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Total synthesis of Natural products

The bioactivity and the complex structure of natural products makes them an interesting target for organic chemists. Thus one of our research topics is the total synthesis of natural products associated with the development of new synthetic methods. We design and carry out multistep organic syntheses, in which chemo-, regio- and stereo-selectivity are key aspects. A representative selection of the latest natural products we were able to accomplish is shown below.

Michel Blitz, Robert C. Heinze, Klaus Harms, Ulrich Koert "Total Synthesis of (+)-Nivetetracyclate A", Org. Lett., 2019, ASAP.

Theodor Peez, Jan-Niclas Luy, Klaus Harms, Ralf Tonner, Ulrich Koert "From Acenaphthenes to (+)‐Delavatine A: Visible‐Light‐Induced Ring Closure of Methyl (α‐Naphthyl) Acrylates", Chem. Eur. J., 2018, 24, 17686-17690.

Fischer, Michel; Harms, Klaus; Koert, Ulrich "Total Syntheses of 7,20-Oxa-Bridged Dinorditerpenes: Antihepatitis C Virus Active (+)-Elevenol from Flueggea virosa and (+)-Przewalskin", Org.Lett. 2016, 18, 5692-5695.

Mike Dischmann, Timo Frassetto, M. André Breuning and Ulrich Koert "Total Synthesis of Isoquinocyclinone" Chem. Eur. J. 2014, 20, 11300-11302.

Tobias Burckhardt, Klaus Harms and Ulrich Koert "Total Synthesis of Lodopyridone", Org. Lett. 2012, 14, 4674-4677.