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B08 - Impact of chronobiologic modulation on behavioural rhythms, neuroplasticity and immune-metabolic parameters

Carsten Culmsee, Kay Jüngling

Disturbed cognitive-behavioural rhythms frequently precede depressive episodes in patients. In project B08, we investigate the impact of circadian rhythm disruption in mice on transition to depressive behaviour, alterations in EEG/sleep rhythm and molecular and cellular readouts of circadian gene expression, neuroplasticity and immune metabolism in brain tissue and in the peripheral blood. This project aims to expose novel neurobiological signatures predictive for behavioural changes of concomitant depression-like behavioural alterations in animals, resembling disease trajectories in human patients.