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2) Comparative analysis of the unfolded protein response during infection with SARS-CoV and SARS-CoV-2

SARS-CoV-2 (scheme and electron micrograph)

Severe acute respiratory syndrome coronavirus (SARS-CoV) and SARS-CoV-2 are coronaviruses (CoV) that can cause severe respiratory diseases in humans. During CoV infection, the accumulation of misfolded and unfolded proteins in the endoplasmic reticulum (ER) activates the unfolded protein response (UPR). However, the molecular processes of the UPR and the consequences in the context of a SARS-CoV and a SARS-CoV-2 infection are not fully understood yet. The aim of the project is the comparative analysis of the UPR in the context of a SARS-CoV and a SARS-CoV-2 infection, as well as a detailed characterization of the influence of certain coronaviral proteins on the UPR and the associated process of translation.