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A05 - Molecular and immunological characterization of symptom changes and course of illness using intense sampling

Andreas Forstner, Judith Alferink, Carmine Pariante

Project A05 aims to systematically characterize the link of molecular and immunological factors to symptom changes, course of illness and cognitive-emotional mechanisms in affective disorders. The project performs genome-wide genetic analyses in all 1,500 SFB/TRR 393 individuals as well as epigenetic, transcriptomic, endocrine and immunological investigations in a subsample of 150 patients and 100 healthy controls. A05 also performs transcriptomic and immunological analyses in selected animal models, and conducts integrative analyses to identify markers shared between species and to characterize multimodal signatures.