Main Content
Selected publications
1. Brichkina A, Ems M, Suezov R, Singh R, Lutz V, Picard FSR, Nist A, Stiewe T, Graumann J, Daude M, Diederich WE, Finkernagel F, Chung H-R, Bartsch DK, Roth K, Keber C, Denkert C, Huber M, Gress TM, Lauth M. DYRK1B blockade promotes tumoricidal macrophage activity in pancreatic cancer. Gut. Published Online First: 04 June 2024. doi: 10.1136/gutjnl-2023-331854. IF=23.0
2. Soll D, Chu C-F, Sun S, Lutz V, Arunkumar M, Gachechiladze M,Schäuble S, Alissa-Alkhalaf M, Nguyen T, Khalil M-A, Garcia-Ribelles I, Mueller M, Buder K, Michalke B, Panagiotou G, Ziegler-Martin K, Benz P, Schatzlmaier P, Hiller K, Stockinger H, Luu M, Schober K, Moosmann C, Schamel WW, Huber M, Zielinski CE. Sodium chloride in the tumor microenvironment enhances T cell metabolic fitness and cytotoxicity. Nat Immunol. 2024 doi: 10.1038/s41590-024-01918-6. IF=27.7
3. Neuhaus F, Lieber S, Shinkevich V, Steitz AM, Raifer H, Roth K, Finkernagel F, Worzfeld T, Burchert A, Keber C, Nist A, Stiewe T, Reinartz S, Beutgen VM, Graumann J, Pauck K, Garn H, Gaida M, Müller R, Huber M. Reciprocal crosstalk between Th17 and mesothelial cells promotes metastasis-associated adhesion of ovarian cancer cells. Clin Transl Med. 2024 Apr;14(4):e1604. doi: 10.1002/ctm2.1604. PMID: 38566518; PMCID: PMC10988119. IF=10.6
4. Rauch E, Amendt T, Lopez Krol A, Lang FB, Linse V, Hohmann M, Keim AC, Kreutzer S, Kawengian K, Buchholz M, Duschner P, Grauer S, Schnierle B, Ruhl A, Burtscher I, Dehnert S, Kuria C, Kupke A, Paul S, Liehr T, Lechner M, Schnare M, Kaufmann A, Huber M, Winkler TH, Bauer S, Yu P. T-bet+ B cells are activated by and control endogenous retroviruses through TLR-dependent mechanisms. Nat Commun. 2024 Feb 9;15(1):1229. doi: 10.1038/s41467-024-45201-6. PMID: 38336876; PMCID: PMC10858178. IF=16.6
5. Brichkina A, Suezov R, Huber M. Methyltransferase-like 3 (METTL3) inhibition potentiates anti-tumor immunity: a novel strategy for improving anti-PD1 therapy. Signal Transduct Target Ther. 2023 Dec 11;8(1):448. doi: 10.1038/s41392-023-01696-x. PMID: 38072988; PMCID: PMC10710993. IF=40.8
6. Nasiri E, Student M, Roth K, Siti Utami N, Huber M, Buchholz M, Gress TM, Bauer C. IL18 Receptor Signaling Inhibits Intratumoral CD8+ T-Cell Migration in a Murine Pancreatic Cancer Model. Cells. 2023 Jan 31;12(3):456. doi: 10.3390/cells12030456. PMID: 36766797; PMCID: PMC9913970. IF=7.66
7. Picard FSR, Lutz V, Brichkina A, Neuhaus F, Ruckenbrod T, Hupfer A, Raifer H, Klein M, Bopp T, Pfefferle PI, Savai R, Prinz I, Waisman A, Moos S, Chang HD, Heinrich S, Bartsch DK, Buchholz M, Singh S, Tu M, Klein L, Bauer C, Liefke R, Burchert A, Chung HR, Mayer P, Gress TM, Lauth M, Gaida M, Huber M. IL-17A-producing CD8+ T cells promote PDAC via induction of inflammatory cancer-associated fibroblasts. Gut. 2023 Aug;72(8):1510-1522. doi: 10.1136/gutjnl-2022-327855. Epub 2023 Feb 9. PMID: 36759154; PMCID: PMC10359545. IF=31.75
8. Lutz V, Hellmund VM, Picard FSR, Raifer H, Ruckenbrod T, Klein M, Bopp T, Savai R, Duewell P, Keber CU, Weigert A, Chung HR, Buchholz M, Menke A, Gress TM, Huber M, Bauer C. IL18 Receptor Signaling Regulates Tumor-Reactive CD8+ T-cell Exhaustion via Activation of the IL2/STAT5/mTOR Pathway in a Pancreatic Cancer Model. Cancer Immunol Res. 2023 Apr 3;11(4):421-434. doi: 10.1158/2326-6066.CIR-22-0398. PMID: 36758176. IF=12.02
9. Locatelli G, Marques-Ferreira F, Katsoulas A, Kalaitzaki V, Krueger M, Ingold-Heppner B, Walthert S, Sankowski R, Prazeres da Costa O, Dolga A, Huber M, Gold M, Culmsee C, Waisman A, Bechmann I, Milchevskaya V, Prinz M, Tresch A, Becher B, Buch T. IGF1R expression by adult oligodendrocytes is not required in the steady-state but supports neuroinflammation. Glia. 2023 Mar;71(3):616-632. doi: 10.1002/glia.24299. Epub 2022 Nov 17. PMID: 36394300. IF=7.45
10. Xu R, Höß C, Swiercz JM, Brandt DT, Lutz V, Petersen N, Li R, Zhao D, Oleksy A, Creigh-Pulatmen T, Trokter M, Fedorova M, Atzberger A, Strandby RB, Olsen AA, Achiam MP, Matthews D, Huber M, Gröne HJ, Offermanns S, Worzfeld T. A semaphorin-plexin-Rasal1 signaling pathway inhibits gastrin expression and protects against peptic ulcers. Sci Transl Med. 2022 Jul 20;14(654):eabf1922. doi: 10.1126/scitranslmed.abf1922. Epub 2022 Jul 20. PMID: 35857828. IF=19.3
11. Kandra P, Nandigama R, Eul B, Huber M, Kobold S, Seeger W, Grimminger F, Savai R. Utility and Drawbacks of Chimeric Antigen Receptor T Cell (CAR-T) Therapy in Lung Cancer. Front Immunol. 2022 Jun 2;13:903562. doi: 10.3389/fimmu.2022.903562. PMID: 35720364; PMCID: PMC9201083. IF=7.5
12. Raifer H, Schulz AR, Theodorou J, Romero-Olmedo AJ, Böck A, Bertrams W, Schmeck BT, Chung HR, Lohoff M, Chang HD, Schaub B, Mei HE, Huber M. Mass cytometry-based identification of a unique T-cell signature in childhood allergic asthma. Allergy. 2022 Jan;77(1):313-316. doi: 10.1111/all.15110. Epub 2021 Oct 4. PMID: 34564874. IF=13.1
13. Hessmann E, Schneider G; 1(st) Virtual Göttingen-Munich-Marburg Pancreatic Cancer Meeting. New Insights Into Pancreatic Cancer: Notes from a Virtual Meeting. Gastroenterology. 2021 Sep;161(3):785-791. doi: 10.1053/j.gastro.2021.04.082. Epub 2021 Jun 2. PMID: 34089734. IF=22.7
14. Luu M, Riester Z, Baldrich A, Reichardt N, Yuille S, Busetti A, Klein M, Wempe A, Leister H, Raifer H, Picard F, Muhammad K, Ohl K, Romero R, Fischer F, Bauer CA, Huber M, Gress TM, Lauth M, Danhof S, Bopp T, Nerreter T, Mulder IE, Steinhoff U, Hudecek M, Visekruna A. Microbial short-chain fatty acids modulate CD8+ T cell responses and improve adoptive immunotherapy for cancer. Nat Commun. 2021 Jul 1;12(1):4077. doi: 10.1038/s41467-021-24331-1. PMID: 34210970; PMCID: PMC8249424. IF=14.9
15. Arnold C, Demuth P, Seiwert N, Wittmann S, Boengler K, Rasenberger B, Christmann M, Huber M, Brunner T, Linnebacher M, Fahrer J. The Mitochondrial Disruptor Devimistat (CPI-613) Synergizes with Genotoxic Anticancer Drugs in Colorectal Cancer Therapy in a Bim-Dependent Manner. Mol Cancer Ther. 2022 Jan;21(1):100-112. doi: 10.1158/1535-7163.MCT-21-0393. Epub 2021 Nov 8. PMID: 34750196. IF=6.3
16. Matthias J, Heink S, Picard F, Zeiträg J, Kolz A, Chao YY, Soll D, de Almeida GP, Glasmacher E, Jacobsen ID, Riedel T, Peters A, Floess S, Huehn J, Baumjohann D, Huber M, Korn T, Zielinski CE. Salt generates antiinflammatory Th17 cells but amplifies pathogenicity in proinflammatory cytokine microenvironments. J Clin Invest. 2020 Sep 1;130(9):4587-4600. doi: 10.1172/JCI137786. PMID: 32484796; PMCID: PMC7456214. IF=14.8
17. Salazar Y, Zheng X, Brunn D, Raifer H, Picard F, Zhang Y, Winter H, Guenther S, Weigert A, Weigmann B, Dumoutier L, Renauld JC, Waisman A, Schmall A, Tufman A, Fink L, Brüne B, Bopp T, Grimminger F, Seeger W, Pullamsetti SS, Huber M, Savai R. Microenvironmental Th9 and Th17 lymphocytes induce metastatic spreading in lung cancer. J Clin Invest. 2020 Jul 1;130(7):3560-3575. doi: 10.1172/JCI124037. PMID: 32229721; PMCID: PMC7324180. IF=14.8
18. Lückel C, Picard F, Raifer H, Campos Carrascosa L, Guralnik A, Zhang Y, Klein M, Bittner S, Steffen F, Moos S, Marini F, Gloury R, Kurschus FC, Chao YY, Bertrams W, Sexl V, Schmeck B, Bonetti L, Grusdat M, Lohoff M, Zielinski CE, Zipp F, Kallies A, Brenner D, Berger M, Bopp T, Tackenberg B, Huber M. IL-17+ CD8+ T cell suppression by dimethyl fumarate associates with clinical response in multiple sclerosis. Nat Commun. 2019 Dec 16;10(1):5722. doi: 10.1038/s41467-019-13731-z. PMID: 31844089; PMCID: PMC6915776. IF=12.1
19. Bohn T, Rapp S, Luther N, Klein M, Bruehl TJ, Kojima N, Aranda Lopez P, Hahlbrock J, Muth S, Endo S, Pektor S, Brand A, Renner K, Popp V, Gerlach K, Vogel D, Lueckel C, Arnold-Schild D, Pouyssegur J, Kreutz M, Huber M, Koenig J, Weigmann B, Probst HC, von Stebut E, Becker C, Schild H, Schmitt E, Bopp T. Tumor immunoevasion via acidosis-dependent induction of regulatory tumor-associated macrophages. Nat Immunol. 2018 Dec;19(12):1319-1329. doi: 10.1038/s41590-018-0226-8. Epub 2018 Nov 5. PMID: 30397348. IF=23.5
20. Inselmann S, Wang Y, Saussele S, Fritz L, Schütz C, Huber M, Liebler S, Ernst T, Cai D, Botschek S, Brendel C, Calogero RA, Pavlinic D, Benes V, Liu ET, Neubauer A, Hochhaus A, Burchert A. Development, Function, and Clinical Significance of Plasmacytoid Dendritic Cells in Chronic Myeloid Leukemia. Cancer Res. 2018 Nov 1;78(21):6223-6234. doi: 10.1158/0008-5472.CAN-18-1477. Epub 2018 Aug 30. PMID: 30166420. IF=8.4
21. Campos Carrascosa L, Klein M, Kitagawa Y, Lückel C, Marini F, König A, Guralnik A, Raifer H, Hagner-Benes S, Rädler D, Böck A, Kang C, Lohoff M, Garn H, Schaub B, Berberich-Siebelt F, Sakaguchi S, Bopp T, Huber M. Reciprocal regulation of the Il9 locus by counteracting activities of transcription factors IRF1 and IRF4. Nat Commun. 2017 May 12;8:15366. doi: 10.1038/ncomms15366. PMID: 28497800; PMCID: PMC5437292. IF=12.3
22. Schütz C, Inselmann S, Saussele S, Dietz CT, Mu Ller MC, Eigendorff E, Brendel CA, Metzelder SK, Bru Mmendorf TH, Waller C, Dengler J, Goebeler ME, Herbst R, Freunek G, Hanzel S, Illmer T, Wang Y, Lange T, Finkernagel F, Hehlmann R, Huber M, Neubauer A, Hochhaus A, Guilhot J, Xavier Mahon F, Pfirrmann M, Burchert A. Expression of the CTLA-4 ligand CD86 on plasmacytoid dendritic cells (pDC) predicts risk of disease recurrence after treatment discontinuation in CML. Leukemia. 2017 Apr;31(4):829-836. doi: 10.1038/leu.2017.9. Epub 2017 Jan 11. Erratum in: Leukemia. 2018 Jan 30;: PMID: 28074067. IF=12.1
23. Mühlberg L, Kühnemuth B, Costello E, Shaw V, Sipos B, Huber M, Griesmann H, Krug S, Schober M, Gress TM, Michl P. miRNA dynamics in tumor-infiltrating myeloid cells modulating tumor progression in pancreatic cancer. Oncoimmunology. 2016 May 9;5(6):e1160181. doi: 10.1080/2162402X.2016.1160181. PMID: 27471627; PMCID: PMC4938301. IF=7.7
24. Bothur E, Raifer H, Haftmann C, Stittrich AB, Brüstle A, Brenner D, Bollig N, Bieringer M, Kang CH, Reinhard K, Camara B, Huber M, Visekruna A, Steinhoff U, Repenning A, Bauer UM, Sexl V, Radbruch A, Sparwasser T, Mashreghi MF, Wah Mak T, Lohoff M. Antigen receptor-mediated depletion of FOXP3 in induced regulatory T-lymphocytes via PTPN2 and FOXO1. Nat Commun. 2015 Oct 13;6:8576. doi: 10.1038/ncomms9576. PMID: 26815406; PMCID: PMC4633965. IF=11.3
25. Grusdat M, McIlwain DR, Xu HC, Pozdeev VI, Knievel J, Crome SQ, Robert-Tissot C, Dress RJ, Pandyra AA, Speiser DE, Lang E, Maney SK, Elford AR, Hamilton SR, Scheu S, Pfeffer K, Bode J, Mittrücker HW, Lohoff M, Huber M, Häussinger D, Ohashi PS, Mak TW, Lang KS, Lang PA. IRF4 and BATF are critical for CD8⁺ T-cell function following infection with LCMV. Cell Death Differ. 2014 Jul;21(7):1050-60. doi: 10.1038/cdd.2014.19. Epub 2014 Feb 14. PMID: 24531538; PMCID: PMC4207473. IF=8.4
26. Huber M, Lohoff M. IRF4 provides rations for cytotoxic CD8(+) T cell soldiers. Immunity. 2013 Nov 14;39(5):797-9. doi: 10.1016/j.immuni.2013.10.008. PMID: 24238334. IF=20.7
27. Huber M, Heink S, Pagenstecher A, Reinhard K, Ritter J, Visekruna A, Guralnik A, Bollig N, Jeltsch K, Heinemann C, Wittmann E, Buch T, Prazeres da Costa O, Brüstle A, Brenner D, Mak TW, Mittrücker HW, Tackenberg B, Kamradt T, Lohoff M. IL-17A secretion by CD8+ T cells supports Th17-mediated autoimmune encephalomyelitis. J Clin Invest. 2013 Jan;123(1):247-60. doi: 10.1172/JCI63681. Epub 2012 Dec 10. PMID: 23221338; PMCID: PMC3533283. IF=13.1
28. Bollig N, Brüstle A, Kellner K, Ackermann W, Abass E, Raifer H, Camara B, Brendel C, Giel G, Bothur E, Huber M, Paul C, Elli A, Kroczek RA, Nurieva R, Dong C, Jacob R, Mak TW, Lohoff M. Transcription factor IRF4 determines germinal center formation through follicular T-helper cell differentiation. Proc Natl Acad Sci USA. 2012 May 29;109(22):8664-9. doi: 10.1073/pnas.1205834109. Epub 2012 May 2. PMID: 22552227; PMCID: PMC3365194. IF=9.7
29. Huber M, Heink S, Grothe H, Guralnik A, Reinhard K, Elflein K, Hünig T, Mittrücker HW, Brüstle A, Kamradt T, Lohoff M. A Th17-like developmental process leads to CD8(+) Tc17 cells with reduced cytotoxic activity. Eur J Immunol. 2009 Jul;39(7):1716-25. doi: 10.1002/eji.200939412. PMID: 19544308. IF=5.1
30. Huber M, Brüstle A, Reinhard K, Guralnik A, Walter G, Mahiny A, von Löw E, Lohoff M. IRF4 is essential for IL-21-mediated induction, amplification, and stabilization of the Th17 phenotype. Proc Natl Acad Sci USA. 2008 Dec 30;105(52):20846-51. doi: 10.1073/pnas.0809077106. Epub 2008 Dec 16. PMID: 19088203; PMCID: PMC2634912. IF=9.7
31. Brüstle A, Heink S, Huber M, Rosenplänter C, Stadelmann C, Yu P, Arpaia E, Mak TW, Kamradt T, Lohoff M. The development of inflammatory T(H)-17 cells requires interferon-regulatory factor 4. Nat Immunol. 2007 Sep;8(9):958-66. doi: 10.1038/ni1500. Epub 2007 Aug 5. PMID: 17676043. IF=26.2
For a complete list of publications please go to PubMed