main content

Prof. Aurelio Teleman, German Cancer Research Center, Heidelberg: Non-uniform regulation of epigenetic marks via metabolism in a developing tissue

Speaker Series. Abstract: Histone acetylation regulates gene expression, cell function, and cell fate. We studied the pattern of histone acetylation in an epithelial tissue, the Drosophila wing disc and find that H3K18ac, H4K8ac, and total lysine acetylation are elevated in the outer rim of the disc. This is due in part to high fatty acid β-oxidation (FABO) in the rim, and partly due to nuclear positioning. This affects gene expression. In sum, there is a physical mark of the outer rim of the wing and other epithelia in Drosophila.

Veranstaltungsdaten

After the lecture and the public discussion, there will be a Meet & Greet of MiNu's doctoral researchers with Prof. Teleman. He will be available for meetings with other researchers on Monday afternoon, 13 May. Please contact  Antje Becker if you wish to speak with our guest.