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A02 - Longitudinal trajectories of brain changes as mediators of course of illness: intermittent sampling

Tilo Kircher, Udo Dannlowski, Eva Mennigen

Project A02 aims to understand the biopsychosocial mechanisms underlying disease trajectories in affective disorders. Utilizing data from DFG FOR 2107 and BMBF Early-BipoLife cohorts (n=4,105) as well as SFB/TRR 393 2-year follow-up data spanning in total 11 years, the project explores the association of brain structure and function with (i) past disease trajectories; (ii) prospective disease trajectories and symptom changes; (iii) early and late environmental risk and protective factors; (iv) biological; and (v) behavioural measures; along with (vi) treatment.