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AG Treccani

The overall goal of the group is to understand in a mechanistic way:

•   how stress (especially early in life) has long-term effects on brain function and ultimately on behavior  
•   how these effects are encoded at the molecular, cellular and structural level
•   how pharmacological and behavioral interventions can ameliorate or reverse stress-related phenotypes and foster resilience
•   how we can identify individual trait/response to stress and intervention

To address these questions, we combine various approaches, including translational animal models, animal models for stress-related psychiatric disorders, transgenic mouse strains, behavioral tests, molecular and biochemical techniques, morphological analysis, and neuropharmacology in a highly interdisciplinary and translational approach.

Our long-term goal is to contribute to a more precise understanding of how stress affects and modulates brain function in order to ultimately develop more targeted strategies for the prevention and treatment of stress-related mental disorders.