Main Content

Publications - 1st Funding Period (2010-2014)

  • A01 - Alexander Brehm

    Bergs, J.W., Neuendorff, N., van der Heijden, G., Wassenaar, E., Rexin, P., Elsässer, H.P., Moll, R., Baarends, W.M., and Brehm, A. (2014). Differential expression and sex chromosome association of CHD3/4 and CHD5 during spermatogenesis. PLoS One 9, e98203. 10.1371/journal.pone.0098203.

    Fasulo, B., Deuring, R., Murawska, M., Gause, M., Dorighi, K.M., Schaaf, C.A., Dorsett, D., Brehm, A., and Tamkun, J.W. (2012). The Drosophila MI-2 chromatin-remodeling factor regulates higher-order chromatin structure and cohesin dynamics in vivo. PLoS Genet 8, e1002878. 10.1371/journal.pgen.1002878.

    Mathieu, E.L., Finkernagel, F., Murawska, M., Scharfe, M., Jarek, M., and Brehm, A. (2012). Recruitment of the ATP-dependent chromatin remodeler dMi-2 to the transcribed region of active heat shock genes. Nucleic Acids Res 40, 4879-4891. 10.1093/nar/gks178.

    Meier, K., Mathieu, E.L., Finkernagel, F., Reuter, L.M., Scharfe, M., Doehlemann, G., Jarek, M., and Brehm, A. (2012). LINT, a novel dL(3)mbt-containing complex, represses malignant brain tumour signature genes. PLoS Genet 8, e1002676. 10.1371/journal.pgen.1002676.

    Murawska, M., Hassler, M., Renkawitz-Pohl, R., Ladurner, A., and Brehm, A. (2011). Stress-induced PARP activation mediates recruitment of Drosophila Mi-2 to promote heat shock gene expression. PLoS Genet 7, e1002206. 10.1371/journal.pgen.1002206.

  • A02 - Thomas Braun/Yonggang Zhou

    Szibor, M., Pöling, J., Warnecke, H., Kubin, T., and Braun, T. (2014). Remodeling and dedifferentiation of adult cardiomyocytes during disease and regeneration. Cell Mol Life Sci 71, 1907-1916. 10.1007/s00018-013-1535-6.

    Günther, S., Kim, J., Kostin, S., Lepper, C., Fan, C.M., and Braun, T. (2013). Myf5-positive satellite cells contribute to Pax7-dependent long-term maintenance of adult muscle stem cells. Cell Stem Cell 13, 590-601. 10.1016/j.stem.2013.07.016.

    Piatkowski, T., Mühlfeld, C., Borchardt, T., and Braun, T. (2013). Reconstitution of the myocardium in regenerating newt hearts is preceded by transient deposition of extracellular matrix components. Stem Cells Dev 22, 1921-1931. 10.1089/scd.2012.0575.

    Pohjoismäki, J.L., Williams, S.L., Boettger, T., Goffart, S., Kim, J., Suomalainen, A., Moraes, C.T., and Braun, T. (2013). Overexpression of Twinkle-helicase protects cardiomyocytes from genotoxic stress caused by reactive oxygen species. Proc Natl Acad Sci U S A 110, 19408-19413. 10.1073/pnas.1303046110.

    Uchida, S., De Gaspari, P., Kostin, S., Jenniches, K., Kilic, A., Izumiya, Y., Shiojima, I., Grosse Kreymborg, K., Renz, H., Walsh, K., and Braun, T. (2013). Sca1-derived cells are a source of myocardial renewal in the murine adult heart. Stem Cell Reports 1, 397-410. 10.1016/j.stemcr.2013.09.004.

    Yuan, X., and Braun, T. (2013). An unexpected switch: regulation of cardiomyocyte proliferation by the homeobox gene meis1. Circ Res 113, 245-248. 10.1161/CIRCRESAHA.113.302023.

    Boonsanay, V., Kim, J., Braun, T., and Zhou, Y. (2012). The emerging role of epigenetic modifiers linking cellular metabolism and gene activity in cardiac progenitor cells. Trends Cardiovasc Med 22, 77-81. 10.1016/j.tcm.2012.06.016.

    Looso, M., Michel, C.S., Konzer, A., Bruckskotten, M., Borchardt, T., Krüger, M., and Braun, T. (2012). Spiked-in pulsed in vivo labeling identifies a new member of the CCN family in regenerating newt hearts. J Proteome Res 11, 4693-4704. 10.1021/pr300521p.

    Boettger, T., and Braun, T. (2012). A new level of complexity: the role of microRNAs in cardiovascular development. Circ Res 110, 1000-1013. 10.1161/CIRCRESAHA.111.247742.

    Witzel, H.R., Jungblut, B., Choe, C.P., Crump, J.G., Braun, T., and Dobreva, G. (2012). The LIM protein Ajuba restricts the second heart field progenitor pool by regulating Isl1 activity. Dev Cell 23, 58-70. 10.1016/j.devcel.2012.06.005.

    Zhou, Y., Kim, J., Yuan, X., and Braun, T. (2011). Epigenetic modifications of stem cells: a paradigm for the control of cardiac progenitor cells. Circ Res 109, 1067-1081. 10.1161/CIRCRESAHA.111.243709.

  • A03 - Uta-Maria Bauer

    Streubel, G., Bouchard, C., Berberich, H., Zeller, M.S., Teichmann, S., Adamkiewicz, J., Müller, R., Klempnauer, K.H., and Bauer, U.M. (2013). PRMT4 is a novel coactivator of c-Myb-dependent transcription in haematopoietic cell lines. PLoS Genet 9, e1003343. 10.1371/journal.pgen.1003343.

    Stein, C., Riedl, S., Rüthnick, D., Nötzold, R.R., and Bauer, U.M. (2012). The arginine methyltransferase PRMT6 regulates cell proliferation and senescence through transcriptional repression of tumor suppressor genes. Nucleic Acids Res 40, 9522-9533. 10.1093/nar/gks767.

  • A04 - Sjaak Philipsen/Thamar van Dijk

     

  • A05 - Peter Verrijzer/Jan van der Knaap

  • A06 - Guntram Suske

    Stielow, C., Stielow, B., Finkernagel, F., Scharfe, M., Jarek, M., and Suske, G. (2014). SUMOylation of the polycomb group protein L3MBTL2 facilitates repression of its target genes. Nucleic Acids Res 42, 3044-3058. 10.1093/nar/gkt1317.

  • A07 - Lienhard Schmitz

    Handschick, K., Beuerlein, K., Jurida, L., Bartkuhn, M., Müller, H., Soelch, J., Weber, A., Dittrich-Breiholz, O., Schneider, H., Scharfe, M., et al. (2014). Cyclin-dependent kinase 6 is a chromatin-bound cofactor for NF-κB-dependent gene expression. Mol Cell 53, 193-208. 10.1016/j.molcel.2013.12.002.

    Milanovic, M., Kracht, M., and Schmitz, M.L. (2014). The cytokine-induced conformational switch of nuclear factor κB p65 is mediated by p65 phosphorylation. Biochem J 457, 401-413. 10.1042/BJ20130780.

    Saul, V.V., de la Vega, L., Milanovic, M., Krüger, M., Braun, T., Fritz-Wolf, K., Becker, K., and Schmitz, M.L. (2013). HIPK2 kinase activity depends on cis-autophosphorylation of its activation loop. J Mol Cell Biol 5, 27-38. 10.1093/jmcb/mjs053.

    de la Vega, L., Hornung, J., Kremmer, E., Milanovic, M., and Schmitz, M.L. (2013). Homeodomain-interacting protein kinase 2-dependent repression of myogenic differentiation is relieved by its caspase-mediated cleavage. Nucleic Acids Res 41, 5731-5745. 10.1093/nar/gkt262.

    Ziesché, E., Kettner-Buhrow, D., Weber, A., Wittwer, T., Jurida, L., Soelch, J., Müller, H., Newel, D., Kronich, P., Schneider, H., et al. (2013). The coactivator role of histone deacetylase 3 in IL-1-signaling involves deacetylation of p65 NF-κB. Nucleic Acids Res 41, 90-109. 10.1093/nar/gks916.

    Schmitz, M.L., and Grishina, I. (2012). Regulation of the tumor suppressor PML by sequential post-translational modifications. Front Oncol 2, 204. 10.3389/fonc.2012.00204.

    Grishina, I., Debus, K., García-Limones, C., Schneider, C., Shresta, A., García, C., Calzado, M.A., and Schmitz, M.L. (2012). SIAH-mediated ubiquitination and degradation of acetyl-transferases regulate the p53 response and protein acetylation. Biochim Biophys Acta 1823, 2287-2296. 10.1016/j.bbamcr.2012.09.011.

    de la Vega, L., Grishina, I., Moreno, R., Krüger, M., Braun, T., and Schmitz, M.L. (2012). A redox-regulated SUMO/acetylation switch of HIPK2 controls the survival threshold to oxidative stress. Mol Cell 46, 472-483. 10.1016/j.molcel.2012.03.003.

    Schmitz, M.L., Weber, A., Roxlau, T., Gaestel, M., and Kracht, M. (2011). Signal integration, crosstalk mechanisms and networks in the function of inflammatory cytokines. Biochim Biophys Acta 1813, 2165-2175. 10.1016/j.bbamcr.2011.06.019.

    de la Vega, L., Fröbius, K., Moreno, R., Calzado, M.A., Geng, H., and Schmitz, M.L. (2011). Control of nuclear HIPK2 localization and function by a SUMO interaction motif. Biochim Biophys Acta 1813, 283-297. 10.1016/j.bbamcr.2010.11.022.

    Ritterhoff, S., Farah, C.M., Grabitzki, J., Lochnit, G., Skurat, A.V., and Schmitz, M.L. (2010). The WD40-repeat protein Han11 functions as a scaffold protein to control HIPK2 and MEKK1 kinase functions. EMBO J 29, 3750-3761. 10.1038/emboj.2010.251.

  • A09 - Raymond Poot

     

  • A10 - Thorsten Stiewe

    Charles, J.P., Fuchs, J., Hefter, M., Vischedyk, J.B., Kleint, M., Vogiatzi, F., Schäfer, J.A., Nist, A., Timofeev, O., Wanzel, M., and Stiewe, T. (2014). Monitoring the dynamics of clonal tumour evolution in vivo using secreted luciferases. Nat Commun 5, 3981. 10.1038/ncomms4981.

    Maas, A.M., Bretz, A.C., Mack, E., and Stiewe, T. (2013). Targeting p73 in cancer. Cancer Lett 332, 229-236. 10.1016/j.canlet.2011.07.030.

    Schlereth, K., Heyl, C., Krampitz, A.M., Mernberger, M., Finkernagel, F., Scharfe, M., Jarek, M., Leich, E., Rosenwald, A., and Stiewe, T. (2013). Characterization of the p53 cistrome--DNA binding cooperativity dissects p53's tumor suppressor functions. PLoS Genet 9, e1003726. 10.1371/journal.pgen.1003726.

    Timofeev, O., Schlereth, K., Wanzel, M., Braun, A., Nieswandt, B., Pagenstecher, A., Rosenwald, A., Elsässer, H.P., and Stiewe, T. (2013). p53 DNA binding cooperativity is essential for apoptosis and tumor suppression in vivo. Cell Rep 3, 1512-1525. 10.1016/j.celrep.2013.04.008. 

  • B01 - Frank Grosveld

     

  • B02 - Michael Kracht

    Milanovic, M., Kracht, M., and Schmitz, M.L. (2014). The cytokine-induced conformational switch of nuclear factor κB p65 is mediated by p65 phosphorylation. Biochem J 457, 401-413. 10.1042/BJ20130780.

    Ziesché, E., Kettner-Buhrow, D., Weber, A., Wittwer, T., Jurida, L., Soelch, J., Müller, H., Newel, D., Kronich, P., Schneider, H., et al. (2013). The coactivator role of histone deacetylase 3 in IL-1-signaling involves deacetylation of p65 NF-κB. Nucleic Acids Res 41, 90-109. 10.1093/nar/gks916.

    Rzeczkowski, K., Beuerlein, K., Müller, H., Dittrich-Breiholz, O., Schneider, H., Kettner-Buhrow, D., Holtmann, H., and Kracht, M. (2011). c-Jun N-terminal kinase phosphorylates DCP1a to control formation of P bodies. J Cell Biol 194, 581-596. 10.1083/jcb.201006089.

    Schmitz, M.L., Weber, A., Roxlau, T., Gaestel, M., and Kracht, M. (2011). Signal integration, crosstalk mechanisms and networks in the function of inflammatory cytokines. Biochim Biophys Acta 1813, 2165-2175. 10.1016/j.bbamcr.2011.06.019.

    Wolf, A., Beuerlein, K., Eckart, C., Weiser, H., Dickkopf, B., Müller, H., Sakurai, H., and Kracht, M. (2011). Identification and functional characterization of novel phosphorylation sites in TAK1-binding protein (TAB) 1. PLoS One 6, e29256. 10.1371/journal.pone.0029256.

  • B03 - Rainer Renkawitz

    Bergmaier, P., Weth, O., Dienstbach, S., Boettger, T., Galjart, N., Mernberger, M., Bartkuhn, M., and Renkawitz, R. (2018). Choice of binding sites for CTCFL compared to CTCF is driven by chromatin and by sequence preference. Nucleic Acids Res 46, 7097-7107. 10.1093/nar/gky483.

    Jox, T., Buxa, M.K., Bohla, D., Ullah, I., Mačinković, I., Brehm, A., Bartkuhn, M., and Renkawitz, R. (2017). CP190- and dCTCF-mediated enhancer blocking is augmented by SUMOylation. Epigenetics Chromatin 10, 32. 10.1186/s13072-017-0140-6.

    Ali, T., Krüger, M., Bhuju, S., Jarek, M., Bartkuhn, M., and Renkawitz, R. (2017). Chromatin binding of Gcn5 in Drosophila is largely mediated by CP190. Nucleic Acids Res 45, 2384-2395. 10.1093/nar/gkw1178.

    Ali, T., Renkawitz, R., and Bartkuhn, M. (2016). Insulators and domains of gene expression. Curr Opin Genet Dev 37, 17-26. 10.1016/j.gde.2015.11.009.

    Buxa, M.K., Slotman, J.A., van Royen, M.E., Paul, M.W., Houtsmuller, A.B., and Renkawitz, R. (2016). Insulator speckles associated with long-distance chromatin contacts. Biol Open 5, 1266-1274. 10.1242/bio.019455.

    Gärtner, S.M., Rothenbusch, S., Buxa, M.K., Theofel, I., Renkawitz, R., Rathke, C., and Renkawitz-Pohl, R. (2015). The HMG-box-containing proteins tHMG-1 and tHMG-2 interact during the histone-to-protamine transition in Drosophila spermatogenesis. Eur J Cell Biol 94, 46-59. 10.1016/j.ejcb.2014.10.005.

    Maksimenko, O., Bartkuhn, M., Stakhov, V., Herold, M., Zolotarev, N., Jox, T., Buxa, M.K., Kirsch, R., Bonchuk, A., Fedotova, A., et al. (2015). Two new insulator proteins, Pita and ZIPIC, target CP190 to chromatin. Genome Res 25, 89-99. 10.1101/gr.174169.114.

    Bohla, D., Herold, M., Panzer, I., Buxa, M.K., Ali, T., Demmers, J., Krüger, M., Scharfe, M., Jarek, M., Bartkuhn, M., and Renkawitz, R. (2014). A functional insulator screen identifies NURF and dREAM components to be required for enhancer-blocking. PLoS One 9, e107765. 10.1371/journal.pone.0107765.

    Ahanger, S.H., Günther, K., Weth, O., Bartkuhn, M., Bhonde, R.R., Shouche, Y.S., and Renkawitz, R. (2014). Ectopically tethered CP190 induces large-scale chromatin decondensation. Sci Rep 4, 3917. 10.1038/srep03917.

  • B04 - Niels Galjart

     

  • B05 - Kerstin Wendt

     

  • B06 - Reinhard Dammann

    Haag, T., Richter, A.M., Schneider, M.B., Jiménez, A.P., and Dammann, R.H. (2016). The dual specificity phosphatase 2 gene is hypermethylated in human cancer and regulated by epigenetic mechanisms. BMC Cancer 16, 49. 10.1186/s12885-016-2087-6.

    Teschler, S., Gotthardt, J., Dammann, G., and Dammann, R.H. (2016). Aberrant DNA Methylation of rDNA and PRIMA1 in Borderline Personality Disorder. Int J Mol Sci 17. 10.3390/ijms17010067.

    Walesch, S.K., Richter, A.M., Helmbold, P., and Dammann, R.H. (2015). Claudin11 Promoter Hypermethylation Is Frequent in Malignant Melanoma of the Skin, but Uncommon in Nevus Cell Nevi. Cancers (Basel) 7, 1233-1243. 10.3390/cancers7030834.

    Haag, T., Herkt, C.E., Walesch, S.K., Richter, A.M., and Dammann, R.H. (2014). The apoptosis associated tyrosine kinase gene is frequently hypermethylated in human cancer and is regulated by epigenetic mechanisms. Genes Cancer 5, 365-374. 10.18632/genesandcancer.28.

    Teschler, S., Bartkuhn, M., Künzel, N., Schmidt, C., Kiehl, S., Dammann, G., and Dammann, R. (2013). Aberrant methylation of gene associated CpG sites occurs in borderline personality disorder. PLoS One 8, e84180. 10.1371/journal.pone.0084180.

  • B07 - Gergana Dobreva

    Cheedipudi, S., Genolet, O., and Dobreva, G. (2014). Epigenetic inheritance of cell fates during embryonic development. Front Genet 5, 19. 10.3389/fgene.2014.00019.

    Dobreva, G., and Braun, T. (2012). When silence is broken: polycomb group proteins in heart development. Circ Res 110, 372-374. 10.1161/CIRCRESAHA.111.263145.

    Witzel, H.R., Jungblut, B., Choe, C.P., Crump, J.G., Braun, T., and Dobreva, G. (2012). The LIM protein Ajuba restricts the second heart field progenitor pool by regulating Isl1 activity. Dev Cell 23, 58-70. 10.1016/j.devcel.2012.06.005.

  • B08 - Renate Renkawitz-Pohl

    Gärtner, S.M., Rothenbusch, S., Buxa, M.K., Theofel, I., Renkawitz, R., Rathke, C., and Renkawitz-Pohl, R. (2015). The HMG-box-containing proteins tHMG-1 and tHMG-2 interact during the histone-to-protamine transition in Drosophila spermatogenesis. Eur J Cell Biol 94, 46-59. 10.1016/j.ejcb.2014.10.005.

    Kost, N., Kaiser, S., Ostwal, Y., Riedel, D., Stützer, A., Nikolov, M., Rathke, C., Renkawitz-Pohl, R., and Fischle, W. (2015). Multimerization of Drosophila sperm protein Mst77F causes a unique condensed chromatin structure. Nucleic Acids Res 43, 3033-3045. 10.1093/nar/gkv015.

    Dottermusch-Heidel, C., Gärtner, S.M., Tegeder, I., Rathke, C., Barckmann, B., Bartkuhn, M., Bhushan, S., Steger, K., Meinhardt, A., and Renkawitz-Pohl, R. (2014). H3K79 methylation: a new conserved mark that accompanies H4 hyperacetylation prior to histone-to-protamine transition in Drosophila and rat. Biol Open 3, 444-452. 10.1242/bio.20147302.

    Gärtner, S.M., Rathke, C., Renkawitz-Pohl, R., and Awe, S. (2014). Ex vivo culture of Drosophila pupal testis and single male germ-line cysts: dissection, imaging, and pharmacological treatment. J Vis Exp, 51868. 10.3791/51868.

    Rathke, C., Baarends, W.M., Awe, S., and Renkawitz-Pohl, R. (2014). Chromatin dynamics during spermiogenesis. Biochim Biophys Acta 1839, 155-168. 10.1016/j.bbagrm.2013.08.004.

    Theofel, I., Bartkuhn, M., Hundertmark, T., Boettger, T., Gärtner, S.M., Leser, K., Awe, S., Schipper, M., Renkawitz-Pohl, R., and Rathke, C. (2014). tBRD-1 selectively controls gene activity in the Drosophila testis and interacts with two new members of the bromodomain and extra-terminal (BET) family. PLoS One 9, e108267. 10.1371/journal.pone.0108267.

    Barckmann, B., Chen, X., Kaiser, S., Jayaramaiah-Raja, S., Rathke, C., Dottermusch-Heidel, C., Fuller, M.T., and Renkawitz-Pohl, R. (2013). Three levels of regulation lead to protamine and Mst77F expression in Drosophila. Dev Biol 377, 33-45. 10.1016/j.ydbio.2013.02.018.

    Leser, K., Awe, S., Barckmann, B., Renkawitz-Pohl, R., and Rathke, C. (2012). The bromodomain-containing protein tBRD-1 is specifically expressed in spermatocytes and is essential for male fertility. Biol Open 1, 597-606. 10.1242/bio.20121255.

    Murawska, M., Hassler, M., Renkawitz-Pohl, R., Ladurner, A., and Brehm, A. (2011). Stress-induced PARP activation mediates recruitment of Drosophila Mi-2 to promote heat shock gene expression. PLoS Genet 7, e1002206. 10.1371/journal.pgen.1002206.

  • B09 - Willy Baarends

    Rathke, C., Baarends, W.M., Awe, S., and Renkawitz-Pohl, R. (2014). Chromatin dynamics during spermiogenesis. Biochim Biophys Acta 1839, 155-168. 10.1016/j.bbagrm.2013.08.004.

    Bergs, J.W., Neuendorff, N., van der Heijden, G., Wassenaar, E., Rexin, P., Elsässer, H.P., Moll, R., Baarends, W.M., and Brehm, A. (2014). Differential expression and sex chromosome association of CHD3/4 and CHD5 during spermatogenesis. PLoS One 9, e98203. 10.1371/journal.pone.0098203.

  • B10 - Joost Gribnau

     

  • B11 - Adriaan Houtsmuller

     

  • Z01 - Marek Bartkuhn

    Ahanger, S.H., Günther, K., Weth, O., Bartkuhn, M., Bhonde, R.R., Shouche, Y.S., and Renkawitz, R. (2014). Ectopically tethered CP190 induces large-scale chromatin decondensation. Sci Rep 4, 3917. 10.1038/srep03917.

    Dottermusch-Heidel, C., Gärtner, S.M., Tegeder, I., Rathke, C., Barckmann, B., Bartkuhn, M., Bhushan, S., Steger, K., Meinhardt, A., and Renkawitz-Pohl, R. (2014). H3K79 methylation: a new conserved mark that accompanies H4 hyperacetylation prior to histone-to-protamine transition in Drosophila and rat. Biol Open 3, 444-452. 10.1242/bio.20147302.

    Handschick, K., Beuerlein, K., Jurida, L., Bartkuhn, M., Müller, H., Soelch, J., Weber, A., Dittrich-Breiholz, O., Schneider, H., Scharfe, M., et al. (2014). Cyclin-dependent kinase 6 is a chromatin-bound cofactor for NF-κB-dependent gene expression. Mol Cell 53, 193-208. 10.1016/j.molcel.2013.12.002.

    Teschler, S., Bartkuhn, M., Künzel, N., Schmidt, C., Kiehl, S., Dammann, G., and Dammann, R. (2013). Aberrant methylation of gene associated CpG sites occurs in borderline personality disorder. PLoS One 8, e84180. 10.1371/journal.pone.0084180.

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