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Prof. Jue Wang, University of Wisconsin-Madison and Mercator Fellow of GRK 2937: Themes and Variations of Stress-Signaling Alarmones

Speaker Series. About the Wang Lab: Bacterial stress responses allow cells to survive fluctuating environments, antibiotic treatments, and host defenses. My current research aims to answer the following fundamental questions: how do bacteria utilize stress-induced small molecules to adapt to their specific environmental niches? How do bacteria enter a metabolically dormant persister state that is intrinsically tolerant to a broad array of antibiotic treatments? How do stressed bacteria mitigate potential conflicts between their DNA replication and transcription machineries to ensure survival? What are the molecular mechanisms of bacterial evolution to fit their specific niches? We combine metabolomics, transcriptomics, and proteomics with biochemical and evolutionary approaches to answer these questions. We study these processes in the Gram-positive bacterium Bacillus subtilis and the Gram-negative bacterium Escherichia coli. These organisms grow fast and are highly amenable to genetic manipulation. Because the fundamentals of information processing mechanisms are conserved across all domains of life, our work in bacteria is broadly applicable to other, less tractable, systems.

Veranstaltungsdaten

We are very much looking forward to welcoming the Mercator Fellow of our RTG to Marburg!  Prof. Wang will be available for meetings with other researchers at various times during the lecture week. Please contact Antje Becker if you wish to speak with our guest.