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Mechanisms of epithelial homeostasis - Dr. Rust

Copyright: Katja Rust

Using the Drosophila follicle stem cell lineage, we do investigate mechanisms of epithelial homeostasis with single cell transcriptomics and high resolution live imaging approaches. Current projects in the lab include:

  • The use of single cell RNA-sequencing approaches to investigate signaling pathway functions in early epithelial development
  • The investigation of epithelial tumorigenesis and associated cancer cachexia
  • The analysis of non-occluding functions of septate junction proteins in epithelial development
Copyright: Katja Rust

Publications

Holtwick, V., Schubert, A., & Rust, K. (2024). Distinct non-occluding functions of septate junction components in signaling pathway regulation and cell polarity during epithelial development. In bioRxiv. https://doi.org/10.1101/2024.09.06.611635 

Hirschhäuser, A., Molitor, D., Salinas, G., Großhans, J., Rust, K., & Bogdan, S. (2023). Single-cell transcriptomics identifies new blood cell populations in Drosophila released at the onset of metamorphosis. Development . https://doi.org/10.1242/dev.201767

Lehne, F., Pokrant, T., Parbin, S., Salinas, G., Großhans, J., Rust, K., Faix, J., & Bogdan, S. (2022). Calcium bursts allow rapid reorganization of EFhD2/Swip-1 cross-linked actin networks in epithelial wound closure. Nature Communications, 13(1), 2492. https://doi.org/10.1038/s41467-022-30167-0.

Li, H., Janssens, J., De Waegeneer, M., Kolluru, S. S., Davie, K., Gardeux, V., Saelens, W., David, F. P. A., Brbić, M., Spanier, K., Leskovec, J., McLaughlin, C. N., Xie, Q., Jones, R. C., Brueckner, K., Shim, J., Tattikota, S. G., Schnorrer, F., Rust, K., … Zinzen, R. P. (2022). Fly Cell Atlas: A single-nucleus transcriptomic atlas of the adult fruit fly. Science, 375(6584), eabk2432. https://doi.org/10.1126/science.abk2432.

Rust, K., and Wodarz, A. Transcriptional Control of Apical-Basal Polarity Regulators. Int J Mol Sci. 2021 Nov 15;22(22):12340. https://doi.org/10.3390/ijms222212340

Rust, K., Byrnes, L. E., Yu, K. S., Park, J. S., Sneddon, J. B., Tward, A. D., & Nystul, T. G. (2020). A single-cell atlas and lineage analysis of the adult Drosophila ovary. Nature Communications, 11(1), 5628. https://doi.org/10.1038/s41467-020-19361-0.

Rust, K., & Nystul, T. (2020). Signal transduction in the early Drosophila follicle stem cell lineage. Current Opinion in Insect Science, 37, 39–48. https://doi.org/10.1016/j.cois.2019.11.005.

Rust, K., Tiwari, M.D., Mishra, V.K., Grawe, F., and Wodarz, A*. Myc and the Tip60 chromatin remodeling complex control neuroblast maintenance and polarity in Drosophila. EMBO J. 2018 Aug 15;37(16):e98659. https://doi.org/10.15252/embj.201798659.

 

Contact:
Dr. Katja Rust
Molecular Cellphysiology
Emil-Mannkopff-Str. 2
35037 Marburg
katja.rust@uni-marburg.de