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Information on Jobs in M4C

Multi-pipette filling
Photo: MPI Marburg / Virginia Geisel

PhD positions

  • Project 6: Metabolite channeling and microcompartment formation for carbon flux adaptation.
    The project focuses on the molecular regulation of carbon flux through direct enzyme-enzyme interactions. These mechanisms are not only fundamental for understanding bacterial cell biology, but are also highly relevant for the targeted influencing of microbial metabolic pathways or medical issues, e.g., in the context of antibiotic resistance. As a second aspect, carbon fixation pathways using microcompartments will be implemented using synthetic biology. Using the latest high-resolution fluorescence microscopy and automated image analysis, substrate-dependent, dynamic formation of microcompartments is studied at a single-molecule level in living cells.
    Your profile: MSc (or equal) degree in the field of biology, biochemistry or chemistry; extensive experience in dealing with different microorganisms (ideally including Bacillus subtilis); ability to carry out molecular biological (cloning) and biochemical experiments (protein purfication); experience with cell biological techniques (e.g. super resolution fluorescence microscopy and/or single molecule tracking); knowledge on or interest in computer programming (e.g. MATLAB, Python, or others); independent, autonomous thinking
    The project will be based primarily in Marburg.
    PIs: Peter Graumann, Tobias Erb, Jan Schuller 

  • Project 10:  Switchable control of synthetic regulons in cell-free systems, protocells, and in vivo. 
    Design and application of transcriptional switches for stepwise control of multiple regulons to operate new-to nature CO2 fixation pathways in vitro and in vivo.
    Your profile: MSc (or equal) degree in Microbiology, Molecular Biology, Biochemistry or related areas. Comprehensive knowledge of bacterial genetics and gene regulation. Expertise and hands-on experience in protein biochemistry and engineering, gene regulatory studies, and a solid background in synthetic biology approaches and genome engineering.
    The project will be based primarily in Marburg.
    PIs: Anke Becker, Tobias Erb 

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