Research

We investigate FGFR signaling elements in the diploblastic, prebilaterian Hydra vulgaris. By comparing the signaling elements to their counterparts in Bilateria using sequence and domain analysis as well as heterologous functional assays (e.g. Drosophila, cell culture or transgenic Hydra), we learn more about their (functional) evolution. Our present focus is on FGFR signaling in boundary formation and tissue separation. Both occur at the interface of the Hydra parent and its buds, where FGFR ensures proper bud detachment. We investigate the function of three FGFRs, four FGFs and several potential downstream elements (docking proteins, adapters, effectors) as well as downstream pathways (Rho-ROCK-Myosin II, MAPK and PIP signaling) for Hydra morphogenesis.