Main Content

Selected publications

    1. Neuhaus F, Lieber S, Shinkevich V, Steitz AM, Raifer H, Roth K, Finkernagel F, Worzfeld T, Burchert A, Keber C, Nist A, Stiewe T, Reinartz S, Beutgen VM, Graumann J, Pauck K, Garn H, Gaida M, Müller R, Huber M. Reciprocal crosstalk between Th17 and mesothelial cells promotes metastasis-associated adhesion of ovarian cancer cells. Clin Transl Med. 2024 Apr;14(4):e1604. doi: 10.1002/ctm2.1604. PMID: 38566518; PMCID: PMC10988119.

    2. Rauch E, Amendt T, Lopez Krol A, Lang FB, Linse V, Hohmann M, Keim AC, Kreutzer S, Kawengian K, Buchholz M, Duschner P, Grauer S, Schnierle B, Ruhl A, Burtscher I, Dehnert S, Kuria C, Kupke A, Paul S, Liehr T, Lechner M, Schnare M, Kaufmann A, Huber M, Winkler TH, Bauer S, Yu P. T-bet+ B cells are activated by and control endogenous retroviruses through TLR-dependent mechanisms. Nat Commun. 2024 Feb 9;15(1):1229. doi: 10.1038/s41467-024-45201-6. PMID: 38336876; PMCID: PMC10858178.

    3. Größer V, Weyh C, Böttrich T, Frech T, Nolte S, Sommer N, Huber M, Eder K, Dörr O, Hoelscher S, Weber R, Akdogan E, Nef H, Most A, Hamm CW, Krüger K, Bauer P. Association of cardiorespiratory fitness level with vascular function and subclinical atherosclerosis in the elderly. Eur J Appl Physiol. 2023 Dec 22. doi: 10.1007/s00421-023-05375-1. Epub ahead of print. PMID: 38133663.

    4. Brichkina A, Suezov R, Huber M. Methyltransferase-like 3 (METTL3) inhibition potentiates anti-tumor immunity: a novel strategy for improving anti-PD1 therapy. Signal Transduct Target Ther. 2023 Dec 11;8(1):448. doi: 10.1038/s41392-023-01696-x. PMID: 38072988; PMCID: PMC10710993.

    5. Steitz AM, Schröder C, Knuth I, Keber CU, Sommerfeld L, Finkernagel F, Jansen JM, Wagner U, Müller-Brüsselbach S, Worzfeld T, Huber M, Beutgen VM, Graumann J, Pogge von Strandmann E, Müller R, Reinartz S. TRAIL-dependent apoptosis of peritoneal mesothelial cells by NK cells promotes ovarian cancer invasion. iScience. 2023 Nov 7;26(12):108401. doi: 10.1016/j.isci.2023.108401. PMID: 38047087; PMCID: PMC10692662.

    6. Böttrich T, Bauer P, Gröβer V, Huber M, Raifer H, Frech T, Nolte S, Dombrowski T, Cemic F, Sommer N, Ringseis R, Eder K, Krüger K, Weyh C. Subpopulations of regulatory T cells are associated with subclinical atherosclerotic plaques, levels of LDL, and cardiorespiratory fitness in the elderly. J Sport Health Sci. 2023 Nov 10:S2095-2546(23)00113-8. doi: 10.1016/j.jshs.2023.11.004. Epub ahead of print. PMID: 37951470.

    7. Leite JA, Menezes L, Martins E, Rodrigues TS, Tavares L, Ebering A, Schelmbauer C, Martelossi Cebinelli GC, Zinina V, Golden A, Soshnikova N, Zamboni DS, Cunha FQ, Huber M, Silva JS, Waisman A, Carlos D, Saraiva Câmara NO. AIM2 promotes TH17 cells differentiation by regulating RORγt transcription activity. iScience. 2023 Oct 4;26(11):108134. doi: 10.1016/j.isci.2023.108134. PMID: 37867943; PMCID: PMC10585393.

    8. Palmowski J, Kohnhorst S, Bauer P, Puta C, Haunhorst S, Gebhardt K, Reichel T, Keller C, Huber M, Raifer H, Krüger K. T-cell-derived TNF-α and a cluster of immunological parameters from plasma allow a separation between SARS-CoV-2 convalescent versus vaccinated elite athletes. Front Physiol. 2023 Jun 22;14:1203983. doi: 10.3389/fphys.2023.1203983. PMID: 37427401; PMCID: PMC10324374.

    9. Nasiri E, Student M, Roth K, Siti Utami N, Huber M, Buchholz M, Gress TM, Bauer C. IL18 Receptor Signaling Inhibits Intratumoral CD8+ T-Cell Migration in a Murine Pancreatic Cancer Model. Cells. 2023 Jan 31;12(3):456. doi: 10.3390/cells12030456. PMID: 36766797; PMCID: PMC9913970.

    10. Picard FSR, Lutz V, Brichkina A, Neuhaus F, Ruckenbrod T, Hupfer A, Raifer H, Klein M, Bopp T, Pfefferle PI, Savai R, Prinz I, Waisman A, Moos S, Chang HD, Heinrich S, Bartsch DK, Buchholz M, Singh S, Tu M, Klein L, Bauer C, Liefke R, Burchert A, Chung HR, Mayer P, Gress TM, Lauth M, Gaida M, Huber M. IL-17A-producing CD8+ T cells promote PDAC via induction of inflammatory cancer-associated fibroblasts. Gut. 2023 Aug;72(8):1510-1522. doi: 10.1136/gutjnl-2022-327855. Epub 2023 Feb 9. PMID: 36759154; PMCID: PMC10359545.

    11. Lutz V, Hellmund VM, Picard FSR, Raifer H, Ruckenbrod T, Klein M, Bopp T, Savai R, Duewell P, Keber CU, Weigert A, Chung HR, Buchholz M, Menke A, Gress TM, Huber M, Bauer C. IL18 Receptor Signaling Regulates Tumor-Reactive CD8+ T-cell Exhaustion via Activation of the IL2/STAT5/mTOR Pathway in a Pancreatic Cancer Model. Cancer Immunol Res. 2023 Apr 3;11(4):421-434. doi: 10.1158/2326-6066.CIR-22-0398. PMID: 36758176.

    12. Locatelli G, Marques-Ferreira F, Katsoulas A, Kalaitzaki V, Krueger M, Ingold-Heppner B, Walthert S, Sankowski R, Prazeres da Costa O, Dolga A, Huber M, Gold M, Culmsee C, Waisman A, Bechmann I, Milchevskaya V, Prinz M, Tresch A, Becher B, Buch T. IGF1R expression by adult oligodendrocytes is not required in the steady-state but supports neuroinflammation. Glia. 2023 Mar;71(3):616-632. doi: 10.1002/glia.24299. Epub 2022 Nov 17. PMID: 36394300.

    13. Xu R, Höß C, Swiercz JM, Brandt DT, Lutz V, Petersen N, Li R, Zhao D, Oleksy A, Creigh-Pulatmen T, Trokter M, Fedorova M, Atzberger A, Strandby RB, Olsen AA, Achiam MP, Matthews D, Huber M, Gröne HJ, Offermanns S, Worzfeld T. A semaphorin-plexin-Rasal1 signaling pathway inhibits gastrin expression and protects against peptic ulcers. Sci Transl Med. 2022 Jul 20;14(654):eabf1922. doi: 10.1126/scitranslmed.abf1922. Epub 2022 Jul 20. PMID: 35857828.

    14. Kandra P, Nandigama R, Eul B, Huber M, Kobold S, Seeger W, Grimminger F, Savai R. Utility and Drawbacks of Chimeric Antigen Receptor T Cell (CAR-T) Therapy in Lung Cancer. Front Immunol. 2022 Jun 2;13:903562. doi: 10.3389/fimmu.2022.903562. PMID: 35720364; PMCID: PMC9201083.

    15. Raifer H, Schulz AR, Theodorou J, Romero-Olmedo AJ, Böck A, Bertrams W, Schmeck BT, Chung HR, Lohoff M, Chang HD, Schaub B, Mei HE, Huber M. Mass cytometry-based identification of a unique T-cell signature in childhood allergic asthma. Allergy. 2022 Jan;77(1):313-316. doi: 10.1111/all.15110. Epub 2021 Oct 4. PMID: 34564874.

    16. Churin Y, Irungbam K, Imiela CS, Schwarz D, Mollenkopf HJ, Drebber U, Odenthal M, Pak O, Huber M, Glebe D, Roderfeld M, Roeb E. Lipid Storage and Interferon Response Determine the Phenotype of Ground Glass Hepatocytes in Mice and Humans. Cell Mol Gastroenterol Hepatol. 2021;12(2):383-394. doi: 10.1016/j.jcmgh.2021.03.009. Epub 2021 Mar 23. PMID: 33766783; PMCID: PMC8255940.

    17. Hessmann E, Schneider G; 1(st) Virtual Göttingen-Munich-Marburg Pancreatic Cancer Meeting. New Insights Into Pancreatic Cancer: Notes from a Virtual Meeting. Gastroenterology. 2021 Sep;161(3):785-791. doi: 10.1053/j.gastro.2021.04.082. Epub 2021 Jun 2. PMID: 34089734.

    18. Luu M, Riester Z, Baldrich A, Reichardt N, Yuille S, Busetti A, Klein M, Wempe A, Leister H, Raifer H, Picard F, Muhammad K, Ohl K, Romero R, Fischer F, Bauer CA, Huber M, Gress TM, Lauth M, Danhof S, Bopp T, Nerreter T, Mulder IE, Steinhoff U, Hudecek M, Visekruna A. Microbial short-chain fatty acids modulate CD8+ T cell responses and improve adoptive immunotherapy for cancer. Nat Commun. 2021 Jul 1;12(1):4077. doi: 10.1038/s41467-021-24331-1. PMID: 34210970; PMCID: PMC8249424.

    19. Arnold C, Demuth P, Seiwert N, Wittmann S, Boengler K, Rasenberger B, Christmann M, Huber M, Brunner T, Linnebacher M, Fahrer J. The Mitochondrial Disruptor Devimistat (CPI-613) Synergizes with Genotoxic Anticancer Drugs in Colorectal Cancer Therapy in a Bim-Dependent Manner. Mol Cancer Ther. 2022 Jan;21(1):100-112. doi: 10.1158/1535-7163.MCT-21-0393. Epub 2021 Nov 8. PMID: 34750196.

    20. Romero-Olmedo AJ, Schulz AR, Huber M, Brehm CU, Chang HD, Chiarolla CM, Bopp T, Skevaki C, Berberich-Siebelt F, Radbruch A, Mei HE, Lohoff M. Deep phenotypical characterization of human CD3+ CD56+ T cells by mass cytometry. Eur J Immunol. 2021 Mar;51(3):672-681. doi: 10.1002/eji.202048941. Epub 2020 Dec 15. PMID: 33231295.

    21. Huber M, Brehm CU, Gress TM, Buchholz M, Alashkar Alhamwe B, von Strandmann EP, Slater EP, Bartsch JW, Bauer C, Lauth M. The Immune Microenvironment in Pancreatic Cancer. Int J Mol Sci. 2020 Oct 3;21(19):7307. doi: 10.3390/ijms21197307. PMID: 33022971; PMCID: PMC7583843.

    22. Stelmach P, Pütz M, Pollmann R, Happel M, Stei S, Schlegel K, Seipelt M, Eienbröker C, Eming R, Mandic R, Huber M, Tackenberg B. Alternative splicing of the TNFSF13B (BAFF) pre-mRNA and expression of the BAFFX1 isoform in human immune cells. Gene. 2020 Nov 15;760:145021. doi: 10.1016/j.gene.2020.145021. Epub 2020 Aug 4. PMID: 32763489.

    23. Matthias J, Heink S, Picard F, Zeiträg J, Kolz A, Chao YY, Soll D, de Almeida GP, Glasmacher E, Jacobsen ID, Riedel T, Peters A, Floess S, Huehn J, Baumjohann D, Huber M, Korn T, Zielinski CE. Salt generates antiinflammatory Th17 cells but amplifies pathogenicity in proinflammatory cytokine microenvironments. J Clin Invest. 2020 Sep 1;130(9):4587-4600. doi: 10.1172/JCI137786. PMID: 32484796; PMCID: PMC7456214.

    24. Lückel C, Picard FSR, Huber M. Tc17 biology and function: Novel concepts. Eur J Immunol. 2020 Sep;50(9):1257-1267. doi: 10.1002/eji.202048627. Epub 2020 Aug 2. PMID: 32697883.

    25. Salazar Y, Zheng X, Brunn D, Raifer H, Picard F, Zhang Y, Winter H, Guenther S, Weigert A, Weigmann B, Dumoutier L, Renauld JC, Waisman A, Schmall A, Tufman A, Fink L, Brüne B, Bopp T, Grimminger F, Seeger W, Pullamsetti SS, Huber M, Savai R. Microenvironmental Th9 and Th17 lymphocytes induce metastatic spreading in lung cancer. J Clin Invest. 2020 Jul 1;130(7):3560-3575. doi: 10.1172/JCI124037. PMID: 32229721; PMCID: PMC7324180.

    26. Salazar Y, Zheng X, Brunn D, Raifer H, Picard F, Zhang Y, Winter H, Guenther S, Weigert A, Weigmann B, Dumoutier L, Renauld JC, Waisman A, Schmall A, Tufman A, Fink L, Brüne B, Bopp T, Grimminger F, Seeger W, Pullamsetti SS, Huber M, Savai R. Microenvironmental Th9 and Th17 lymphocytes induce metastatic spreading in lung cancer. J Clin Invest. 2020 Jul 1;130(7):3560-3575. doi: 10.1172/JCI124037. PMID: 32229721; PMCID: PMC7324180.

    27. Lückel C, Picard F, Raifer H, Campos Carrascosa L, Guralnik A, Zhang Y, Klein M, Bittner S, Steffen F, Moos S, Marini F, Gloury R, Kurschus FC, Chao YY, Bertrams W, Sexl V, Schmeck B, Bonetti L, Grusdat M, Lohoff M, Zielinski CE, Zipp F, Kallies A, Brenner D, Berger M, Bopp T, Tackenberg B, Huber M. IL-17+ CD8+ T cell suppression by dimethyl fumarate associates with clinical response in multiple sclerosis. Nat Commun. 2019 Dec 16;10(1):5722. doi: 10.1038/s41467-019-13731-z. PMID: 31844089; PMCID: PMC6915776.

    28. Bohn T, Rapp S, Luther N, Klein M, Bruehl TJ, Kojima N, Aranda Lopez P, Hahlbrock J, Muth S, Endo S, Pektor S, Brand A, Renner K, Popp V, Gerlach K, Vogel D, Lueckel C, Arnold-Schild D, Pouyssegur J, Kreutz M, Huber M, Koenig J, Weigmann B, Probst HC, von Stebut E, Becker C, Schild H, Schmitt E, Bopp T. Tumor immunoevasion via acidosis-dependent induction of regulatory tumor-associated macrophages. Nat Immunol. 2018 Dec;19(12):1319-1329. doi: 10.1038/s41590-018-0226-8. Epub 2018 Nov 5. PMID: 30397348.

    29. Inselmann S, Wang Y, Saussele S, Fritz L, Schütz C, Huber M, Liebler S, Ernst T, Cai D, Botschek S, Brendel C, Calogero RA, Pavlinic D, Benes V, Liu ET, Neubauer A, Hochhaus A, Burchert A. Development, Function, and Clinical Significance of Plasmacytoid Dendritic Cells in Chronic Myeloid Leukemia. Cancer Res. 2018 Nov 1;78(21):6223-6234. doi: 10.1158/0008-5472.CAN-18-1477. Epub 2018 Aug 30. PMID: 30166420.

    30. Lieber S, Reinartz S, Raifer H, Finkernagel F, Dreyer T, Bronger H, Jansen JM, Wagner U, Worzfeld T, Müller R, Huber M. Prognosis of ovarian cancer is associated with effector memory CD8+ T cell accumulation in ascites, CXCL9 levels and activation-triggered signal transduction in T cells. Oncoimmunology. 2018 Mar 15;7(5):e1424672. doi: 10.1080/2162402X.2018.1424672. PMID: 29721385; PMCID: PMC5927536.

    31. Campos Carrascosa L, Klein M, Kitagawa Y, Lückel C, Marini F, König A, Guralnik A, Raifer H, Hagner-Benes S, Rädler D, Böck A, Kang C, Lohoff M, Garn H, Schaub B, Berberich-Siebelt F, Sakaguchi S, Bopp T, Huber M. Reciprocal regulation of the Il9 locus by counteracting activities of transcription factors IRF1 and IRF4. Nat Commun. 2017 May 12;8:15366. doi: 10.1038/ncomms15366. PMID: 28497800; PMCID: PMC5437292.

    32. Huber M, Suprunenko T, Ashhurst T, Marbach F, Raifer H, Wolff S, Strecker T, Viengkhou B, Jung SR, Obermann HL, Bauer S, Xu HC, Lang PA, Tom A, Lang KS, King NJC, Campbell IL, Hofer MJ. IRF9 Prevents CD8+ T Cell Exhaustion in an Extrinsic Manner during Acute Lymphocytic Choriomeningitis Virus Infection. J Virol. 2017 Oct 27;91(22):e01219-17. doi: 10.1128/JVI.01219-17. PMID: 28878077; PMCID: PMC5660491.

    33. Schütz C, Inselmann S, Saussele S, Dietz CT, Mu Ller MC, Eigendorff E, Brendel CA, Metzelder SK, Bru Mmendorf TH, Waller C, Dengler J, Goebeler ME, Herbst R, Freunek G, Hanzel S, Illmer T, Wang Y, Lange T, Finkernagel F, Hehlmann R, Huber M, Neubauer A, Hochhaus A, Guilhot J, Xavier Mahon F, Pfirrmann M, Burchert A. Expression of the CTLA-4 ligand CD86 on plasmacytoid dendritic cells (pDC) predicts risk of disease recurrence after treatment discontinuation in CML. Leukemia. 2017 Apr;31(4):829-836. doi: 10.1038/leu.2017.9. Epub 2017 Jan 11. Erratum in: Leukemia. 2018 Jan 30;: PMID: 28074067.

    34. Ribechini E, Hutchinson JA, Hergovits S, Heuer M, Lucas J, Schleicher U, Jordán Garrote AL, Potter SJ, Riquelme P, Brackmann H, Müller N, Raifer H, Berberich I, Huber M, Beilhack A, Lohoff M, Bogdan C, Eyrich M, Hermanns HM, Geissler EK, Lutz MB. Novel GM-CSF signals via IFN-γR/IRF-1 and AKT/mTOR license monocytes for suppressor function. Blood Adv. 2017 Jun 7;1(14):947-960. doi: 10.1182/bloodadvances.2017006858. PMID: 29296736; PMCID: PMC5737598.

    35. Worzfeld T, Pogge von Strandmann E, Huber M, Adhikary T, Wagner U, Reinartz S, Müller R. The Unique Molecular and Cellular Microenvironment of Ovarian Cancer. Front Oncol. 2017 Feb 22;7:24. doi: 10.3389/fonc.2017.00024. PMID: 28275576; PMCID: PMC5319992.

    36. Mahnke J, Schumacher V, Ahrens S, Käding N, Feldhoff LM, Huber M, Rupp J, Raczkowski F, Mittrücker HW. Interferon Regulatory Factor 4 controls TH1 cell effector function and metabolism. Sci Rep. 2016 Oct 20;6:35521. doi: 10.1038/srep35521. PMID: 27762344; PMCID: PMC5071867.

    37. Mühlberg L, Kühnemuth B, Costello E, Shaw V, Sipos B, Huber M, Griesmann H, Krug S, Schober M, Gress TM, Michl P. miRNA dynamics in tumor-infiltrating myeloid cells modulating tumor progression in pancreatic cancer. Oncoimmunology. 2016 May 9;5(6):e1160181. doi: 10.1080/2162402X.2016.1160181. PMID: 27471627; PMCID: PMC4938301.

    38. Bothur E, Raifer H, Haftmann C, Stittrich AB, Brüstle A, Brenner D, Bollig N, Bieringer M, Kang CH, Reinhard K, Camara B, Huber M, Visekruna A, Steinhoff U, Repenning A, Bauer UM, Sexl V, Radbruch A, Sparwasser T, Mashreghi MF, Wah Mak T, Lohoff M. Antigen receptor-mediated depletion of FOXP3 in induced regulatory T-lymphocytes via PTPN2 and FOXO1. Nat Commun. 2015 Oct 13;6:8576. doi: 10.1038/ncomms9576. PMID: 26815406; PMCID: PMC4633965.

    39. Huber M, Lohoff M. Change of paradigm: CD8+ T cells as important helper for CD4+ T cells during asthma and autoimmune encephalomyelitis. Allergo J Int. 2015;24(1):8-15. doi: 10.1007/s40629-015-0038-4. Epub 2015 Feb 9. PMID: 26120542; PMCID: PMC4479451.

    40. Klein M, Brühl TJ, Staudt V, Reuter S, Grebe N, Gerlitzki B, Hoffmann M, Bohn T, Ulges A, Stergiou N, de Graaf J, Löwer M, Taube C, Becker M, Hain T, Dietzen S, Stassen M, Huber M, Lohoff M, Campos Chagas A, Andersen J, Kotál J, Langhansová H, Kopecký J, Schild H, Kotsyfakis M, Schmitt E, Bopp T. Tick Salivary Sialostatin L Represses the Initiation of Immune Responses by Targeting IRF4-Dependent Transcription in Murine Mast Cells. J Immunol. 2015 Jul 15;195(2):621-31. doi: 10.4049/jimmunol.1401823. Epub 2015 Jun 15. PMID: 26078269; PMCID: PMC4841271.

    41. Pick J, Arra A, Lingel H, Hegel JK, Huber M, Nishanth G, Jorch G, Fischer KD, Schlüter D, Tedford K, Brunner-Weinzierl MC. CTLA-4 (CD152) enhances the Tc17 differentiation program. Eur J Immunol. 2014 Jul;44(7):2139-52. doi: 10.1002/eji.201343497. Epub 2014 May 30. PMID: 24723371.

    42. Grusdat M, McIlwain DR, Xu HC, Pozdeev VI, Knievel J, Crome SQ, Robert-Tissot C, Dress RJ, Pandyra AA, Speiser DE, Lang E, Maney SK, Elford AR, Hamilton SR, Scheu S, Pfeffer K, Bode J, Mittrücker HW, Lohoff M, Huber M, Häussinger D, Ohashi PS, Mak TW, Lang KS, Lang PA. IRF4 and BATF are critical for CD8⁺ T-cell function following infection with LCMV. Cell Death Differ. 2014 Jul;21(7):1050-60. doi: 10.1038/cdd.2014.19. Epub 2014 Feb 14. PMID: 24531538; PMCID: PMC4207473.

    43. Huber M, Lohoff M. IRF4 at the crossroads of effector T-cell fate decision. Eur J Immunol. 2014 Jul;44(7):1886-95. doi: 10.1002/eji.201344279. Epub 2014 Jun 16. PMID: 24782159.

    44. Mittrücker HW, Visekruna A, Huber M. Heterogeneity in the differentiation and function of CD8⁺ T cells. Arch Immunol Ther Exp (Warsz). 2014 Dec;62(6):449-58. doi: 10.1007/s00005-014-0293-y. Epub 2014 May 31. PMID: 24879097.

    45. Huber M, Lohoff M. IRF4 provides rations for cytotoxic CD8(+) T cell soldiers. Immunity. 2013 Nov 14;39(5):797-9. doi: 10.1016/j.immuni.2013.10.008. PMID: 24238334.

    46. Mahnke J, Schumacher V, Ahrens S, Käding N, Feldhoff LM, Huber M, Rupp J, Raczkowski F, Mittrücker HW. Interferon Regulatory Factor 4 controls TH1 cell effector function and metabolism. Sci Rep. 2016 Oct 20;6:35521. doi: 10.1038/srep35521. PMID: 27762344; PMCID: PMC5071867.

    47. Visekruna A, Ritter J, Scholz T, Campos L, Guralnik A, Poncette L, Raifer H, Hagner S, Garn H, Staudt V, Bopp T, Reuter S, Taube C, Loser K, Huber M. Tc9 cells, a new subset of CD8(+) T cells, support Th2-mediated airway inflammation. Eur J Immunol. 2013 Mar;43(3):606-18. doi: 10.1002/eji.201242825. Epub 2013 Jan 31. PMID: 23254356.

    48. Huber M, Heink S, Pagenstecher A, Reinhard K, Ritter J, Visekruna A, Guralnik A, Bollig N, Jeltsch K, Heinemann C, Wittmann E, Buch T, Prazeres da Costa O, Brüstle A, Brenner D, Mak TW, Mittrücker HW, Tackenberg B, Kamradt T, Lohoff M. IL-17A secretion by CD8+ T cells supports Th17-mediated autoimmune encephalomyelitis. J Clin Invest. 2013 Jan;123(1):247-60. doi: 10.1172/JCI63681. Epub 2012 Dec 10. PMID: 23221338; PMCID: PMC3533283.

    49. Raifer H, Mahiny AJ, Bollig N, Petermann F, Hellhund A, Kellner K, Guralnik A, Reinhard K, Bothur E, Huber M, Bauer S, Löhning M, Kiss EA, Ganal SC, Diefenbach A, Korn T, Lohoff M. Unlike αβ T cells, γδ T cells, LTi cells and NKT cells do not require IRF4 for the production of IL-17A and IL-22. Eur J Immunol. 2012 Dec;42(12):3189-201. doi: 10.1002/eji.201142155. Epub 2012 Oct 17. PMID: 22961652.

    50. Bollig N, Brüstle A, Kellner K, Ackermann W, Abass E, Raifer H, Camara B, Brendel C, Giel G, Bothur E, Huber M, Paul C, Elli A, Kroczek RA, Nurieva R, Dong C, Jacob R, Mak TW, Lohoff M. Transcription factor IRF4 determines germinal center formation through follicular T-helper cell differentiation. Proc Natl Acad Sci U S A. 2012 May 29;109(22):8664-9. doi: 10.1073/pnas.1205834109. Epub 2012 May 2. PMID: 22552227; PMCID: PMC3365194.

    51. Reinhard K, Huber M, Lohoff M, Visekruna A. The role of NF-κB activation during protection against Leishmania infection. Int J Med Microbiol. 2012 Oct;302(4-5):230-5. doi: 10.1016/j.ijmm.2012.07.006. Epub 2012 Aug 14. PMID: 22901377.

    52. Reinhard K, Huber M, Wostl C, Hellhund A, Toboldt A, Abass E, Casper B, Joeris T, Herr C, Bals R, Steinhoff U, Lohoff M, Visekruna A. c-Rel promotes type 1 and type 17 immune responses during Leishmania major infection. Eur J Immunol. 2011 May;41(5):1388-98. doi: 10.1002/eji.201041056. Epub 2011 Apr 11. PMID: 21469108.

    53. Visekruna A, Huber M, Hellhund A, Bothur E, Reinhard K, Bollig N, Schmidt N, Joeris T, Lohoff M, Steinhoff U. c-Rel is crucial for the induction of Foxp3(+) regulatory CD4(+) T cells but not T(H)17 cells. Eur J Immunol. 2010 Mar;40(3):671-6. doi: 10.1002/eji.200940260. PMID: 20049877.

    54. Huber M, Heink S, Grothe H, Guralnik A, Reinhard K, Elflein K, Hünig T, Mittrücker HW, Brüstle A, Kamradt T, Lohoff M. A Th17-like developmental process leads to CD8(+) Tc17 cells with reduced cytotoxic activity. Eur J Immunol. 2009 Jul;39(7):1716-25. doi: 10.1002/eji.200939412. PMID: 19544308.

    55. Huber M, Brüstle A, Reinhard K, Guralnik A, Walter G, Mahiny A, von Löw E, Lohoff M. IRF4 is essential for IL-21-mediated induction, amplification, and stabilization of the Th17 phenotype. Proc Natl Acad Sci U S A. 2008 Dec 30;105(52):20846-51. doi: 10.1073/pnas.0809077106. Epub 2008 Dec 16. PMID: 19088203; PMCID: PMC2634912.

    56. Huber M, Steinwald V, Guralnik A, Brüstle A, Kleemann P, Rosenplänter C, Decker T, Lohoff M. IL-27 inhibits the development of regulatory T cells via STAT3. Int Immunol. 2008 Feb;20(2):223-34. doi: 10.1093/intimm/dxm139. Epub 2007 Dec 21. PMID: 18156621.

    57. Brüstle A, Heink S, Huber M, Rosenplänter C, Stadelmann C, Yu P, Arpaia E, Mak TW, Kamradt T, Lohoff M. The development of inflammatory T(H)-17 cells requires interferon-regulatory factor 4. Nat Immunol. 2007 Sep;8(9):958-66. doi: 10.1038/ni1500. Epub 2007 Aug 5. PMID: 17676043.

    58. Kleemann P, Casper B, Huber M, Schuetz JD, Lohoff M. Multidrug-resistance-associated protein 1 (Mrp1) is probably not required for murine Th cell activation. Int Immunol. 2006 Nov;18(11):1603-6. doi: 10.1093/intimm/dxl094. Epub 2006 Sep 28. PMID: 17008412.

    59. Lohoff M, Mittrücker HW, Brüstle A, Sommer F, Casper B, Huber M, Ferrick DA, Duncan GS, Mak TW. Enhanced TCR-induced apoptosis in interferon regulatory factor 4-deficient CD4(+) Th cells. J Exp Med. 2004 Jul 19;200(2):247-53. doi: 10.1084/jem.20040182. Epub 2004 Jul 12. PMID: 15249594; PMCID: PMC2212018.

    60. Huber M, Timms E, Mak TW, Röllinghoff M, Lohoff M. Effective and long-lasting immunity against the parasite Leishmania major in CD8-deficient mice. Infect Immun. 1998 Aug;66(8):3968-70. doi: 10.1128/IAI.66.8.3968-3970.1998. PMID: 9673288; PMCID: PMC108466.

    61. Huber M, Beuscher HU, Rohwer P, Kurrle R, Röllinghoff M, Lohoff M. Costimulation via TCR and IL-1 receptor reveals a novel IL-1alpha-mediated autocrine pathway of Th2 cell proliferation. J Immunol. 1998 May 1;160(9):4242-7. PMID: 9574525.

    62. Huber M, Rutherford A, Meister W, Weiss A, Röllinghoff M, Lohoff M. TCR- and IL-1-mediated co-stimulation reveals an IL-4-independent way of Th2 cell proliferation. Int Immunol. 1996 Aug;8(8):1257-63. doi: 10.1093/intimm/8.8.1257. PMID: 8918695.

    63. Sommer F, Huber M, Röllinghoff M, Lohoff M. CD44 plays a co-stimulatory role in murine T cell activation: ligation of CD44 selectively co-stimulates IL-2 production, but not proliferation in TCR-stimulated murine Th1 cells. Int Immunol. 1995 Nov;7(11):1779-86. doi: 10.1093/intimm/7.11.1779. PMID: 8580076.

    64. Lasek W, Sora (Huber) M, Wańkowicz A, Jakóbisiak M. Combination of immunotherapy with cyclophosphamide/actinomycin D chemotherapy potentiates antileukemic effect and reduces toxicity in a L1210 leukemia model in mice. Cancer Lett. 1995 Feb 10;89(1):137-43. doi: 10.1016/0304-3835(95)90169-8. PMID: 7882296.

    65. Lasek W, Sora (Huber) M, Jakóbisiak M. Effect of blood transfusion and cyclophosphamide on cardiac allograft survival in sensitized mice. Arch Immunol Ther Exp (Warsz). 1994;42(5-6):399-403. PMID: 8572899.

    66. Sora (Huber) MK, Kruszewski AA, Stokłosa T, Czyzyk J, Lasek W, Malejczyk J, Jakóbisiak M. Synergistic antiproliferative activity of tumor necrosis factor alpha (TNF-alpha) and lovastatin. Arch Immunol Ther Exp (Warsz). 1994;42(4):269-74. PMID: 7487365.