Main Content

Publications

2022

Thallmair V, Schultz L, Zhao W, Marrink SJ, Oliver D, Thallmair S. (2022) Two cooperative binding sites sensitize PI(4,5)P2 recognition by the tubby domain. Sci Adv 8:eabp9471.

Lenz D, Oliver D. (2022) Progress in understanding the structural mechanism underlying prestin's electromotile activity. Hear Res 423:108423.

2021

Lindner M, Gilhooley MJ, Peirson SN, Hughes S, Hankins MW (2021) The functional characteristics of optogenetic gene therapy for vision restoration. Cell. Mol. Life Sci. 78:1597-613

Schlingmann KP, Renigunta A, Hoorn EJ, Forst AL, Renigunta V, Atanasov V, Mahendran S, Barakat TS, Gillion V, Godefroid N, Brooks AS, Lugtenberg D, Lake J, Debaix H, Rudin C, Knebelmann B, Tellier S, Rousset-Rouvière C, Viering D, de Baaij JHF, Weber S, Palygin O, Staruschenko A, Kleta R, Houillier P, Bockenhauer D, Devuyst O, Rosa Vargas-Poussou R, Warth R, Zdebik AA, Konrad M (2021)  Defects in KCNJ16 Cause a Novel Tubulopathy with Hypokalemia, Salt Wasting, Disturbed Acid-Base Homeostasis, and Sensorineural Deafness. 
J Am Soc Nephrol.  32:1498-1512

2020

Dierich M, Altoè A, Koppelmann J, Evers S, Renigunta V, Schäfer MK, Naumann R, Verhulst S, Oliver D, Leitner MG (2020) Optimized Tuning of Auditory Inner Hair Cells to Encode Complex Sound through Synergistic Activity of Six Independent K+ Current Entities. Cell Rep. 32:107869.

Effertz T, Moser T, Oliver D. Recent advances in cochlear hair cell nanophysiology: subcellular compartmentalization of electrical signaling in compact sensory cells. Fac Rev. 2020 Dec 21;9:24. doi: 10.12703/r/9-24.

Lindner M, Gilhooley MJ, Palumaa T, Morton AJ, Hughes S, Hankins MW (2020) Expression and Localization of KCNE2 in the Vertebrate Retina. Invest. Ophthalmol. Vis. Sci. 61:33.

Pfau M, von der Emde L, Dysli C, Möller PT, Thiele S, Lindner M, Schmid M, Rubin DL, Fleckenstein M, Holz FG, Schmitz-Valckenberg S (2020) Determinants of Cone and Rod Functions in Geographic Atrophy: AI-Based Structure-Function Correlation. Am. J. Ophthalmol. 217:162-73.

Schladt TM, Berger TK (2020) Voltage and pH difference across the membrane control the S4 voltage-sensor motion of the Hv1 proton channel. Sci. Rep. 10:21293.

Thallmair, V., Schultz, L., Evers, S., Goecke, C., Thallmair, S., Leitner, M.G., Oliver, D. (2020) ‘Local PI(4,5)P2 pool dynamics detected by the coincidence biosensor tubbyCT maintain the integrity of ER-PM junctions during PLC signaling‘, bioRxiv 2020.09.25.313403.

Thallmair, V., Schultz, L., Marrink, S.J., Oliver, D., Thallmair, S. (2020) ‘A second PI(4,5)P2 binding site determines PI(4,5)P2 sensitivity of the tubby domain‘, bioRxiv 2020.09.23.309492.

Wobig L, Wolfenstetter T, Fechner S, Bönigk W, Körschen HG, Jikeli JF, Trötschel C, Feederle R, Kaupp UB, Seifert R, Berger TK (2020) A family of hyperpolarization-activated channels selective for protons. Proc. Natl. Acad. Sci. U. S. A. 117:13783-91.

Zou X, Conrad LJ, Koschinsky K, Schlichthörl G, Preisig-Müller R, Netz E, Krüger J, Daut J, Renigunta V (2020) The Phosphodiesterase Inhibitor IBMX Blocks the Potassium Channel THIK-1 from the Extracellular Side. Mol. Pharmacol. 98:143-55.

2019

Chang Y-N, Jaumann EA, Reichel K, Hartmann J, Oliver D, Hummer G, Joseph B, Geertsma ER (2019) Structural basis for functional interactions in dimers of SLC26 transporters. Nat. Commun. 10:2032.

Dierich M, van Ham WB, Stary-Weinzinger A, Leitner MG (2019) Histidine at position 462 determines the low quinine sensitivity of ether-a-go-go channel superfamily member Kv 12.1. Br. J. Pharmacol. 176:2708-23.

Dierich M, Hartmann S, Dietrich N, Moeser P, Brede F, Johnson Chacko L, Tziridis K, Schilling A, Krauss P, Hessler S, Karch S, Schrott-Fischer A, Blumer M, Birchmeier C, Oliver D, Moser T, Schulze H, Alzheimer C, Leitner MG, Huth T (2019) β-secretase BACE1 is required for normal cochlear function. J. Neurosci. 39:9013-27.

Hou J, Renigunta V, Nie M, Sunq A, Himmerkus N, Quintanova C, Bleich M, Renigunta A, Wolf MTF (2019) Phosphorylated claudin-16 interacts with Trpv5 and regulates transcellular calcium transport in the kidney.  Proc. Natl. Acad. Sci. U.S.A. 116:19176-86.

Leitner MG, Oliver D (2019) A choreography of intracellular Ca(2+) and extracellular ATP to refine auditory nociceptors before hearing. EMBO J. 38:e101980.

Leitner MG, Thallmair V, Wilke BU, Neubert V, Kronimus Y, Halaszovich CR, Oliver D (2019) The N-terminal homology (ENTH) domain of Epsin 1 is a sensitive reporter of physiological PI(4,5)P2 dynamics. BBA - Mol. Cell. Biol. Lipids. 1864:433-42.

2018

Leitner MG, Hobiger K, Mavrantoni A, Feuer A, Oberwinkler J, Oliver D, Halaszovich CR (2018) A126 in the active site and TI167/168 in the TI loop are essential determinants of the substrate specificity of PTEN. Cell Mol. Life Sci. 75:4235-50.

Hackelberg S, Oliver D (2018) Metabotropic Acetylcholine and Glutamate Receptors mediate PI(4,5)P2 Depletion and Oscillations in Hippocampal CA1 Pyramidal Neurons in situ. Sci. Rep. 8:12987.

Dierich M, Leitner MG (2018) Kv12.1 channels are not sensitive to GqPCR-triggered activation of phospholipase Cβ. Channels 12:228-239.

Dierich M, Evers S, Wilke BU, Leitner MG (2018) Inverse Modulation of Neuronal Kv12.1 and Kv11.1 Channels by 4-Aminopyridine and NS1643. Front. Mol. Neurosci. 11:11.

Qi Y, Mair N, Kummer KK, Leitner MG, Camprubi-Robles M, Langeslag M, Kress M (2018) Identification of Chloride Channels CLCN3 and CLCN5 Mediating the Excitatory Cl(-) Currents Activated by Sphingosine-1-Phosphate in Sensory Neurons. Front. Mol. Neurosci. 11:33.

2017

Vogl C, Butola T, Haag N, Hausrat TJ, Leitner MG, Moutschen M, Lefebvre PP, Speckmann C, Garrett L, Becker L, Fuchs H, Hrabe de Angelis M, Nietzsche S, Kessels MM, Oliver D, Kneussel M, Kilimann MW, Strenzke N (2017) The BEACH protein LRBA is required for hair bundle maintenance in cochlear hair cells and for hearing. EMBO Rep. 18:2015-29.

Dembla, S., M. Behrendt, F. Mohr, C. Goecke, J. Sondermann, F. M. Schneider, M. Schmidt, J. Stab, R. Enzeroth, M. G. Leitner, P. Nunez-Badinez, J. Schwenk, B. Nurnberg, A. Cohen, S. E. Philipp, W. Greffrath, M. Bunemann, D. Oliver, E. Zakharian, M. Schmidt and J. Oberwinkler (2017). Anti-nociceptive action of peripheral mu-opioid receptors by G-beta-gamma protein-mediated inhibition of TRPM3 channels. Elife 6:e26280.

Constantin CE, Müller CS, Leitner MG, Bildl W, Schulte U, Oliver D, Fakler B (2017) Identification of Cav2–PKCβ and Cav2–NOS1 complexes as entities for ultrafast electrochemical coupling.
Proc. Natl. Acad. Sci. U.S.A. 114:5707-12.

Santos-Sacchi J, Navaratnam D, Raphael RM, Oliver D (2017) Prestin - molecular mechanisms underlying outer hair cell electromotility. In: Understanding the cochlea (Manley GA, Gummer AW, eds). New York: Springer.

2016

Leitner MG, Michel N, Behrendt M, Dierich M, Sembla S, Wilke BU, Konrad M, Lindner M, Oberwinkler J, Oliver D (2016) Direct modulation of TRPM4 and TRPM3 channels by the phospholipase C inhibitor U73122. Br. J. Pharmacol. 173:2555-69.

2015

Costa HA, Leitner MG, Sos ML, Mavrantoni A, Rychkova A, Johnson JR, Newton BW, Yee M-C, De La Vega FM, Ford JM, Krogan NJ, Shokat KM, Oliver D, Halaszovich CR, Bustamante CD (2015) Discovery and functional characterization of a neomorphic PTEN mutation. Proc. Natl. Acad. Sci. U.S.A. 112:13976-81.

Bista P, Pawlowski M, Cerina M, Ehling P, Leist M, Meuth P, Aissaoui A, Borsotto M, Heurteaux C, Decher N, Pape HP, Oliver D, Meuth SG & Budde T (2015) Differential phospholipase C-dependent modulation of TWIK-related acid-sensitive K+ (TASK) and TWIK-related K+ (TREK) channels in rat thalamocortical relay neurons. J. Physiol. 593:127-44.

Kavlie RG, Fritz JL, Nies F, Göpfert MC, Oliver D, Albert JT, Eberl DF (2015) Prestin is an anion transporter dispensable for mechanical feedback amplification in Drosophila hearing. J. Comp. Physiol. A 201:51-60.

Mavrantoni A, Thallmair V, Leitner MG, Schreiber DN,  Oliver D, Halaszovich CR (2015) A method to control phosphoinositides and to analyze PTEN function in living cells using voltage sensitive phosphatases. Front. Pharmacol. 6:68.

Rjasanow A, Leitner MG, Thallmair V, Halaszovich CR, Oliver D (2015) Ion channel regulation by phosphoinositides analyzed with VSPs – PI(4,5)P2 affinity, phosphoinositide selectivity, and PI(4,5)P2 pool accessibility. Front. Pharmacol. 6:127.

Tóth BI, Konrad M, Ghosh D, Mohr F, Halaszovich CR, Leitner MG, Vriens J, Oberwinkler J, Voets T (2015) Regulation of the transient receptor potential channel TRPM3 by phosphoinositides. J. Gen. Physiol. 146:51-63.

Hobiger K, Friedrich T (2015) Voltage sensitive phosphatases: emerging kinship to protein tyrosine phosphatases from structure-function research. Front. Pharmacol. 6:20.

Leitner MG, Halaszovich CR, Ivanova O, Oliver D (2015) Phosphoinositide dynamics in the postsynaptic membrane compartment: Mechanisms and experimental approach. Eur. J. Cell Biol. 94:401-14.

2014

Gorbunov D, Sturlese M, Nies F, Kluge M, Bellanda M, Battistutta R, Oliver D (2014) Molecular architecture and the structural basis for anion interaction in prestin and SLC26 transporters. Nat. Commun. 5:3622.

Wilke BU, Linder M, Greifenberg L, Albus A, Kronimus Y, Bünemann M, Leitner MG, Oliver D (2014) Diacylglycerol mediates regulation of TASK potassium channels by Gq-coupled receptors. Nat. Commun. 5:5540.

Leitner MG (2014) Zebrafish in auditory research: are fish better than mice? J. Physiol. 592:4611-2.

2013

Deng W, Nies F, Feuer A, Bočina I, Oliver D, Jiang D (2013) Anion Transport through Slc26 Family Protein Regulates Lumen Expansion during Tubulogenesis. Proc. Natl. Acad. Sci. U.S.A. 110:14972-7.

Schiekel J, Lindner M, Hetzel A, Wemhöner K, Renigunta V, Schlichthörl G, Decher N, Oliver D, Daut J (2013) Inhibition of the potassium channel TASK-1 in rat cardiac muscle by endothelin-1 is mediated by phospholipase C. Cardiovasc. Res. 97:97-105.

Cimerman J, Waldhaus J, Harasztosi C, Duncker SV, Dettling J, Heidrych P, Bress A, Braig C, Frank G, Oliver D, Gummer AW, Knipper M, Zimmermann U (2013) Generation of somatic electromechanical force by outer hair cells may be influenced by prestin-CASK interaction at the basal junction with the Deiter’s cell. Histochem. Cell Biol. 140:119-35.

2012

Halaszovich CR*, Leitner MG*, Le A, Frezza L, Feuer A, Schreiber DN, Villalba-Galea CA, Oliver D (2012) A human phospholipid phosphatase activated by a transmembrane control module.
J. Lip. Res. 53:2266-74.

2011

Leitner MG, Feuer A, Ebers O, Schreiber DN, Halaszovich CR, Oliver D (2011) Restoration of ion channel function in deafness-causing KCNQ4 mutants by synthetic channel openers. Brit. J. Pharmacol. 165:2244–59.

Schaechinger TJ, Gorbunov D, Halaszovich CR, Moser T, Kuegler S, Fakler B, Oliver D (2011) A synthetic prestin reveals protein domains and molecular operation of outer hair cell piezoelectricity. EMBO J. 30:2793-804.

Lindner M, Leitner MG, Halaszovich CR, Hammond GR, Oliver D (2011) Probing the regulation of TASK potassium channels by PI(4,5)P2 with switchable phosphoinositide phosphatases. J. Physiol. 589:3149-62.

Lacroix J*, Halaszovich CR*, Schreiber DN, Leitner MG, Bezanilla F, Oliver D**, Villalba-Galea CA** (2011) Controlling the Activity of a Phosphatase and Tensin Homolog (PTEN) by Membrane Potential. J. Biol. Chem. 286:17945-53.

Leitner MG, Halaszovich CR, Oliver D (2011) Aminoglycosides inhibit KCNQ4 channels in cochlear outer hair cells via depletion of phosphatidylinositol(4,5)bisphosphate. Mol. Pharmacol. 79: 51-60.

2010

Reisinger E, Meintrup D, Oliver D, Fakler B (2010) Gene expression associated with the onset of hearing detected by differential display in rat organ of Corti. Eur. J. Hum. Genet. 18:1327-32.

pre 2010

Halaszovich CR, Schreiber DN, Oliver D (2009) Ci-VSP is a depolarization-activated phosphatidylinositol-4,5-bisphosphate and phosphatidylinositol-3,4,5-trisphosphate 5'-phosphatase. J. Biol. Chem. 284:2106-13.

Oliver D, Brinkmann M, Sieger T, Thurm U (2008) Hydrozoan nematocytes send and receive synaptic signals induced by mechano-chemical stimuli. J. Exp. Biol. 211:2876-88.

Schaechinger TJ, Oliver D (2007) Nonmammalian orthologs of prestin (SLC26A5) are electrogenic divalent/chloride anion exchangers. Proc. Natl. Acad. Sci. U.S.A. 104:7693-8.

Albert JT, Winter H, Schaechinger TJ, Weber T, Wang X, He DZZ, Hendrich O, Geisler H-S, Zimmermann U, Oelmann K, Knipper M, Gopfert MC, Oliver D (2007) Voltage-sensitive prestin orthologue expressed in zebrafish hair cells. J. Physiol. 580:451-61.

Oliver D (2007) Prestin. In: Handbook of the Senses: Audition (Dallos P, Oertel D, eds), pp 309-317. San Diego: Elsevier.

Oliver D, Taberner AM, Thurm H, Sausbier M, Arntz C, Ruth P, Fakler B, Liberman MC (2006) The Role of BKCa Channels in Electrical Signal Encoding in the Mammalian Auditory Periphery. J. Neurosci. 26:6181-9.

Berkefeld H, Sailer CA, Bildl W, Rohde V, Thumfart JO, Eble S, Klugbauer N, Reisinger E, Bischofberger J, Oliver D, Knaus HG, Schulte U, Fakler B (2006) BKCa-Cav channel complexes mediate rapid and localized Ca2+-activated K+ signaling. Science 314:615-20.

Thurm H, Fakler B, Oliver D (2005) Ca2+-independent activation of BKCa channels at negative potentials in mammalian inner hair cells. J. Physiol. 569:137-51.

Reisinger E, Zimmermann U, Knipper M, Ludwig J, Klocker N, Fakler B, Oliver D (2005) Cod106, a novel synaptic protein expressed in sensory hair cells of the inner ear and in CNS neurons. Mol. Cell. Neurosci. 28:106-17.

Oliver D, Lien CC, Soom M, Baukrowitz T, Jonas P, Fakler B (2004) Functional conversion between A-type and delayed rectifier K+ channels by membrane lipids. Science 304:265-70.

Bildl W, Strassmaier T, Thurm H, Andersen J, Eble S, Oliver D, Knipper M, Mann M, Schulte U, Adelman JP, Fakler B (2004) Protein kinase CK2 is coassembled with small conductance Ca(2+)-activated K+ channels and regulates channel gating. Neuron 43:847-58.

Wissmann R, Bildl W, Oliver D, Beyermann M, Kalbitzer HR, Bentrop D, Fakler B (2003) Solution structure and function of the "tandem inactivation domain" of the neuronal A-type potassium channel Kv1.4. J. Biol. Chem. 278:16142-50.

Oliver D, Knipper M, Derst C, Fakler B (2003) Resting potential and submembrane calcium concentration of inner hair cells in the isolated mouse cochlea are set by KCNQ-type potassium channels. J. Neurosci. 23:2141-9.

Oliver D, Fakler B (2002) Functional properties of prestin - how the motormolecule works work. In: Biophysics of the cochlea: from molecules to models (Gummer AW, ed), pp 110-115. Singapore: World Scientific.

Zheng J, Madison LD, Oliver D, Fakler B, Dallos P (2002) Prestin, the motor protein of outer hair cells. Audiol. Neurootol. 7:9-12.

Rüsch A, Ng L, Goodyear R, Oliver D, Lisoukov I, Vennstrom B, Richardson G, Kelley MW, Forrest D (2001) Retardation of cochlear maturation and impaired hair cell function caused by deletion of all known thyroid hormone receptors. J. Neurosci. 21:9792-800.

Pedarzani P, Mosbacher J, Rivard A, Cingolani LA, Oliver D, Stocker M, Adelman JP, Fakler B (2001) Control of Electrical Activity in Central Neurons by Modulating the Gating of Small Conductance Ca2+-activated K+ Channels. J. Biol. Chem. 276:9762-9.

Oliver D, Ludwig J, Reisinger E, Zoellner W, Ruppersberg JP, Fakler B (2001) Memantine inhibits efferent cholinergic transmission in the cochlea by blocking nicotinic acetylcholine receptors of outer hair cells. Mol. Pharmacol. 60:183-9.

Oliver D, He DZ, Klocker N, Ludwig J, Schulte U, Waldegger S, Ruppersberg JP, Dallos P, Fakler B (2001) Intracellular anions as the voltage sensor of prestin, the outer hair cell motor protein. Science 292:2340-3.

Ludwig J*, Oliver D*, Frank G, Klocker N, Gummer AW, Fakler B (2001) Reciprocal electromechanical properties of rat prestin: The motor molecule from rat outer hair cells. Proc. Natl. Acad. Sci. U.S.A. 98:4178-83.

Klöcker N, Oliver D, Ruppersberg JP, Knaus HG, Fakler B (2001) Developmental expression of the small-conductance Ca2+-activated potassium channel SK2 in the rat retina. Mol. Cell. Neurosci. 17:514-20.

Oliver D, Klocker N, Schuck J, Baukrowitz T, Ruppersberg JP, Fakler B (2000) Gating of Ca2+-activated K+ channels controls fast inhibitory synaptic transmission at auditory outer hair cells. Neuron 26:595-601.

Oliver D, Baukrowitz T, Fakler B (2000) Polyamines as gating molecules of inward-rectifier K+ channels. Eur. J. Biochem. 267:5824-9.

Oliver D, Fakler B (1999) Expression density and functional characteristics of the outer hair cell motor protein are regulated during postnatal development in rat. J. Physiol. 519:791-800.

Rüsch A, Erway LC, Oliver D, Vennstrom B, Forrest D (1998) Thyroid hormone receptor beta-dependent expression of a potassium conductance in inner hair cells at the onset of hearing. Proc. Natl. Acad. Sci. U.S.A. 95:15758-62.

Oliver D, Hahn H, Antz C, Ruppersberg JP, Fakler B (1998) Interaction of permeant and blocking ions in cloned inward-rectifier K+ channels. Biophys. J. 74:2318-26.

Baukrowitz T, Schulte U, Oliver D, Herlitze S, Krauter T, Tucker SJ, Ruppersberg JP, Fakler B (1998) PIP2 and PIP as determinants for ATP inhibition of KATP channels. Science 282:1141-4.

Oliver D, Plinkert P, Zenner HP, Ruppersberg JP (1997) Sodium current expression during postnatal development of rat outer hair cells. Pflügers Arch. 434:772-8.

Brinkmann M, Oliver D, Thurm U (1996) Mechanoelectric transduction in nematocytes of a hydropolyp (Corynidae). J. Comp. Physiol. A 178:125-38.

Gitter AH, Oliver D, Thurm U (1994) Calcium-dependence and voltage-dependence of nematocyst discharge in Hydra vulgaris. J. Comp. Physiol. A 175:115-22.

Gitter AH, Oliver D, Thurm U (1993) Streptomycin inhibits nematocyte discharge in Hydra vulgaris by blockage of mechanosensitivity. Naturwissenschaften 80:273-6.