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B02 - Characterization of life event-triggered inflection signals and emotion regulation in a Cacna1c mouse model

Kay Jüngling, Nadine Bernhardt

B02 uses a Cacna1c mouse model to investigate the impact of gene x stress interactions on the occurrence and time course of symptom changes and alterations in emotion regulation. (i) We use validated stressors inducing the physiological response to stressful life events; (ii) we assess changes in key cognitive-emotional mechanisms, most notably emotion regulation, by continuous sampling of home cage behaviour with relevance to anxiety and depression-like changes; (iii) we investigate stressor-induced differences in prefrontal network activity using in vivo and ex vivo electrophysiology.