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CAPSys

Systems medicine in Community Aquired Pneumonia

BMBF e:med: Maßnahmen zur Etablierung der Systemmedizin

e:Med is a new large-scale research program on Systems Medicine, funded by the Federal Ministry of Education and Research (BMBF) for 8 years.
e:Med brings together leading scientists and exceptional young researchers from all over Germany in the emerging field of Systems Medicine. Systems medicine uses interdisciplinary systems-oriented research on diseases to create a basis for understanding complex physiological and pathological processes for development of innovative personalized diagnosis, therapies, and preventive measures. Key to the appropriate analysis and possibly to the modelling of Big Data derived from information levels such as Genomics, Proteomics and Metabolomics is electronic processing (e:Med) i.e. computerized archiving, analysis and integration of data.

TP04: Experimental modelling and validation of pneumonia pathophysiology

In this subproject, central aspects of pneumonia pathology inaccessible to patient-centered research were elucidated in highly standardized and well-controlled experimental models in vitro, ex vivo and in vivo to provide homogenous data as starting points for mathematical modeling of pathophysiologic sequences. The experimental models were designed to parallel the patient’s course of disease or specific aspects thereof. Further experiments were hypothesis-driven and focus on promising signaling pathways and specific pathogen and host factors. With increasing progress of the mathematical modeling, the project was aimed at tightly interacting iteratively with the mathematical modelers to answer their questions regarding specific pathophysiological sequences of pneumonia that are considered particularly relevant or remain unclear.

Collaboration Partner:

Prof. Dr. med. Martin Witzenrath, Charité - Universitätsmedizin Berlin