaiss MM, Kastbom A, Chen X, Schett G, Bozec A. Ann Rheum Dis. 2023 Sep 29:ard-2022-223626. doi: 10.1136/ard-2022-223626.
A supervised machine-learning approach for the efficient development of a multi method (LC-MS) for a large number of drugs and subsets thereof: focus on oral antitumor agents. Kehl N, Gessner A, Maas R, Fromm MF and Taudte, RV. Clinical Chemistry and Laboratory Medicine (CCLM), 2023. https://doi.org/10.1515/cclm-2023-0468
High-fat-diet-associated intestinal microbiota exacerbates psoriasis-like inflammation by enhancing systemic γδ T cell IL-17 production. Sonomoto K, Song R, Eriksson D, Hahn AM, Meng X, Lyu P, Cao S, Liu N, Taudte RV, Wirtz S, Tanaka Y, Winkler TH, Schett G, Soulat D, Bozec A. Cell Rep. 2023 Jul 6;42(7):112713. doi: 10.1016/j.celrep.2023.112713.
Cold Atmospheric Plasma Triggers Apoptosis via the Unfolded Protein Response in Melanoma Cells. Zimmermann T, Staebler S, Taudte RV, Ünüvar S, Grösch S, Arndt S, Karrer S, Fromm MF, Bosserhoff A-K. Cancers. 2023; 15(4):1064. https://doi.org/10.3390/cancers15041064
Cancer-type organic anion transporting polypeptide 1B3 (Ct-OATP1B3) is localized in lysosomes and mediates resistance against kinase inhibitors. Haberkorn B, Oswald S, Kehl N, Gessner A, Taudte RV, Dobert JP, Zunke F, Fromm MF, König J. Mol Pharmacol. 2022 Sep 27:MOLPHARM-AR-2022-000539.doi: 10.1124/molpharm.122.000539. Online ahead of print. PMID: 36167426
Mitochondrial respiration in B lymphocytes is essential for humoral immunity by controlling the flux of the TCA cycle. Urbanczyk S, Baris OR, Hofmann J, Taudte RV, Guegen N, Golombek F, Castiglione K, Meng X, Bozec A, Thomas J, Weckwerth L, Mougiakakos D, Schulz SR, Schuh W, Schlötzer-Schrehardt U, Steinmetz TD, Brodesser S, Wiesner RJ, Mielenz D. Cell Rep. 2022 Jun 7;39(10):110912. doi: 10.1016/j.celrep.2022.110912.
Exposure of Fexofenadine, but Not Pseudoephedrine, Is Markedly Decreased by Green Tea Extract in Healthy Volunteers. Misaka S, Ono Y, Taudte RV, Hoier E, Ogata H, Ono T, König J, Watanabe H, Fromm MF, Shimomura K. Clin Pharmacol Ther. 2022 Sep;112(3):627-634. doi: 10.1002/cpt.2682. Epub 2022 Jun 29. PMID: 35678032
An Easily Expandable Multi-Drug LC-MS Assay for the Simultaneous Quantification of 57 Oral Antitumor Drugs in Human Plasma. Kehl N, Schlichtig K, Dürr P, Bellut L, Dörje F, Fietkau R, Pavel M, Mackensen A, Wullich B, Maas R, Fromm MF, Gessner A, Taudte RV. Cancers (Basel). 2021 Dec 16;13(24):6329. doi: 10.3390/cancers13246329. PMID: 34944950
Headspace analysis of E-cigarette fluids using comprehensive two dimensional GC× GC-TOF-MS reveals the presence of volatile and toxic compounds. Patel D, Taudte RV, Nizio K, Herok G, Cranfield C, Shimmon R. J Pharm Biomed Anal. 2021 Mar 20;196:113930. doi: 10.1016/j.jpba.2021.113930. Epub 2021 Jan 27.
High-throughput screening for target compounds in smokeless powders using online-SPE tandem mass spectrometry. Taudte RV, Roux C, Bishop DP, Fouracre C, Beavis A. Australian Journal of Forensic Sciences 53 (1), 16-26. DOI: 10.1080/00450618.2019.1629019
Vectorial transport of the arginine derivatives asymmetric dimethylarginine (ADMA) and L-homoarginine by OATP4C1 and P-glycoprotein studied in double-transfected MDCK cells. Taghikhani E, Maas R, Taudte RV, Gessner A, Fromm MF, König J. Amino Acids. 2020 Jul;52(6-7):975-985. doi: 10.1007/s00726-020-02867-8. Epub 2020 Jul 8. PMID: 32642843 Free PMC article.
Regiospecific Introduction of Halogens on the 2-Aminobiphenyl Subunit Leading to Highly Potent and Selective M3 Muscarinic Acetylcholine Receptor Antagonists and Weak Inverse Agonists. Fischer O, Hofmann J, Rampp H, Kaindl J, Pratsch G, Bartuschat A, Taudte RV, Fromm MF, Hübner H, Gmeiner P, Heinrich MR. J Med Chem. 2020 Apr 23;63(8):4349-4369. doi: 10.1021/acs.jmedchem.0c00297. Epub 2020 Apr 9. PMID: 32202101
Matching sensitivity to abundance: high resolution immuno-mass spectrometry imaging of lanthanide labels and endogenous elements in the murine brain. Clases D, de Vega RG, Funke S, Lockwood T, Westerhausen MT, Taudte RV, Adlard PA, Doble PA. Journal of Analytical Atomic Spectrometry 35 (4), 728-735. DOI: 10.1039/C9JA00405J
Stability of smokeless powder compounds on collection devices. Taudte RV, Roux C, Beavis A. Forensic Sci Int. 2017 Jan;270:55-60. doi: 10.1016/j.forsciint.2016.11.027. Epub 2016 Nov 24. PMID: 27914281
The development and comparison of collection techniques for inorganic and organic gunshot residues. Taudte RV, Roux C, Blanes L, Horder M, Kirkbride KP, Beavis A. Anal Bioanal Chem. 2016 Apr;408(10):2567-76. doi: 10.1007/s00216-016-9357-7. Epub 2016 Feb 12. PMID: 26873197
Capillary-driven microfluidic paper-based analytical devices for lab on a chip screening of explosive residues in soil. Ueland M, Blanes L, Taudte RV, Stuart BH, Cole N, Willis P, Roux C, Doble P. J Chromatogr A. 2016 Mar 4;1436:28-33. doi: 10.1016/j.chroma.2016.01.054. Epub 2016 Jan 24. PMID: 26850317
Determination of selenium in serum in the presence of gadolinium with ICP-QQQ-MS. Bishop DP, Hare DJ, Fryer F, Taudte RV, Cardoso BR, Cole N, Doble PA. Analyst. 2015 Apr 21;140(8):2842-6. doi: 10.1039/c4an02283a. Epub 2015 Mar 2. PMID: 25730383
Development of a UHPLC method for the detection of organic gunshot residues using artificial neural networks. Taudte RV, Roux C, Bishop D, Blanes L, Doble P, Beavis A. Analytical Methods 7 (18), 7447-7454. DOI: 10.1039/C5AY00306G
Detection of gunshot residues using mass spectrometry. Taudte RV, Beavis A, Blanes L, Cole N, Doble P, Roux C. Biomed Res Int. 2014;2014:965403. doi: 10.1155/2014/965403. Epub 2014 May 22. PMID: 24977168
Coupling paper-based microfluidics and lab on a chip technologies for confirmatory analysis of trinitro aromatic explosives. Pesenti A, Taudte RV, McCord B, Doble P, Roux C, Blanes L. Anal Chem. 2014 May 20;86(10):4707-14. doi: 10.1021/ac403062y. Epub 2014 May 5. PMID: 24766256
A portable explosive detector based on fluorescence quenching of pyrene deposited on coloured wax-printed μPADs. Taudte RV, Beavis A, Wilson-Wilde L, Roux C, Doble P, Blanes L. Lab Chip. 2013 Nov 7;13(21):4164-72. doi: 10.1039/c3lc50609f. PMID: 23959203
Clostridium sporogenes-derived metabolites protect mice against colonic inflammation. Krause FF, Mangold KI, Ruppert AL, Leister H, Hellhund-Zingel A, Lopez Krol A, Pesek J, Watzer B, Winterberg S, Raifer H, Binder K, Kinscherf R, Walker A, Nockher WA, Taudte RV, Bertrams W, Schmeck B, Kühl AA, Siegmund B, Romero R, Luu M, Göttig S, Bekeredjian-Ding I, Steinhoff U, Schütz B, Visekruna A. Gut Microbes 2024; 16(1). https://doi.org/10.1080/19490976.2024.2412669
A Novel Approach for Glioblastoma Treatment by Combining Apoptosis Inducers (TMZ, MTX, and Cytarabine) with E.V.A. (Eltanexor, Venetoclax, and A1210477) Inhibiting XPO1, Bcl-2, and Mcl-1. Zhao K, Braun M, Meyer L, Otte K, Raifer H, Helmprobst F, Möschl V, Pagenstecher A, Urban H, Ronellenfitsch MW, Steinbach JP, Pesek J, Watzer B, Nockher WA, Taudte RV, Neubauer A, Nimsky C, Bartsch JW, Rusch T. Cells. 2024; 13(7), 632. https://doi.org/10.3390/cells13070632
Prostacyclin Released by Cancer-Associated Fibroblasts Promotes Immunosuppressive and Pro-Metastatic Macrophage Polarization in the Ovarian Cancer Microenvironment. Sommerfeld L, Knuth I, Finkernagel F, Pesek J, Nockher WA, Jansen JM, Wagner U, Nist A, Stiewe T, Müller-Brüsselbach S, Müller R, Reinartz S Cancers 2022, 14(24), 6154. https://doi.org/10.3390/cancers14246154
Arachidonic acid, a clinically adverse mediator in the ovarian cancer microenvironment, impairs JAK-STAT signaling in macrophages by perturbing lipid raft structures. Hammoud MK, Dietze R, Pesek J, Finkernagel F, Unger A, Bieringer T, Nist A, Stiewe T, Bhagwat AM, Nockher WA, Reinartz S, Müller-Brüsselbach S, Graumann J and Müller R Mol Oncol. 2022 Sep; 16 (17): 3146-3166. https://doi.org/10.1002/1878-0261.13221
Cell type-selective pathways and clinical associations of lysophosphatidic acid biosynthesis and signaling in the ovarian cancer microenvironment. Reinartz S*, Lieber S*, Pesek J*, Brandt DT*, Asafova A, Finkernagel F, Watzer B, Nockher WA, Nist A, Stiewe T, Jansen JM, Wagner U, Konzer A, Graumann J, Grosse R, Worzfeld T, Müller-Brüsselbach S, Müller R. Mol Oncol. 2019 Feb;13(2):185-201. doi: 10.1002/1878-0261.12396. Epub 2018 Nov 15. (*equally contributed)
Proteomic biomarkers for psoriasis and psoriasis arthritis. Reindl J, Pesek J, Krüger T, Wendler S, Nemitz S, Muckova P, Büchler R, Opitz S, Krieg N, Norgauer J, Rhode H. J Proteomics. 2016 May 17;140:55-61. doi: 10.1016/j.jprot.2016.03.040. Epub 2016 Apr 6.
Biosynthesis of 8-hydroxyquinoline-2-carboxylic acid, an iron chelator from the gut of the lepidopteran Spodoptera littoralis. Pesek J, Svoboda J, Sattler M, Bartram S, Boland W. Org Biomol Chem. 2015 Jan 7;13(1):178-84. doi: 10.1039/c4ob01857e.
Colorful quality control of chromatographic sample preparation. Pesek J, Krüger T, Tautkus B, Rhode H. J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Sep 1;934:66-70. doi: 10.1016/j.jchromb.2013.07.001. Epub 2013 Jul 6.
Native chromatographic sample preparation of serum, plasma and cerebrospinal fluid does not comprise a risk for proteolytic biomarker loss. Pesek J, Krüger T, Krieg N, Schiel M, Norgauer J, Großkreutz J, Rhode H. J Chromatogr B Analyt Technol Biomed Life Sci. 2013 Apr 1;923-924:102-9.
Structure and mechanism of iron translocation by a Dps protein from Microbacterium arborescens. Pesek J, Büchler R, Albrecht R, Boland W, Zeth K. J Biol Chem. 2011 Oct 7;286(40):34872-82. doi: 10.1074/jbc.M111.246108. Epub 2011 Jul 16.
Oxepin Formation in Fungi Implies Specific and Stereoselective Ring Expansion. Zheng L, Wang H, Ludwig-Radtke L, Li SM. Org Lett. 2021 Mar 19;23(6):2024-2028. doi: 10.1021/acs.orglett.1c00166. Epub 2021 Mar 3. PMID: 33656898.
Isocoumarin formation by heterologous gene expression and modification by host enzymes. Xiang P, Ludwig-Radtke L, Yin WB, Li SM. Org Biomol Chem. 2020 Jul 8;18(26):4946-4948. doi: 10.1039/d0ob00989j. PMID: 32588866.
Formation of Terrestric Acid in Penicillium crustosum Requires Redox-Assisted Decarboxylation and Stereoisomerization. Fan J, Liao G, Ludwig-Radtke L, Yin WB, Li SM. Org Lett. 2020 Jan 3;22(1):88-92. doi: 10.1021/acs.orglett.9b04002. Epub 2019 Dec 13. PMID: 31833773.
Peniphenone and Penilactone Formation in Penicillium crustosum via 1,4-Michael Additions of ortho-Quinone Methide from Hydroxyclavatol to γ-Butyrolactones from Crustosic Acid. Fan J, Liao G, Kindinger F, Ludwig-Radtke L, Yin WB, Li SM. J Am Chem Soc. 2019 Mar 13;141(10):4225-4229. doi: 10.1021/jacs.9b00110. Epub 2019 Mar 4. PMID: 30811183.
Manipulation of the Precursor Supply in Yeast Significantly Enhances the Accumulation of Prenylated β-Carbolines. Backhaus K, Ludwig-Radtke L, Xie X, Li SM. ACS Synth Biol. 2017 Jun 16;6(6):1056-1064. doi: 10.1021/acssynbio.6b00387. Epub 2017 Mar 2. PMID: 28221769.
Actions of Tryptophan Prenyltransferases Toward Fumiquinazolines and their Potential Application for the Generation of Prenylated Derivatives by Combining Chemical and Chemoenzymatic Syntheses. Mai, P., Zocher, G., Ludwig, L., Stehle, T. and Li, S.-M. Adv. Synth. Catal. 2016, 358: 1639-1653. https://doi.org/10.1002/adsc.201600064
Friedel-crafts alkylation of acylphloroglucinols catalyzed by a fungal indole prenyltransferase. Zhou K, Ludwig L, Li SM. J Nat Prod. 2015 Apr 24;78(4):929-33. doi: 10.1021/np5009784. Epub 2015 Mar 10. PMID: 25756361.
AstPT catalyses both reverse N1- and regular C2 prenylation of a methylated bisindolyl benzoquinone. Tarcz S, Ludwig L, Li SM. Chembiochem. 2014 Jan 3;15(1):108-16. doi: 10.1002/cbic.201300610. Epub 2013 Dec 2. PMID: 24302698.
New insights into the biosynthesis of prenylated xanthones: Xptb from Aspergillus nidulans catalyses an O-prenylation of xanthones. Pockrandt D, Ludwig L, Fan A, König GM, Li SM. Chembiochem. 2012 Dec 21;13(18):2764-71. doi: 10.1002/cbic.201200545. Epub 2012 Nov 13. PMID: 23150454.
Breaking the regioselectivity of indole prenyltransferases: identification of regular C3-prenylated hexahydropyrrolo[2,3-b]indoles as side products of the regular C2-prenyltransferase FtmPT1. Wollinsky B, Ludwig L, Xie X, Li SM. Org Biomol Chem. 2012 Dec 14;10(46):9262-70. doi: 10.1039/c2ob26149a. Epub 2012 Oct 23. PMID: 23090579.
Prenylation at the indole ring leads to a significant increase of cytotoxicity of tryptophan-containing cyclic dipeptides. Wollinsky B, Ludwig L, Hamacher A, Yu X, Kassack MU, Li SM. Bioorg Med Chem Lett. 2012 Jun 15;22(12):3866-9. doi: 10.1016/j.bmcl.2012.04.119. Epub 2012 May 4. PMID: 22617493.