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Publications

2024

SAMD1 suppresses epithelial-mesenchymal transition pathways in pancreatic ductal adenocarcinoma.

Clara Simon, Inka D. Brunke, Bastian Stielow, Ignasi Forné, Anna Mary Steitz, Merle Geller, Iris Rohner, Lea Marie Jeude, Lisa M Weber, Sabrina Fischer, Andrea Nist, Thorsten Stiewe, Magdalena Huber, Malte Buchholz, Robert Liefke
PLOS Biology, 2024, Aug 13;22(8):e3002739. PMID: 39137238

IRF2BP2 counteracts the ATF7/JDP2 AP-1 heterodimer to prevent inflammatory overactivation in acute myeloid leukemia (AML) cells.

Sabrina Fischer, Lisa Marie Weber, Bastian Stielow, Miriam Frech, Clara Simon, Merle Geller, Julie Könnecke, Florian Finkernagel, Ignasi Forné, Andrea Nist, Uta-Maria Bauer, Thorsten Stiewe, Andreas Neubauer, Robert Liefke
Nucleic Acids Research, 2024 Jul 22;52(13):7590-7609. PMID: 38801077

2023

Peptide-mediated inhibition of the transcriptional regulator Elongin BC induces apoptosis in cancer cells.

Sabrina Fischer*, Van Tuan Trinh*, Clara Simon, Lisa Marie Weber, Ignasi Forné, Andrea Nist, Gert Bange, Frank Abendroth, Thorsten Stiewe, Wieland Steinchen, Robert Liefke^# and Olalla Vázquez^# 
Cell Chemical Biology, 2023 Jul 20;30(7):766-779.e11. PMID: 37354906
*co-first authors, ^#corresponding authors

Polycomb-Like Proteins in Gene Regulation and Cancer.

Fischer S, Liefke R
Genes (Basel). 2023 14(4), 938. PMID: 37107696

Investigation of SAMD1 ablation in mice.

Campbell B*^,#, Weber LM^*, Engle SJ, Ozolinš TRS, Bourassa P, Aiello R, Liefke R^#
Scientific Reports. 2023 Feb 21;13(1):3000. PMID: 36810619
*co-first authors, ^#corresponding authors

IL-17A-producing CD8+ T cells promote PDAC via induction of inflammatory cancer-associated fibroblasts.

Picard FSR, Lutz V, Brichkina A, Neuhaus F, Ruckenbrod T, Hupfer A, Raifer H, Klein M, Bopp T, Pfefferle PI, Savai R, Prinz I, Waisman A, Moos S, Chang HD, Heinrich S, Bartsch DK, Buchholz M, Singh S, Tu M, Klein L, Bauer C, Liefke R, Burchert A, Chung HR, Mayer P, Gress TM, Lauth M, Gaida M, Huber M.
Gut. 2023 Aug;72(8):1510-1522. PMID: 36759154

The histone acetyltransferase KAT6A is recruited to unmethylated CpG islands via a DNA binding winged helix domain.

Weber LM*, Jia Y*, Stielow B, Gisselbrecht SS, Cao Y, Ren Y, Rohner I, King J, Rothman E, Fischer S, Simon C, Forné I, Nist A, Stiewe T, Bulyk ML, Wang Z^#, Liefke R^#.
Nucleic Acids Res.  2023 Jan 25;51(2):574-594. PMID: 36537216
*co-first authors, ^#corresponding authors

2022

A TRIM66/DAX1/Dux axis suppresses the totipotent 2-cell-like state in murine embryonic stem cells.

Zuo F, Jiang J, Fu H, Yan K, Liefke R, Zhang J, Hong Y, Chang Z, Liu N, Wang Z, Xi Q.
Cell Stem Cell. 2022 Jun 2;29(6):948-961.e6. PMID: 35659877

The CpG Island-Binding Protein SAMD1 Contributes to an Unfavorable Gene Signature in HepG2 Hepatocellular Carcinoma Cells.

Simon C, Stielow B, Nist A, Rohner I, Weber LM, Geller M, Fischer S, Stiewe T, Liefke R.
Biology (Basel). 2022 Apr 6;11(4):557. PMID: 35453756

Evolutionary adaptation of the Polycomb repressive complex 2.

Fischer S*, Weber LM*, Liefke R.
Epigenetics Chromatin. 2022 Feb 22;15(1):7. PMID: 35193659
*co-first authors

2021

SUMOylated non-canonical polycomb PRC1.6 complex as a prerequisite for recruitment of transcription factor RBPJ.

Sotomska M, Liefke R, Ferrante F, Schwederski H, Oswald F, Borggrefe T.
Epigenetics Chromatin. 2021 Jul 31;14(1):38. PMID: 34332624

Making fundamental scientific discoveries by combining information from literature, databases, and computational tools - An example.

Stielow B, Simon C, Liefke R.
Comput Struct Biotechnol J. 2021 May 14;19:3027-3033. PMID: 34136100

The SAM domain-containing protein 1 (SAMD1) acts as a repressive chromatin regulator at unmethylated CpG islands.

Stielow B^*, Zhou Y^*, Cao Y, Simon C, Pogoda HM, Jiang J, Ren Y, Phanor SK, Rohner I, Nist A, Stiewe T, Hammerschmidt M, Shi Y, Bulyk ML, Wang Z^#, Liefke R^#.
Sci Adv. 2021 May 12;7(20):eabf2229. PMID: 33980486
*co-first authors, ^#corresponding authors

IRF8 Is an AML-Specific Susceptibility Factor That Regulates Signaling Pathways and Proliferation of AML Cells.

Liss F, Frech M, Wang Y, Giel G, Fischer S, Simon C, Weber LM, Nist A, Stiewe T, Neubauer A, Burchert A, Liefke R.
Cancers (Basel). 2021 Feb 12;13(4):764. PMID: 33673123

Ush regulates hemocyte-specific gene expression, fatty acid metabolism and cell cycle progression and cooperates with dNuRD to orchestrate hematopoiesis.

Lenz J, Liefke R, Funk J, Shoup S, Nist A, Stiewe T, Schulz R, Tokusumi Y, Albert L, Raifer H, Förstemann K, Vázquez O, Tokusumi T, Fossett N, Brehm A.
PLoS Genet. 2021 Feb 18;17(2):e1009318. PMID: 33600407

2019

The HRP3 PWWP domain recognizes the minor groove of double-stranded DNA and recruits HRP3 to chromatin.

Tian W, Yan P, Xu N, Chakravorty A, Liefke R^#, Xi Q^#, Wang Z^#.
Nucleic Acids Res. 2019 Jun 4;47(10):5436-5448. PMID: 31162607
^#corresponding authors

NF-κB p65 dimerization and DNA-binding is important for inflammatory gene expression.

Riedlinger T, Liefke R, Meier-Soelch J, Jurida L, Nist A, Stiewe T, Kracht M, Schmitz ML.
FASEB J. 2019 Mar;33(3):4188-4202. PMID: 30526044

2018

Enhancer-driven transcriptional regulation is a potential key determinant for human visceral and subcutaneous adipocytes.

Liefke R^*#, Bokelmann K^*, Ghadimi BM, Dango S.
Biochim Biophys Acta Gene Regul Mech. 2018 Jun 30:S1874-9399(18)30095-6. PMID: 29966764
*co-first authors, ^#corresponding author

2017

Polycomb-like proteins link the PRC2 complex to CpG islands.

Li H*, Liefke R*, Jiang J*, Kurland JV, Tian W, Deng P, Zhang W, He Q, Patel DJ, Bulyk ML, Shi Y, Wang Z.
Nature. 2017 Sep 14;549(7671):287-291. PMID: 28869966
*co-first authors

2016

EPOP Interacts with Elongin BC and USP7 to Modulate the Chromatin Landscape.

Liefke R, Karwacki-Neisius V, Shi Y.
Mol Cell. 2016 Nov 17;64(4):659-672. PMID: 27863226

Biochemical Features of Recombinant Human Cyclophilin J.

Chen J*, Liefke R*, Jiang L, Wang J, Huang C, Gong Z, Schiene-Fischer C, Yu L.
Anticancer Res. 2016 Mar;36(3):1175-80. PMID: 26977013
*co-first authors

2015

The oxidative demethylase ALKBH3 marks hyperactive gene promoters in human cancer cells.

Liefke R^*, Windhof-Jaidhauser IM^*, Gaedcke J, Salinas-Riester G, Wu F, Ghadimi M, Dango S.
Genome Med. 2015 Jun 30;7(1):66. PMID: 26221185

The PRC2-associated factor C17orf96 is a novel CpG island regulator in mouse ES cells.

Liefke R, Shi Y.
Cell Discov. 2015 Apr 28;1:15008. PMID: 27462409

Site-specific methylation of Notch1 controls the amplitude and duration of the Notch1 response.

Hein K, Mittler G, Cizelsky W, Kühl M, Ferrante F, Liefke R, Berger IM, Just S, Sträng JE, Kestler HA, Oswald F, Borggrefe T.
Sci Signal. 2015 Mar 24;8(369):ra30. PMID: 25805888

2014

Probing the epigenetic status at Notch target genes.

Liefke R, Borggrefe T.
Methods Mol Biol. 2014;1187:255-76. PMID: 25053496

2012

Phf19 links methylated Lys36 of histone H3 to regulation of Polycomb activity.

Ballaré C, Lange M, Lapinaite A, Martin GM, Morey L, Pascual G, Liefke R, Simon B, Shi Y, Gozani O, Carlomagno T, Benitah SA, Di Croce L.
Nat Struct Mol Biol. 2012 Dec;19(12):1257-65. PMID: 23104054

Fine-tuning of the intracellular canonical Notch signaling pathway.

Borggrefe T, Liefke R.
Cell Cycle. 2012 Jan 15;11(2):264-76. PMID: 22223095

2010

Histone demethylase KDM5A is an integral part of the core Notch-RBP-J repressor complex. 

Liefke R^*, Oswald F^*, Alvarado C, Ferres-Marco D, Mittler G, Rodriguez P, Dominguez M, Borggrefe T.
Genes Dev. 2010 Mar 15;24(6):590-601. PMID: 20231316
*co-first authors

2008

ETO, but not leukemogenic fusion protein AML1/ETO, augments RBP-Jkappa/SHARP-mediated repression of notch target genes.

Salat D^*, Liefke R^*, Wiedenmann J, Borggrefe T, Oswald F.
Mol Cell Biol. 2008 May;28(10):3502-12. PMID: 18332109
*co-first authors