Mammalian brain development

While morphology and function of excitatory synapses was fully preserved in profilin1 mutant mice (Görlich, PLoS One 2012), we found it relevant for brain development.

Specifically, we showed that profilin1 controls glial cell adhesion and radial migration of cerebellar granule neurons (Kullmann, EMBO Rep 2012; Kullman, Neuroscience 2012; Kullmann, Cell Adhes Migr 2015) as well as fate of neural stem cells in the cerebral cortex (Kullmann, Cereb Cortex 2020). Currently, we search for proteins that cooperate with profilin1 during brain development.