Main Content

Selected Publications

Hupfer, Brichkina A, Koeniger A, Keber C, Denkert C, Pfefferle P, Helmprobst F, Pagenstecher A, Visekruna A, Lauth M (2021). Matrix stiffness drives stromal autophagy and promotes formation of a pro-tumorigenic niche. Proc Natl Acad Sci., 2021, in press.

Luu M, Riester Z, Baldrich A, Reichardt N, Yuille S, Busetti A, Klein M, Wempe A, Leister H, Raifer H, Picard F, Muhammad K, Ohl K, Romero R, Fischer F, Bauer CA, Huber M, Gress TM, Lauth M, Danhof S, Bopp T, Nerreter T, Mulder IE, Steinhoff U, Hudecek M, Visekruna A (2021). Microbial short-chain fatty acids modulate CD8+ T cell responses and improve adoptive immunotherapy for cancer. Nat Commun. 2021; 12(1):4077.

Koeniger, A., Brichkina, A., Nee, I., Dempwolff, L., Hupfer, A., Galperin, I., Finkernagel, F., Nist, A., Stiewe, T., Adhikary, T., Diederich, W., and Lauth, M. (2021). Activation of Cilia-Independent Hedgehog/GLI1 Signaling as a Novel Concept for Neuroblastoma Therapy. Cancers, 2021, 13, 1908.

Singh, R., Holz, P.S., Roth, K., Hupfer, A., Meissner, W., Muller, R., Buchholz, M., Gress, T.M., Elsasser, H.P., Jacob, R., et al., Lauth M. DYRK1B regulates Hedgehog-induced microtubule acetylation. Cell Mol Life Sci. 2019; 76(1):193-207.

Neesse A, Bauer CA, Öhlund D, Lauth M, Buchholz M, Michl P, Tuveson DA, Gress TM. Stromal biology and therapy in pancreatic cancer: ready for clinical translation? GUT. 2019; 68(1):159-171.

Singh R, Dhanyamraju PK, Lauth M. DYRK1B blocks canonical and promotes non-canonical Hedgehog signaling through activation of the mTOR/AKT pathway. Oncotarget; 2017; 8(1):833-845.

Didiasova M, Singh R, Wilhelm J, Kwapiszewska G, Wujak L, Zakrzewicz D, Schaefer L, Markart P, Seeger W, Lauth M*, Wygrecka M* (*Equal contribution). Pirfenidone exerts antifibrotic effects through inhibition of GLI transcription factors. FASEB J.; 2017; 31(5):1916-1928.

Schneider P, Bayo-Fina JM, Singh R, Dhanyamraju PK, Holz P, Baier A, Fendrich V, Ramaswamy A, Baumeister S, Martinez ED, Lauth M. Identification of a novel actin-dependent signal transducing module allows for the targeted degradation of GLI1. Nat Commun.; 2015; 6:8023.

Lauth M, Bergström Å, Shimokawa T, Tostar U, Qianren J, Guerra C, Barbacid M, Toftgård R. DYRK1B-dependent shift of Hedgehog signaling from an autocrine towards a paracrine mode by mutant RAS. Nat Struct Mol Biol. 2010, 17(6):718-25.

Lauth M, Bergström Å, Shimokawa T, Toftgård R. Inhibition of GLI-mediated transcription and tumor cell growth by small molecule antagonists. Proc Natl Acad Sci, 2007, 104(20), 8455-8460.

For a complete list please go to PubMed:

http://www.ncbi.nlm.nih.gov/pubmed/?term=lauth+m

 If you are interested in our group:

We are always looking for motivated Bachelor- and Master-students!

                                       please contact: lauth AT staff.uni-marburg.de