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Research Group Taudte

Mass spectrometry-based metabolomics

Our research group is concentrating on changes in the metabolome in pathophysiological processes.

Various pathologies such as infectious diseases, cancer, cardiovascular and neuropsychiatric diseases or diabetes show significant changes in normal cellular metabolism in order to adapt to and/or manipulate their micro-environment. In cancer cells, the Warburg effect, which describes the increased and preferential conversion of glucose into lactate, is a prominent example of such metabolic perturbations. Understanding which metabolic pathways are altered and which signaling pathway steps are affected provides valuable information for many different research areas, such as drug development or the determination of new biomarkers.

The working group utilizes mass spectrometry-based methods to elucidate these changes in the metabolic pathways. In particular, high-resolution mass spectrometry, which allows the detection of a large number of low molecular weight molecules (< 1500 Da), has taken metabolomics to a new level. The great potential of this technology features the possibility of directly assigning the detected mass/charge ratios (m/z) to a molecular formula and identity. Our group evolves and optimizes mass spectrometry-based methods, including both, targeted and untargeted metabolomics, and flux analysis (tracer analysis), and applies them to biomedical questions.

Please find the list of the instrumental equipment on the website of the Core Facility Medical Mass Spectrometry: Website Core Facility Medizinische Massenspektrometrie

Current biomedical questions include changes in the metabolome of immune cells due to different diets and infections, metabolomics of fibrotic diseases. More details will follow shortly.

Contact: Regina Verena Taudte; Email