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We use state of the art technologies, including single cell/ single nuclei RNA sequencing and multiplex staining as well as imaging approaches to investigate lung aging. Here, our focus is on applying this technology on clinically relevant human models. To this end, we develop alveolar organoids that can be supplemented with immune cells. To be able to test potential anti-senescent therapies in the human system, we are developing a human aging model based on human precision cut lung slices (PCLS), which displays relevant hallmarks of aging, such as cellular senescence. We will use this model to verify target engagement of anti-senescent therapies in the human system and to screen for relevant biomarkers for companion diagnostics development.