Main Content

Publications - 3rd Funding Period (2018-2022)

A01 - Alexander Brehm

Lenz, J., Liefke, R., Funk, J., Shoup, S., Nist, A., Stiewe, T., Schulz, R., Tokusumi, Y., Albert, L., Raifer, H., et al. (2021). Ush regulates hemocyte-specific gene expression, fatty acid metabolism and cell cycle progression and cooperates with dNuRD to orchestrate hematopoiesis. PLoS Genet 17, e1009318. 10.1371/journal.pgen.1009318.

Hundertmark, T., Kreutz, S., Merle, N., Nist, A., Lamp, B., Stiewe, T., Brehm, A., Renkawitz-Pohl, R., and Rathke, C. (2019). Drosophila melanogaster tPlus3a and tPlus3b ensure full male fertility by regulating transcription of Y-chromosomal, seminal fluid, and heat shock genes. PLoS One 14, e0213177. 10.1371/journal.pone.0213177.

Mačinković, I., Theofel, I., Hundertmark, T., Kovač, K., Awe, S., Lenz, J., Forné, I., Lamp, B., Nist, A., Imhof, A., et al. (2019). Distinct CoREST complexes act in a cell-type-specific manner. Nucleic Acids Res 47, 11649-11666. 10.1093/nar/gkz1050.
A02 - Thomas Braun/Xuejun Yuan

Dobersch, S., Rubio, K., Singh, I., Günther, S., Graumann, J., Cordero, J., Castillo-Negrete, R., Huynh, M.B., Mehta, A., Braubach, P., et al. (2021). Positioning of nucleosomes containing γ-H2AX precedes active DNA demethylation and transcription initiation. Nat Commun 12, 1072. 10.1038/s41467-021-21227-y.

Valussi, M., Besser, J., Wystub-Lis, K., Zukunft, S., Richter, M., Kubin, T., Boettger, T., and Braun, T. (2021). Repression of. Sci Adv 7, eabi6648. 10.1126/sciadv.abi6648.

Kaneshige, A., Kaji, T., Zhang, L., Saito, H., Nakamura, A., Kurosawa, T., Ikemoto-Uezumi, M., Tsujikawa, K., Seno, S., Hori, M., et al. (2021). Relayed signaling between mesenchymal progenitors and muscle stem cells ensures adaptive stem cell response to increased mechanical load. Cell Stem Cell. 10.1016/j.stem.2021.11.003.

Ianni, A., Hofmann, M., Kumari, P., Tarighi, S., Al-Tamari, H.M., Görgens, A., Giebel, B., Nolte, H., Krüger, M., Salwig, I., et al. (2021). Depletion of. Front Cell Dev Biol 9, 639162. 10.3389/fcell.2021.639162.

Kumari, P., Tarighi, S., Braun, T., and Ianni, A. (2021). The complex role of SIRT7 in p53 stabilization: nucleophosmin joins the debate. Mol Cell Oncol 8, 1896349. 10.1080/23723556.2021.1896349.

Chen, Y., Lüttmann, F.F., Schoger, E., Schöler, H.R., Zelarayán, L.C., Kim, K.P., Haigh, J.J., Kim, J., and Braun, T. (2021). Reversible reprogramming of cardiomyocytes to a fetal state drives heart regeneration in mice. Science 373, 1537-1540. 10.1126/science.abg5159.

Simonet, N.G., Thackray, J.K., Vazquez, B.N., Ianni, A., Espinosa-Alcantud, M., Morales-Sanfrutos, J., Hurtado-Bagès, S., Sabidó, E., Buschbeck, M., Tischfield, J., et al. (2020). SirT7 auto-ADP-ribosylation regulates glucose starvation response through mH2A1. Sci Adv 6, eaaz2590.

Schutt, C., Hallmann, A., Hachim, S., Klockner, I., Valussi, M., Atzberger, A., Graumann, J., Braun, T., and Boettger, T. (2020). Linc-MYH configures INO80 to regulate muscle stem cell numbers and skeletal muscle hypertrophy. EMBO J 39, e105098.

Salwig, I., Spitznagel, B., Wiesnet, M., and Braun, T. (2020). Imaging lung regeneration by light sheet microscopy. Histochem Cell Biol.

Sreenivasan, K., Ianni, A., Künne, C., Strilic, B., Günther, S., Perdiguero, E., Krüger, M., Spuler, S., Offermanns, S., Gómez-Del Arco, P., et al. (2020). Attenuated Epigenetic Suppression of Muscle Stem Cell Necroptosis Is Required for Efficient Regeneration of Dystrophic Muscles. Cell Rep 31, 107652. 10.1016/j.celrep.2020.107652.

Taei, A., Kiani, T., Taghizadeh, Z., Moradi, S., Samadian, A., Mollamohammadi, S., Sharifi-Zarchi, A., Guenther, S., Akhlaghpour, A., Asgari Abibeiglou, B., et al. (2020). Temporal activation of LRH-1 and RAR-γ in human pluripotent stem cells induces a functional naïve-like state. EMBO Rep 21, e47533. 10.15252/embr.201847533.

Shaban, M.S., Müller, C., Mayr-Buro, C., Weiser, H., Meier-Soelch, J., Albert, B.V., Weber, A., Linne, U., Hain, T., Babayev, I., et al. (2021). Multi-level inhibition of coronavirus replication by chemical ER stress. Nat Commun 12, 5536. 10.1038/s41467-021-25551-1.

Maroli, G., and Braun, T. (2020). The long and winding road of cardiomyocyte maturation. Cardiovasc Res.

Seibert, M., Krüger, M., Watson, N.A., Sen, O., Daum, J.R., Slotman, J.A., Braun, T., Houtsmuller, A.B., Gorbsky, G.J., Jacob, R., et al. (2019). CDK1-mediated phosphorylation at H2B serine 6 is required for mitotic chromosome segregation. J Cell Biol 218, 1164-1181.

Gao, R., Liang, X., Cheedipudi, S., Cordero, J., Jiang, X., Zhang, Q., Caputo, L., Günther, S., Kuenne, C., Ren, Y., et al. (2019). Pioneering function of Isl1 in the epigenetic control of cardiomyocyte cell fate. Cell Res 29, 486-501. 10.1038/s41422-019-0168-1.

Salwig, I., Spitznagel, B., Vazquez-Armendariz, A.I., Khalooghi, K., Guenther, S., Herold, S., Szibor, M., and Braun, T. (2019). Bronchioalveolar stem cells are a main source for regeneration of distal lung epithelia. EMBO J 38.

Jia, Y., Vong, J.S., Asafova, A., Garvalov, B.K., Caputo, L., Cordero, J., Singh, A., Boettger, T., Günther, S., Fink, L., et al. (2019). Lamin B1 loss promotes lung cancer development and metastasis by epigenetic derepression of RET. J Exp Med 216, 1377-1395. 10.1084/jem.20181394.

Wüst, S., Dröse, S., Heidler, J., Wittig, I., Klockner, I., Franko, A., Bonke, E., Günther, S., Gärtner, U., Boettger, T., et al. (2018). Metabolic Maturation during Muscle Stem Cell Differentiation Is Achieved by miR-1/133a-Mediated Inhibition of the Dlk1-Dio3 Mega Gene Cluster. Cell Metab 27, 1026-1039.e1026.

Moradi, S., Braun, T., and Baharvand, H. (2018). miR-302b-3p Promotes Self- Renewal Properties in Leukemia Inhibitory Factor-Withdrawn Embryonic Stem Cells. Cell J 20, 61-72.

Jia, G., Preussner, J., Chen, X., Guenther, S., Yuan, X., Yekelchyk, M., Kuenne, C., Looso, M., Zhou, Y., Teichmann, S., and Braun, T. (2018). Single cell RNA-seq and ATAC-seq analysis of cardiac progenitor cell transition states and lineage settlement. Nat Commun 9, 4877. 10.1038/s41467-018-07307-6.

Meier-Soelch, J., Jurida, L., Weber, A., Newel, D., Kim, J., Braun, T., Schmitz, M.L., and Kracht, M. (2018). RNAi-Based Identification of Gene-Specific Nuclear Cofactor Networks Regulating Interleukin-1 Target Genes. Front Immunol 9, 775.

Kumari, P., Popescu, D., Yue, S., Bober, E., Ianni, A., and Braun, T. (2018). Sirt7 inhibits Sirt1-mediated activation of Suv39h1. Cell Cycle 17, 1403-1412.

Ianni, A., Yuan, X., Bober, E., and Braun, T. (2018). Sirtuins in the Cardiovascular System: Potential Targets in Pediatric Cardiology. Pediatr Cardiol 39, 983-992.
A03 - Uta-Maria Bauer

Hamey, J.J., Rakow, S., Bouchard, C., Senst, J.M., Kolb, P., Bauer, U.M., Wilkins, M.R., and Hart-Smith, G. (2021). Systematic investigation of PRMT6 substrate recognition reveals broad specificity with a preference for an RG motif or basic and bulky residues. FEBS J. 10.1111/febs.15837.

Repenning, A., Happel, D., Bouchard, C., Meixner, M., Verel-Yilmaz, Y., Raifer, H., Holembowski, L., Krause, E., Kremmer, E., Feederle, R., et al. (2021). PRMT1 promotes the tumor suppressor function of p14. EMBO J, e106777. 10.15252/embj.2020106777.

Rakow, S., Pullamsetti, S.S., Bauer, U.M., and Bouchard, C. (2020). Assaying epigenome functions of PRMTs and their substrates. Methods 175, 53-65.

Chelladurai, P., Dabral, S., Basineni, S.R., Chen, C.N., Schmoranzer, M., Bender, N., Feld, C., Nötzold, R.R., Dobreva, G., Wilhelm, J., et al. (2020). Isoform-specific characterization of class I histone deacetylases and their therapeutic modulation in pulmonary hypertension. Sci Rep 10, 12864.

Bouchard, C., Sahu, P., Meixner, M., Nötzold, R.R., Rust, M.B., Kremmer, E., Feederle, R., Hart-Smith, G., Finkernagel, F., Bartkuhn, M., et al. (2018). Genomic Location of PRMT6-Dependent H3R2 Methylation Is Linked to the Transcriptional Outcome of Associated Genes. Cell Rep 24, 3339-3352.
A04 - Sjaak Philipsen/Thamar van Dijk

J Verheul, T.C., Trinh, V.T., Vázquez, O., and Philipsen, S. (2020). Targeted Protein Degradation as a Promising Tool for Epigenetic Upregulation of Fetal Hemoglobin. ChemMedChem 15, 2436-2443. 10.1002/cmdc.202000574.

Bouchard, C., Sahu, P., Meixner, M., Nötzold, R.R., Rust, M.B., Kremmer, E., Feederle, R., Hart-Smith, G., Finkernagel, F., Bartkuhn, M., et al. (2018). Genomic Location of PRMT6-Dependent H3R2 Methylation Is Linked to the Transcriptional Outcome of Associated Genes. Cell Rep 24, 3339-3352.
A07 - Lienhard Schmitz

Busch, J., Moreno, R., de la Vega, L., Saul, V.V., Bacher, S., von Zweydorf, F., Ueffing, M., Weber, A., Gloeckner, C.J., Linne, U., et al. (2021). TRAF6 Phosphorylation Prevents Its Autophagic Degradation and Re-Shapes LPS-Triggered Signaling Networks. Cancers (Basel) 13. 10.3390/cancers13143618.

Bacher, S., Meier-Soelch, J., Kracht, M., and Schmitz, M.L. (2021a). Regulation of Transcription Factor NF-κB in Its Natural Habitat: The Nucleus. Cells 10. 10.3390/cells10040753.

Bacher, S., Stekman, H., Farah, C.M., Karger, A., Kracht, M., and Schmitz, M.L. (2021b). MEKK1-Dependent Activation of the CRL4 Complex Is Important for DNA Damage-Induced Degradation of p21 and DDB2 and Cell Survival. Mol Cell Biol 41, e0008121. 10.1128/MCB.00081-21.

Meier-Soelch, J., Mayr-Buro, C., Juli, J., Leib, L., Linne, U., Dreute, J., Papantonis, A., Schmitz, M.L., and Kracht, M. (2021). Monitoring the Levels of Cellular NF-κB Activation States. Cancers (Basel) 13. 10.3390/cancers13215351.

Shaban, M.S., Müller, C., Mayr-Buro, C., Weiser, H., Meier-Soelch, J., Albert, B.V., Weber, A., Linne, U., Hain, T., Babayev, I., et al. (2021). Multi-level inhibition of coronavirus replication by chemical ER stress. Nat Commun 12, 5536. 10.1038/s41467-021-25551-1.

Groeger, S., Denter, F., Lochnit, G., Schmitz, M.L., and Meyle, J. (2020). Porphyromonas gingivalis Cell Wall Components Induce Programmed Death Ligand 1 (PD-L1) Expression on Human Oral Carcinoma Cells by a Receptor-Interacting Protein Kinase 2 (RIP2)-Dependent Mechanism. Infect Immun 88. 10.1128/IAI.00051-20.

Haas, J., Bloesel, D., Bacher, S., Kracht, M., and Schmitz, M.L. (2020). Chromatin Targeting of HIPK2 Leads to Acetylation-Dependent Chromatin Decondensation. Front Cell Dev Biol 8, 852. 10.3389/fcell.2020.00852.

Kracht, M., Müller-Ladner, U., and Schmitz, M.L. (2020). Mutual regulation of metabolic processes and proinflammatory NF-κB signaling. J Allergy Clin Immunol 146, 694-705. 10.1016/j.jaci.2020.07.027.

Schmitz, M.L., Higgins, J.M.G., and Seibert, M. (2020). Priming chromatin for segregation: functional roles of mitotic histone modifications. Cell Cycle 19, 625-641. 10.1080/15384101.2020.1719585.

Weiterer, S.S., Meier-Soelch, J., Georgomanolis, T., Mizi, A., Beyerlein, A., Weiser, H., Brant, L., Mayr-Buro, C., Jurida, L., Beuerlein, K., et al. (2020). Distinct IL-1α-responsive enhancers promote acute and coordinated changes in chromatin topology in a hierarchical manner. EMBO J 39, e101533. 10.15252/embj.2019101533.

Zarnack, K., Balasubramanian, S., Gantier, M.P., Kunetsky, V., Kracht, M., Schmitz, M.L., and Sträßer, K. (2020). Dynamic mRNP Remodeling in Response to Internal and External Stimuli. Biomolecules 10. 10.3390/biom10091310.

Mayr-Buro, C., Schlereth, E., Beuerlein, K., Tenekeci, U., Meier-Soelch, J., Schmitz, M.L., and Kracht, M. (2019). Single-Cell Analysis of Multiple Steps of Dynamic NF-κB Regulation in Interleukin-1α-Triggered Tumor Cells Using Proximity Ligation Assays. Cancers (Basel) 11. 10.3390/cancers11081199.

Riedlinger, T., Bartkuhn, M., Zimmermann, T., Hake, S.B., Nist, A., Stiewe, T., Kracht, M., and Schmitz, M.L. (2019a). Chemotherapeutic Drugs Inhibiting Topoisomerase 1 Activity Impede Cytokine-Induced and NF-κB p65-Regulated Gene Expression. Cancers (Basel) 11. 10.3390/cancers11060883.

Riedlinger, T., Liefke, R., Meier-Soelch, J., Jurida, L., Nist, A., Stiewe, T., Kracht, M., and Schmitz, M.L. (2019b). NF-κB p65 dimerization and DNA-binding is important for inflammatory gene expression. FASEB J 33, 4188-4202. 10.1096/fj.201801638R.

Ritter, O., and Schmitz, M.L. (2019). Differential intracellular localization and dynamic nucleocytoplasmic shuttling of homeodomain-interacting protein kinase family members. Biochim Biophys Acta Mol Cell Res 1866, 1676-1686. 10.1016/j.bbamcr.2019.04.009.

Saul, V.V., Seibert, M., Krüger, M., Jeratsch, S., Kracht, M., and Schmitz, M.L. (2019). ULK1/2 Restricts the Formation of Inducible SINT-Speckles, Membraneless Organelles Controlling the Threshold of TBK1 Activation. iScience 19, 527-544. 10.1016/j.isci.2019.08.0

Seibert, M., Krüger, M., Watson, N.A., Sen, O., Daum, J.R., Slotman, J.A., Braun, T., Houtsmuller, A.B., Gorbsky, G.J., Jacob, R., et al. (2019). CDK1-mediated phosphorylation at H2B serine 6 is required for mitotic chromosome segregation. J Cell Biol 218, 1164-1181. 10.1083/jcb.201806057.

Weber, A., Dam, S., Saul, V.V., Kuznetsova, I., Müller, C., Fritz-Wolf, K., Becker, K., Linne, U., Gu, H., Stokes, M.P., et al. (2019). Phosphoproteome Analysis of Cells Infected with Adapted and Nonadapted Influenza A Virus Reveals Novel Pro- and Antiviral Signaling Networks. J Virol 93. 10.1128/JVI.00528-19.

Schmitz, M.L., Shaban, M.S., Albert, B.V., Gökçen, A., and Kracht, M. (2018). The Crosstalk of Endoplasmic Reticulum (ER) Stress Pathways with NF-κB: Complex Mechanisms Relevant for Cancer, Inflammation and Infection. Biomedicines 6. 10.3390/biomedicines6020058.
A09 - Raymond Poot
A10 - Thorsten Stiewe

Lenz, J., Liefke, R., Funk, J., Shoup, S., Nist, A., Stiewe, T., Schulz, R., Tokusumi, Y., Albert, L., Raifer, H., et al. (2021). Ush regulates hemocyte-specific gene expression, fatty acid metabolism and cell cycle progression and cooperates with dNuRD to orchestrate hematopoiesis. PLoS Genet 17, e1009318. 10.1371/journal.pgen.1009318.

Timofeev, O., and Stiewe, T. (2021). Rely on Each Other: DNA Binding Cooperativity Shapes p53 Functions in Tumor Suppression and Cancer Therapy. Cancers (Basel) 13. 10.3390/cancers13102422.

Stielow, B., Zhou, Y., Cao, Y., Simon, C., Pogoda, H.M., Jiang, J., Ren, Y., Phanor, S.K., Rohner, I., Nist, A., et al. (2021). The SAM domain-containing protein 1 (SAMD1) acts as a repressive chromatin regulator at unmethylated CpG islands. Sci Adv 7. 10.1126/sciadv.abf2229.

Linden, G., Janga, H., Franz, M., Nist, A., Stiewe, T., Schmeck, B., Vázquez, O., and Schulte, L.N. (2021). Efficient antisense inhibition reveals microRNA-155 to restrain a late-myeloid inflammatory programme in primary human phagocytes. RNA Biol 18, 604-618. 10.1080/15476286.2021.1885209.

Liss, F., Frech, M., Wang, Y., Giel, G., Fischer, S., Simon, C., Weber, L.M., Nist, A., Stiewe, T., Neubauer, A., et al. (2021). IRF8 Is an AML-Specific Susceptibility Factor That Regulates Signaling Pathways and Proliferation of AML Cells. Cancers (Basel) 13. 10.3390/cancers13040764.

Gremke, N., Polo, P., Dort, A., Schneikert, J., Elmshäuser, S., Brehm, C., Klingmüller, U., Schmitt, A., Reinhardt, H.C., Timofeev, O., et al. (2020). mTOR-mediated cancer drug resistance suppresses autophagy and generates a druggable metabolic vulnerability. Nat Commun 11, 4684.

Klimovich, B., Stiewe, T., and Timofeev, O. (2020). Inactivation of Mdm2 restores apoptosis proficiency of cooperativity mutant p53 in vivo. Cell Cycle 19, 109-123.

Pavlakis, E., and Stiewe, T. (2020). p53's Extended Reach: The Mutant p53 Secretome. Biomolecules 10.

Pavlakis, E., Neumann, M., and Stiewe, T. (2020). Extracellular Vesicles: Messengers of p53 in Tumor-Stroma Communication and Cancer Metastasis. Int J Mol Sci 21. 10.3390/ijms21249648.

Ferrante, F., Giaimo, B.D., Bartkuhn, M., Zimmermann, T., Close, V., Mertens, D., Nist, A., Stiewe, T., Meier-Soelch, J., Kracht, M., et al. (2020). HDAC3 functions as a positive regulator in Notch signal transduction. Nucleic Acids Res 48, 3496-3512. 10.1093/nar/gkaa088.

Weiterer, S.S., Meier-Soelch, J., Georgomanolis, T., Mizi, A., Beyerlein, A., Weiser, H., Brant, L., Mayr-Buro, C., Jurida, L., Beuerlein, K., et al. (2020). Distinct IL-1α-responsive enhancers promote acute and coordinated changes in chromatin topology in a hierarchical manner. EMBO J 39, e101533. 10.15252/embj.2019101533.

Timofeev, O., Koch, L., Niederau, C., Tscherne, A., Schneikert, J., Klimovich, M., Elmshäuser, S., Zeitlinger, M., Mernberger, M., Nist, A., et al. (2020). Phosphorylation control of p53 DNA binding cooperativity balances tumorigenesis and aging. Cancer Res.

Hundertmark, T., Kreutz, S., Merle, N., Nist, A., Lamp, B., Stiewe, T., Brehm, A., Renkawitz-Pohl, R., and Rathke, C. (2019). Drosophila melanogaster tPlus3a and tPlus3b ensure full male fertility by regulating transcription of Y-chromosomal, seminal fluid, and heat shock genes. PLoS One 14, e0213177. 10.1371/journal.pone.0213177.

Riedlinger, T., Bartkuhn, M., Zimmermann, T., Hake, S.B., Nist, A., Stiewe, T., Kracht, M., and Schmitz, M.L. (2019a). Chemotherapeutic Drugs Inhibiting Topoisomerase 1 Activity Impede Cytokine-Induced and NF-κB p65-Regulated Gene Expression. Cancers (Basel) 11. 10.3390/cancers11060883.

Riedlinger, T., Liefke, R., Meier-Soelch, J., Jurida, L., Nist, A., Stiewe, T., Kracht, M., and Schmitz, M.L. (2019b). NF-κB p65 dimerization and DNA-binding is important for inflammatory gene expression. FASEB J 33, 4188-4202. 10.1096/fj.201801638R.

Sachs, P., Ding, D., Bergmaier, P., Lamp, B., Schlagheck, C., Finkernagel, F., Nist, A., Stiewe, T., and Mermoud, J.E. (2019). SMARCAD1 ATPase activity is required to silence endogenous retroviruses in embryonic stem cells. Nat Commun 10, 1335. 10.1038/s41467-019-09078-0.

Mačinković, I., Theofel, I., Hundertmark, T., Kovač, K., Awe, S., Lenz, J., Forné, I., Lamp, B., Nist, A., Imhof, A., et al. (2019). Distinct CoREST complexes act in a cell-type-specific manner. Nucleic Acids Res 47, 11649-11666. 10.1093/nar/gkz1050.

Klimovich, B., Mutlu, S., Schneikert, J., Elmshäuser, S., Klimovich, M., Nist, A., Mernberger, M., Timofeev, O., and Stiewe, T. (2019). Loss of p53 function at late stages of tumorigenesis confers ARF-dependent vulnerability to p53 reactivation therapy. Proc Natl Acad Sci U S A 116, 22288-22293.

Link, S., Spitzer, R.M.M., Sana, M., Torrado, M., Völker-Albert, M.C., Keilhauer, E.C., Burgold, T., Pünzeler, S., Low, J.K.K., Lindström, I., et al. (2018). PWWP2A binds distinct chromatin moieties and interacts with an MTA1-specific core NuRD complex. Nat Commun 9, 4300. 10.1038/s41467-018-06665-5.

Giaimo, B.D., Ferrante, F., Vallejo, D.M., Hein, K., Gutierrez-Perez, I., Nist, A., Stiewe, T., Mittler, G., Herold, S., Zimmermann, T., et al. (2018). Histone variant H2A.Z deposition and acetylation directs the canonical Notch signaling response. Nucleic Acids Res 46, 8197-8215. 10.1093/nar/gky551.

Bouchard, C., Sahu, P., Meixner, M., Nötzold, R.R., Rust, M.B., Kremmer, E., Feederle, R., Hart-Smith, G., Finkernagel, F., Bartkuhn, M., et al. (2018). Genomic Location of PRMT6-Dependent H3R2 Methylation Is Linked to the Transcriptional Outcome of Associated Genes. Cell Rep 24, 3339-3352. 10.1016/j.celrep.2018.08.052.
A12 - Tilman Borggrefe

Sotomska, M., Liefke, R., Ferrante, F., Schwederski, H., Oswald, F., and Borggrefe, T. (2021). SUMOylated non-canonical polycomb PRC1.6 complex as a prerequisite for recruitment of transcription factor RBPJ. Epigenetics Chromatin 14, 38. 10.1186/s13072-021-00412-9.

Frankenreiter, L., Gahr, B.M., Schmid, H., Zimmermann, M., Deichsel, S., Hoffmeister, P., Turkiewicz, A., Borggrefe, T., Oswald, F., and Nagel, A.C. (2021). Phospho-Site Mutations in Transcription Factor Suppressor of Hairless Impact Notch Signaling Activity During Hematopoiesis in. Front Cell Dev Biol 9, 658820. 10.3389/fcell.2021.658820.

Robert-Finestra, T., Tan, B.F., Mira-Bontenbal, H., Timmers, E., Gontan, C., Merzouk, S., Giaimo, B.D., Dossin, F., van IJcken, W.F.J., Martens, J.W.M., et al. (2021). SPEN is required for Xist upregulation during initiation of X chromosome inactivation. Nat Commun 12, 7000. 10.1038/s41467-021-27294-5.

Pan, L., Hoffmeister, P., Turkiewicz, A., Huynh, N.N.D., Große-Berkenbusch, A., Knippschild, U., Gebhardt, J.C.M., Baumann, B., Borggrefe, T., and Oswald, F. (2021). Transcription Factor RBPJL Is Able to Repress Notch Target Gene Expression but Is Non-Responsive to Notch Activation. Cancers (Basel) 13. 10.3390/cancers13195027.

Giaimo, B.D., Friedrich, T., and Borggrefe, T. (2021a). A Comprehensive Toolbox to Analyze Enhancer-Promoter Functions. Methods Mol Biol 2351, 3-22. 10.1007/978-1-0716-1597-3_1.

Giaimo, B.D., Gagliani, E.K., Kovall, R.A., and Borggrefe, T. (2021b). Transcription Factor RBPJ as a Molecular Switch in Regulating the Notch Response. Adv Exp Med Biol 1287, 9-30. 10.1007/978-3-030-55031-8_2.

Giaimo, B.D., Robert-Finestra, T., Oswald, F., Gribnau, J., and Borggrefe, T. (2021c). Chromatin Regulator SPEN/SHARP in X Inactivation and Disease. Cancers (Basel) 13. 10.3390/cancers13071665.

Ferrante, F., Giaimo, B.D., Bartkuhn, M., Zimmermann, T., Close, V., Mertens, D., Nist, A., Stiewe, T., Meier-Soelch, J., Kracht, M., et al. (2020). HDAC3 functions as a positive regulator in Notch signal transduction. Nucleic Acids Res 48, 3496-3512.

Agrawal, M., Schwarz, P., Giaimo, B.D., Bedzhov, I., Corbacioglu, A., Weber, D., Gaidzik, V.I., Jahn, N., Rücker, F.G., Schroeder, T., et al. (2020). Functional and clinical characterization of the alternatively spliced isoform AML1-ETO9a in adult patients with translocation t(8;21)(q22;q22.1) acute myeloid leukemia (AML). Leukemia 34, 630-634.

Diéguez-Hurtado, R., Kato, K., Giaimo, B.D., Nieminen-Kelhä, M., Arf, H., Ferrante, F., Bartkuhn, M., Zimmermann, T., Bixel, M.G., Eilken, H.M., et al. (2019). Loss of the transcription factor RBPJ induces disease-promoting properties in brain pericytes. Nat Commun 10, 2817.

Wolf, D., Smylla, T.K., Reichmuth, J., Hoffmeister, P., Kober, L., Zimmermann, M., Turkiewicz, A., Borggrefe, T., Nagel, A.C., Oswald, F., et al. (2019). Nucleo- cytoplasmic shuttling of Drosophila Hairless/Su(H) heterodimer as a means of regulating Notch dependent transcription. Biochim Biophys Acta Mol Cell Res 1866, 1520-1532.

Yuan, Z., VanderWielen, B.D., Giaimo, B.D., Pan, L., Collins, C.E., Turkiewicz, A., Hein, K., Oswald, F., Borggrefe, T., and Kovall, R.A. (2019). Structural and Functional Studies of the RBPJ-SHARP Complex Reveal a Conserved Corepressor Binding Site.

Giaimo, B.D., Ferrante, F., Herchenröther, A., Hake, S.B., and Borggrefe, T. (2019). The histone variant H2A.Z in gene regulation. Epigenetics Chromatin 12, 37.

Giaimo, B.D., Ferrante, F., Vallejo, D.M., Hein, K., Gutierrez-Perez, I., Nist, A., Stiewe, T., Mittler, G., Herold, S., Zimmermann, T., et al. (2018). Histone variant H2A.Z deposition and acetylation directs the canonical Notch signaling response. Nucleic Acids Res 46, 8197-8215.

Giaimo, B.D., and Borggrefe, T. (2018). Introduction to Molecular Mechanisms in Notch Signal Transduction and Disease Pathogenesis. Adv Exp Med Biol 1066, 3-30. 10.1007/978-3-319-89512-3_1.

Zakrzewicz, D., Didiasova, M., Krüger, M., Giaimo, B.D., Borggrefe, T., Mieth, M., Hocke, A.C., Zakrzewicz, A., Schaefer, L., Preissner, K.T., et al. (2018). Protein arginine methyltransferase 5 mediates enolase-1 cell surface trafficking in human lung adenocarcinoma cells. Biochim Biophys Acta Mol Basis Dis 1864, 1816-1827.
A14 - Danny Huylebroek

Birkhoff, J.C., Huylebroeck, D., and Conidi, A. (2021). ZEB2, the Mowat-Wilson Syndrome Transcription Factor: Confirmations, Novel Functions, and Continuing Surprises. Genes (Basel) 12. 10.3390/genes12071037.
A15 - Sandra Hake

Armache, A., Yang, S., Martínez de Paz, A., Robbins, L.E., Durmaz, C., Cheong, J.Q., Ravishankar, A., Daman, A.W., Ahimovic, D.J., Klevorn, T., et al. (2020). Histone H3.3 phosphorylation amplifies stimulation-induced transcription. Nature 583, 852- 857.

Low, J.K.K., Silva, A.P.G., Sharifi Tabar, M., Torrado, M., Webb, S.R., Parker, B.L., Sana, M., Smits, C., Schmidberger, J.W., Brillault, L., et al. (2020). The Nucleosome Remodeling and Deacetylase Complex Has an Asymmetric, Dynamic, and Modular Architecture. Cell Rep 33, 108450. 10.1016/j.celrep.2020.108450.

Giaimo, B.D., Ferrante, F., Herchenröther, A., Hake, S.B., and Borggrefe, T. (2019). The histone variant H2A.Z in gene regulation. Epigenetics Chromatin 12, 37. 10.1186/s13072-019-0274-9.

Riedlinger, T., Bartkuhn, M., Zimmermann, T., Hake, S.B., Nist, A., Stiewe, T., Kracht, M., and Schmitz, M.L. (2019). Chemotherapeutic Drugs Inhibiting Topoisomerase 1 Activity Impede Cytokine-Induced and NF-κB p65-Regulated Gene Expression. Cancers (Basel) 11. 10.3390/cancers11060883.

Link, S., Spitzer, R.M.M., Sana, M., Torrado, M., Völker-Albert, M.C., Keilhauer, E.C., Burgold, T., Pünzeler, S., Low, J.K.K., Lindström, I., et al. (2018). PWWP2A binds distinct chromatin moieties and interacts with an MTA1-specific core NuRD complex. Nat Commun 9, 4300.
A16 - Ralph Stadthouders
A17 - Robert Liefke

Fischer, S., Weber, L.M., and Liefke, R. (2022). Evolutionary adaptation of the Polycomb repressive complex 2. Epigenetics Chromatin 15, 7. 10.1186/s13072-022-00439-6.

Sotomska, M., Liefke, R., Ferrante, F., Schwederski, H., Oswald, F., and Borggrefe, T. (2021). SUMOylated non-canonical polycomb PRC1.6 complex as a prerequisite for recruitment of transcription factor RBPJ. Epigenetics Chromatin 14, 38. 10.1186/s13072-021-00412-9.

Stielow, B., Simon, C., and Liefke, R. (2021). Making fundamental scientific discoveries by combining information from literature, databases, and computational tools - an example. Comput Struct Biotechnol J, 10.1016/j.csbj.2021.04.052.

Stielow, B., Zhou, Y., Cao, Y., Simon, C., Pogoda, H.M., Jiang, J., Ren, Y., Phanor, S.K., Rohner, I., Nist, A., et al. (2021). The SAM domain-containing protein 1 (SAMD1) acts as a repressive chromatin regulator at unmethylated CpG islands. Sci Adv 7. 10.1126/sciadv.abf2229.

Lenz, J., Liefke, R., Funk, J., Shoup, S., Nist, A., Stiewe, T., Schulz, R., Tokusumi, Y., Albert, L., Raifer, H., et al. (2021). Ush regulates hemocyte-specific gene expression, fatty acid metabolism and cell cycle progression and cooperates with dNuRD to orchestrate hematopoiesis. PLoS Genet 17, e1009318. 10.1371/journal.pgen.1009318.

Liss, F., Frech, M., Wang, Y., Giel, G., Fischer, S., Simon, C., Weber, L.M., Nist, A., Stiewe, T., Neubauer, A., et al. (2021). IRF8 Is an AML-Specific Susceptibility Factor That Regulates Signaling Pathways and Proliferation of AML Cells. Cancers (Basel) 13. 10.3390/cancers13040764.

Tian, W., Yan, P., Xu, N., Chakravorty, A., Liefke, R., Xi, Q., and Wang, Z. (2019). The HRP3 PWWP domain recognizes the minor groove of double-stranded DNA and recruits HRP3 to chromatin. Nucleic Acids Res 47, 5436-5448.

Riedlinger, T., Liefke, R., Meier-Soelch, J., Jurida, L., Nist, A., Stiewe, T., Kracht, M., and Schmitz, M.L. (2019). NF-κB p65 dimerization and DNA-binding is important for inflammatory gene expression. FASEB J 33, 4188-4202.
B01 - Frank Grosveld
B02 - Michael Kracht

Bacher, S., Meier-Soelch, J., Kracht, M., and Schmitz, M.L. (2021a). Regulation of Transcription Factor NF-κB in Its Natural Habitat: The Nucleus. Cells 10. 10.3390/cells10040753.

Bacher, S., Stekman, H., Farah, C.M., Karger, A., Kracht, M., and Schmitz, M.L. (2021b). MEKK1-Dependent Activation of the CRL4 Complex Is Important for DNA Damage-Induced Degradation of p21 and DDB2 and Cell Survival. Mol Cell Biol 41, e0008121. 10.1128/MCB.00081-21.

Busch, J., Moreno, R., de la Vega, L., Saul, V.V., Bacher, S., von Zweydorf, F., Ueffing, M., Weber, A., Gloeckner, C.J., Linne, U., et al. (2021). TRAF6 Phosphorylation Prevents Its Autophagic Degradation and Re-Shapes LPS-Triggered Signaling Networks. Cancers (Basel) 13. 10.3390/cancers13143618.

Meier-Soelch, J., Mayr-Buro, C., Juli, J., Leib, L., Linne, U., Dreute, J., Papantonis, A., Schmitz, M.L., and Kracht, M. (2021). Monitoring the Levels of Cellular NF-κB Activation States. Cancers (Basel) 13. 10.3390/cancers13215351.

Shaban, M.S., Müller, C., Mayr-Buro, C., Weiser, H., Meier-Soelch, J., Albert, B.V., Weber, A., Linne, U., Hain, T., Babayev, I., et al. (2021). Multi-level inhibition of coronavirus replication by chemical ER stress. Nat Commun 12, 5536. 10.1038/s41467-021-25551-1.

Zarnack, K., Balasubramanian, S., Gantier, M.P., Kunetsky, V., Kracht, M., Schmitz, M.L., and Sträßer, K. (2020). Dynamic mRNP Remodeling in Response to Internal and External Stimuli. Biomolecules 10. 10.3390/biom10091310.

Ferrante, F., Giaimo, B.D., Bartkuhn, M., Zimmermann, T., Close, V., Mertens, D., Nist, A., Stiewe, T., Meier-Soelch, J., Kracht, M., et al. (2020). HDAC3 functions as a positive regulator in Notch signal transduction. Nucleic Acids Res 48, 3496-3512. 10.1093/nar/gkaa088.

Haas, J., Bloesel, D., Bacher, S., Kracht, M., and Schmitz, M.L. (2020). Chromatin Targeting of HIPK2 Leads to Acetylation-Dependent Chromatin Decondensation. Front Cell Dev Biol 8, 852. 10.3389/fcell.2020.00852.

Kracht, M., Müller-Ladner, U., and Schmitz, M.L. (2020). Mutual regulation of metabolic processes and proinflammatory NF-κB signaling. J Allergy Clin Immunol 146, 694-705. 10.1016/j.jaci.2020.07.027.

Weiterer, S.S., Meier-Soelch, J., Georgomanolis, T., Mizi, A., Beyerlein, A., Weiser, H., Brant, L., Mayr-Buro, C., Jurida, L., Beuerlein, K., et al. (2020). Distinct IL-1α-responsive enhancers promote acute and coordinated changes in chromatin topology in a hierarchical manner. EMBO J 39, e101533. 10.15252/embj.2019101533.

Mayr-Buro, C., Schlereth, E., Beuerlein, K., Tenekeci, U., Meier-Soelch, J., Schmitz, M.L., and Kracht, M. (2019). Single-Cell Analysis of Multiple Steps of Dynamic NF-κB Regulation in Interleukin-1α-Triggered Tumor Cells Using Proximity Ligation Assays. Cancers (Basel) 11. 10.3390/cancers11081199.

Riedlinger, T., Bartkuhn, M., Zimmermann, T., Hake, S.B., Nist, A., Stiewe, T., Kracht, M., and Schmitz, M.L. (2019a). Chemotherapeutic Drugs Inhibiting Topoisomerase 1 Activity Impede Cytokine-Induced and NF-κB p65-Regulated Gene Expression. Cancers (Basel) 11. 10.3390/cancers11060883.

Riedlinger, T., Liefke, R., Meier-Soelch, J., Jurida, L., Nist, A., Stiewe, T., Kracht, M., and Schmitz, M.L. (2019b). NF-κB p65 dimerization and DNA-binding is important for inflammatory gene expression. FASEB J 33, 4188-4202. 10.1096/fj.201801638R.

Saul, V.V., Seibert, M., Krüger, M., Jeratsch, S., Kracht, M., and Schmitz, M.L. (2019). ULK1/2 Restricts the Formation of Inducible SINT-Speckles, Membraneless Organelles Controlling the Threshold of TBK1 Activation. iScience 19, 527-544. 10.1016/j.isci.2019.08.001.

Seibert, M., Krüger, M., Watson, N.A., Sen, O., Daum, J.R., Slotman, J.A., Braun, T., Houtsmuller, A.B., Gorbsky, G.J., Jacob, R., et al. (2019). CDK1-mediated phosphorylation at H2B serine 6 is required for mitotic chromosome segregation. J Cell Biol 218, 1164-1181. 10.1083/jcb.201806057.

Weber, A., Dam, S., Saul, V.V., Kuznetsova, I., Müller, C., Fritz-Wolf, K., Becker, K., Linne, U., Gu, H., Stokes, M.P., et al. (2019). Phosphoproteome Analysis of Cells Infected with Adapted and Nonadapted Influenza A Virus Reveals Novel Pro- and Antiviral Signaling Networks. J Virol 93. 10.1128/JVI.00528-19.
B04 - Niels Galjart

Bergmaier, P., Weth, O., Dienstbach, S., Boettger, T., Galjart, N., Mernberger, M., Bartkuhn, M., and Renkawitz, R. (2018). Choice of binding sites for CTCFL compared to CTCF is driven by chromatin and by sequence preference. Nucleic Acids Res 46, 7097-7107. 10.1093/nar/gky483.
B05 - Kerstin Wendt

Zhang, S., Übelmesser, N., Josipovic, N., Forte, G., Slotman, J.A., Chiang, M., Gothe, H.J., Gusmao, E.G., Becker, C., Altmüller, J., et al. (2021). RNA polymerase II is required for spatial chromatin reorganization following exit from mitosis. Sci Adv 7, eabg8205. 10.1126/sciadv.abg8205.
B07 - Gergana Dobreva

Dobersch, S., Rubio, K., Singh, I., Günther, S., Graumann, J., Cordero, J., Castillo-Negrete, R., Huynh, M.B., Mehta, A., Braubach, P., et al. (2021). Positioning of nucleosomes containing γ-H2AX precedes active DNA demethylation and transcription initiation. Nat Commun 12, 1072. 10.1038/s41467-021-21227-y.

Lityagina, O., and Dobreva, G. (2021). The LINC Between Mechanical Forces and Chromatin. Front Physiol 12, 710809. 10.3389/fphys.2021.710809.

Garvalov, B.K., Muhammad, S., and Dobreva, G. (2019). Lamin B1 in cancer and aging. Aging (Albany NY) 11, 7336-7338.

Gao, R., Liang, X., Cheedipudi, S., Cordero, J., Jiang, X., Zhang, Q., Caputo, L., Günther, S., Kuenne, C., Ren, Y., et al. (2019). Pioneering function of Isl1 in the epigenetic control of cardiomyocyte cell fate. Cell Res 29, 486-501.

Jia, Y., Vong, J.S., Asafova, A., Garvalov, B.K., Caputo, L., Cordero, J., Singh, A., Boettger, T., Günther, S., Fink, L., et al. (2019). Lamin B1 loss promotes lung cancer development and metastasis by epigenetic derepression of RET. J Exp Med 216, 1377-1395.
B09 - Willy Baarends/Adriaan Houtsmuller

Zhang, S., Übelmesser, N., Josipovic, N., Forte, G., Slotman, J.A., Chiang, M., Gothe, H.J., Gusmao, E.G., Becker, C., Altmüller, J., et al. (2021). RNA polymerase II is required for spatial chromatin reorganization following exit from mitosis. Sci Adv 7, eabg8205. 10.1126/sciadv.abg8205.

Seibert, M., Krüger, M., Watson, N.A., Sen, O., Daum, J.R., Slotman, J.A., Braun, T., Houtsmuller, A.B., Gorbsky, G.J., Jacob, R., et al. (2019). CDK1-mediated phosphorylation at H2B serine 6 is required for mitotic chromosome segregation. J Cell Biol 218, 1164-1181. 10.1083/jcb.201806057.
B10 - Joost Gribnau

Giaimo, B.D., Robert-Finestra, T., Oswald, F., Gribnau, J., and Borggrefe, T. (2021). Chromatin Regulator SPEN/SHARP in X Inactivation and Disease. Cancers (Basel) 13. 10.3390/cancers13071665.

Robert-Finestra, T., Tan, B.F., Mira-Bontenbal, H., Timmers, E., Gontan, C., Merzouk, S., Giaimo, B.D., Dossin, F., van IJcken, W.F.J., Martens, J.W.M., et al. (2021). SPEN is required for Xist upregulation during initiation of X chromosome inactivation. Nat Commun 12, 7000. 10.1038/s41467-021-27294-5.
B14 - Argyris Papantonis

Zhang, S., Übelmesser, N., Josipovic, N., Forte, G., Slotman, J.A., Chiang, M., Gothe, H.J., Gusmao, E.G., Becker, C., Altmüller, J., et al. (2021). RNA polymerase II is required for spatial chromatin reorganization following exit from mitosis. Sci Adv 7, eabg8205. 10.1126/sciadv.abg8205.

Kargapolova, Y., Rehimi, R., Kayserili, H., Brühl, J., Sofiadis, K., Zirkel, A., Palikyras, S., Mizi, A., Li, Y., Yigit, G., et al. (2021). Overarching control of autophagy and DNA damage response by CHD6 revealed by modeling a rare human pathology. Nat Commun 12, 3014. 10.1038/s41467-021-23327-1.

Meier-Soelch, J., Mayr-Buro, C., Juli, J., Leib, L., Linne, U., Dreute, J., Papantonis, A., Schmitz, M.L., and Kracht, M. (2021). Monitoring the Levels of Cellular NF-κB Activation States. Cancers (Basel) 13. 10.3390/cancers13215351.

Rippe, K., and Papantonis, A. (2021). RNA polymerase II transcription compartments: from multivalent chromatin binding to liquid droplet formation? Nat Rev Mol Cell Biol 22, 645-646. 10.1038/s41580-021-00401-6.

Sofiadis, K., Josipovic, N., Nikolic, M., Kargapolova, Y., Übelmesser, N., Varamogianni-Mamatsi, V., Zirkel, A., Papadionysiou, I., Loughran, G., Keane, J., et al. (2021). HMGB1 coordinates SASP-related chromatin folding and RNA homeostasis on the path to senescence. Mol Syst Biol 17, e9760. 10.15252/msb.20209760.

Casa, V., Moronta Gines, M., Gade Gusmao, E., Slotman, J.A., Zirkel, A., Josipovic, N., Oole, E., van IJcken, W.F.J., Houtsmuller, A.B., Papantonis, A., et al. (2020). Redundant and specific roles of cohesin STAG subunits in chromatin looping and transcriptional control. Genome Res 30, 515-527.Weiterer, S.S., Meier-Soelch, J., Georgomanolis, T., Mizi, A., Beyerlein, A., Weiser, H., Brant, L., Mayr-Buro, C., Jurida, L., Beuerlein, K., et al. (2020). Distinct IL-1α- responsive enhancers promote acute and coordinated changes in chromatin topology in a hierarchical manner. EMBO J 39, e101533.

Weiterer, S.S., Meier-Soelch, J., Georgomanolis, T., Mizi, A., Beyerlein, A., Weiser, H., Brant, L., Mayr-Buro, C., Jurida, L., Beuerlein, K., et al. (2020). Distinct IL-1α-responsive enhancers promote acute and coordinated changes in chromatin topology in a hierarchical manner. EMBO J 39, e101533. 10.15252/embj.2019101533.

Übelmesser, N., and Papantonis, A. (2019). Technologies to study spatial genome organization: beyond 3C. Brief Funct Genomics 18, 395-401.

Palikyras, S., and Papantonis, A. (2019). Modes of phase separation affecting chromatin regulation. Open Biol 9, 190167.

Rada-Iglesias, A., Grosveld, F.G., and Papantonis, A. (2018). Forces driving the three-dimensional folding of eukaryotic genomes. Mol Syst Biol 14, e8214.
B15 - Debbie van den Berg
B16 - Bas van Steensel
Z01 - Marek Bartkuhn/Ho-Ryun Chung/Alexander Goesmann

Procida, T., Friedrich, T., Jack, A.P.M., Peritore, M., Bönisch, C., Eberl, H.C., Daus, N., Kletenkov, K., Nist, A., Stiewe, T., et al. (2021). JAZF1, A Novel p400/TIP60/NuA4 Complex Member, Regulates H2A.Z Acetylation at Regulatory Regions. Int J Mol Sci 22. 10.3390/ijms22020678.

Ferrante, F., Giaimo, B.D., Bartkuhn, M., Zimmermann, T., Close, V., Mertens, D., Nist, A., Stiewe, T., Meier-Soelch, J., Kracht, M., et al. (2020). HDAC3 functions as a positive regulator in Notch signal transduction. Nucleic Acids Res 48, 3496-3512. 10.1093/nar/gkaa088.

Weiterer, S.S., Meier-Soelch, J., Georgomanolis, T., Mizi, A., Beyerlein, A., Weiser, H., Brant, L., Mayr-Buro, C., Jurida, L., Beuerlein, K., et al. (2020). Distinct IL-1α-responsive enhancers promote acute and coordinated changes in chromatin topology in a hierarchical manner. EMBO J 39, e101533. 10.15252/embj.2019101533.

Diéguez-Hurtado, R., Kato, K., Giaimo, B.D., Nieminen-Kelhä, M., Arf, H., Ferrante, F., Bartkuhn, M., Zimmermann, T., Bixel, M.G., Eilken, H.M., et al. (2019). Loss of the transcription factor RBPJ induces disease-promoting properties in brain pericytes. Nat Commun 10, 2817. 10.1038/s41467-019-10643-w.

Riedlinger, T., Bartkuhn, M., Zimmermann, T., Hake, S.B., Nist, A., Stiewe, T., Kracht, M., and Schmitz, M.L. (2019). Chemotherapeutic Drugs Inhibiting Topoisomerase 1 Activity Impede Cytokine-Induced and NF-κB p65-Regulated Gene Expression. Cancers (Basel) 11. 10.3390/cancers11060883.

Bergmaier, P., Weth, O., Dienstbach, S., Boettger, T., Galjart, N., Mernberger, M., Bartkuhn, M., and Renkawitz, R. (2018). Choice of binding sites for CTCFL compared to CTCF is driven by chromatin and by sequence preference. Nucleic Acids Res 46, 7097-7107. 10.1093/nar/gky483.

Bouchard, C., Sahu, P., Meixner, M., Nötzold, R.R., Rust, M.B., Kremmer, E., Feederle, R., Hart-Smith, G., Finkernagel, F., Bartkuhn, M., et al. (2018). Genomic Location of PRMT6-Dependent H3R2 Methylation Is Linked to the Transcriptional Outcome of Associated Genes. Cell Rep 24, 3339-3352. 10.1016/j.celrep.2018.08.052.

Giaimo, B.D., Ferrante, F., Vallejo, D.M., Hein, K., Gutierrez-Perez, I., Nist, A., Stiewe, T., Mittler, G., Herold, S., Zimmermann, T., et al. (2018). Histone variant H2A.Z deposition and acetylation directs the canonical Notch signaling response. Nucleic Acids Res 46, 8197-8215. 10.1093/nar/gky551.

Link, S., Spitzer, R.M.M., Sana, M., Torrado, M., Völker-Albert, M.C., Keilhauer, E.C., Burgold, T., Pünzeler, S., Low, J.K.K., Lindström, I., et al. (2018). PWWP2A binds distinct chromatin moieties and interacts with an MTA1-specific core NuRD complex. Nat Commun 9, 4300. 10.1038/s41467-018-06665-5.
Z04 - Wibke Diederich/Peter Kolb/Olalla Vázquez

Hamey, J.J., Rakow, S., Bouchard, C., Senst, J.M., Kolb, P., Bauer, U.M., Wilkins, M.R., and Hart-Smith, G. (2021). Systematic investigation of PRMT6 substrate recognition reveals broad specificity with a preference for an RG motif or basic and bulky residues. FEBS J 288, 5668-5691. 10.1111/febs.15837.

Lenz, J., Liefke, R., Funk, J., Shoup, S., Nist, A., Stiewe, T., Schulz, R., Tokusumi, Y., Albert, L., Raifer, H., et al. (2021). Ush regulates hemocyte-specific gene expression, fatty acid metabolism and cell cycle progression and cooperates with dNuRD to orchestrate hematopoiesis. PLoS Genet 17, e1009318. 10.1371/journal.pgen.1009318.

Linden, G., Janga, H., Franz, M., Nist, A., Stiewe, T., Schmeck, B., Vázquez, O., and Schulte, L.N. (2021). Efficient antisense inhibition reveals microRNA-155 to restrain a late-myeloid inflammatory programme in primary human phagocytes. RNA Biol 18, 604-618. 10.1080/15476286.2021.1885209.

J Verheul, T.C., Trinh, V.T., Vázquez, O., and Philipsen, S. (2020). Targeted Protein Degradation as a Promising Tool for Epigenetic Upregulation of Fetal Hemoglobin. ChemMedChem 15, 2436-2443. 10.1002/cmdc.202000574.

Albert, L., and Vázquez, O. (2019). Photoswitchable peptides for spatiotemporal control of biological functions. Chem Commun (Camb) 55, 10192-10213. 10.1039/c9cc03346g.

Heinrich, B., Bouazoune, K., Wojcik, M., Bakowsky, U., and Vázquez, O. (2019). ortho-Fluoroazobenzene derivatives as DNA intercalators for photocontrol of DNA and nucleosome binding by visible light. Org Biomol Chem 17, 1827-1833. 10.1039/c8ob02343c.

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