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Selected publications:

Mathijs P. Verhagen, Mark Schmitt, Riccardo Fodde. Western lifestyle, metaflammation and the cell of origin of colon cancer. Nat Rev Gastroenterol Hepatol. September 2024 ;21(9):603-604. doi: 10.1038/s41575-024-00964-7.

Mathijs P. Verhagen, Rosalie Joosten, Mark Schmitt, Niko Välimäki, andrea Sacchetti, Kristiina Rajamäki, Jiahn Choi, Paola Procopio, Sara Silva, Berdine van der Steen, Thierry P. P. van den Bosch, Danielle Seinstra, Annemarie C. de Vries, Michail Doukas, Leonard H. Augenlicht, Lauri A. Aaltonen, Riccardo Fodde. 1)   Non-stem cell lineages as an alternative origin of intestinal tumorigenesis in the context of inflammation. Nat Genet, July 2024 ;56(7):1456-1467. doi: 10.1038/s41588-024-01801-y.

Mark Schmitt, Fatih Ceteci, Jalaj Gupta, Marina Pesic, Tim W Böttger, Adele M Nicolas, Kilian B Kennel, Esther Engel, Matthias Schewe, Asude Callak Kirisözü, Valentina Petrocelli, Yasamin Dabiri, Julia Varga, Mallika Ramakrishnan, Madina Karimova, Andrea Ablasser, Toshiro Sato, Melek C Arkan, Frederic J de Sauvage, Florian R Greten (2022). Colon tumour cell death causes mTOR dependence by paracrine P2X4 stimulation. Nature Nov 16; online ahead of print. doi: 10.1038/s41586-022-05426-1.

Romina J Walter, Steffen J Sonnentag, Leonel Munoz-Sagredo, Melanie Merkel, Ludovic Richert, Felix Bunert, Yvonne M Heneka, Thomas Loustau, Michael Hodder, Rachel A Ridgway, Owen J Sansom, Yves Mely, Ulrich Rothbauer, Mark Schmitt, Véronique Orian-Rousseau (2022). Wnt signaling is boosted during intestinal regeneration by a CD44-positive feedback loop. Cell Death Dis Feb 21;13(2):168.

Christopher Berlin, Félicie Cottard, Dominica Willmann, Sylvia Urban, Stephan M Tirier , Lisa Marx , Karsten Rippe, Mark Schmitt, Valentina Petrocelli, Florian R Greten, Stefan Fichtner-Feigl, Rebecca Kesselring, Eric Metzger, Roland Schüle (2022). KMT9 Controls Stemness and Growth of Colorectal Cancer. Cancer Res Jan 15;82(2):210-220. DOI: 10.1158/0008-5472.CAN-21-1261

Schmitt M & Greten FR. The inflammatory pathogenesis of colorectal cancer.  Nat Rev Immunol 2021 Apr 28. doi: 10.1038/s41577-021-00534-x.

Schmitt M*, Schewe M*, Sacchetti A, Feijtel D, van de Geer W S, Teeuwssen M, Sleddens H F, Joosten R, van Royen M E, van de Werken H J G, van Es J, Clevers H, Fodde R (2018). Paneth cells respond to inflammation and contribute to tissue regeneration by acquiring stem-like features through activation of the SCF/c-Kit signalling axis. Cell Rep Aug 28;24(9):2312-2328.e7. * contributed equally

Schewe M, Sacchetti A, Schmitt M, Fodde R (2017). Organoid Reconstitution Assay (ORA) for the Functional Analysis of Intestinal Stem and Niche Cells. JoVE, ISSUE 129, November 20.

Schewe M, Franken P F, Sacchetti A, Schmitt M, Joosten R, Böttcher R, van Royen M E, Jeammet L, Payré C, Scott P M, Webb N R, Gelb M, Cormier R T, Lambeau G, Fodde R (2016). Secreted Phospholipases A2 Are Intestinal Stem Cell Niche Factors with Distinct Roles in Homeostasis, Inflammation, and Cancer.  Cell Stem Cell 19, 38-51 July 7.

Li L,* Schmitt M,* Wadhwani P, Matzke A, Orian-Rousseau V, Levkin P (2016). CD44v6 peptide functionalized nanoparticles selectively bind to metastatic cancer cells. Adv Sci 4(1): 1600202. * contributed equally

Schmitt M, Metzger M, Gradl D, Davidson G, Orian-Rousseau V (2015). CD44 functions in Wnt-signaling by regulating LRP6 localization and activation. Cell Death Differ 22, 677–689.