Main Content

Publications

19 | Heydenreich, F. M.; Marti-Solano, M.; Sandhu, M.; Kobilka, B. K.; Bouvier, M.; Babu, M. M.
Molecular Determinants of Ligand Efficacy and Potency in GPCR Signaling.
Science 2023, 382 (6677), eadh1859. https://doi.org/10.1126/science.adh1859.

18 | Janetzko, J.; Kise, R.; Barsi-Rhyne, B.; Siepe, D. H.; Heydenreich, F. M.; Kawakami, K.; Masureel, M.; Maeda, S.; Garcia, K. C.; Zastrow, M. von; Inoue, A.; Kobilka, B. K.
Membrane Phosphoinositides Regulate GPCR-β-Arrestin Complex Assembly and Dynamics.
Cell 2022, 185 (24), 4560-4573.e19. https://doi.org/10.1016/j.cell.2022.10.018.

17 | Paradis, J. S.; Feng, X.; Murat, B.; Jefferson, R. E.; Sokrat, B.; Szpakowska, M.; Hogue, M.; Bergkamp, N. D.; Heydenreich, F. M.; Smit, M. J.; Chevigné, A.; Bouvier, M.; Barth, P.
Computationally Designed GPCR Quaternary Structures Bias Signaling Pathway Activation.
Nat. Commun. 2022, 13 (1), 6826. https://doi.org/10.1038/s41467-022-34382-7.

16 | Heydenreich, F. M.; Plouffe, B.; Rizk, A.; Milic, D.; Zhou, J.; Breton, B.; Gouill, C. L.; Inoue, A.; Bouvier, M.; Veprintsev, D.
Michaelis-Menten Quantification of Ligand Signalling Bias Applied to the Promiscuous Vasopressin V2 Receptor.
Mol. Pharmacol. 2022. https://doi.org/10.1124/molpharm.122.000497.

15 | Hedderich, J. B.; Persechino, M.; Becker, K.; Heydenreich, F. M.; Gutermuth, T.; Bouvier, M.; Bünemann, M.; Kolb, P.
The Pocketome of G-Protein-Coupled Receptors Reveals Previously Untargeted Allosteric Sites.
Nat. Commun. 2022, 13 (1), 2567. https://doi.org/10.1038/s41467-022-29609-6.

14 | Hauser, A. S.; Kooistra, A. J.; Munk, C.; Heydenreich, F. M.; Veprintsev, D. B.; Bouvier, M.; Babu, M. M.; Gloriam, D. E.
GPCR Activation Mechanisms across Classes and Macro/Microscales.
Nat. Struct. Mol. Biol. 2021, 28 (11), 879–888. https://doi.org/10.1038/s41594-021-00674-7.

13 | Harwood, C. R.; Sykes, D. A.; Hoare, B. L.; Heydenreich, F. M.; Uddin, R.; Poyner, D. R.; Briddon, S. J.; Veprintsev, D. B.
Functional Solubilization of the Β2-Adrenoceptor Using Diisobutylene Maleic Acid.
iScience 2021, 24 (12). https://doi.org/10.1016/j.isci.2021.103362.

12 | Latorraca, N. R.; Masureel, M.; Hollingsworth, S. A.; Heydenreich, F. M.; Suomivuori, C.-M.; Brinton, C.; Townshend, R. J. L.; Bouvier, M.; Kobilka, B. K.; Dror, R. O.
How GPCR Phosphorylation Patterns Orchestrate Arrestin-Mediated Signaling.
Cell 2020, 183 (7), 1813-1825.e18. https://doi.org/10.1016/j.cell.2020.11.014.

11 | Heydenreich, F. M.; Miljus, T.; Milic, D.; Veprintsev, D. B.
High-Throughput Site-Directed Scanning Mutagenesis Using a Two-Fragment PCR Approach.
Bio-protocol 2020, 10 (01), e3484. https://doi.org/10.21769/BioProtoc.3484

10 | Heydenreich, F. M.; Miljuš, T.; Jaussi, R.; Benoit, R.; Milić, D.; Veprintsev, D. B.
High-Throughput Mutagenesis Using a Two-Fragment PCR Approach.
Sci. Rep. 2017, 7 (1), 6787. https://doi.org/10.1038/s41598-017-07010-4.

9 | Gosztolai, A.; Schumacher, J.; Behrends, V.; Bundy, J. G.; Heydenreich, F.; Bennett, M. H.; Buck, M.; Barahona, M.
GlnK Facilitates the Dynamic Regulation of Bacterial Nitrogen Assimilation.
Biophys. J. 2017, 112 (10), 2219–2230. https://doi.org/10.1016/j.bpj.2017.04.012.

8 | Beautrait, A.; Paradis, J. S.; Zimmerman, B.; Giubilaro, J.; Nikolajev, L.; Armando, S.; Kobayashi, H.; Yamani, L.; Namkung, Y.; Heydenreich, F. M.; Khoury, E.; Audet, M.; Roux, P. P.; Veprintsev, D. B.; Laporte, S. A.; Bouvier, M.
A New Inhibitor of the β-Arrestin/AP2 Endocytic Complex Reveals Interplay between GPCR Internalization and Signalling.
Nat. Commun. 2017, 8 (1), 15054. https://doi.org/10.1038/ncomms15054.

7 | Venkatakrishnan, A. J.; Deupi, X.; Lebon, G.; Heydenreich, F. M.; Flock, T.; Miljus, T.; Balaji, S.; Bouvier, M.; Veprintsev, D. B.; Tate, C. G.; Schertler, G. F. X.; Babu, M. M.
Diverse Activation Pathways in Class A GPCRs Converge near the G-Protein-Coupling Region.
Nature 2016, 536 (7617), 484–487. https://doi.org/10.1038/nature19107.

6 | Thomsen, A. R. B.; Plouffe, B.; Cahill, T. J.; Shukla, A. K.; Tarrasch, J. T.; Dosey, A. M.; Kahsai, A. W.; Strachan, R. T.; Pani, B.; Mahoney, J. P.; Huang, L.; Breton, B.; Heydenreich, F. M.; Sunahara, R. K.; Skiniotis, G.; Bouvier, M.; Lefkowitz, R. J.
GPCR-G Protein-β-Arrestin Super-Complex Mediates Sustained G Protein Signaling.
Cell 2016, 166 (4), 907–919. https://doi.org/10.1016/j.cell.2016.07.004.

5 | Isogai, S.; Deupi, X.; Opitz, C.; Heydenreich, F. M.; Tsai, C.-J.; Brueckner, F.; Schertler, G. F. X.; Veprintsev, D. B.; Grzesiek, S.
Backbone NMR Reveals Allosteric Signal Transduction Networks in the β1-Adrenergic Receptor.
Nature 2016, 530 (7589), 237–241. https://doi.org/10.1038/nature16577.

4 | Heydenreich, F. M.; Vuckovic, Z.; Matkovic, M.; Veprintsev, D. B.
Stabilization of G Protein-Coupled Receptors by Point Mutations.
Front. Pharmacol. 2015, 6. https://doi.org/10.3389/fphar.2015.00082.

3 | Schumacher, J.; Behrends, V.; Pan, Z.; Brown, D. R.; Heydenreich, F.; Lewis, M. R.; Bennett, M. H.; Razzaghi, B.; Komorowski, M.; Barahona, M.; Stumpf, M. P. H.; Wigneshweraraj, S.; Bundy, J. G.; Buck, M.
Nitrogen and Carbon Status Are Integrated at the Transcriptional Level by the Nitrogen Regulator NtrC In Vivo.
mBio 2013, 4 (6), 10.1128/mbio.00881-13. https://doi.org/10.1128/mbio.00881-13.

2 | Sun, D.; Ostermaier, M. K.; Heydenreich, F. M.; Mayer, D.; Jaussi, R.; Standfuss, J.; Veprintsev, D. B. AAscan, PCRdesign and MutantChecker:
A Suite of Programs for Primer Design and Sequence Analysis for High-Throughput Scanning Mutagenesis.
PLOS ONE 2013, 8 (10), e78878. https://doi.org/10.1371/journal.pone.0078878.

1 | Delley, C. L.; Striebel, F.; Heydenreich, F. M.; Özcelik, D.; Weber-Ban, E.
Activity of the Mycobacterial Proteasomal ATPase Mpa Is Reversibly Regulated by Pupylation.
J. Biol. Chem. 2012, 287 (11), 7907–7914. https://doi.org/10.1074/jbc.M111.331124.