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Prospective study of walking on imaging-guided programming of deep brain stimulation in the subthalamic nucleus

Description

Although deep brain stimulation (DBS) in the subthalamic nucleus (STN) effectively alleviates the cardinal symptoms of Parkinson's disease, its efficacy in treating gait disorders and other axial symptoms is less well established. Low-frequency stimulation at 85 Hz could offer a promising approach, but there is disagreement about which stimulation targets are associated with optimal clinical outcomes. Against this background, mapping stimulation profiles using connectivity measurements has proven to be an effective method for identifying network structures underlying the development and successful treatment of symptoms. In this randomized controlled trial, we will investigate the effect of low-frequency DBS of the non-motor subregions of the STN on gait disorders and other axial symptoms. Using an image-guided DBS setting, brain tissue activation will be simulated in real time, allowing for precise stimulation of the associative subregion. Pre- and postoperative imaging will be used to generate a normative fingerprint of structural connectivity at the group level, which will be linked to changes in clinical symptoms based on DBS activation patterns.

Contact

Dr. med. Alexander Calvano
Dana Kasten
Telefone: 06421/58 - 65299
Telefax: 06421/58 - 67055
alexander.calvano@staff.*

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