Main Content

B06 - Trajectories of behaviour and brain activity correlates of socio-affective cognition under genetic risk and psychosocial stress

Nadine Bernhardt, Markus Wöhr

Social distress and deficits in social cognition are thought to elicit symptoms and their fluctuations in affective disorders. In project B06 we aim to investigate the differential contributions of genetic risk and psychosocial stressors to short-term symptom changes and long-term behavioural trajectories in a rat model. Our experimental design incorporates continuous and intermittent behavioural observation, in vivo recording of brain activity with innovative neuroprosthetic technology, and molecular techniques to reveal neurobiological correlates and predictive signatures of concurrent behavioural changes.