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ERAGON - Inflammation cascades as Regulators of adaptive vascular Remodeling

TP 9: Epigenetic Mechanisms of vascular Remodeling in COPD

Vascular injury of any kind leads to unphysiological vascular remodeling with destruction of the vascular structure, the maladaptive vascular remodeling. This is known not only for chronic changes in atherosclerosis or arterial and pulmonary hypertension, but also after acute injury, for example due to balloon dilation. All these maladaptive regeneration processes have in common that they are driven and maintained by mechanisms of innate and acquired immunity and downstream inflammatory signaling cascades (NF-κB, MAP kinase, etc.). The central theme of the Research Training Group is the consideration of the pathological remodeling processes of the vascular wall. Specific pathophysiological spectra are to be displayed and analyzed along the anatomical structures from luminal to abluminal.