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Research
Our disciplines at a glance
Inhalt ausklappen Inhalt einklappen Pharmaceutical Biology and Biotechnology
The research at our Institute focuses on various biosynthetic pathways of biologically active natural products from fungi and plants. Besides the elucidation of the genomic organization of biosynthetic pathways, the focus is on studies of their evolution and thus metabolic diversity and the identification and characterization of the enzymes involved. Another branch of research is the biotechnological production of interesting natural products from fungi and plants.
Institute for Pharmaceutical Biology and Biotechnology (GER)
Inhalt ausklappen Inhalt einklappen Pharmaceutical Chemistry
The common research goal of the working groups is the development of new therapeutics for a variety of target proteins. The expertise and methodological approaches include: (i) the development of new efficient synthesis methods of molecular libraries provided as test substances for drug screening; (ii) methods for ligand "fishing" from complex natural substance libraries; (iii) organic chemical syntheses of chemotherapeutics against pathogenic bacteria and fungi; (iv) the development of small ligands that inhibit or modulate protein function by combining protein crystallography, protein/ligand functional studies, molecular modeling, and structure-based design and chemical synthesis of ligands; (v) evaluation of natural ribozymes, RNA/protein complexes, and protein enzymes of RNA metabolism as drug targets, and the application and further development of RNA technologies (antisense, aptamers, RNA interference); (vi) physicochemical characterization of macromolecule/ligand interactions and development of biosensing techniques.
Inhalt ausklappen Inhalt einklappen Pharmacology and Clinical Pharmacy
The Institute of Pharmacology and Clinical Pharmacy focuses on the investigation of cellular and molecular mechanisms of drug effects in various cardiovascular and neurodegenerative diseases. In particular, the dynamics of cellular signal transduction is investigated using the example of G protein-coupled signaling pathways, calcium homeostasis, and apoptotic/necrotic processes to better understand drug effects and novel therapeutic approaches.
Inhalt ausklappen Inhalt einklappen Pharmaceutical Technology and Biopharmacy
Pharmaceutical technology and biopharmacy research groups are developing new application systems for active ingredients. On the one hand, liposomes and, on the other hand, degradable polymers are used as carriers for high-molecular-weight active ingredients (peptides, proteins, nucleic acids). Directed targeting of drugs to specific target tissues is to be achieved via colloidal carrier molecules with modified surface structures.
Institute for Pharmaceutical Technology and Biopharmacy (GER)
Inhalt ausklappen Inhalt einklappen History of Pharmacy and Medicine
Research at the Institute of the History of Pharmacy and Medicine is characterized by a broad spectrum of topics, ranging from the Middle Ages to contemporary history and including, in particular, work on the history of pharmaceuticals, institutions and culture.