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Investigating the effects of different deep brain stimulation settings on inhibition control using EEG

Description

Parkinson's patients show a marked impairment in inhibitory control; they find it more difficult to suppress reflexive eye movements towards a stimulus. This is evidenced by a higher error rate and longer latency when performing antisaccades, i.e. eye movements against a light stimulus. This study aims to investigate the effects of different frequencies of deep brain stimulation (DBS) on inhibitory control. Brain activity during antisaccades is measured with a 128-electrode EEG, which can now be evaluated with the stimulation switched on thanks to high-resolution amplifiers. At the same time, the patients' eye movements are recorded with an eye tracker. The experiment is performed at four different THS frequencies (OFF, 60 Hz, 130 Hz, 180 Hz), while the other THS parameters remain unchanged.

Publications

• Waldthaler, J., Sperlich, A., König, A., Stüssel, C., Bremmer, F., Timmermann, L., & Pedrosa, D. (2022). High-and Low-Frequency Deep Brain Stimulation in the Subthalamic Nucleus differentially modulate Response Inhibition and Action Selection in Parkinson’s Disease. bioRxiv, 2022-05.
• Waldthaler, J., Sperlich, A., König, A., Stüssel, C., Bremmer, F., Timmermann, L., & Pedrosa, D. (2023). High (130 Hz)-and mid (60 Hz)-frequency deep brain stimulation in the subthalamic nucleus differentially modulate response inhibition: A preliminary combined EEG and eye tracking study. NeuroImage: Clinical, 103314.

Contact

Dr. Josefine Waldthaler
Mrs. Charlotte Stüssel
Telefone: 06421/58 - 65299
Telefax: 06421/58 - 67055
waldthaj@staff.*

* please add "uni-marburg.de" for a full email-address.