Main Content
Publications of the Institute
2024
Rötte M, Höhne MY, Klug D, Zedler C, Lehne F, Schneider M, Ramlow K, Bischoff M and S. Bogdan. CYRI controls epidermal wound closure and cohesion of invasive border cell cluster in Drosophila. Journal of Cell Biology. 2024;223(12). DOI: 10.1083/jcb.202310153
Thiele PJ, Mela-Lopez R, Blandin SA, Klug D. Let it glow: genetically encoded fluorescent reporters in Plasmodium. Malar J. 2024 Apr 20;23(1):114.
Renigunta V, Xhaferri N, Shaikh IG, Schlegel J, Bisen R, Sanvido I, Kalpachidou T, Kummer K, Oliver D, Leitner MG, Lindner M. A versatile functional interaction between electrically silent K(V) subunits and K(V)7 potassium channels. Cell Mol Life Sci 2024 81:301. 10.1007/s00018-024-05312-1
Reis MC, Mandler L, Kang JS, Oliver D, Halaszovich C, Nolte D. A novel KCND3 variant in the N-terminus impairs the ionic current of Kv4.3 and is associated with SCA19/22. J Cell Mol Med 2024 28:e70039. 10.1111/jcmm.70039
Kuwabara MF, Klemptner J, Muth J, De Martino E, Oliver D, Berger TK. Zinc inhibits the voltage-gated proton channel HCNL1. Biophys J. 2024 10.1016/j.bpj.2024.08.018
Künzel SH, Broadbent E, Möller PT, Lindner M, Goerdt L, Czauderna J, Schmitz-Valckenberg S, Holz FG, Pfau M, Fleckenstein M. Association of Lesion Location and Functional Parameters with Vision-Related Quality of Life in Geographic Atrophy Secondary to Age-related Macular Degeneration. Ophthalmol Retina 2024 8:794-803. 10.1016/j.oret.2024.01.025
Geertsma ER, Oliver D. SLC26 Anion Transporters. Handb Exp Pharmacol 2024 283:319-360. 10.1007/164_2023_69
Bernhard FP, Schütte S, Heidenblut M, Oehme M, Rinné S & Decher N. A novel KCNC3 gene variant in the voltage-dependent Kv3.3 channel in an atypical form of SCA13 with dominant central vertigo. Front. Cell. Neurosci. 2024 18:1441257.
*Neelsen LC, *Riel EB, *Rinné S, Schmid F-R, Jürs BC, Bedoya M, Langer JP, Eymsh B, Kiper AK, Cordeiro S, #Decher N, #Baukrowitz T & #Schewe M. Ion occupancy of the selectivity filter controls opening of a cytoplasmic gate in the K2P channel TALK-2. Nature commun 2024 15: 7545. *shared first authors. #shared last and corresponding authors.
Rinné S, Schick F, Vowinkel K, Schütte S, Krasel C, Kauferstein S, Schäfer MK-H, Kiper AK, Müller T & #Decher N. Potassium channel TASK-5 forms functional heterodimers with TASK-1 and TASK-3 to break its silence. Nature Commun 2024 15: 7548. *shared first authors. #corresponding author.
Kiper AK, Wegner S, Kadala A, Rinné S, Schütte S, Winter Z, Bertoune MAR, Touska F, Matschke V, Wrobel E, Streit A-K, Lang F, Schmidt C, Schulze-Bahr E, Schäfer MK-H, Voelkl J, Seebohm G, Zimmermann K & Decher N. KCNQ1 is an essential mediator of the sex-dependent perception of moderate cold temperatures. Proc. Natl. Acad. Sci. 2024 USA 121: e2322475121.
Rinné S, Kiper AK, Jacob R, Ortiz-Bonnin B, Schindler RFR, Fischer S, Komadowski M, De Martino E, Schäfer MK-H, Cornelius T, Fabritz L, Helker CSM, Brand T & Decher N. Popeye-domain-containing proteins modulate the voltage-gated cardiac sodium channel Nav1.5. iScience. 2024 27: 109696.
Zhang Y, Shaabani S, Vowinkel K, Trombetta-Lima M, Sabogal-Guáqueta AM, Chen T, Hoekstra J, Lembeck J, Decher N, Dömling A & Dolga AM. Novel SK channel positive modulators prevent ferroptosis and excitotoxicity in neuronal cells. Biomed. Pharmacother. 2024 171: 116163.
2023
Geertsma ER, Oliver D. SLC26 Anion Transporters. Handb Exp Pharmacol. 2023 Nov 11. doi: 10.1007/164_2023_698. Epub ahead of print. PMID: 37947907.
Kuwabara MF, Haddad BG, Lenz-Schwab D, Hartmann J, Longo P, Huckschlag BM, Fuß A, Questino A, Berger TK, Machtens JP, Oliver D. Elevator-like movements of prestin mediate outer hair cell electromotility. Nat Commun. 2023 Nov 6;14(1):7145.
Hirschhaeuser A., Molitor D., Salinas G., Grosshans J., Rust K. and Bogdan S. (2023). Single-cell transcriptomics identifies new blood cell populations in Drosophila released at the onset of metamorphosis. Development. Sep 15;150(18):dev201767.Lehne F. and Bogdan S. (2023). Getting cells into shape by calcium-dependent actin cross-linking proteins. Front Cell Dev Biol. Mar 21;11:1171930.
Lehne F. and Bogdan S. (2023). Swip-1 promotes exocytosis of glue granules in the exocrine Drosophila salivary gland. J Cell Sci. Mar 15;136(6):jcs260366.
Bischoff M.C. and S. Bogdan (2023). Dissecting Collective Cell Behavior in Migrating Testis Myotubes in Drosophila. Methods Mol Biol. 2608:117-129.
Labbaf A, Dellin M, Komadowski M, Chetkovich D, Decher N, Pape H-C, Seebohm G, Budde T & Zobeiri M. (2023). Characterization of Kv1.2-mediated outward current in TRIP8b-deficient mice. Biol Chem. Mar 1;404(4):291-302.
Vera-Zambrano A, Baena-Nuevo M, Rinné S, Villegas-Esguevillas M, Barreira B, Telli G, de Benito-Bueno A, Antonio Blázquez J, Climent B, Pérez-Vizcaino F, Valenzuela C, Decher N, Gonzalez T & Cogolludo A. (2023). Sigma-1 receptor modulation fine-tunes Kv1.5 channels and impacts pulmonary vascular function. Pharmacol Res. Mar;189:106684.
*Rinné S, *Oertli A, Nagel C, Tomsits P, Jenewein T, Kääb S, Kauferstein S, Loewe A, ‡Beckmann BM & ‡,#Decher N. (2023). Functional characterization of a spectrum of novel Romano-Ward Syndrome KCNQ1 variants. Int. J. Mol. Sci. 24: 1350. *shared first authors. ‡shared senior authors. #corresponding author.
Swan A, Schindler R, Savarese M, Mayer I, Rinné S, Bleser F, Schaenzer A, Hahn A, Sabatelli M, Perna F, Chapman K, Pfuhl M, Spivey A, Decher N, Udd B, Tasca G & Brand T. (2023). Differential effects of mutations of POPDC proteins on heteromeric interaction and membrane trafficking. Acta Neuropathol Commun 11: 4.
Schreiber JA, Derksen A, Goerges G, Schütte S, Sörgel J, Kiper AK, Strutz-Seebohm N, Ruck T, Meuth SG, Decher N & Seebohm G. (2023). Cloxyquin activates hTRESK by allosteric modulation of the selectivity filter. Communications Biology. In Press.
Fender H, Walter K, Kiper AK, Plačkić J, Kisko TM, Braun MD, Schwarting RKW, Rohrbach S, Wöhr M, Decher N & Kockskämper J. (2023). Calcium handling remodeling underlies impaired sympathetic stress response in ventricular myocardium from CACNA1C haploinsufficient rats. Int J Mol Sci. Jun 6;24(12):9795.
Grahn E, Kaufmann SV, Askarova M, Ninov M, Welp LM, Berger TK, Urlaub H, Kaupp UB. Control of intracellular pH and bicarbonate by CO2 diffusion into human sperm. Nat Commun. 2023 Sep 5;14(1):5395.
Thallmair V, Schultz L, Evers S, Jolie T, Goecke C, Leitner MG, Thallmair S, Oliver D. Localization of the tubby domain, a PI(4,5)P2 biosensor, to E-Syt3-rich endoplasmic reticulum-plasma membrane junctions. J Cell Sci. 2023 Aug 1;136(15):jcs260848.
Lindner LA, Derstroff D, Oliver D, Reimann K. Distribution of ciliary adaptor proteins tubby and TULP3 in the organ of Corti. Front Neurosci. 2023 Apr 18;17:1162937.
Rodgers J, Hughes S, Lindner M, Allen AE, Ebrahimi AS, Storchi R, Peirson SN, Lucas RJ, Hankins MW. Functional integrity of visual coding following advanced photoreceptor degeneration. Curr Biol. 2023 Feb 6;33(3):474-486.e5.
Del Rey A, Besedovsky H. The immune system tends to eliminate the host when it cannot control pathogenic threats: Evolutionary, medical, and epidemiologic perspectives. Brain Behav Immun. 2023 Mar;109:90-91.
2022
Borkuti, P., I. Kristo, A. Szabo, C. Bajusz, Z. Kovacs, Z. Rethi-Nagy, Z. Lipinszki, T. Lukacsovich, S. Bogdan, and P. Vilmos. 2022. Parallel import mechanisms ensure the robust nuclear localization of actin in Drosophila. Front Mol Biosci. 9:963635.
Thallmair V, Schultz L, Zhao W, Marrink SJ, Oliver D, Thallmair S. (2022) Two cooperative binding sites sensitize PI(4,5)P2 recognition by the tubby domain. Sci Adv 8:eabp9471.Lenz D, Oliver D. (2022) Progress in understanding the structural mechanism underlying prestin's electromotile activity. Hear Res 423:108423.
Lehne, F., T. Pokrant, S. Parbin, G. Salinas, J. Grosshans, K. Rust, J. Faix, and S. Bogdan (2022) Calcium bursts allow rapid reorganization of EFhD2/Swip-1 cross-linked actin networks in epithelial wound closure. Nature Communications 13:2492.
Keshavarz M, Faraj Tabrizi S, Ruppert AL, Pfeil U, Schreiber Y, Klein J, Brandenburger I, Lochnit G, Bhushan S, Perniss A, Deckmann K, Hartmann P, Meiners M, Mermer P, Rafiq A, Winterberg S, Papadakis T, Thomas D, Angioni C, Oberwinkler J, Chubanov V, Gudermann T, Gärtner U, Offermanns S, Schütz B, Kummer W. Cysteinyl (2022) Leukotrienes and acetylcholine are biliary tuft cell cotransmitters. Sci Immunol. Mar 4;7(69):eabf6734. doi: 10.1126/sciimmunol.abf6734. Epub 2022 Mar 4. PMID: 35245090
Schreiber JA, Möller M, Zaydman M, Zhao L, Beller Z, Becker S, Ritter N, Hou P, Shi J, Silva J, Wrobel E, Strutz-Seebohm N, Decher N, Schmitt N, Meuth SG, Düfer M, Wünsch B, Cui J & Seebohm G. (2022). A benzodiazepine activator locks Kv7.1 channels open by electro-mechanical uncoupling. Communications Biology. In Press.
Valdés-Jiménez A, Jiménez-González D, Reyes-Parada M, Rinné S, Kiper AK, Decher N, González W & Núñez-Vivanco G. (2022). A new strategy for multitarget drug discovery/repositioning through the identification of similar 3D amino acid patterns among proteins structures: the case of tafluprost and its effects on cardiac ion channels. Frontiers in Pharmacology. In Press.
Matschke LA, Komadowski MA, Stöhr A, Lee B, Henrich MT, Griesbach M, Rinné S, Geibl FF, Chiu W-H, Koprich JB, Brotchie JM, Kiper AK, Dolga AM, Oertel WH & Decher N. (2022). Enhanced firing of locus coeruleus neurons and SK channel dysfunction are conserved in distinct models of prodromal Parkinson’s disease. Scientific Reports. In Press.
Wiedmann F, Beyersdorf C, Zhou X-B, Kraft M, Paasche A, Jávorszky N, Rinné S, Sutanto H, Büscher A, Foerster KI, Blank A, El-Battrawy I, Li X, Lang S, Tochtermann U, Kremer J, Arif R, Karck M, Decher N, van Loon G, Akin I, Borggrefe M, Kallenberger S, Heijman J, Haefeli WE, Katus HA & Schmidt C. (2022). Treatment of atrial fibrillation with doxapram: TASK‑1 potassium channel inhibition as a novel pharmacological strategy. Card. Res. In Press.
Li, H., Janssens, J., De Waegeneer, M., Kolluru, S.S., Davie, K., Gardeux, V., Saelens, W., David, F., Brbić, M., Leskovec, J., Rust, K., et al. (2022). Fly Cell Atlas: a single-cell transcriptomic atlas of the adult fruit fly. Science, Mar 4;375(6584).
Rust, K.*, and Wodarz, A*. (2021). Transcriptional Control of Apical-Basal Polarity Regulators. Int J Mol Sci. 2021 Nov 15;22(22):12340.
Bischoff, M.C., and S. Bogdan (2022). Analysis of collective cell behavior in migrating testis myotubes in Drosophila. Methods Molecular Biology, in press.
2021
Lindner M, Gilhooley MJ, Peirson SN, Hughes S, Hankins MW (2021). The functional characteristics of optogenetic gene therapy for vision restoration. Cell. Mol. Life Sci. 78:1597-613
Schlingmann KP, Renigunta A, Hoorn EJ, Forst AL, Renigunta V, Atanasov V, Mahendran S, Barakat TS, Gillion V, Godefroid N, Brooks AS, Lugtenberg D, Lake J, Debaix H, Rudin C, Knebelmann B, Tellier S, Rousset-Rouvière C, Viering D, de Baaij JHF, Weber S, Palygin O, Staruschenko A, Kleta R, Houillier P, Bockenhauer D, Devuyst O, Rosa Vargas-Poussou R, Warth R, Zdebik AA, Konrad M (2021). Defects in KCNJ16 Cause a Novel Tubulopathy with Hypokalemia, Salt Wasting, Disturbed Acid-Base Homeostasis, and Sensorineural Deafness.
J Am Soc Nephrol. 32:1498-1512Ramírez D, Mejía-Gutiérrez M, Insuasty B, Rinné S, Kiper AK, Platzk M, Müller T, Decher N, Quiroga J, De-la-Torre P & González W. (2021). 5-(indol-2-yl)pyrazolo[3,4-b]pyridines as a new family of TASK-3 Channel Blockers: a Pharmacophore-based Regioselective Synthesis. Molecules. 2021 Jun 25;26(13):3897.
Wiedmann F, Beyersdorf C, Zhou X-B, Kraft M, Paasche A, Jávorszky N, Rinné S, Sutanto H, Büscher A, Foerster KI, Blank A, El-Battrawy I, Li X, Lang S, Tochtermann U, Kremer J, Arif R, Karck M, Decher N, van Loon G, Akin I, Borggrefe M, Kallenberger S, Heijman J, Haefeli WE, Katus HA & Schmidt C. (2021). Treatment of atrial fibrillation with doxapram: TASK‑1 potassium channel inhibition as a novel pharmacological strategy. Cardiovasc Res. 2021 May 24:cvab177.
Hirschhäuser A, van Cann M, Bogdan S. (2021). CK1α protects WAVE from degradation to regulate cell shape and motility in immune response. J Cell Sci. 2021 Nov 3;. https://doi.org/10.1242/jcs.258891
Bischoff M, Bogdan S (2021). Collective cell migration driven by filopodia—New insights from the social behavior of myotubes. BioEssays. https://doi.org/10.1002/bies.202100124
Rust K, Byrnes LE, Yu KS, Park JS, Sneddon JB, Tward AD, Nystul TG (2021).Author Correction: A single-cell atlas and lineage analysis of the adult Drosophila ovary. Nat Commun 2021 Oct 6;12(1):5951.
*Kiper AK, *Bedoya M, *Stalke S, *Marzian S, Ramírez D, Cruz Adl, Peraza DA, Vera-Zambrano A, Márquez Montesinos JCE, Arévalo Ramos BA, Rinné S, Gonzalez T, Valenzuela C, Gonzalez W & #Decher N. (2021). Identification of a critical binding site for local anesthetics in the side pockets of Kv1 channels. Br. J. Pharmacol. In Press. *shared first authors. #corresponding author.*,#Decher N, *Rinné S, Bedoya M, González W & Kiper AK. (2021). Molecular pharmacology of K2P potassium channels. Cell. Physiol. Biochem. 55: 87-107. Invited Review. *shared first author. #corresponding author.
*Oertli A, *Rinné S, Moss KR, Kääb S, Seemann G, Beckmann BM & Decher N. (2021). Molecular mechanism of autosomal recessive long QT-syndrome 1 without deafness. Int. J. Mol. Sci. 22:1112. *shared first author.
Bischoff, M.C., S. Lieb, R. Renkawitz-Pohl, and S. Bogdan. (2021). Filopodia-based contact stimulation of cell migration drives tissue morphogenesis. Nature Communications 12:791.
Wiedmann F, Rinné S, Donner B, Decher N, Katus HA & Schmidt C (2021). Mechanosensitive TREK-1 two-pore-domain potassium (K2P) channels in the cardiovascular system. Prog Biophys Mol Biol Jan;159:126-135.2020
*Endres D, *Decher N, Röhr I, Vowinkel K, Domschke K, Komlosi K, Tzschach A, Gläser B, Schiele M, Runge K, Süß P, Schuchardt F, Nickel K, Stallmeyer B, Rinné S, Schulze-Bahr E & Tebartz van Elst L. (2020). New Cav1.2 Channelopathy with high-functioning autism, affective disorder, severe dental enamel defects, a short QT interval, and a novel CACNA1C loss-of-function mutation. Int. J. Mol. Sci. 21: 8611. * shared first author.
Erlenhardt N, Kletke O, Wohlfarth F, Komadowski MA, Clasen L, Makimoto H, Rinné S, Kelm M, Jungen C, Decher N, Meyer C & Klöcker N. (2020). Disease-associated HCN4 V759I variant is not sufficient to impair cardiac pacemaking. Pflügers Archive. 472: 1733-1742.
Rinné S, Ortiz-Bonnin B, Stallmeyer B, Kiper AK, Fortmüller L, Schindler RFR, Herbort-Brand U, Kabir NS, Dittmann S, Friedrich C, Zumhagen S, Gualandi F, Selvatici R, Rapezzi C, Arbustini E, Ferlini A, Fabritz L, Schulze-Bahr E, Brand T & *Decher N. (2020). POPDC2 a novel susceptibility gene for conduction disorders. J. Mol. Cell Cardiol. 145: 74-83. *corresponding author.
Lindner M, Gilhooley MJ, Peirson SN, Hughes S, Hankins MW (2020). The functional characteristics of optogenetic gene therapy for vision restoration. Cell. Mol. Life Sci Jul 29.
Pfau M, von der Emde L, Dysli C, Möller PT, Thiele S, Lindner M, Schmid M, Rubin DL, Fleckenstein M, Holz FG, Schmitz-Valckenberg S (2020). Determinants of Cone and Rod Functions in Geographic Atrophy: AI-Based Structure-Function Correlation. Am. J. Ophthalmol 217:162-73.
Zou X, Conrad LJ, Koschinsky K, Schlichthörl G, Preisig-Müller R, Netz E, Krüger J, Daut J, Renigunta V (2020). The Phosphodiesterase Inhibitor IBMX Blocks the Potassium Channel THIK-1 from the Extracellular Side. Mol Pharmacol 98:143-55.
#Rödström KEJ, #Kiper AK, Zhang W, Rinné S, Pike ACW, Goldstein M, Conrad LJ, Delbeck M, Hahn MG, Meier H, Platzk M, Quigley A, Speedman D, Shrestha L, Mukhopadhyay SMM, Burgess-Brown NA, Tucker SJ, Mueller T, *Decher N & *Carpenter EP (2020). A lower X-gate in TASK channels traps inhibitors within the vestibule. Nature Jun;582(7812):443-447. *Shared senior and corresponding authors. #Shared first authors.
Lindner M, Gilhooley MJ, Palumaa T, Morton AJ, Hughes S, Hankins MW (2020). Expression and Localization of KCNE2 in the Vertebrate Retina. Invest. Ophtalmol. Vis. Sci 61:33.
Bustos D, Bedoya M, Ramirez D, Concha G, Zúñiga L, Decher N, Hernandez EW, Sepúlveda FV, Martinez L & González W (2020). Elucidating the structural basis of the intracellular pH sensing mechanism of TASK-2 K2P channel. Int. J. Mol. Sci 21: E532.
Perniss A, Liu S, Boonen B, Keshavarz M, Ruppert AL, Timm T, Pfeil U, Soultanova A, Kusumakshi S, Delventhal L, Aydin Ö, Pyrski M, Deckmann K, Hain T, Schmidt N, Ewers C, Günther A, Lochnit G, Chubanov V, Gudermann T, Oberwinkler J, Klein J, Mikoshiba K, Leinders-Zufall T, Offermanns S, Schütz B, Boehm U, Zufall F, Bufe B, Kummer W (2020). Chemosensory Cell-Derived Acetylcholine Drives Tracheal Mucociliary Clearance in Response to Virulence-Associated Formyl Peptides. Immunity Apr 14;52(4):683-699.e11.
Rust K and Nystul TG. (2020) ‘Signal transduction in the early Drosophila follicle stem cell lineage’, Current Opinion in Insect Science, 37, pp. 39–48.
Rust K, Byrnes LE, Shengyang K, Park JS, Sneddon JB, Tward AD, Nystul TG. (2020) ‘A Single-Cell Atlas and Lineage Analysis of the Adult Drosophila Ovary’, Nature Communications 11(1):5628
Behrendt M, Gruss F, Enzeroth R, Dembla S, Zhao S, Crassous PA, Mohr F, Nys M, Louros N, Gallardo R, Zorzini V, Wagner D, Economou A, Rousseau F, Schymkowitz J, Philipp SE, Rohacs T, Ulens C, Oberwinkler J (2020). The structural basis for an on-off switch controlling Gbetagamma-mediated inhibition of TRPM3 channels. Proc Natl Acad Sci U S A 117(46):29090-29100Ruppert AL, Keshavarz M, Winterberg S, Oberwinkler J, Kummer W, Schütz B (2020). Advillin is a tuft cell marker in the mouse alimentary tract. J Mol Histol 51(4):421-435
Dierich M, Altoè A, Koppelmann J, Evers S, Renigunta V, Schäfer MK, Naumann R, Verhulst S, Oliver D, Leitner MG (2020) Optimized Tuning of Auditory Inner Hair Cells to Encode Complex Sound through Synergistic Activity of Six Independent K+ Current Entities. Cell Rep. 32:107869.Schladt TM, Berger TK (2020) Voltage and pH difference across the membrane control the S4 voltage-sensor motion of the Hv1 proton channel. Sci. Rep. 10:21293.
Wobig L, Wolfenstetter T, Fechner S, Bönigk W, Körschen HG, Jikeli JF, Trötschel C, Feederle R, Kaupp UB, Seifert R, Berger TK (2020) A family of hyperpolarization-activated channels selective for protons. Proc. Natl. Acad. Sci. U. S. A. 117:13783-91.
2019
Dierich M, Hartmann S, Dietrich N, Moeser P, Brede F, Johnson Chacko L, Tziridis K, Schilling A, Krauss P, Hessler S, Karch S, Schrott-Fischer A, Blumer M, Birchmeier C, Oliver D, Moser T, Schulze H, Alzheimer C, Leitner MG, Huth T (2019). β-secretase BACE1 is required for normal cochlear function. The Journal of Neuroscience Nov 6;39(45):9013-9027 (coverpicture).
Dierich M, van Ham WB, Stary-Weinzinger A, Leitner MG (2019). Histidine at position 462 determines the low quinine sensitivity of ether-a-go-go channel superfamily member Kv 12.1. Br J Pharmacol 176:2708-2723.
Chang Y-N, Jaumann EA, Reichel K, Hartmann J, Oliver D, Hummer G, Joseph B, Geertsma ER (2019).
Structural basis for functional interactions in dimers of SLC26 transporters. Nature Communications 10:2032.
Leitner MG, Oliver D (2019). A choreography of intracellular Ca(2+) and extracellular ATP to refine auditory nociceptors before hearing. EMBO J May 2;38(9):e101980.
Leitner MG, Thallmair V, Wilke BU, Neubert V, Kronimus Y, Halaszovich CR, Oliver D (2019). The N-terminal homology (ENTH) domain of Epsin 1 is a sensitive reporter of physiological PI(4,5)P2 dynamics. BBA - Mol Cell Biol Lipids 1864:433-442.
Horsthemke, M., Nutter, L.M.J., Bachg, A.C., Skryabin, B.V., Honnert, U., Zobel, T., Bogdan, S., Stoll, M., Seidl, M.D., Mueller, F.U., et al. (2019). A novel isoform of myosin 18A (Myo18Agamma) is an essential sarcomeric protein in mouse heart. J Biol Chem. 3;294(18):7202-7218.
Stuerner, T., Tatarnikova, A., Mueller, J., Schaffran, B., Cuntz, H., Zhang, Y., Nemetova, M., Bogdan, S., Small, V. and Tavosanis, G. (2019). Transient localization of the Arp2/3 complex initiates neuronal dendrite branching in vivo. Development Apr 4;146(7):dev171397.
Bedoya M, Rinné S, Kiper AK, Decher N, González W, Ramírez D. (2019). TASK Channels Pharmacology: New Challenges in Drug Design. J Med Chem 62(22):10044-10058.
Ramírez D*, Bedoya M, Kiper AK, Rinné S, Morales-Navarro S, Hernández-Rodríguez EW, Sepúlveda FV, Decher N* & González W*. (2019). Structure/activity analysis of TASK-3 channel antagonists based on a 5,6,7,8 tetrahydropyrido[4,3-d]pyrimidine. Int. J. Mol. Sci 7;20(9):2252. *shared corresponding author *shared corresponding author
Wiedmann F, Kiper AK, Bedoya M, Ratte A, Rinné S, Kraft M, Waibel M, Anad P, Wenzel W, Gonzalez W, Katus HA, Decher N* & Constanze Schmidt*. (2019). Identification of the A293 (AVE1231) binding site in the cardiac two-pore domain potassium channel TASK-1: a common low affinity antiarrhythmic drug binding site. Cell. Physiol. Biochem. 52: 1223-1235. *shared senior and corresponding author
Rinné S, Kiper AK, Vowinkel KS, Ramírez D, Schewe M, Bedoya M, Aser D, Gensler I, Netter MF, Stansfeld PJ, Baukrowitz T, González W & Decher N*. (2019). The molecular basis for an allosteric inhibition of K+-flux gating in K2P channels. eLIFE. Feb 26: 8. *corresponding author
Schewe M, Sun H, Mert Ü, Mackenzie A, Pike ACW, Schulz F, Constantin C, Vowinkel KS, Conrad LJ, Kiper AK, Gonzalez W, Musinszki M, Tegtmeier M, Pryde DC, Belabed H, Nazare M, de Groot BL, Decher N, Fakler B, Carpenter EP, Tucker SJ & Baukrowitz T. (2019). A pharmacological master key mechanism that unlocks the selectivity filter gate in K+ channels. Science. 363: 875-880.
Key J, Mueller A-K, Gispert S, Matschke L, Wittig I, Corti O, Münch C, Decher N* & Auburger G*. (2019).
Ubiquitylome profiling of Parkin-null brain reveals dysregulation of calcium homeostasis factors ATP1A2,Hippocalcin and GNA11, reflected by altered firing of noradrenergic neurons. Neurobiol. Dis 127:114-130. *shared corresponding authors
Kuß J, Stallmeyer B, Hain E, Goldstein M, Rinné S, Pees C, Zumhagen S, Seebohm G, Decher N, Pott L, Kienitz M-C & Schulze-Bahr E. (2019). Familial sinus node disease caused by a gain of GIRK channel function. Circ. Genom. Precis. Med. 12: e002238.
2018
Hackelberg S, Oliver D (2018) Metabotropic Acetylcholine and Glutamate Receptors mediate PI(4,5)P2 Depletion and Oscillations in Hippocampal CA1 Pyramidal Neurons in situ. Sci Rep Aug 28;8(1):12987.
Dierich M, Leitner MG (2018) Kv12.1 channels are not sensitive to GqPCR-triggered activation of phospholipase Cβ. Channels 12:228-239.
Leitner MG, Hobiger K, Mavrantoni A, Feuer A, Oberwinkler J, Oliver D, Halaszovich CR (2018) A126 in the active site and TI167/168 in the TI loop are essential determinants of the substrate specificity of PTEN. Cell Mol Life Sci 75:4235-4250.
Dierich M, Evers S, Wilke BU, Leitner MG (2018) Inverse Modulation of Neuronal Kv12.1 and Kv11.1 Channels by 4-Aminopyridine and NS1643. Front Mol Neurosci 11:11.
Qi Y, Mair N, Kummer KK, Leitner MG, Camprubi-Robles M, Langeslag M, Kress M (2018) Identification of Chloride Channels CLCN3 and CLCN5 Mediating the Excitatory Cl(-) Currents Activated by Sphingosine-1-Phosphate in Sensory Neurons. Front Mol Neurosci 11:33.Scherzinger, A., Hugenroth, P., Rüder, M., Bogdan, S. and Jiang, X. (2018). Multi-class Cell Segmentation using CNNs with F1-measure Loss Function. Contributed to the Proc. of 40th German Conference on Pattern Recognition (GCPR), Stuttgart.
Rüder M, Nagel BM, Bogdan S. (2018). Analysis of Cell Shape and Cell Migration of Drosophila Macrophages In Vivo. Methods Molecular Biology Vol. 1749, 978-1-4939-7700-0.
Soufi M, Ruppert V, Rinné S, Mueller T, Kurt B, Pilz G, Maieron A, Dodel R, Decher N & Schaefer JR. (2018). Increased KCNJ18 promoter activity as a mechanism in atypical normokalemic periodic paralysis. Neurol. Genet. 4: e274.
Möller M, Silbernagel N, Wrobel E, Stallmayer B, Amedonu E, Rinné S, Peischard S, Meuth SG, Wünsch B, Strutz-Seebohm N, Decher N, Schulze-Bahr E & Seebohm G. (2018). In vitro analyses of novel HCN4 gene mutations. Cell. Physiol. Biochem. 49: 1197-1207.
Silbernagel N, Walecki M, Schäfer MK-H, Kessler M, Zobeiri M, Rinné S, Kiper AK, Komadowski MA, Vowinkel KS, Wemhöner K, Fortmüller L, Schewe M, Dolga AM, Scekic‑Zahirovic J, Matschke LA, Culmsee C, Baukrowitz T, Monassier L, Ullrich ND, Dupuis L, Just S, Budde T, Fabritz L & Decher N.* (2018). The VAMP-associated protein VAPB is required for cardiac and neuronal pacemaker channel function. FASEB J. 32: 6159-6173. *corresponding author
Pott A, Bock S, Berger IM, Frese K, Dahme T, Kessler M, Rinné S, Decher N, Just S & Rottbauer W. (2018). Mutation of the Na+/K+-ATPase Atp1a1a.1 causes QT interval prolongation and bradycardia in zebrafish.
J. Mol. Cell. Cardiol. 120: 42–52.Henrich MT, Geibl FF, Lee B, Chiu W-H, Koprich JB, Brotchie JM, Timmermann L, Decher N, §Matschke LA & §Oertel WH. (2018). A53T-α-synuclein overexpression in murine locus coeruleus induces Parkinson's disease-like pathology in neurons and glia. Acta. Neuropathol. Commun. 6: 39. §shared last authors
*Matschke LA, Rinné S, Snutch TP, Oertel WH, Dolga AM & *Decher N. (2018). Calcium-activated SK potassium channels are key modulators of the pacemaker frequency in locus coeruleus neurons. Mol. Cell. Neuroci. 88: 330–341. *corresponding authors
2017
Vogl C, Butola T, Haag N, Hausrat TJ, Leitner MG, Moutschen M, Lefebvre PP, Speckmann C, Garrett L, Becker L, Fuchs H, Hrabe de Angelis M, Nietzsche S, Kessels MM, Oliver D, Kneussel M, Kilimann MW, Strenzke N (2017) The BEACH protein LRBA is required for hair bundle maintenance in cochlear hair cells and for hearing. EMBO Rep 18:2015-2029.
Dembla, S., M. Behrendt, F. Mohr, C. Goecke, J. Sondermann, F. M. Schneider, M. Schmidt, J. Stab, R. Enzeroth, M. G. Leitner, P. Nunez-Badinez, J. Schwenk, B. Nurnberg, A. Cohen, S. E. Philipp, W. Greffrath, M. Bunemann, D. Oliver, E. Zakharian, M. Schmidt and J. Oberwinkler (2017). Anti-nociceptive action of peripheral mu-opioid receptors by G-beta-gamma protein-mediated inhibition of TRPM3 channels. Elife Aug 15;6:e26280.
Constantin CE, Müller CS, Leitner MG, Bildl W, Schulte U, Oliver D, Fakler B (2017) Identification of Cav2–PKCβ and Cav2–NOS1 complexes as entities for ultrafast electrochemical coupling. Proc Natl Acad Sci USA 114:5707-5712.
Santos-Sacchi J, Navaratnam D, Raphael RM, Oliver D (2017) Prestin - molecular mechanisms underlying outer hair cell electromotility. In: Understanding the cochlea (Manley GA, Gummer AW, eds). New York: Springer.Nagel BM, Bechtold M, Rodriguez LG, Bogdan S. (2017). Drosophila WASH is required for integrin-mediated cell adhesion, cell motility and lysosomal neutralization. Journal of cell Science 130: 344-359, cover picture.
Rottner K, Faix J, Bogdan S, Linder S, Kerkhoff E. (2017). Actin assembly mechanisms at a glance. Journal of Cell Science Oct 15;130(20):3427-3435.
Brüser L, Bogdan S. (2017). Molecular Control of Actin Dynamics In Vivo: Insights from Drosophila. Handbook of experimental pharmacology 235: 285-310.
Rothenbusch-Fender S, Fritzen K, Bischoff MC, Buttgereit D, Oenel SF, Renkawitz-Pohl R (2017). Myotube migration to cover and shape the testisof Drosophila depends on Heartless, Cadherin/Catenin, and myosin II. Biology Open. Dec 15;6(12):1876-1888
Brüser L, Bogdan S. (2017). Adherens Junctions on the Move-Membrane Trafficking of E-Cadherin. Cold Spring Harb Perspect Biol Mar 1;9(3):a029140.
Rinné S, Kiper AK, Schmidt C, Ortiz-Bonnin B, Zwiener S, Seebohm G & *Decher N. (2017). Stress-Kinase Regulation of TASK-1 and TASK-3. Cell. Physiol. Biochem. 44: 1024-1037. *corresponding author
Leist M, Rinné S, Datunashvili M, Aissaoui A, Pape H-C, Decher N, Meuth SG & Budde T. (2017). Acetylcholine-dependent upregulation of TASK-1 channels in thalamic interneurons by a smooth muscle-like signalling pathway. J. Physiol. 595: 5875-5893.
see also Perspectives by Kim D. (2017). Endocytosis: another pathway in receptor-Gq-TASK signalling.
*Decher N, Kiper AK & Rinné S. (2017). Stretch-activated potassium currents in the heart: focus on TREK-1 and arrhythmias. Prog. Biophys. Mol. Biol. 130: 223-232. Invited Review. *corresponding author
Ramirez D, Arévalo B, Martínez G, Rinné S, Sepúlveda F, *Decher N & *González W. (2017). Side fenestrations provide an `anchor´ for a stable binding of A1899 to the pore of TASK-1 potassium channels. Mol. Pharm. 14: 2197-2208. *corresponding authorsHonrath B, Matschke L, Meyer T, Magerhans L, Perocchi F, Ganjam GK, Zischka H, Krasel C, Gerding A, Bakker BM, Bünemann M, Strack S, Decher N, Culmsee C & Dolga A. (2017). SK2 channels regulate mitochondrial respiration and mitochondrial Ca2+ uptake. Cell. Death Differ. 24: 761-773.
*Decher N, Ortiz-Bonnin B, Friedrich C, Schewe M, Kiper AK, Rinné S, Seemann G, Peyronnet R, Zumhagen S, Bustos D, Kockskämper J, Kohl P, Just S, González W, Baukrowitz T, Stallmeyer B & Schulze-Bahr E. (2017). Sodium permeable and `hypersensitive´ TREK-1 channels cause ventricular tachycardia. EMBO Mol. Med. 9: 403-414. *corresponding authorsee also Editorial by Goldstein SA. (2017). Sodium leak through K2P potassium channels and cardiac arrhythmia, an emerging theme
Stallmeyer B, Kuß J, Kotthoff S, Zumhagen S, Vowinkel K, Rinné S, Matschke LA, Friedrich C, Schulze-Bahr E, Rust S, Seebohm G, Decher N & Schulze-Bahr E. (2017). A mutation in the G-protein gene GNB2 causes familial sinus node and atrioventricular conduction dysfunction. Circ. Res. 120: e33-e44.
2016
Leitner MG, Michel N, Behrendt M, Dierich M, Sembla S, Wilke BU, Konrad M, Lindner M, Oberwinkler J, Oliver D (2016) Direct modulation of TRPM4 and TRPM3 channels by the phospholipase C inhibitor U73122. Br J Pharmacol 173:2555-69. doi:10.1111/bph.13538
Squarr AJ, Brinkmann K, Chen B, Steinbacher T, Ebnet K, Rosen MK, Bogdan S. (2016). Fat2 acts through the WAVE regulatory complex to drive collective cell migration during tissue rotation. Journal of Cell Biology, Volume 212, No 5, Feb. 29, cover picture.
Brinkmann, K., Schulz J., Önel, S.-F., Faix, J, Winterhoff, M. and Bogdan S. (2016). WHAMY is a novel actin polymerase promoting myoblast fusion, macrophage cell motility and sensory organ development in Drosophila. Journal of Cell Science, Volume 129 Issue 3, 604-620, cover picture.
Hamp J, Löwer A, Dottermusch-Heidel C, Beck L, Moussian B, Flötenmeyer M, Önel SF. Drosophila Kette coordinates myoblast junction dissolution and the ratio of Scar-to-WASp during myoblast fusion. Journal of Cell Science, 2016 Sep 15;129(18):3426-36. Epub 2016 Aug 12.
Oezel L, Then H, Jung AL, Jabari S, Bonaterra GA, Wissniowski TT, Önel SF, Ocker M, Thieme K, Kinscherf R, Di Fazio P. (2016) Fibromyalgia syndrome: metabolic and autophagic processes in intermittent cold stress mice. Pharmacol Res Perspect. Sep 27;4(5):e00248. eCollection 2016 Oct.
Ortiz-Bonnin B, Rinné S, Moss R, Streit AK, Scharf M, Richter K, Stöber A, Pfeufer A, Seemann G, Kääb S, Beckmann BM & *Decher N. (2016). Electrophysiological characterization of a large set of novel variants in the SCN5A-gene: Identification of novel LQTS3 und BrS mutations. Pflügers Archiv. 468: 1375-1387. *corresponding author
Goldstein M, Rinné S, Kiper AK, Ramírez D, Netter MF, Bustos D, Ortiz-Bonnin B, González W & *Decher N. (2016). Functional mutagenesis screens reveal the `cap structure´ formation in disulfide-bridge free TASK channels. Sci. Rep. 6: 19492. *corresponding author
Schindler RFR, Scotton C, Zhang J, Passarelli C, Ortiz-Bonnin B, Simrick S, Schwerte T, Poon K-L, Fang M, Rinné S, Froese A, Nikolaev VO, Grunert C, Müller T, Tasca G, Sarathchandra P, Drago F, Dallapiccola B, Rapezzi C, Arbustini E, Di Raimo FR, Neri M, Selvatici R, Gualandi F, Fattori F, Pietrangelo A, Li W, Jiang H, Xu X, Bertini E, Decher N, Wang J, Brand T & Ferlini A. (2016). POPDC1S201F causes muscular dystrophy and arrhythmia by affecting protein trafficking. J. Clin. Invest. 126: 239-253.
2015
Costa HA, Leitner MG, Sos ML, Mavrantoni A, Rychkova A, Johnson JR, Newton BW, Yee M-C, De La Vega FM, Ford JM, Krogan NJ, Shokat KM, Oliver D, Halaszovich CR, Bustamante CD (2015) Discovery and functional characterization of a neomorphic PTEN mutation. Proc Natl Acad Sci USA 112:13976-13981.
Bista P, Pawlowski M, Cerina M, Ehling P, Leist M, Meuth P, Aissaoui A, Borsotto M, Heurteaux C, Decher N, Pape HP, Oliver D, Meuth SG & Budde T (2015) Differential phospholipase C-dependent modulation of TWIK-related acid-sensitive K+ (TASK) and TWIK-related K+ (TREK) channels in rat thalamocortical relay neurons. J Physiol 593:127-144.
Kavlie RG, Fritz JL, Nies F, Göpfert MC, Oliver D, Albert JT, Eberl DF (2015) Prestin is an anion transporter dispensable for mechanical feedback amplification in Drosophila hearing. J Comp Physiol A 201:51-60.
Mavrantoni A, Thallmair V, Leitner MG, Schreiber DN, Oliver D, Halaszovich CR (2015) A method to control phosphoinositides and to analyze PTEN function in living cells using voltage sensitive phosphatases. Front Pharmacol 6:68.
Rjasanow A, Leitner MG, Thallmair V, Halaszovich CR, Oliver D (2015) Ion channel regulation by phosphoinositides analyzed with VSPs – PI(4,5)P2 affinity, phosphoinositide selectivity, and PI(4,5)P2 pool accessibility. Front Pharmacol 6:127.
Tóth BI, Konrad M, Ghosh D, Mohr F, Halaszovich CR, Leitner MG, Vriens J, Oberwinkler J, Voets T (2015) Regulation of the transient receptor potential channel TRPM3 by phosphoinositides J Gen Physiol 146(1):51-63
Hobiger K, Friedrich T (2015) Voltage sensitive phosphatases: emerging kinship to protein tyrosine phosphatases from structure-function research. Front Pharmacol 6:20. (Review)
Leitner MG, Halaszovich CR, Ivanova O, Oliver D (2015) Phosphoinositide dynamics in the postsynaptic membrane compartment: Mechanisms and experimental approach. Eur J Cell Biol 94:401-414. (Review)Seebach, J., Taha, A., Lenk, J., Lindemann, N., Jiang, X., Brinkmann, K., Bogdan, S. and Schnittler, H.-J. (2015). CellBorderTracker: A Video Analysis Package for the quantification of complex cell junction dynamics in endothelium. Histochem Cell Biol. 2015 144(6):517-32, cover picture.
Zobel, T., Brinkmann K., Koch N., Schneider K., Seemann E., Kessels, M., Qualmann, B. and Bogdan, S. (2015). Cooperative functions of the two F-BAR proteins Cip4 and Nostrin in regulating E-cadherin in epithelial morphogenesis. Journal of Cell Science, Vol. 128, Issue 3, 499-515, cover picture.
Wemhöner K, Kanyshkova T, Silbernagel N, Fernandez-Orth J, Bittner S, Kiper AK, Rinné S, Netter MF, Meuth SG, Budde T & *Decher N. (2015). An N-terminal deletion variant of HCN1 in the epileptic WAG/Rij strain modulates HCN current densities. Front. Mol. Neurosci. 8: 63.*corresponding author
Matschke LA, Bertoune M, Röper J, Snutch TP, Oertel WH, Rinné S & *Decher N. (2015). A concerted action of L- and T-type Ca2+ channels regulates locus coeruleus pacemaking. Mol. Cell. Neurosci. 68:293-302. *corresponding author
Rinné S, Kiper AK, Schlichthörl G, Dittmann S, Netter MF, Limberg SH, Silbernagel N, Zuzarte M, Moosdorf R, Wulf H, Schulze-Bahr E, Rolfes C & *Decher N. (2015). TASK-1 and TASK-3 may form heterodimers in human atrial cardiomyocytes. J. Mol. Cell. Cardiol. 81: 71-80. *corresponding author
Wemhöner K, Friedrich C, Stallmeyer B, Coffey AJ, Grace A, Zumhagen S, Seebohm G, Ortiz-Bonnin B, Rinné S, Sachse FB, Schulze-Bahr E & *Decher N. (2015). Gain-of-function mutations in the calcium channel CACNA1C (Cav1.2) cause non-syndromic long-QT but not Timothy syndrome. J. Mol. Cell. Cardiol. 80: 186-195. *corresponding author
Kiper AK, Rinné S, Rolfes C, Ramírez D, Seebohm G, Netter MF, González W & *Decher N. (2015). Kv1.5 blockers preferentially inhibit TASK-1 channels: TASK-1 as a target against atrial fibrillation and obstructive sleep apnea? Pflügers Arch. 467: 1081-1090. *corresponding author
*Decher N, Kiper AK, Rolfes C, Schulze-Bahr E & Rinné S. (2015). The role of acid-sensitive two-pore domain potassium channels in cardiac electrophysiology: focus on arrhythmias. Pflügers Arch. 467: 1055-1067. Invited Review. *corresponding author
Tóth BI, Konrad M, Ghosh D, Mohr F, Halaszovich CR, Leitner MG, Vriens J, Oberwinkler J, Voets T (2015). Regulation of the transient receptor potential channel TRPM3 by phosphoinositides. J Gen Physiol 146(1):51-63
Schneider FM, Mohr F, Behrendt M, Oberwinkler J (2015). Properties and functions of TRPM1 channels in the dendritic tips of retinal ON-bipolar cells. Eur J Cell Biol Jul-Sep; 94(7-9):420-7.
Bouron A, Kiselyov K, Oberwinkler J (2015). Permeation, regulation and control of expression of TRP channels by trace metal ions. Pflügers Arch 467(6):1143-64. Review
