Main Content

Publications of our lab members

• Inhalt ausklappen Inhalt einklappen 2024

  Lehmann M, Krishnan R, Sucre J, Kulkarni HS, Pineda RH, Anderson C, Banovich NE, Behrsing HP, Dean CH, Haak A, Gosens R, Kaminski N, Zagorska A, Koziol-White C, Metcalf JP, Kim YH, Loebel C, Neptune E, Noel A, Raghu G, Sewald K, Sharma A, Suki B, Sperling A, Tatler A, Turner S, Rosas IO, van Ry P, Wille T, Randell SH, Pryhuber G, Rojas M, Bourke J, Königshoff M. Precision Cut Lung Slices: Emerging Tools for Preclinical and Translational Lung Research. An Official American Thoracic Society Workshop Report. Am J Respir Cell Mol Biol. 2024 . doi: 10.1165/rcmb.2024-0479ST.
  
  Pott H, Weckler B, Gaffron S, Martin R, Maier D, Alter P, Biertz F, Speicher T, Bertrams W, Jung A L, Laakmann K, Heider D, Wouters M, Vogelmeier C F, Schmeck B; COSYCONET Study Group. Diffusion capacity and static hyperinflation as markers of disease progression predict 3-year mortality in COPD: Results from COSYCONET. Respirology, 2024 Oct 24. doi: 10.1111/resp.14843.
  
  Krause FF, Mangold KI , Ruppert A-L, Leister H, Hellhund-Zingel A , A Lopez Krol, Pesek J, Watzer B , Winterberg S, Raifer H, Binder K, Kinscherf R, Walker A, WA, Taudte RV, Bertrams W, Schmeck B, A Kühl AA, Siegmund B, Romero R, Luu M, Göttig S, Bekeredjian-Ding I, Steinhoff U, Schütz B, Visekruna A. Clostridium sporogenes-derived metabolites protect mice against colonic inflammation. Gut Microbes, 2024 Oct. 14; doi: 10.1080/19490976.2024.2412669.
  
  Burgy O, Mayr CH, Schenesse D, Fousekis Papakonstantinou E, Ballester B, Sengupta A,She Y, Hu Q, Melo-Narvaéz MC, Jain E, Pestoni JC, Mozurak M, Estrada-Bernal A, Onwuka U, Coughlan C, Parimon T, Chen P, Heimerl T, Bange G, Schmeck BT, Lindner M, Hilgendorff A, Ruppert C, Güenther A, Mann M, Yildirim AÖ, Eickelberg O, Jung AL, Schiller HB, Lehmann M, Burgstaller G, Königshoff M. 2024. Fibroblast-derived extracellular vesicles contain SFRP1 and mediate pulmonary fibrosis. JCI Insight. 2024; 9(18): e168889. doi.org/10.1172/jci.insight.168889. 
  
  Bonifay A, Mackman N, Hisada Y, Azevedo Sachetto AT, Hau C, Gray E, Hogwood J, Aharon A, Badimon L, Barile L, Baudar J, Beckmann L, Benedikter B, Bolis S, Bouriche T, Brambilla M, Burrello J, Camera M, Campello E, Ettelaie C, Faille D, Featherby S, Franco C, Guldenpfennig M, Hansen J-B, Judicone C, Kim Y, Kristensen SR, Laakmann K, Langer F, Latysheva N, Lucien F, Marques de Menezes E, Mullier F, Norris P, Nybo J, Orbe J, Osterud B, Paramo JA, Radu CM, Roncal C, Samadi N, Snir O, Suades R, Wahlund C, Chareyre C, Abdili E, Martinod K, Thaler J, Dignat-George F, Nieuwland R, Lacroix R. Comparison of assays measuring extracellular vesicle tissue factor in plasma samples: communication from the ISTH SSC Subcommittee on Vascular Biology.  J Thromb Haemost. 2024 Jun 25:S1538-7836(24)00367-2. doi: 10.1016/j.jtha.2024.05.037
  
  Weckler BC, Pott H, Race A, Nattika Jugkaeo N, Karki K, Ringshandl S, Seidemann C, Schöndorf I, Renz H, Fähndrich S, Jung AL, Bertrams W, Makoudjou A, Zöller D, Finotto S, Schild S, Seuchter SA, Rohde G, Trinkmann F, Greulich T, Vogelmeier CF, Schmeck B. Eosinopenia as predictor of disease severity in patients with community-acquired pneumonia: an observational study.  Chest , 2024, Jul 5: S0012-3692(24)04580-X. doi: 10.1016/j.chest.2024.05.041.
  
  Melo-Narváez, M. C., Bramey, N., See, F., Heinzelmann, K., Ballester, B., Steinchen, C., Jain, E., Federl, K., Hu, Q. ,Dhakad, D., Behr, J., Eickelberg, O., Yildirim, A. Ö., Königshoff, M., Lehmann, M. Stimuli-Specific Senescence of Primary Human Lung Fibroblasts Modulates Alveolar Stem Cell Function. Cells 2024. https://doi.org/10.3390/cells13131129
  
  Burt M, Angelidou G, Mais CN, Preußer C, Glatter T, Heimerl T, Groß R, Serrania J, Boosarpu G, Pogge von Strandmann E, Müller JA, Bange G, Becker A, Lehmann M, Jonigk D, Neubert L, Freitag H, Paczia N, Schmeck B, Jung AL. Lipid A in outer membrane vesicles shields bacteria from polymyxins. JEV 2024 May. https://doi.org/10.1002/jev2.12447
  
  Bertrams W, Wilhelm J, Veeger P-M, Hanko C, auf dem Brinke K, Klabunde B, Pott H, Weckler B, Greulich T, Vogelmeier C F, Schmeck B. A mRNA panel for differentiation between acute exacerbation or pneumonia on COPD patients.  Front. Med. 2024 March 22. doi: 10.3389/fmed.2024.1234068
  
  Tulen CBM, van de Wetering C, Schiffers CHJ, Weltjens E, Benedikter BJ, Leermakers PA, Boukhaled JH, Drittij MJ, Schmeck BT, Reynaert NL, Opperhuizen A, van Schooten FJ, Remels AHV. Alterations in the molecular control of mitochondrial turnover in COPD lung and airway epithelial cells.  Sci Rep. 2024 Feb 27;14(1):4821. doi: 10.1038/s41598-024-55335-8. PMID: 38413800
  
  Möbs C, Jung AL. Extracellular vesicles: Messengers of allergic immune responses and noval theraputic strategy. Eur J Immunol, 2024; https://doi.org/10.1002/eji.202350392
  
  Fähndrich S, Herr C, Teuteberg S, Alter P, Söhler S, Soriano D, Classen J, Adams J, Weinhold V, Watz H, Waschki B, Zeller T, Eichenlaub M, Trudzinski FC, Michels JD, Omlor A, Seiler F, Moneke I, Biertz F, Stolz D, Welte T, Kauczor HU, Kahnert K, Jörres RA, Vogelmeier CF, Bals R; German COSYCONET Cohort. Midregional proatrial naturetic peptide (MRproANP) and copeptin (COPAVP) as predictors of all-cause mortality in recently diagnosed mild to moderate COPD-results from COSYCONET. Respir Res. 2024 Jan 24;25(1):56. doi: 10.1186/s12931-024-02690-9. PMID: 38267944
  
  Zöller D, Haverkamp C, Makoudjou A, Sofack G, Kiefer S, Gebele D, Pfaffenlehner M, Boeker M, Binder H, Karki, K, Seidemann C, Schmeck B, Greulich T, Renz H, Schild S, Seuchter SA, Tibyampansha D, Buhl R, Rohde G, Trudzinski FC, Bals R, Janciauskiene S, Stolz D, Fähndrich S. Alpha-1-antitrypsin-deficiency is associated with lower cardiovascular risk: an approach based on federated learning. Respir Res 2024; Jan 18;25(1):38. doi: 10.1186/s12931-023-02607-y.

• Inhalt ausklappen Inhalt einklappen 2023

  Lang N*, Gote-Schniering J*, Porras-Gonzalez D, Yang L, De  Sadeleer L, Jentzsch CR, Shitov VA, Zhou S, Ansari M, Agami A, Mayr C, Kashani BH, Chen Y, Heumos L, Pestoni JC, Monar ES, Geeraerts E, Anquetil V, Saniere L, Wögrath M, Gerckens M, Lehmann M, Yildirim AÖ, Hatz R, Kneidinger N, Behr J, Wuyts WA, Stoleriu GM,Luecken MD, Theis FJ, Burgstaller G*, Schiller H*. Ex vivo tissue perturbations coupled to single cell RNA-seq reveal multi-lineage cell circuit dynamics in human lung fibrogenesis. Science Translational Medicine, 2023, 15, eadh0908; *equal contribution
  
  Pandi A, Adam D, Zare A, Trinh VT, Schaefer SL, Burt M, Klabunde B, Bobkova E, Kushwaha M, Foroughhijabbari Y, Braun P, Spahn C, Preußer C, Pogge von Standmann E, Bode HB, von Buttlar H, Bertrams W, Jung AL, Abendroth F, Schmeck, B, Hummer G, Vázquez O, Erb TJ. Cell-free biosynthesis combined with deep learning accelerates de novo-development of antimicrobial peptides. Nat. Commun. 2023 Nov 8; 14(1): 7197. doi: 10.1038/s41467-023-42434-9.
  
  Klabunde B, Wesener A, Bertrams W, Beinborn I, Paczia N, Surmann K, Blankenburg S, Wilhelm J, Serrania J, Knoops K, Elsayed E M, Laakmann K, Jung A L, Kirschbaum A, Hammerschmidt S, Alshaar B, Gisch N, Abu Mraheil M, Becker A, Völker U, Vollmeister E, Benedikter B J, Schmeck B. NAD⁺ metabolism is a key modulator of bacterial respiratory epithelial infections. Nat. Commun. 2023 Oct. 2; 14(1):5818
  
  Klabunde B, Wesener A, Bertrams W, Ringshandl S, Halder LD, Vollmeister E, Schmeck B, Benedikter BJ. Streptococcus pneumoniae disrupts the structure of the golgi apparatus and subsequent epithelial cytokine response in an H₂O₂-dependent manner. Cell. Commun. Signal. 2023 Aug 17;21(1):208.
  
  Saini M, Schmidleitner L, Domínguez Moreno H, Donato E , Falcone M, Bartsch JM, Klein C, Vogel V, Würth R, Pfarr N, Espinet E, Lehmann M, Königshoff M, Reitberger M, Haas S, Graf E, Schwarzmayr T, Strom T-M, Spaich S, Sütterlin  M, Schneeweiss A, Weichert W, Schotta G, Reichert M, Aceto N, Sprick M R, Trumpp A, Scheel CH. Resistance to mesenchymal reprogramming sustains clonal propagation in metastatic breast cancer.  Cell Rep. 2023 Jun 27; 42(6):112533. doi: 10.1016/j.celrep.2023.112533. 
  
  Kapellos T, Conlon T, Yildirim AÖ, Lehmann M. The impact of the immune system on lung injury and regeneration in chronic obstructive pulmonary disease. European Respiratory Journal, 2023, 62,4 
  
  Vidacovic L, Mikhaleva S, Jeckel H, Nisnevich V, Strenger K, Neuhaus K, Raveendran K, Bossel Ben-Moshe N, Aznaourova M, Nosho K, Drescher A, Schmeck B, Schulte LN, Persat A, Avraham R, Drescher K. Biofilm formation on human immune cells is a multicellular predation strategy of Vibrio cholerae. Cell. 2023 June 8, 186:2690-2704.e20.
  
  Jung AL, Han M, Griss K, Bertrams W, Nell C, Greulich T, Klemmer A, Pott H, Heider D, Vogelmeier CF, Hippenstiel S, Suttorp N, Schmeck B. Novel protein biomarkers for pneumonia and acute exacerbations in COPD: a pilot study. Front Med. 2023 June 5. doi: 10.3389/fmed.2023.1180746.
  
  Shi Y, Strobl R, Apfelbacher C, Bahmer T, Geisler R, Heuschmann P, Horn A, Hoven H, Keil T, Krawczak M, Krist L, Lemhöfer C, Lieb W, Lorenz-Depiereux B, Mikolajczyk R, Montellano FA, Reese JP, Schreiber S, Skoetz N, Störk S, Vehreschild JJ, Witzenrath M, Grill E; NAPKON Study Group. Persistent symptoms and risk factors predicting prolonged time to symptom-free after SARS‑CoV‑2 infection: an analysis of the baseline examination of the German COVIDOM/NAPKON-POP cohort. Infection. 2023 May 25:1-16. doi: 10.1007/s15010-023-02043-6.
  
  Kastlmeier MT, Gonzalez-Rodriguez E, Cabanis P, Guenther EM, König AC, Han L, Hauck SM, See F, Asgharpour S, Bukas C, Burgstaller G, Pieraud M, Lehmann M, Hatz RA, Behr J, Stöger T, Hilgendorff A, Voss C.  Cytokine signaling converging on IL11 in ILD fibroblasts provokes aberrant epithelial differentiation signatures. Frontiers in Immunology 2023; 14: 1128239
  
  Schwerdtner M, Skalik A, Limburg H, Bierwagen J, Jung AL, Dorna J, Kaufmann A, Bauer S, Schmeck B, Böttcher-Friebertshäuser E. Expression of TMPRSS2 is up-regulated by bacterial flagellin, LPS, and Pam3Cys in human airway cells. Life Sci Alliance. 2023 May 19;6(8):e202201813. doi: 10.26508/lsa.202201813.
  
  Laakmann K, Eckersberg JM, Hapke M, Wiegand M, Bierwagen J, Beinborn I, Preußer C, Pogge von Strandmann E, Heimerl T, Schmeck B, Jung AL. Bacterial extracellular vesicles repress the vascular protective factor RNase1 in human lung endothelial cells. Cell Commun Signal. 2023 May 15;21(1):111. doi: 10.1186/s12964-023-01131-2.
  
  Lehmann M, Kolb M. Another piece in the Pirfenidone Puzzle. European Respiratory Journal, 2023, Apr 27;61(4):2300240. 
  
  Del Fresno C, Schulte LN, López-Collazo E. Role of hypoxia-inducible factors in metabolic immune cell adaptation during sepsis. Front Immunol. 2023 Apr 18;14:1194504. doi: 10.3389/fimmu.2023.1194504. (Editorial)
  
  Bramey N, Schmeck B, Lehmann M. Altern und Regeneration in der Lunge – Bedeutung   für die COPD, Atemwegs- und Lungenerkrankungen. 2023, 49, 4 /2023, 140-146. 
  
  Cuevas Ocaña S, El-Merhie  N, Kuipers ME, Lehmann M , Rolandsson Enes S, Voss C, Dean LSN, Loxham M, Boots AW, Cloonan SM, Greene CM, Heijink IH, Joannes A, Mailleux AA, Mansouri  N, Reynaert NL, van der Does AM, Wagner DE, Ubags N. ERS International Congress 2022: highlights from the Basic and Translational Science Assembly.  ERJ Open Res. 2023 Apr 17; 9(2): 00561-2022. doi: 10.1183/23120541.00561-2022. 
  
  Bierwagen J, Wiegand M, Laakmann K, Danov O, Limburg H, Herbel SM, Heimerl T, Dorna J, Jonigk D, Preußer C, Bertrams W, Braun A, Sewald K, Schulte LN, Bauer S, Pogge von Strandmann E, Böttcher-Friebertshäuser E, Schmeck B, Jung AL. Bacterial vesicles block viral replication in macrophages via TLR4-TRIF-axis. Cell Commun Signal. 2023 Mar 28;21(1):65. doi: 10.1186/s12964-023-01086-4.
  
  Jung AL, Møller Jørgensen M, Bæk R, Artho M, Griss K, Han M, Bertrams W, Greulich T, Koczulla R, Hippenstiel S, Heider D, Suttorp N, Schmeck B. Surface proteome of plasma extracellular vesicles as mechanistic and clinical biomarkers for malaria. Infection. 2023 Mar 24. doi: 10.1007/s15010-023-02022-x. 
  
  Feng A, Yang EY, Moore AR, Dhingra S, Chang SE, Yin X, Pi R, Mack EK, Völkel S, Geßner R, Gündisch M, Neubauer A, Renz H, Tsiodras S, Fragkou PC, Asuni AA, Levitt JE, Wilson JG, Leong M, Lumb JH, Mao R, Pinedo K, Roque J, Richards CM, Stabile M, Swaminathan G, Salagianni ML, Triantafyllia V, Bertrams W, Blish CA, Carette JE, Frankovich J, Meffre E, Nadeau KC, Singh U, Wang TT, Luning Prak ET, Herold S, Andreakos E, Schmeck B, Skevaki C, Rogers AJ, Utz PJ.  Autoantibodies are highly prevalent in non-SARS-CoV-2 respiratory infections and critical illness. JCI Insight. 2023 Feb 8;8(3):e163150.
  
  Zhang B, Zhang Z, Koeken VACM, Kumar S, Aillaud M, Tsay HC, Liu Z, Kraft ARM, Soon CF, Odak I, Bošnjak B, Vlot A; Deutsche COVID-19 OMICS Initiative (DeCOI); Swertz MA, Ohler U, Geffers R, Illig T, Huehn J, Saliba AE, Sander LE, Förster R, Xu CJ, Cornberg M, Schulte LN, Li Y. Altered and allele-specific open chromatin landscape reveals epigenetic and genetic regulators of innate immunity in COVID-19. Cell Genom. 2023 Feb 8;3(2):100232.

• Inhalt ausklappen Inhalt einklappen 2022

  Oestreich MA, Seidel K, Bertrams W, Müller HH, Sassen M, Steinfeldt T, Wulf H, Schmeck B. Pulmonary inflammatory response and immunomodulation to multiple trauma and hemorrhagic shock in pigs. PLoS One. 2022 Dec 7;17(12):e0278766.
  
  Bertrams W*, Hönzke K*, Obermayer B, Tönnies M, Bauer TT, Schneider P, Neudecker J, Rückert JC, Stiewe T, Nist A, Eggeling S, Suttorp N, Wolff T, Hippenstiel S, Schmeck B*, Hocke AC* (*contributed equally). Transcriptomic comparison of primary human lung cells with lung tissue samples and the human A549 lung cell line highlights cell type specific responses during infections with influenza A virus. Sci Rep. 2022 Nov 29;12(1):20608. 
  
  Herbel SM, Moyon L, Christ M, Elsayed EM, Caffrey BE, Malmsheimer S, Grin I, Hoffmann K, Surmann K, Blankenburg S, Jung AL, Herkt CE, Borsò M, Bozdag B, Imhof A, Becker A, Wagner S, Bange G, Völker U, Bertrams W, Marsico A, Schmeck B. Screening for eukaryotic motifs in Legionella pneumophila reveals Smh1 as bacterial deacetylase of host histones. Virulence. 2022 Nov 21. doi: 10.1080/21505594.2022.2149973.
  
  Lopez Krol A, Nehring HP, Krause FF, Wempe A, Raifer H, Nist A, Stiewe T, Bertrams W, Schmeck B, Luu M, Leister H, Chung HR, Bauer UM, Adhikary T, Visekruna A. Lactate induces metabolic and epigenetic reprogramming of pro-inflammatory Th17 cells. EMBO Rep. 2022 Oct 10:e54685.
  
  Romero R, Zarzycka A, Preussner M, Fischer F, Hain T, Herrmann JP, Roth K, Keber CU, Suryamohan K, Raifer H, Luu M, Leister H, Bertrams W, Klein M, Shams-Eldin H, Jacob R, Mollenkopf HJ, Rajalingam K, Visekruna A, Steinhoff U. Selected commensals educate the intestinal vascular and immune system for immunocompetence. Microbiome. 2022 Sep 28;10(1):158.
  
  Aznaourova M, Schmerer N, Janga H, Zhang Z, Pauck K, Bushe J, Volkers SM, Wendisch D, Georg P, Ntini E, Aillaud M, Gündisch M, Mack E, Skevaki C, Keller C, Bauer C, Bertrams W, Marsico A, Nist A, Stiewe T, Gruber AD, Ruppert C, Li Y, Garn H, Sander LE, Schmeck B, Schulte LN. Single-cell RNA sequencing uncovers the nuclear decoy lincRNA PIRAT as a regulator of systemic monocyte immunity during COVID-19. Proc Natl Acad Sci U S A. 2022 Sep 6;119(36):e2120680119.
  
  Sommer N & Schmeck B. Pulmonale Manifestationen bei Long-COVID. Die Innere Medizin. July 2022.
  
  Siebenbrodt K, Schütz V, Costard LS, Neubert V, Alvarez-Fischer D, Seidel K, Schmeck B, Meuth SG, Rosenow F, Bauer S. Hippocampal Cytokine Release in Experimental Epileptogenesis — A Longitudinal In Vivo Microdialysis Study. Brain Sci. May 2022, 12, 677.
  
  Conrad C, Yildiz D, Cleary SJ, Margraf A, Cook L, Schlomann U, Panaretou B, Bowser JL, Karmouty-Quintana H, Li J, Berg NK, Martin SC, Aljohmani A, Moussavi-Harami SF, Wang KM, Tian JJ, Magnen M, Valet C, Qiu L, Singer JP, Eltzschig HK; CAPSys Study Group, Bertrams W, Herold S, Suttorp N, Schmeck B, Ball ZT, Zarbock A, Looney MR, Bartsch JW. ADAM8 signaling drives neutrophil migration and ARDS severity. JCI Insight. 2022 Feb 8;7(3):e149870.
  
  Kahnert K, Andreas S, Kellerer C, Lutter JI, Lucke T, Yildirim Ö, Lehmann M, Seissler J, Behr J, Frankenberger M, Bals R, Watz H, Welte T, Trudzinski FC, Vogelmeier CF, Alter P, Jörres RA; COSYCONET Study Group. Reduced decline of lung diffusing capacity in COPD patients with diabetes and metformin treatment. Sci Rep. 2022 Jan 26;12(1):1435.
  
  Feng A, Yang E, Moore A, Dhingra S, Chang S, Yin X, Pi R, Mack E, Völkel S, Geßner R, Gundisch M, Neubauer A, Renz H, Tsiodras S, Fragkou P, Asuni A, Levitt J, Wilson J, Leong M, Lumb J, Mao R, Pinedo K, Roque J, Richards C, Stabile M, Swaminathan G, Salagianni M, Triantafyllia V, Bertrams W, Blish C, Carette J, Frankovich J, Meffre E, Nadeau KC, Singh U, Wang T, Prak EL, Herold S, Andreakos E, Schmeck B, Skevaki C, Rogers A, Utz P. Autoantibodies targeting cytokines and connective tissue disease autoantigens are common in acute non-SARS-CoV-2 infections. Res Sq. 2022 Jan 20:rs.3.rs-1233038.

• Inhalt ausklappen Inhalt einklappen 2021

  Steuder R, Pott H, Maxheim M, Schmeck B. Pneumonie und COVID-19 bei COPD-Patienten. Pneumo News. 2021;13(5):30-35. (Review)
  
  Walther K, Schulte LN. The role of lncRNAs in innate immunity and inflammation.  RNA Biol. 2021 May; 18(5): 587-603. doi: 10.1080/15476286.2020.1845505. 
  
  Raifer H, Schulz AR, Theodorou J, Romero-Olmedo AJ, Böck A, Bertrams W, Schmeck B, Chung HR, Lohoff M, Chang HD, Schaub B, Mei HE, Huber M. Mass cytometry-based identification of a unique T-cell signature in childhood allergic asthma. Allergy 2021 Sept 26. doi: 10.1111/all.15110. Online ahead of print.
  
  Vogelmeier C, Schmeck B. Genetics of pulmonary diseases. Pneumologe (Berl). 2021;18(4):209-211. (Editorial)
  
  Jung AL, Schmeck B, Wiegand M, Bedenbender K, Benedikter BJ. The clinical role of host and bacterial-derived extracellular vesicles in pneumonia. Adv Drug Deliv Rev. 2021 May 19;S0169-409X(21)00185-X. (Review)
  
  Schmerer N, Schulte LN. Long noncoding RNAs in bacterial infection. Wiley Interdiscip Rev RNA. 2021 May 14:e1664.
  
  Roessler FK, Benedikter BJ, Schmeck B, Bar N. Novel computational analysis of large transcriptome datasets identifies sets of genes distinguishing chronic obstructive pulmonary disease from healthy lung samples. Sci Rep. 2021 May 13;11(1):10258.
  
  Bertrams W, Lindhauer NS, Rieke MC, Paas A, Hoffmann K, Greene B, Visekruna A, Vilcinskas A, Seidel K, Schmeck B. Tribolium castaneum defensin 1 kills Moraxella catarrhalisin an in vitro infection model but does not harm commensal bacteria. Virulence. 2021 Dec;12(1):1003-1010.
  
  Linden G, Janga H, Franz M, Nist A, Stiewe T, Schmeck B, Vázquez O , Schulte LN. Efficient antisense inhibition reveals microRNA-155 to restrain a late-myeloid inflammatory programme in primary human phagocytes.  RNA Biol. 2021 May; 18(5):604-618. doi: 10.1080/15476286.2021.1885209.
  
  Bertrams W, Jung AL, Maxheim M, Schmeck B. Role of genetic factors in pneumonia and COVID-19. Pneumologe (Berl). 2021 Mar 5:1-5. (Review)
  
  Leister H, Luu M, Staudenraus D, Lopez Krol A, Mollenkopf H, Sharma A, Schmerer N, Schulte LN, Bertrams W, Schmeck B, Bosmann M, Steinhoff U, Visekruna A. Pro- and anti-tumorigenic capacity of immunoproteasomes in shaping the tumor microenvironment. Cancer Immunol Res. 2021 Mar 11:canimm.0492.2020.
  
  Bertrams W, Griss K, Han M, Seidel K, Hippenstiel S, Suttorp N, Finkernagel F, Wilhelm J, Vogelmeier CF, Schmeck B. Transcriptional analysis identifies potential biomarkers and molecular regulators in acute malaria infection. Life Sci. 2021 Apr 1;270:119158.
  
  Chillappagari S, Garapati V, Mahavadi P, Naehrlich L, Schmeck BT, Schmitz ML, Guenther A. Defective BACH₁/HO-1 regulatory circuits in cystic fibrosis bronchial epithelial cells. J Cyst Fibros. 2021 Jan; 20(1): 140 - 148; doi: 10.1016/j.jcf.2020.05.006.

• Inhalt ausklappen Inhalt einklappen 2020

  • Aznaourova M, Schmerer N, Schmeck B, Schulte LN. Disease-Causing Mutations and Rearrangements in Long Non-coding RNA Gene Loci. Front Genet. 2020 Nov 30;11:527484.
    
    
  • Fischer F, Romero R, Hellhund A, Linne U, Bertrams W, Pinkenburg O, Shams Eldin H, Binder K, Jacob R, Walker A, Stecher B, Basic M, Luu M, Mahdavi R, Heintz-Buschart A, Visekruna A, Steinhoff U. Dietary cellulose induces anti-inflammatory immunity and transcriptional programs via maturation of the intestinal microbiota. Gut Microbes. 2020 Nov 9;12(1):1-17.
    
    
  • Tariq I, Ali MY, Janga H, Ali S, Amin MU, Ambreen G, Ali U, Pinnapireddy SR, Schäfer J, Schulte LN, Bakowsky U. Downregulation of MDR 1 gene contributes to tyrosine kinase inhibitor induce apoptosis and reduction in tumor metastasis: A gravity to space investigation. Int J Pharm. 2020 Dec 15;591:119993.
    
    
  • Aillaud M, Schulte LN. Emerging Roles of Long Noncoding RNAs in the Cytoplasmic Milieu. Noncoding RNA. 2020 Nov 9;6(4):44.
    
    
  • Walther K, Schulte LN. The role of lncRNAs in innate immunity and inflammation. RNA Biol. 2020 Nov 19:1-17.
    
    
  • Hanschmann EM, Berndt C, Hecker C, Garn H, Bertrams W, Lillig CH, Hudemann C. Glutaredoxin 2 Reduces Asthma-Like Acute Airway Inflammation in Mice. Front Immunol. 2020 Nov 3;11:561724.
    
    
  • Karwelat D, Schmeck B, Ringel M, Benedikter BJ, Hübner K, Beinborn I, Maisner A, Schulte LN, Vollmeister E. Influenza virus-mediated suppression of bronchial Chitinase-3-like 1 secretion promotes secondary pneumococcal infection. FASEB J. 2020;00:1–17.
    
    
  • Bedenbender K, Beinborn I, Vollmeister E, Schmeck B. p38 and Casein Kinase 2 mediate Ribonuclease 1 repression in inflamed human endothelial cells via promoter remodeling through Nucleosome Remodeling and Deacetylase complex. Front Cell Develop Biol. 2020 Oct 15.
    
    
  • Jung S, von Thülen T, Yang I, Laukemper V, Rupf B, Janga H, Panagiotidis GD, Schoen A, Nicolai M, Schulte LN, Obermann HL, Weber F, Kaufmann A, Bauer S. A ribosomal RNA fragment with 2',3'-cyclic phosphate and GTP-binding activity acts as RIG-I ligand. Nucleic Acids Res. 2020 Sep 18:gkaa739.
    
    
  • Korfhage N, Mühling M, Ringshandl S, Becker A, Schmeck B, Freisleben B. Detection and segmentation of morphologically complex eukaryotic cells in fluorescence microscopy images via feature pyramid fusion. PLoS Comput Biol. 2020 Sep 8;16(9):e1008179.
    
    
  • Jendrek S, Lai X, Riemekasten G, Vera-González J, Schmeck B, Bertrams W. Sepsis and Autoimmune Disease: Pathology, Systems Medicine, and Artificial Intelligence. Systems Medicine: Integrative, Qualitative and Computational Approaches. 2021. Vol. 2, 581-592.
    
    
  • Bertrams W, Jung AL, Schmeck B. Modeling of Pneumonia and Acute Lung Injury: Bioinformatics, Systems Medicine, and Artificial Intelligence. Systems Medicine: Integrative, Qualitative and Computational Approaches. 2021. Vol 2, 573-580.
    
    
  • Aznaourova M & Schulte LN. Non-coding RNA Networks in Infection. Systems Medicine: Integrative, Qualitative and Computational Approaches. 2021. Vol 2, 565-572.
    
    
  • Bedenbender K & Schmeck B. Endothelial Ribonuclease 1 in Cardiovascular and Systemic Inflammation. Front Cell Develop Biol. 2020 Sept 4. doi: 10.3389/fcell.2020.576491.
    
    
  • Chillappagari S, Garapati V, Mahavadi P, Naehrlich L, Schmeck B, Schmitz ML, Guenther A. Defective BACH1/HO-1 regulatory circuits in cystic fibrosis bronchial epithelial cells. J Cyst Fibros. 2020 Jun 11:S1569-1993(20)30150-8.
    
    
  • Benedikter BJ, Koenen RR. Vaping, vapor, vesicles! Electronic cigarettes provoke vascular extracellular vesicle release in healthy volunteers. Atherosclerosis 2020 May;301:79-81.
    
    
  • Aguirre LA, Montalbán-Hernández K, Avendaño-Ortiz J, Marín E, Lozano R, Toledano V, Sánchez-Maroto L , Terrón V, Valentín J, Pulido E, Casalvilla JC , Rubio C, Diekhorst L, Laso-García F, del Fresno C , Collazo-Lorduy A, Jiménez-Munarriz B, Gómez-Campelo P, Llanos-González E, Fernández-Velasco M,  Rodríguez-Antolín C, Pérez de Diego R, Cantero-Cid R, Hernádez-Jimenez E, Álvarez E, Rosas R, dies López-Ayllón B, deCastro J, Wculek SK, Cubillos-Zapata C, Ibáñezde Cáceres I, Díaz-Agero P, Gutiérrez Fernández M, Pazde Miguel M, Sancho D, Schulte LN, Perona R, Belda-Iniesta C, Boscá L,  López-Collazo E. Tumor stem cells fuse with monocytes to form highly invasive tumor-hybrid cells. OncoImmunology. 2020 May 10;9:1-17.
    
    
  • Alter P, Baker JR, Dauletbaev N, Donnelly LE, Pistenmaa C, Schmeck B, Washko G, Vogelmeier CF. Update in Chronic Obstructive Pulmonary Disease 2019. Am J Respir Crit Care Med. 2020 May 14.
    
    
  • Greulich T, Tüffers J, Mager S, Eder A, Maxheim M, Alter P, Schmeck B, Vogelmeier CF. High eosinophil blood counts are associated with a shorter length of hospital stay in exacerbated COPD patients - a retrospective analysis. Respir Res. 2020 May 6;21(1):106. doi: 10.1186/s12931-020-01365-5.
    
    
  • Vlacil AK, Vollmeister E, Bertrams W, Schoesser F, Oberoi R, Schuett J, Schuett H, Huehn S, Bedenbender K, Schmeck BT, Schieffer B, Grote K. Identification of microRNAs Involved in NOD-dependent Induction of Pro-Inflammatory Genes in Pulmonary Endothelial Cells. PLoS One. 2020 Apr 30;15(4):e0228764.
    
    
  • Aznaourova M, Janga H, Sefried S, Kaufmann A, Dorna J, Volkers SM, Georg P, Lechner M, Hoppe J, Dökel S, Schmerer N, Gruber AD, Linne U, Bauer S, Sander LE, Schmeck B, Schulte LN. Noncoding RNA MaIL1 is an integral component of the TLR4-TRIF pathway. Proc Natl Acad Sci U S A. 2020 Apr 2. pii: 201920393.
    
    
  • Aznaourova M & Schulte LN. Non-coding RNA networks in Infection. Ref Mod in Biol Sci. 2020 Mar 29.
    
    
  • Herkt CE, Caffrey BE, Surmann K, Blankenburg S, Gesell Salazar M, Jung AL, Herbel SM, Hoffmann K, Schulte LN, Chen W, Sittka-Stark A, Völker U, Vingron M, Marsico A, Bertrams W, Schmeck B. A miRNA network controls Legionella pneumophila replication in human macrophages via LGALS8 and MX1. mBio. 2020 Mar 24;11(2). pii: e03155-19. 
    
    
  • Zasłona Z, Flis E, Wilk MM, Carroll RG, Palsson-McDermott EM, Hughes MM, Diskin C, Banahan K, Ryan DG, Hooftman A, Misiak A, Kearney J, Lochnit G, Bertrams W, Greulich T, Schmeck B, McElvaney OJ, Mills KHG, Lavelle EC, Wygrecka M, Creagh EM, O'Neill LAJ. Caspase-11 promotes allergic airway inflammation. Nat Commun. 2020 Feb 26;11(1):1055. 
    
    
  • Gomez I, Ward B, Souilhol C, Recarti C, Ariaans M, Johnston J, Burnett A, Mahmoud M, Luong LA, West L, Long M, Parry S, Woods R, Hulston C, Benedikter B, Niespolo C, Bazaz R, Francis S, Kiss-Toth E, van Zandvoort M, Schober A, Hellewell P, Evans PC, Ridger V. Neutrophil microvesicles drive atherosclerosis by delivering miR-155 to atheroprone endothelium. Nat Commun. 2020 Jan 10;11(1):214. doi: 10.1038/s41467-019-14043-y.
    
    
  • Bertrams W, Griss K, Han M, Seidel K, Klemmer A, Sittka-Stark A, Hippenstiel S, Suttorp N, Finkernagel F, Wilhelm J, Greulich T, Vogelmeier C, Vera J, Schmeck B. Transcriptional analysis identifies potential biomarkers and molecular regulators in pneumonia and COPD exacerbation. Sci Rep. 2020 Jan 14;10(1):241.

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  • Hübner K, Karwelat D, Pietsch E, Beinborn I, Winterberg S, Bedenbender K, Benedikter BJ, Schmeck B, Vollmeister E. NF-κB-mediated inhibition of microRNA-149-5p regulates Chitinase-3-like 1 expression in human airway epithelial cells. Cell Signal. 2019 Dec 16;67:109498.
    
    
  • Lückel C, Picard F, Raifer H, Campos Carrascosa L, Guralnik A, Zhang Y, Klein M, Bittner S, Steffen F, Moos S, Marini F, Gloury R, Kurschus FC, Chao YY, Bertrams W, Sexl V, Schmeck B, Bonetti L, Grusdat M, Lohoff M, Zielinski CE, Zipp F, Kallies A, Brenner D, Berger M, Bopp T, Tackenberg B, Huber M. IL-17+ CD8+ T cell suppression by dimethyl fumarate associates with clinical response in multiple sclerosis. Nat Commun. 2019 Dec 16;10(1):5722.
    
    
  • Jung AL, Møller Jørgensen M, Bæk R, Griss K, Han M, auf dem Brinke K, Timmesfeld N, Bertrams W, Greulich T, Koczulla AR, Hippenstiel S, Suttorp N, Schmeck B. Surface Proteome of Plasma Extracellular Vesicles as Biomarkers for Pneumonia and Acute Exacerbation of Chronic Obstructive Pulmonary Disease. J Inf Dis. 2019 Oct 16. pii: jiz460.
    
    
  • Lindhauer N, Bertrams W, Pöppel A, Herkt C, Wesener A, Hoffmann K, Greene B, van der Linden M, Vilcinskas A, Seidel K, Schmeck B. Antibacterial activity of a Tribolium castaneum defensin in an in vitro infection model of Streptococcus pneumoniae. Virulence 2019 Dec;10(1):902-909. 
    
    
  • Dabrowski AN, Shrivastav A, Conrad C, Komma K, Weigel M, Dietert K, Gruber A, Bertrams W, Wilhelm J, Schmeck B, Reppe K, N'Guessan PD, Aly S, Suttorp N, Hain T, Zahlten J. Peptidoglycan recognition protein 4 limits bacterial clearance and inflammation in lungs by control of the gut microbiota. Front Immunol. 2019 Sep 20;10:2106.
    
    
  • Franssen FME, Alter P, Bar N, Benedikter BJ, Iurato S, Maier D, Maxheim M, Roessler FK, Spruit MA, Vogelmeier CF, Wouters EFM, Schmeck B. Personalized medicine for patients with COPD: where are we? Int J Chron Obstruct Pulmon Dis. 2019 July 9;14:1465-1484
    
    
  • Bedenbender K, Scheller N, Fischer S, Leiting S, Preissner KT, Schmeck BT, Vollmeister E. Inflammation-mediated deacetylation of the ribonuclease 1 promoter via histone deacetylase 2 in endothelial cells. FASEB J. 2019
    
    
  • Visekruna A, Hartmann S, Sillke YR, Glauben R, Fischer F, Raifer H, Mollenkopf H, Bertrams W, Schmeck B, Klein M, Pagenstecher A, Lohoff M, Jacob R, Pabst O, Bland PW, Luu M, Romero R, Siegmund B, Rajalingam K, Steinhoff U. Intestinal development and homeostasis require activation and apoptosis of diet-reactive T cells. J Clin Invest. 2019 Apr 2;130. pii: 98929.
    
    
  • Nandakumar R, Tschismarov R, Meissner F, Prabakaran T, Krissanaprasit A, Farahani E, Zhang BC, Assil S, Martin A, Bertrams W, Holm CK, Ablasser A, Klause T, Thomsen MK, Schmeck B, Howard KA, Henry T, Gothelf KV, Decker T, Paludan SR. Intracellular bacteria engage a STING-TBK1-MVB12b pathway to enable paracrine cGAS-STING signalling. Nat Microbiol. 2019 Apr;4(4):701-713.
    
    
  • Schulte LN, Bertrams W, Stielow C, Schmeck B. ncRNAs in Inflammatory and Infectious Diseases. Methods Mol Biol. 2019;1912:3-32.
    
    
  • Scheller N, Herold S, Kellner R, Bertrams W, Jung AL, Janga H, Greulich T, Schulte LN, Vogelmeier CF, Lohmeyer J, Schmeck B. Proviral MicroRNAs Detected in Extracellular Vesicles From Bronchoalveolar Lavage Fluid of Patients With Influenza Virus-Induced Acute Respiratory Distress Syndrome. J Infect Dis. 2019 Jan 29;219(4):540-543.

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  • Apweiler R, Beissbarth T, Berthold MR, Blüthgen N, Burmeister Y, Dammann O, Deutsch A, Feuerhake F, Franke A, Hasenauer J, Hoffmann S, Höfer T, Jansen PL, Kaderali L, Klingmüller U, Koch I, Kohlbacher O, Kuepfer L, Lammert F, Maier D, Pfeifer N, Radde N, Rehm M, Roeder I, Saez-Rodriguez J, Sax U, Schmeck B, Schuppert A, Seilheimer B, Theis FJ, Vera J, Wolkenhauer O. Whither systems medicine? Exp Mol Med. 2018 Mar 2;50(3):e453. Review.
  • Gutbier B, Schönrock SM, Ehrler C, Haberberger R, Dietert K, Gruber AD, Kummer W, Michalick L, Kuebler WM, Hocke AC, Szymanski K, Letsiou E, Lüth A, Schumacher F, Kleuser B, Mitchell TJ, Bertrams W, Schmeck B, Treue D, Klauschen F, Bauer TT, Tönnies M, Weissmann N, Hippenstiel S, Suttorp N, Witzenrath M; CAPNETZ Study Group. Sphingosine Kinase 1 Regulates Inflammation and Contributes to Acute Lung Injury in Pneumococcal Pneumonia via the Sphingosine-1-Phosphate Receptor 2. Crit Care Med. 2018 Mar;46(3):e258-e267.
    
    
  • Schulte LN, Heinrich B, Janga H, Schmeck BT, Vázquez O. A Far-Red Fluorescent DNA Binder for Interaction Studies of Live Multidrug-Resistant Pathogens and Host Cells. Angew Chem Int Ed Engl. 2018 Jul 4.
    
    
  • Janga H, Aznaourova M, Boldt F, Damm K, Grünweller A, Schulte LN. Cas9-mediated excision of proximal DNaseI/H3K4me3 signatures confers robust silencing of microRNA and long non-coding RNA genes. PLoS One. 2018 Feb 16;13(2):e0193066.

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  • Jung AL, Herkt CE, Schulz C, Bolte K, Seidel K, Scheller N, Sittka-Stark A, Bertrams W, Schmeck B. Legionella pneumophila infection activates bystander cells differentially by bacterial and host cell vesicles. Sci Rep. 2017 Jul 24;7(1):6301.
    
    
  • Jentho E, Bodden M, Schulz C, Jung AL, Seidel K, Schmeck B, Bertrams W. microRNA-125a-3p is regulated by MyD88 in Legionella pneumophila infection and targets NTAN1. PLoS One. 2017 Apr 26;12(4):e0176204. eCollection 2017.
    
    
  • Wentker P, Eberhardt M, Dreyer FS, Bertrams W, Cantone M, Griss K, Schmeck B, Vera J. An Interactive Macrophage Signal Transduction Map Facilitates Comparative Analyses of High-Throughput Data. J Immunol. 2017 Mar 1;198(5):2191-2201.
    
    
  • Jung AL, Hoffmann K, Herkt CE, Schulz C, Bertrams W, Schmeck B. Legionella pneumophila Outer Membrane Vesicles: Isolation and Analysis of Their Pro-inflammatory Potential on Macrophages. J Vis Exp. 2017 Feb 22;(120).

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  • Saliba AE, Li L, Westermann A, Appenzeller S. Stapels DAC, Schulte LN, Helaine S, Vogel J. Single‐cell RNA‐seq ties macrophage polarization to growth rate of intracellular Salmonella. Nature Microbiology, 2016, 2:16206
    
    
  • Garn  H, Bahn S, Baune BT, Binder EB, Bisgaard H, Chatila TA, Chavakis T, Culmsee C, Dannlowski U, Gay S, Gern J, Haahtela T, Kircher T, Müller-Ladner U, Neurath MF, Preissner KT, Reinhardt C, Rook G, Russell S, Schmeck B,  Stappenbeck T, Steinhoff U, van Os J, Weiss S, Zemlin M, Renz H. Current Concepts in Chronic Inflammatory Diseases: Interactions Between Microbes, Cellular Metabolism, and Inflammation. J Allergy Clin Immunol. 2016 Jul;138(1):47-56.
    
    
  • Du Bois I, Marsico A, Bertrams W, Schweiger MR, Caffrey BE, Sittka-Stark A, Eberhardt M, Vera J, Vingron M, Schmeck B. Genome-wide chromatin profiling of Legionella pneumophila-infected human macrophages reveals activation of the pro-bacterial host factor TNFAIP2. J Infect Dis. 2016 Apr 29. pii: jiw171.
    
    
  • Jung AL, Stoiber C, Herkt CE, Schulz C, Bertrams W, Schmeck B. Legionella pneumophila-Derived Outer Membrane Vesicles Promote Bacterial Replication in Macrophages. PLoS Pathog. 2016 Apr 22;12(4):e1005592. doi: 10.1371/journal.ppat.1005592. eCollection 2016 Apr.
    
    
  • Griss K, Bertrams W, Sittka-Stark A, Seidel K, Stielow C, Hippenstiel S, Suttorp N, Eberhardt M, Wilhelm J, Vera J, Schmeck B. MicroRNAs Constitute a Negative Feedback Loop in Streptococcus pneumoniae-Induced Macrophage Activation. J Infect Dis. 2016 Mar 16. pii: jiw109.
    
    
  • Westermann AJ, Förstner KU, Amman F, Barquist L, Chao Y, Schulte LN, Müller L, Reinhardt R, Stadler PF, Vogel J. Dual RNA-seq unveils noncoding RNA functions in host-pathogen interactions. Nature. 2016 Jan 28;529:496-501.
    
    
  • Eberhardt M, Lai X, Tomar N, Gupta S, Schmeck B, Steinkasserer A, Schuler G, Vera J. Third-Kind Encounters in Biomedicine: Immunology Meets Mathematics and Informatics to Become Quantitative and Predictive. Methods Mol Biol. 2016;1386:135-79.
    
    
  • Schmeck B, Bertrams W, Lai X, Vera J. Systems Medicine for Lung Diseases: Phenotypes and Precision Medicine in Cancer, Infection, and Allergy. Methods Mol Biol. 2016;1386:119-33.
    
    
  • Rozman D, Acimovic J, Schmeck B. Training in Systems Approaches for the Next Generation of Life Scientists and Medical Doctors. Methods Mol Biol. 2016;1386:73-86.

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  • Rohwer N, Bindel F, Grimm C, Lin SJ, Wappler J, Klinger B, Blüthgen N, Du Bois I, Schmeck B, Lehrach H, de Graauw M, Goncalves E, Saez-Rodriguez J, Tan P, Grabsch HI, Prigione A, Kempa S, Cramer T. Annexin A1 sustains tumor metabolism and cellular proliferation upon stable loss of HIF1A. Oncotarget. 2015 Dec 29.
    
    
  • Koepke J, Dresel M, Schmid S, Greulich T, Beutel B, Schmeck B, Vogelmeier CF, Janciauskiene S, Koczulla AR. Therapy with plasma purified alpha1-antitrypsin (Prolastin®) induces time-dependent changes in plasma levels of MMP-9 and MPO. PLoS One. 2015;10:e0117497.

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  • Chillappagari S, Venkatesan S, Garapati V, Mahavadi P, Munder A, Seubert A, Sarode G, Guenther A, Schmeck BT, Tümmler B, Henke MO. Impaired TLR4 and HIF expression in cystic fibrosis bronchial epithelial cells downregulates hemeoxygenase-1 and alters iron homeostasis in vitro. Am J Physiol Lung Cell Mol Physiol. 2014;307:L791-9.
    
    
  • von Deetzen MC, Schmeck BT, Gruber AD, Klopfleisch R. Malignancy Associated MicroRNA Expression Changes in Canine Mammary Cancer of Different Malignancies. ISRN Vet Sci.; 2014:148597.
    
    
  • Greulich T, Nell C, Koepke J, Fechtel J, Franke M, Schmeck B, Haid D, Apelt S, Filipovic S, Kenn K, Janciauskiene S, Vogelmeier C, Koczulla AR. Benefits of whole body vibration training in patients hospitalised for COPD exacerbations - a randomized clinical trial. BMC Pulm Med. 2014;14:60.

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  • Sittka A, Schmeck B. MicroRNAs in the lung. Adv Exp Med Biol. 2013; 774:121-34.
    
    
  • Sittka A, Vera J, Lai X, Schmeck BT. Asthma phenotyping, therapy, and prevention: what can we learn from systems biology? Pediatr Res. 2013; 73(4 Pt 2):543-52.
    
    
  • Zahlten J, Steinicke R, Bertrams W, Hocke AC, Scharf S, Schmeck B, Witzenrath M, Hammerschmidt S, Suttorp N, Hippenstiel S. TLR9- and Src-dependent expression of Krueppel-like factor 4 controls interleukin-10 expression in pneumonia. Eur Respir J. 2013; 41:384-91.

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  • Fuellen G, Dengjel J, Hoeflich A, Hoeijemakers J, Kestler HA, Kowald A, Priebe S, Rebholz-Schuhmann D, Schmeck B, Schmitz U, Stolzing A, Sühnel J, Wuttke D, Vera J. Systems biology and bioinformatics in aging research: a workshop report. Rejuvenation Res. 2012; 15:631-41.
  • Eitel J, Meixenberger K, van Laak C, Orlovski C, Hocke A, Schmeck B, Hippenstiel S, N'Guessan PD, Suttorp N, Opitz B. Rac1 regulates the NLRP3 inflammasome which mediates IL-1beta production in Chlamydophila pneumoniae infected human mononuclear cells. PLoS One. 2012; 7:e30379.

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  • Lorenz J, Zahlten J, Pollok I, Lippmann J, Scharf S, N'Guessan PD, Opitz B, Flieger A, Suttorp N, Hippenstiel S, Schmeck B. Legionella pneumophila-induced I?B?-dependent expression of interleukin-6 in lung epithelium. Eur Respir J. 2011;37:648-57.

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  • Müller HC, Hellwig K, Rosseau S, Tschernig T, Schmiedl A, Gutbier B, Schmeck B, Hippenstiel S, Peters H, Morawietz L, Suttorp N, Witzenrath M. Simvastatin attenuates ventilator-induced lung injury in mice. Crit Care. 2010; 14:R143.
    
    
  • Scharf S, Vardarova K, Lang F, Schmeck B, Opitz B, Flieger A, Heuner K, Hippenstiel S, Suttorp N, N'Guessan PD. Legionella pneumophila induces human beta defensin-3 in pulmonary cells. Respir Res. 2010; 11:93.
    
    
  • Zahlten J, Steinicke R, Opitz B, Eitel J, N'guessan PD, Vinzing M, Witzenrath M, Schmeck B, Hammerschmidt S, Suttorp N, Hippenstiel S. TLR2- and nucleotide-binding oligomerization domain 2-dependent Krüppel-like factor 2 expression downregulates NF-kappa B-related gene expression. J Immunol. 2010; 185:597-604
    
    
  • Meixenberger K, Pache F, Eitel J, Schmeck B, Hippenstiel S, Slevogt H, N'Guessan P, Witzenrath M, Netea MG, Chakraborty T, Suttorp N, Opitz B. Listeria monocytogenes-infected human peripheral blood mononuclear cells produce IL-1beta, depending on listeriolysin O and NLRP3. J Immunol. 2010; 184:922-30.

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  • Dje N'Guessan P, Riediger F, Vardarova K, Scharf S, Eitel J, Opitz B, Slevogt H, Weichert W, Hocke AC, Schmeck B, Suttorp N, Hippenstiel S. Statins control oxidized LDL-mediated histone modifications and gene expression in cultured human endothelial cells. Arterioscler Thromb Vasc Biol. 2009; 29:380-6.
    
    
  • Witzenrath M, Gutbier B, Schmeck B, Tenor H, Seybold J, Kuelzer R, Grentzmann G, Hatzelmann A, van Laak V, Tschernig T, Mitchell TJ, Schudt C, Rosseau S, Suttorp N, Schütte H. Phosphodiesterase 2 inhibition diminished acute lung injury in murine pneumococcal pneumonia. Crit Care Med. 2009; 37:584-90.
    
    
  • Witzenrath M, Schmeck B, Doehn JM, Tschernig T, Zahlten J, Loeffler JM, Zemlin M, Müller H, Gutbier B, Schütte H, Hippenstiel S, Fischetti VA, Suttorp N, Rosseau S. Systemic use of the endolysin Cpl-1 rescues mice with fatal pneumococcal pneumonia. Crit Care Med. 2009; 37:642-9.

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  • Eitel J, Krüll M, Hocke AC, N'Guessan PD, Zahlten J, Schmeck B, Slevogt H, Hippenstiel S, Suttorp N, Opitz B. Beta-PIX and Rac1 GTPase mediate trafficking and negative regulation of NOD2. J Immunol. 2008; 181:2664-71.
    
    
  • Schmeck B, Lorenz J, N'guessan PD, Opitz B, van Laak V, Zahlten J, Slevogt H, Witzenrath M, Flieger A, Suttorp N, Hippenstiel S. Histone acetylation and flagellin are essential for Legionella pneumophila-induced cytokine expression. J Immunol. 2008; 181:940-7.
    
    
  • Witzenrath M, Ahrens B, Schmeck B, Kube SM, Hippenstiel S, Rosseau S, Hamelmann E, Suttorp N, Schütte H. Rho-kinase and contractile apparatus proteins in murine airway hyperresponsiveness. Exp Toxicol Pathol. 2008; 60:9-15.
    
    
  • Vinzing M, Eitel J, Lippmann J, Hocke AC, Zahlten J, Slevogt H, N'guessan PD, Günther S, Schmeck B, Hippenstiel S, Flieger A, Suttorp N, Opitz B. NAIP and Ipaf control Legionella pneumophila replication in human cells. J Immunol. 2008; 180:6808-15.
    
    
  • Galka F, Wai SN, Kusch H, Engelmann S, Hecker M, Schmeck B, Hippenstiel S, Uhlin BE, Steinert M. Proteomic characterization of the whole secretome of Legionella pneumophila and functional analysis of outer membrane vesicles. Infect Immun. 2008; 76:1825-36.
    
    
  • Schmeck B, Beermann W, N'Guessan PD, Hocke AC, Opitz B, Eitel J, Dinh QT, Witzenrath M, Krüll M, Suttorp N, Hippenstiel S. Simvastatin reduces Chlamydophila pneumoniae-mediated histone modifications and gene expression in cultured human endothelial cells. Circ Res. 2008; 102:888-95.

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  • Witzenrath M, Gutbier B, Owen JS, Schmeck B, Mitchell TJ, Mayer K, Thomas MJ, Ishii S, Rosseau S, Suttorp N, Schütte H. Role of platelet-activating factor in pneumolysin-induced acute lung injury. Crit Care Med. 2007; 35:1756-62.
    
    
  • N'Guessan PD, Vigelahn M, Bachmann S, Zabel S, Opitz B, Schmeck B, Hippenstiel S, Zweigner J, Riesbeck K, Singer BB, Suttorp N, Slevogt H. The UspA1 protein of Moraxella catarrhalis induces CEACAM-1-dependent apoptosis in alveolar epithelial cells. J Infect Dis. 2007; 195:1651-60.
    
    
  • Hocke AC, Lampe MP, Witzenrath M, Mollenkopf H, Zerrahn J, Schmeck B, Kessler U, Krüll M, Hammerschmidt S, Hippenstiel S, Schütte H, Suttorp N, Rosseau S. Cell-specific interleukin-15 and interleukin-15 receptor subunit expression and regulation in pneumococcal pneumonia--comparison to chlamydial lung infection. Cytokine. 2007; 38:61-73
    
    
  • Temmesfeld-Wollbrück B, Brell B, Dávid I, Dorenberg M, Adolphs J, Schmeck B, Suttorp N, Hippenstiel S. Adrenomedullin reduces vascular hyperpermeability and improves survival in rat septic shock. Intensive Care Med. 2007; 33:703-10.
    
    
  • Opitz B, Rejaibi A, Dauber B, Eckhard J, Vinzing M, Schmeck B, Hippenstiel S, Suttorp N, Wolff T. IFNbeta induction by influenza A virus is mediated by RIG-I which is regulated by the viral NS1 protein. Cell Microbiol. 2007; 9:930-8.
    
    
  • Rosseau S, Hocke A, Mollenkopf H, Schmeck B, Suttorp N, Kaufmann SH, Zerrahn J. Comparative transcriptional profiling of the lung reveals shared and distinct features of Streptococcus pneumoniae and influenza A virus infection. Immunology. 2007; 120:380-91.
    
    
  • N'Guessan PD, Etouem MO, Schmeck B, Hocke AC, Scharf S, Vardarova K, Opitz B, Flieger A, Suttorp N, Hippenstiel S. Legionella pneumophila-induced PKCalpha-, MAPK-, and NF-kappaB-dependent COX-2 expression in human lung epithelium. Am J Physiol Lung Cell Mol Physiol. 2007; 292:L267-77.
    
    

• Inhalt ausklappen Inhalt einklappen 2006

  • Opitz B, Vinzing M, van Laak V, Schmeck B, Heine G, Günther S, Preissner R, Slevogt H, N'Guessan PD, Eitel J, Goldmann T, Flieger A, Suttorp N, Hippenstiel S. Legionella pneumophila induces IFNbeta in lung epithelial cells via IPS-1 and IRF3, which also control bacterial replication. J Biol Chem. 2006; 281:36173-9.
    
    
  • Schmeck B, Beermann W, van Laak V, Opitz B, Hocke AC, Meixenberger K, Eitel J, Chakraborty T, Schmidt G, Barth H, Suttorp N, Hippenstiel S. Listeria monocytogenes induced Rac1-dependent signal transduction in endothelial cells. Biochem Pharmacol. 2006; 72:1367-74.
    
    
  • Hocke AC, Temmesfeld-Wollbrueck B, Schmeck B, Berger K, Frisch EM, Witzenrath M, Brell B, Suttorp N, Hippenstiel S. Perturbation of endothelial junction proteins by Staphylococcus aureus alpha-toxin: inhibition of endothelial gap formation by adrenomedullin. Histochem Cell Biol. 2006; 126:305-16.
    
    
  • Schmeck B, Moog K, Zahlten J, van Laak V, N'Guessan PD, Opitz B, Rosseau S, Suttorp N, Hippenstiel S. Streptococcus pneumoniae induced c-Jun-N-terminal kinase- and AP-1 -dependent IL-8 release by lung epithelial BEAS-2B cells. Respir Res. 2006; 7:98.
    
    
  • Hippenstiel S, Opitz B, Schmeck B, Suttorp N. Lung epithelium as a sentinel and effector system in pneumonia--molecular mechanisms of pathogen recognition and signal transduction. Respir Res. 2006; 7:97.
    
    
  • Witzenrath M, Gutbier B, Hocke AC, Schmeck B, Hippenstiel S, Berger K, Mitchell TJ, de los Toyos JR, Rosseau S, Suttorp N, Schütte H. Role of pneumolysin for the development of acute lung injury in pneumococcal pneumonia. Crit Care Med. 2006; 34:1947-54.
    
    
  • N'Guessan PD, Hippenstiel S, Etouem MO, Zahlten J, Beermann W, Lindner D, Opitz B, Witzenrath M, Rosseau S, Suttorp N, Schmeck B. Streptococcus pneumoniae induced p38 MAPK- and NF-kappaB-dependent COX-2 expression in human lung epithelium. Am J Physiol Lung Cell Mol Physiol. 2006; 290:L1131-8.
    
    
  • Slevogt H, Tiwari KN, Schmeck B, Hocke A, Opitz B, Suttorp N, Seybold J. Adhesion of Moraxella catarrhalis to human bronchial epithelium characterized by a novel fluorescence-based assay. Med Microbiol Immunol. 2006; 195:73-83.
    
    
  • Slevogt H, Schmeck B, Jonatat C, Zahlten J, Beermann W, van Laak V, Opitz B, Dietel S, N'Guessan PD, Hippenstiel S, Suttorp N, Seybold J. Moraxella catarrhalis induces inflammatory response of bronchial epithelial cells via MAPK and NF-kappaB activation and histone deacetylase activity reduction. Am J Physiol Lung Cell Mol Physiol. 2006; 290:L818-26.
    
    
  • Schmeck B, Huber S, Moog K, Zahlten J, Hocke AC, Opitz B, Hammerschmidt S, Mitchell TJ, Kracht M, Rosseau S, Suttorp N, Hippenstiel S. Pneumococci induced TLR- and Rac1-dependent NF-kappaB-recruitment to the IL-8 promoter in lung epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2006; 290:L730-L737.
    
    
  • Krüll M, Bockstaller P, Wuppermann FN, Klucken AC, Mühling J, Schmeck B, Seybold J, Walter C, Maass M, Rosseau S, Hegemann JH, Suttorp N, Hippenstiel S. Mechanisms of Chlamydophila pneumoniae-mediated GM-CSF release in human bronchial epithelial cells. Am J Respir Cell Mol Biol. 2006; 34:375-82.
    
    
  • Opitz B, Püschel A, Beermann W, Hocke AC, Förster S, Schmeck B, van Laak V, Chakraborty T, Suttorp N, Hippenstiel S. Listeria monocytogenes activated p38 MAPK and induced IL-8 secretion in a nucleotide-binding oligomerization domain 1-dependent manner in endothelial cells. J Immunol. 2006; 176:484-90.

• Inhalt ausklappen Inhalt einklappen 2005

  • Brell B, Hippenstiel S, Dávid I, Pries AR, Habazettl H, Schmeck B, Suttorp N, Temmesfeld-Wollbrück B. Adrenomedullin treatment abolishes ileal mucosal hypoperfusion induced by Staphylococcus aureus alpha-toxin--an intravital microscopic study on an isolated rat ileum. Crit Care Med. 2005; 33:2810-016.
    
    
  • Schmeck B, Beermann W, van Laak V, Zahlten J, Opitz B, Witzenrath M, Hocke AC, Chakraborty T, Kracht M, Rosseau S, Suttorp N, Hippenstiel S. Intracellular bacteria differentially regulated endothelial cytokine release by MAPK-dependent histone modification. J Immunol. 2005; 175:2843-50.
    
    
  • N'Guessan PD, Schmeck B, Ayim A, Hocke AC, Brell B, Hammerschmidt S, Rosseau S, Suttorp N, Hippenstiel S. Streptococcus pneumoniae R6x induced p38 MAPK and JNK-mediated caspase-dependent apoptosis in human endothelial cells. Thromb Haemost. 2005; 94:295-303.
    
    
  • Brell B, Temmesfeld-Wollbrück B, Altzschner I, Frisch E, Schmeck B, Hocke AC, Suttorp N, Hippenstiel S. Adrenomedullin reduces Staphylococcus aureus alpha-toxin-induced rat ileum microcirculatory damage. Crit Care Med. 2005; 33:819-26.
    
    
  • Opitz B, Förster S, Hocke AC, Maass M, Schmeck B, Hippenstiel S, Suttorp N, Krüll M. Nod1-mediated endothelial cell activation by Chlamydophila pneumoniae. Circ Res. 2005; 96:319-26.
    

• Inhalt ausklappen Inhalt einklappen 2004

  • Schmeck B, Zahlten J, Moog K, van Laak V, Huber S, Hocke AC, Opitz B, Hoffmann E, Kracht M, Zerrahn J, Hammerschmidt S, Rosseau S, Suttorp N, Hippenstiel S. Streptococcus pneumoniae-induced p38 MAPK-dependent phosphorylation of RelA at the interleukin-8 promotor. J Biol Chem. 2004; 279:53241-7.
    
    
  • Walter C, Zahlten J, Schmeck B, Schaudinn C, Hippenstiel S, Frisch E, Hocke AC, Pischon N, Kuramitsu HK, Bernimoulin JP, Suttorp N, Krüll M. Porphyromonas gingivalis strain-dependent activation of human endothelial cells. Infect Immun. 2004; 72:5910-8.
    
    
  • Schmeck B, Gross R, N'Guessan PD, Hocke AC, Hammerschmidt S, Mitchell TJ, Rosseau S, Suttorp N, Hippenstiel S. Streptococcus pneumoniae-induced caspase 6-dependent apoptosis in lung epithelium. Infect Immun. 2004; 72:4940-7.
    
    
  • Opitz B, Püschel A, Schmeck B, Hocke AC, Rosseau S, Hammerschmidt S, Schumann RR, Suttorp N, Hippenstiel S. Nucleotide-binding oligomerization domain proteins are innate immune receptors for internalized Streptococcus pneumoniae.J Biol Chem. 2004; 279:36426-32.