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DZL - Disease Area COPD

Transition from lung health to COPD: Combining population-based and clinical cohorts including cohort-associated basic research and health economics

Population-based (KORA, Hamburg City Health Study [HCHS], NAKO) and clinical cohorts (COSYCONET-1 and COSYCONET-2 with a strong focus on early origins of COPD) will be combined to examine the full spectrum from respiratory health to very severe COPD. The overarching assessments include comprehensive phenotyping (lung function, comorbidities, physical activity) and biosampling (collaboration with basic science, proteasome, “sputum-omics”, imaging) to study disease trajectories, driving mechanisms and predictors for transition from respiratory health to COPD and its progression. HCHS includes lung function assessments (spirometry and bodyplethysmography) and comprehensive cardiovascular phenotyping (cardiac MRI), which allow to study respiratory and cardiovascular disease interactions. NAKO includes lung function assessments (spirometry) and comprehensive cardiovascular and pulmonary MRI. COSYCONET-1 and -2 (new cohort with strong focus on mild COPD subjects including CT and MRI) and KORA will continue and extend their close collaboration based on harmonized longitudinal assessments covering e.g. comorbidities, physical activity measurement, patient self-management, healthcare utilization and patient-reported outcomes as compared to COPD patients enrolled in a Bavarian DMP. The PACE Cohort recruiting in Berchtesgaden and the digital health project recruiting at ARCN will collect phenotyping data and biomaterial related to hospital-treated exacerbations with external funding.

Involved DZL Sites:
ARCN - Airway Research Center North
BREATH - Biomedical Research in End-stage and Obstructive Lung Disease Hannover
CPC-M - Comprehensive Pneumology Center Munich
UGMLC - Universities of Giessen and Marburg Lung Center
TLRC - Translational Lung Research Center