Main Content

Publications - 2nd Funding Period (2014-2018)

A01 - Alexander Brehm

Kovač, K., Sauer, A., Mačinković, I., Awe, S., Finkernagel, F., Hoffmeister, H., Fuchs, A., Müller, R., Rathke, C., Längst, G., and Brehm, A. (2018). Tumour-associated missense mutations in the dMi-2 ATPase alters nucleosome remodelling properties in a mutation-specific manner. Nat Commun 9, 2112. 10.1038/s41467-018-04503-2.

Kreher, J., Kovač, K., Bouazoune, K., Mačinković, I., Ernst, A.L., Engelen, E., Pahl, R., Finkernagel, F., Murawska, M., Ullah, I., and Brehm, A. (2017). EcR recruits dMi-2 and increases efficiency of dMi-2-mediated remodelling to constrain transcription of hormone-regulated genes. Nat Commun 8, 14806. 10.1038/ncomms14806.

Theofel, I., Bartkuhn, M., Boettger, T., Gärtner, S.M.K., Kreher, J., Brehm, A., and Rathke, C. (2017). tBRD-1 and tBRD-2 regulate expression of genes necessary for spermatid differentiation. Biol Open 6, 439-448. 10.1242/bio.022467.

Jox, T., Buxa, M.K., Bohla, D., Ullah, I., Mačinković, I., Brehm, A., Bartkuhn, M., and Renkawitz, R. (2017). CP190- and dCTCF-mediated enhancer blocking is augmented by SUMOylation. Epigenetics Chromatin 10, 32. 10.1186/s13072-017-0140-6.

Kim, J., Lu, C., Srinivasan, S., Awe, S., Brehm, A., and Fuller, M.T. (2017). Blocking promiscuous activation at cryptic promoters directs cell type-specific gene expression. Science 356, 717-721. 10.1126/science.aal3096.

Fritsch, K., Mernberger, M., Nist, A., Stiewe, T., Brehm, A., and Jacob, R. (2016). Galectin-3 interacts with components of the nuclear ribonucleoprotein complex. BMC Cancer 16, 502. 10.1186/s12885-016-2546-0.
A02 - Thomas Braun/Yonggang Zhou/Xuejun Yuan

Ianni, A., Yuan, X., Bober, E., and Braun, T. (2018). Sirtuins in the Cardiovascular System: Potential Targets in Pediatric Cardiology. Pediatr Cardiol 39, 983-992. 10.1007/s00246-018-1848-1.

Meier-Soelch, J., Jurida, L., Weber, A., Newel, D., Kim, J., Braun, T., Schmitz, M.L., and Kracht, M. (2018). RNAi-Based Identification of Gene-Specific Nuclear Cofactor Networks Regulating Interleukin-1 Target Genes. Front Immunol 9, 775. 10.3389/fimmu.2018.00775.

Wüst, S., Dröse, S., Heidler, J., Wittig, I., Klockner, I., Franko, A., Bonke, E., Günther, S., Gärtner, U., Boettger, T., and Braun, T. (2018). Metabolic Maturation during Muscle Stem Cell Differentiation Is Achieved by miR-1/133a-Mediated Inhibition of the Dlk1-Dio3 Mega Gene Cluster. Cell Metab 27, 1026-1039.e1026. 10.1016/j.cmet.2018.02.022.

Moradi, S., Braun, T., and Baharvand, H. (2018). miR-302b-3p Promotes Self-Renewal Properties in Leukemia Inhibitory Factor-Withdrawn Embryonic Stem Cells. Cell J 20, 61-72. 10.22074/cellj.2018.4846.

Sreenivasan, K., Braun, T., and Kim, J. (2017). Systematic Identification of Genes Regulating Muscle Stem Cell Self-Renewal and Differentiation. Methods Mol Biol 1556, 343-353. 10.1007/978-1-4939-6771-1_19.

Fang, J., Ianni, A., Smolka, C., Vakhrusheva, O., Nolte, H., Krüger, M., Wietelmann, A., Simonet, N.G., Adrian-Segarra, J.M., Vaquero, A., et al. (2017). Sirt7 promotes adipogenesis in the mouse by inhibiting autocatalytic activation of Sirt1. Proc Natl Acad Sci U S A 114, E8352-E8361. 10.1073/pnas.1706945114.

Moradi, S., Sharifi-Zarchi, A., Ahmadi, A., Mollamohammadi, S., Stubenvoll, A., Günther, S., Salekdeh, G.H., Asgari, S., Braun, T., and Baharvand, H. (2017). Small RNA Sequencing Reveals Dlk1-Dio3 Locus-Embedded MicroRNAs as Major Drivers of Ground-State Pluripotency. Stem Cell Reports 9, 2081-2096. 10.1016/j.stemcr.2017.10.009.

Joshi, S., Davidson, G., Le Gras, S., Watanabe, S., Braun, T., Mengus, G., and Davidson, I. (2017). TEAD transcription factors are required for normal primary myoblast differentiation in vitro and muscle regeneration in vivo. PLoS Genet 13, e1006600. 10.1371/journal.pgen.1006600.

Bergmann, O., and Braun, T. (2016). Caught Red-Handed: Cycling Cardiomyocytes. Circ Res 118, 3-5. 10.1161/CIRCRESAHA.115.307936.

Shin, J., Watanabe, S., Hoelper, S., Krüger, M., Kostin, S., Pöling, J., Kubin, T., and Braun, T. (2016). BRAF activates PAX3 to control muscle precursor cell migration during forelimb muscle development. Elife 5. 10.7554/eLife.18351.

Boonsanay, V., Zhang, T., Georgieva, A., Kostin, S., Qi, H., Yuan, X., Zhou, Y., and Braun, T. (2016). Regulation of Skeletal Muscle Stem Cell Quiescence by Suv4-20h1-Dependent Facultative Heterochromatin Formation. Cell Stem Cell 18, 229-242. 10.1016/j.stem.2015.11.002.

Rodriguez-Gil, A., Ritter, O., Hornung, J., Stekman, H., Krüger, M., Braun, T., Kremmer, E., Kracht, M., and Schmitz, M.L. (2016). HIPK family kinases bind and regulate the function of the CCR4-NOT complex. Mol Biol Cell 27, 1969-1980. 10.1091/mbc.E15-09-0629.

Caputo, L., Witzel, H.R., Kolovos, P., Cheedipudi, S., Looso, M., Mylona, A., van IJcken, W.F., Laugwitz, K.L., Evans, S.M., Braun, T., et al. (2015). The Isl1/Ldb1 Complex Orchestrates Genome-wide Chromatin Organization to Instruct Differentiation of Multipotent Cardiac Progenitors. Cell Stem Cell 17, 287-299. 10.1016/j.stem.2015.08.007.

Biesemann, N., and Braun, T. (2015). Response to letter regarding article, "Myostatin regulates energy homeostasis in the heart and prevents heart failure". Circ Res 116, e97-98. 10.1161/CIRCRESAHA.115.306486.

Al-Furoukh, N., Ianni, A., Nolte, H., Hölper, S., Krüger, M., Wanrooij, S., and Braun, T. (2015). ClpX stimulates the mitochondrial unfolded protein response (UPRmt) in mammalian cells. Biochim Biophys Acta 1853, 2580-2591. 10.1016/j.bbamcr.2015.06.016.

Piatkowski, T., and Braun, T. (2015). Long-term organ cultures of newt hearts. Methods Mol Biol 1290, 241-251. 10.1007/978-1-4939-2495-0_19.

Stubenvoll, A., Rice, M., Wietelmann, A., Wheeler, M., and Braun, T. (2015). Attenuation of Wnt/β-catenin activity reverses enhanced generation of cardiomyocytes and cardiac defects caused by the loss of emerin. Hum Mol Genet 24, 802-813. 10.1093/hmg/ddu498.

Looso, M., and Braun, T. (2015). Data mining in newt-omics, the repository for omics data from the newt. Methods Mol Biol 1290, 337-351. 10.1007/978-1-4939-2495-0_26.

Zhang, T., Günther, S., Looso, M., Künne, C., Krüger, M., Kim, J., Zhou, Y., and Braun, T. (2015). Prmt5 is a regulator of muscle stem cell expansion in adult mice. Nat Commun 6, 7140. 10.1038/ncomms8140.

Biesemann, N., Mendler, L., Wietelmann, A., Hermann, S., Schäfers, M., Krüger, M., Boettger, T., Borchardt, T., and Braun, T. (2014). Myostatin regulates energy homeostasis in the heart and prevents heart failure. Circ Res 115, 296-310. 10.1161/CIRCRESAHA.115.304185.

Kim, J., and Braun, T. (2014). Skeletal muscle stem cells for muscle regeneration. Methods Mol Biol 1213, 245-253. 10.1007/978-1-4939-1453-1_20.
A03 - Uta-Maria Bauer

Feld, C., Sahu, P., Frech, M., Finkernagel, F., Nist, A., Stiewe, T., Bauer, U.M., and Neubauer, A. (2018). Combined cistrome and transcriptome analysis of SKI in AML cells identifies SKI as a co-repressor for RUNX1. Nucleic Acids Res 46, 3412-3428. 10.1093/nar/gky119.

Frech, M., Teichler, S., Feld, C., Bouchard, C., Berberich, H., Sorg, K., Mernberger, M., Bullinger, L., Bauer, U.M., and Neubauer, A. (2018). MYB induces the expression of the oncogenic corepressor SKI in acute myeloid leukemia. Oncotarget 9, 22423-22435. 10.18632/oncotarget.25051.

Berberich, H., Terwesten, F., Rakow, S., Sahu, P., Bouchard, C., Meixner, M., Philipsen, S., Kolb, P., and Bauer, U.M. (2017). Identification and. FEBS Open Bio 7, 1909-1923. 10.1002/2211-5463.12323.

Stein, C., Nötzold, R.R., Riedl, S., Bouchard, C., and Bauer, U.M. (2016). The Arginine Methyltransferase PRMT6 Cooperates with Polycomb Proteins in Regulating HOXA Gene Expression. PLoS One 11, e0148892. 10.1371/journal.pone.0148892.
A04 - Sjaak Philipsen/Thamar van Dijk

Berberich, H., Terwesten, F., Rakow, S., Sahu, P., Bouchard, C., Meixner, M., Philipsen, S., Kolb, P., and Bauer, U.M. (2017). Identification and. FEBS Open Bio 7, 1909-1923. 10.1002/2211-5463.12323.
A05 - Peter Verrijzer/Adone Mohd-Sarip
A06 - Guntram Suske

Stielow, B., Finkernagel, F., Stiewe, T., Nist, A., and Suske, G. (2018). MGA, L3MBTL2 and E2F6 determine genomic binding of the non-canonical Polycomb repressive complex PRC1.6. PLoS Genet 14, e1007193. 10.1371/journal.pgen.1007193.
A07 - Lienhard Schmitz

Meier-Soelch, J., Jurida, L., Weber, A., Newel, D., Kim, J., Braun, T., Schmitz, M.L., and Kracht, M. (2018). RNAi-Based Identification of Gene-Specific Nuclear Cofactor Networks Regulating Interleukin-1 Target Genes. Front Immunol 9, 775. 10.3389/fimmu.2018.00775.

Riedlinger, T., Haas, J., Busch, J., van de Sluis, B., Kracht, M., and Schmitz, M.L. (2018). The Direct and Indirect Roles of NF-κB in Cancer: Lessons from Oncogenic Fusion Proteins and Knock-in Mice. Biomedicines 6. 10.3390/biomedicines6010036.

Rodríguez-Gil, A., Riedlinger, T., Ritter, O., Saul, V.V., and Schmitz, M.L. (2018). Formaldehyde-assisted Isolation of Regulatory Elements to Measure Chromatin Accessibility in Mammalian Cells. J Vis Exp. 10.3791/57272.

Schmitz, M.L., Shaban, M.S., Albert, B.V., Gökçen, A., and Kracht, M. (2018). The Crosstalk of Endoplasmic Reticulum (ER) Stress Pathways with NF-κB: Complex Mechanisms Relevant for Cancer, Inflammation and Infection. Biomedicines 6. 10.3390/biomedicines6020058.

Rodríguez-Gil, A., Ritter, O., Saul, V.V., Wilhelm, J., Yang, C.Y., Grosschedl, R., Imai, Y., Kuba, K., Kracht, M., and Schmitz, M.L. (2017). The CCR4-NOT complex contributes to repression of Major Histocompatibility Complex class II transcription. Sci Rep 7, 3547. 10.1038/s41598-017-03708-7.

Hagenbucher, J., Stekman, H., Rodriguez-Gil, A., Kracht, M., and Schmitz, M.L. (2017). Testing the Effects of SIAH Ubiquitin E3 Ligases on Lysine Acetyl Transferases. Methods Mol Biol 1510, 297-312. 10.1007/978-1-4939-6527-4_22.

Poppe, M., Wittig, S., Jurida, L., Bartkuhn, M., Wilhelm, J., Müller, H., Beuerlein, K., Karl, N., Bhuju, S., Ziebuhr, J., et al. (2017). The NF-κB-dependent and -independent transcriptome and chromatin landscapes of human coronavirus 229E-infected cells. PLoS Pathog 13, e1006286. 10.1371/journal.ppat.1006286.

Riedlinger, T., Dommerholt, M.B., Wijshake, T., Kruit, J.K., Huijkman, N., Dekker, D., Koster, M., Kloosterhuis, N., Koonen, D.P.Y., de Bruin, A., et al. (2017). NF-κB p65 serine 467 phosphorylation sensitizes mice to weight gain and TNFα-or diet-induced inflammation. Biochim Biophys Acta Mol Cell Res 1864, 1785-1798. 10.1016/j.bbamcr.2017.07.005.

Tenekeci, U., Poppe, M., Beuerlein, K., Buro, C., Müller, H., Weiser, H., Kettner-Buhrow, D., Porada, K., Newel, D., Xu, M., et al. (2016). K63-Ubiquitylation and TRAF6 Pathways Regulate Mammalian P-Body Formation and mRNA Decapping. Mol Cell 62, 943-957. 10.1016/j.molcel.2016.05.017.

Dam, S., Kracht, M., Pleschka, S., and Schmitz, M.L. (2016). The Influenza A Virus Genotype Determines the Antiviral Function of NF-κB. J Virol 90, 7980-7990. 10.1128/JVI.00946-16.

Rodriguez-Gil, A., Ritter, O., Hornung, J., Stekman, H., Krüger, M., Braun, T., Kremmer, E., Kracht, M., and Schmitz, M.L. (2016). HIPK family kinases bind and regulate the function of the CCR4-NOT complex. Mol Biol Cell 27, 1969-1980. 10.1091/mbc.E15-09-0629.

Schmitz, M.L., and Kracht, M. (2016). Cyclin-Dependent Kinases as Coregulators of Inflammatory Gene Expression. Trends Pharmacol Sci 37, 101-113. 10.1016/j.tips.2015.10.004.

Katzav, S., and Schmitz, M.L. (2015). Mutations of c-Cbl in myeloid malignancies. Oncotarget 6, 10689-10696. 10.18632/oncotarget.3986.

Jurida, L., Soelch, J., Bartkuhn, M., Handschick, K., Müller, H., Newel, D., Weber, A., Dittrich-Breiholz, O., Schneider, H., Bhuju, S., et al. (2015). The Activation of IL-1-Induced Enhancers Depends on TAK1 Kinase Activity and NF-κB p65. Cell Rep 10, 726-739. 10.1016/j.celrep.2015.01.001.
A09 - Raymond Poot

Ding, D., Bergmaier, P., Sachs, P., Klangwart, M., Rückert, T., Bartels, N., Demmers, J., Dekker, M., Poot, R.A., and Mermoud, J.E. (2018). The CUE1 domain of the SNF2-like chromatin remodeler SMARCAD1 mediates its association with KRAB-associated protein 1 (KAP1) and KAP1 target genes. J Biol Chem 293, 2711-2724. 10.1074/jbc.RA117.000959.
A10 - Thorsten Stiewe

Stielow, B., Finkernagel, F., Stiewe, T., Nist, A., and Suske, G. (2018). MGA, L3MBTL2 and E2F6 determine genomic binding of the non-canonical Polycomb repressive complex PRC1.6. PLoS Genet 14, e1007193. 10.1371/journal.pgen.1007193.

Feld, C., Sahu, P., Frech, M., Finkernagel, F., Nist, A., Stiewe, T., Bauer, U.M., and Neubauer, A. (2018). Combined cistrome and transcriptome analysis of SKI in AML cells identifies SKI as a co-repressor for RUNX1. Nucleic Acids Res 46, 3412-3428. 10.1093/nar/gky119.

Bretz, A.C., Gittler, M.P., Charles, J.P., Gremke, N., Eckhardt, I., Mernberger, M., Mandic, R., Thomale, J., Nist, A., Wanzel, M., and Stiewe, T. (2016). ΔNp63 activates the Fanconi anemia DNA repair pathway and limits the efficacy of cisplatin treatment in squamous cell carcinoma. Nucleic Acids Res 44, 3204-3218. 10.1093/nar/gkw036.

Fritsch, K., Mernberger, M., Nist, A., Stiewe, T., Brehm, A., and Jacob, R. (2016). Galectin-3 interacts with components of the nuclear ribonucleoprotein complex. BMC Cancer 16, 502. 10.1186/s12885-016-2546-0.

Vogiatzi, F., Brandt, D.T., Schneikert, J., Fuchs, J., Grikscheit, K., Wanzel, M., Pavlakis, E., Charles, J.P., Timofeev, O., Nist, A., et al. (2016). Mutant p53 promotes tumor progression and metastasis by the endoplasmic reticulum UDPase ENTPD5. Proc Natl Acad Sci U S A 113, E8433-E8442. 10.1073/pnas.1612711114.

Wanzel, M., Vischedyk, J.B., Gittler, M.P., Gremke, N., Seiz, J.R., Hefter, M., Noack, M., Savai, R., Mernberger, M., Charles, J.P., et al. (2016). CRISPR-Cas9-based target validation for p53-reactivating model compounds. Nat Chem Biol 12, 22-28. 10.1038/nchembio.1965.
A12 - Tilman Borggrefe

Thiel, V.N., Giaimo, B.D., Schwarz, P., Soller, K., Vas, V., Bartkuhn, M., Blätte, T.J., Döhner, K., Bullinger, L., Borggrefe, T., et al. (2017). Heterodimerization of AML1/ETO with CBFβ is required for leukemogenesis but not for myeloproliferation. Leukemia 31, 2491-2502. 10.1038/leu.2017.105.

Giaimo, B.D., Ferrante, F., and Borggrefe, T. (2017a). Chromatin Immunoprecipitation (ChIP) in Mouse T-cell Lines. J Vis Exp. 10.3791/55907.

Giaimo, B.D., Oswald, F., and Borggrefe, T. (2017b). Dynamic chromatin regulation at Notch target genes. Transcription 8, 61-66. 10.1080/21541264.2016.1265702.

Borggrefe, T., Lauth, M., Zwijsen, A., Huylebroeck, D., Oswald, F., and Giaimo, B.D. (2016). The Notch intracellular domain integrates signals from Wnt, Hedgehog, TGFβ/BMP and hypoxia pathways. Biochim Biophys Acta 1863, 303-313. 10.1016/j.bbamcr.2015.11.020.

Borggrefe, T., and Oswald, F. (2016). Setting the Stage for Notch: The Drosophila Su(H)-Hairless Repressor Complex. PLoS Biol 14, e1002524. 10.1371/journal.pbio.1002524.

Oswald, F., Rodriguez, P., Giaimo, B.D., Antonello, Z.A., Mira, L., Mittler, G., Thiel, V.N., Collins, K.J., Tabaja, N., Cizelsky, W., et al. (2016). A phospho-dependent mechanism involving NCoR and KMT2D controls a permissive chromatin state at Notch target genes. Nucleic Acids Res 44, 4703-4720. 10.1093/nar/gkw105.

Hein, K., Mittler, G., Cizelsky, W., Kühl, M., Ferrante, F., Liefke, R., Berger, I.M., Just, S., Sträng, J.E., Kestler, H.A., et al. (2015). Site-specific methylation of Notch1 controls the amplitude and duration of the Notch1 response. Sci Signal 8, ra30. 10.1126/scisignal.2005892.
A13 - Yuri Moshkin

Chereji, R.V., Kan, T.W., Grudniewska, M.K., Romashchenko, A.V., Berezikov, E., Zhimulev, I.F., Guryev, V., Morozov, A.V., and Moshkin, Y.M. (2016). Genome-wide profiling of nucleosome sensitivity and chromatin accessibility in Drosophila melanogaster. Nucleic Acids Res 44, 1036-1051. 10.1093/nar/gkv978.
A14 - Danny Huylebroek

Borggrefe, T., Lauth, M., Zwijsen, A., Huylebroeck, D., Oswald, F., and Giaimo, B.D. (2016). The Notch intracellular domain integrates signals from Wnt, Hedgehog, TGFβ/BMP and hypoxia pathways. Biochim Biophys Acta 1863, 303-313. 10.1016/j.bbamcr.2015.11.020.
B01 - Frank Grosveld

Knoch, T.A., Wachsmuth, M., Kepper, N., Lesnussa, M., Abuseiris, A., Ali Imam, A.M., Kolovos, P., Zuin, J., Kockx, C.E.M., Brouwer, R.W.W., et al. (2016). The detailed 3D multi-loop aggregate/rosette chromatin architecture and functional dynamic organization of the human and mouse genomes. Epigenetics Chromatin 9, 58. 10.1186/s13072-016-0089-x.

Caputo, L., Witzel, H.R., Kolovos, P., Cheedipudi, S., Looso, M., Mylona, A., van IJcken, W.F., Laugwitz, K.L., Evans, S.M., Braun, T., et al. (2015). The Isl1/Ldb1 Complex Orchestrates Genome-wide Chromatin Organization to Instruct Differentiation of Multipotent Cardiac Progenitors. Cell Stem Cell 17, 287-299. 10.1016/j.stem.2015.08.007.
B02 - Michael Kracht

Meier-Soelch, J., Jurida, L., Weber, A., Newel, D., Kim, J., Braun, T., Schmitz, M.L., and Kracht, M. (2018). RNAi-Based Identification of Gene-Specific Nuclear Cofactor Networks Regulating Interleukin-1 Target Genes. Front Immunol 9, 775. 10.3389/fimmu.2018.00775.

Riedlinger, T., Haas, J., Busch, J., van de Sluis, B., Kracht, M., and Schmitz, M.L. (2018). The Direct and Indirect Roles of NF-κB in Cancer: Lessons from Oncogenic Fusion Proteins and Knock-in Mice. Biomedicines 6. 10.3390/biomedicines6010036.

Schmitz, M.L., Shaban, M.S., Albert, B.V., Gökçen, A., and Kracht, M. (2018). The Crosstalk of Endoplasmic Reticulum (ER) Stress Pathways with NF-κB: Complex Mechanisms Relevant for Cancer, Inflammation and Infection. Biomedicines 6. 10.3390/biomedicines6020058.

Hagenbucher, J., Stekman, H., Rodriguez-Gil, A., Kracht, M., and Schmitz, M.L. (2017). Testing the Effects of SIAH Ubiquitin E3 Ligases on Lysine Acetyl Transferases. Methods Mol Biol 1510, 297-312. 10.1007/978-1-4939-6527-4_22.

Rodríguez-Gil, A., Ritter, O., Saul, V.V., Wilhelm, J., Yang, C.Y., Grosschedl, R., Imai, Y., Kuba, K., Kracht, M., and Schmitz, M.L. (2017). The CCR4-NOT complex contributes to repression of Major Histocompatibility Complex class II transcription. Sci Rep 7, 3547. 10.1038/s41598-017-03708-7.

Poppe, M., Wittig, S., Jurida, L., Bartkuhn, M., Wilhelm, J., Müller, H., Beuerlein, K., Karl, N., Bhuju, S., Ziebuhr, J., et al. (2017). The NF-κB-dependent and -independent transcriptome and chromatin landscapes of human coronavirus 229E-infected cells. PLoS Pathog 13, e1006286. 10.1371/journal.ppat.1006286.

Dam, S., Kracht, M., Pleschka, S., and Schmitz, M.L. (2016). The Influenza A Virus Genotype Determines the Antiviral Function of NF-κB. J Virol 90, 7980-7990. 10.1128/JVI.00946-16.

Schmitz, M.L., and Kracht, M. (2016). Cyclin-Dependent Kinases as Coregulators of Inflammatory Gene Expression. Trends Pharmacol Sci 37, 101-113. 10.1016/j.tips.2015.10.004.

Rodriguez-Gil, A., Ritter, O., Hornung, J., Stekman, H., Krüger, M., Braun, T., Kremmer, E., Kracht, M., and Schmitz, M.L. (2016). HIPK family kinases bind and regulate the function of the CCR4-NOT complex. Mol Biol Cell 27, 1969-1980. 10.1091/mbc.E15-09-0629.

Jurida, L., Soelch, J., Bartkuhn, M., Handschick, K., Müller, H., Newel, D., Weber, A., Dittrich-Breiholz, O., Schneider, H., Bhuju, S., et al. (2015). The Activation of IL-1-Induced Enhancers Depends on TAK1 Kinase Activity and NF-κB p65. Cell Rep 10, 726-739. 10.1016/j.celrep.2015.01.001.
B04 - Niels Galjart
B05 - Kerstin Wendt

Knoch, T.A., Wachsmuth, M., Kepper, N., Lesnussa, M., Abuseiris, A., Ali Imam, A.M., Kolovos, P., Zuin, J., Kockx, C.E.M., Brouwer, R.W.W., et al. (2016). The detailed 3D multi-loop aggregate/rosette chromatin architecture and functional dynamic organization of the human and mouse genomes. Epigenetics Chromatin 9, 58. 10.1186/s13072-016-0089-x.
B07 - Gergana Dobreva

Yuan, X., Qi, H., Li, X., Wu, F., Fang, J., Bober, E., Dobreva, G., Zhou, Y., and Braun, T. (2017). Disruption of spatiotemporal hypoxic signaling causes congenital heart disease in mice. J Clin Invest 127, 2235-2248. 10.1172/JCI88725.

Caputo, L., Witzel, H.R., Kolovos, P., Cheedipudi, S., Looso, M., Mylona, A., van IJcken, W.F., Laugwitz, K.L., Evans, S.M., Braun, T., et al. (2015). The Isl1/Ldb1 Complex Orchestrates Genome-wide Chromatin Organization to Instruct Differentiation of Multipotent Cardiac Progenitors. Cell Stem Cell 17, 287-299. 10.1016/j.stem.2015.08.007.
B09 - Willy Baarends
B10 - Joost Gribnau
B11 - Adriaan Houtsmuller

Buxa, M.K., Slotman, J.A., van Royen, M.E., Paul, M.W., Houtsmuller, A.B., and Renkawitz, R. (2016). Insulator speckles associated with long-distance chromatin contacts. Biol Open 5, 1266-1274. 10.1242/bio.019455.
B12 - Jacqueline Mermoud

Sachs, P., Ding, D., Bergmaier, P., Lamp, B., Schlagheck, C., Finkernagel, F., Nist, A., Stiewe, T., and Mermoud, J.E. (2019). SMARCAD1 ATPase activity is required to silence endogenous retroviruses in embryonic stem cells. Nat Commun 10, 1335. 10.1038/s41467-019-09078-0.

Ding, D., Bergmaier, P., Sachs, P., Klangwart, M., Rückert, T., Bartels, N., Demmers, J., Dekker, M., Poot, R.A., and Mermoud, J.E. (2018). The CUE1 domain of the SNF2-like chromatin remodeler SMARCAD1 mediates its association with KRAB-associated protein 1 (KAP1) and KAP1 target genes. J Biol Chem 293, 2711-2724. 10.1074/jbc.RA117.000959.
B13 - Christina Pütz-Rathke

Hundertmark, T., Kreutz, S., Merle, N., Nist, A., Lamp, B., Stiewe, T., Brehm, A., Renkawitz-Pohl, R., and Rathke, C. (2019). Drosophila melanogaster tPlus3a and tPlus3b ensure full male fertility by regulating transcription of Y-chromosomal, seminal fluid, and heat shock genes. PLoS One 14, e0213177. 10.1371/journal.pone.0213177.

Mačinković, I., Theofel, I., Hundertmark, T., Kovač, K., Awe, S., Lenz, J., Forné, I., Lamp, B., Nist, A., Imhof, A., et al. (2019). Distinct CoREST complexes act in a cell-type-specific manner. Nucleic Acids Res 47, 11649-11666. 10.1093/nar/gkz1050.

Hundertmark, T., Gärtner, S.M.K., Rathke, C., and Renkawitz-Pohl, R. (2018). Nejire/dCBP-mediated histone H3 acetylation during spermatogenesis is essential for male fertility in Drosophila melanogaster. PLoS One 13, e0203622. 10.1371/journal.pone.0203622.

Kovač, K., Sauer, A., Mačinković, I., Awe, S., Finkernagel, F., Hoffmeister, H., Fuchs, A., Müller, R., Rathke, C., Längst, G., and Brehm, A. (2018). Tumour-associated missense mutations in the dMi-2 ATPase alters nucleosome remodelling properties in a mutation-specific manner. Nat Commun 9, 2112. 10.1038/s41467-018-04503-2.

Hundertmark, T., Theofel, I., Eren-Ghiani, Z., Miller, D., and Rathke, C. (2017). Analysis of Chromatin Dynamics During Drosophila Spermatogenesis. Methods Mol Biol 1471, 289-303. 10.1007/978-1-4939-6340-9_17.

Theofel, I., Bartkuhn, M., Boettger, T., Gärtner, S.M.K., Kreher, J., Brehm, A., and Rathke, C. (2017). tBRD-1 and tBRD-2 regulate expression of genes necessary for spermatid differentiation. Biol Open 6, 439-448. 10.1242/bio.022467.

Eren-Ghiani, Z., Rathke, C., Theofel, I., and Renkawitz-Pohl, R. (2015). Prtl99C Acts Together with Protamines and Safeguards Male Fertility in Drosophila. Cell Rep 13, 2327-2335. 10.1016/j.celrep.2015.11.023.

Gärtner, S.M., Rothenbusch, S., Buxa, M.K., Theofel, I., Renkawitz, R., Rathke, C., and Renkawitz-Pohl, R. (2015). The HMG-box-containing proteins tHMG-1 and tHMG-2 interact during the histone-to-protamine transition in Drosophila spermatogenesis. Eur J Cell Biol 94, 46-59. 10.1016/j.ejcb.2014.10.005.

Kost, N., Kaiser, S., Ostwal, Y., Riedel, D., Stützer, A., Nikolov, M., Rathke, C., Renkawitz-Pohl, R., and Fischle, W. (2015). Multimerization of Drosophila sperm protein Mst77F causes a unique condensed chromatin structure. Nucleic Acids Res 43, 3033-3045. 10.1093/nar/gkv015.

Gärtner, S.M., Rathke, C., Renkawitz-Pohl, R., and Awe, S. (2014). Ex vivo culture of Drosophila pupal testis and single male germ-line cysts: dissection, imaging, and pharmacological treatment. J Vis Exp, 51868. 10.3791/51868.

Rathke, C., Baarends, W.M., Awe, S., and Renkawitz-Pohl, R. (2014). Chromatin dynamics during spermiogenesis. Biochim Biophys Acta 1839, 155-168. 10.1016/j.bbagrm.2013.08.004.

Theofel, I., Bartkuhn, M., Hundertmark, T., Boettger, T., Gärtner, S.M., Leser, K., Awe, S., Schipper, M., Renkawitz-Pohl, R., and Rathke, C. (2014). tBRD-1 selectively controls gene activity in the Drosophila testis and interacts with two new members of the bromodomain and extra-terminal (BET) family. PLoS One 9, e108267. 10.1371/journal.pone.0108267.

Dottermusch-Heidel, C., Gärtner, S.M., Tegeder, I., Rathke, C., Barckmann, B., Bartkuhn, M., Bhushan, S., Steger, K., Meinhardt, A., and Renkawitz-Pohl, R. (2014). H3K79 methylation: a new conserved mark that accompanies H4 hyperacetylation prior to histone-to-protamine transition in Drosophila and rat. Biol Open 3, 444-452. 10.1242/bio.20147302.
Z01 - Marek Bartkuhn/Alexander Goesmann

Ali, T., Krüger, M., Bhuju, S., Jarek, M., Bartkuhn, M., and Renkawitz, R. (2017). Chromatin binding of Gcn5 in Drosophila is largely mediated by CP190. Nucleic Acids Res 45, 2384-2395. 10.1093/nar/gkw1178.

Jox, T., Buxa, M.K., Bohla, D., Ullah, I., Mačinković, I., Brehm, A., Bartkuhn, M., and Renkawitz, R. (2017). CP190- and dCTCF-mediated enhancer blocking is augmented by SUMOylation. Epigenetics Chromatin 10, 32. 10.1186/s13072-017-0140-6.

Poppe, M., Wittig, S., Jurida, L., Bartkuhn, M., Wilhelm, J., Müller, H., Beuerlein, K., Karl, N., Bhuju, S., Ziebuhr, J., et al. (2017). The NF-κB-dependent and -independent transcriptome and chromatin landscapes of human coronavirus 229E-infected cells. PLoS Pathog 13, e1006286. 10.1371/journal.ppat.1006286.

Theofel, I., Bartkuhn, M., Boettger, T., Gärtner, S.M.K., Kreher, J., Brehm, A., and Rathke, C. (2017). tBRD-1 and tBRD-2 regulate expression of genes necessary for spermatid differentiation. Biol Open 6, 439-448. 10.1242/bio.022467.

Thiel, V.N., Giaimo, B.D., Schwarz, P., Soller, K., Vas, V., Bartkuhn, M., Blätte, T.J., Döhner, K., Bullinger, L., Borggrefe, T., et al. (2017). Heterodimerization of AML1/ETO with CBFβ is required for leukemogenesis but not for myeloproliferation. Leukemia 31, 2491-2502. 10.1038/leu.2017.105.

Zink, L.M., Delbarre, E., Eberl, H.C., Keilhauer, E.C., Bönisch, C., Pünzeler, S., Bartkuhn, M., Collas, P., Mann, M., and Hake, S.B. (2017). H3.Y discriminates between HIRA and DAXX chaperone complexes and reveals unexpected insights into human DAXX-H3.3-H4 binding and deposition requirements. Nucleic Acids Res 45, 5691-5706. 10.1093/nar/gkx131.

Hilker, R., Stadermann, K.B., Schwengers, O., Anisiforov, E., Jaenicke, S., Weisshaar, B., Zimmermann, T., and Goesmann, A. (2016). ReadXplorer 2-detailed read mapping analysis and visualization from one single source. Bioinformatics 32, 3702-3708. 10.1093/bioinformatics/btw541.

Maksimenko, O., Bartkuhn, M., Stakhov, V., Herold, M., Zolotarev, N., Jox, T., Buxa, M.K., Kirsch, R., Bonchuk, A., Fedotova, A., et al. (2015). Two new insulator proteins, Pita and ZIPIC, target CP190 to chromatin. Genome Res 25, 89-99. 10.1101/gr.174169.114.

Jurida, L., Soelch, J., Bartkuhn, M., Handschick, K., Müller, H., Newel, D., Weber, A., Dittrich-Breiholz, O., Schneider, H., Bhuju, S., et al. (2015). The Activation of IL-1-Induced Enhancers Depends on TAK1 Kinase Activity and NF-κB p65. Cell Rep 10, 726-739. 10.1016/j.celrep.2015.01.001.

Bohla, D., Herold, M., Panzer, I., Buxa, M.K., Ali, T., Demmers, J., Krüger, M., Scharfe, M., Jarek, M., Bartkuhn, M., and Renkawitz, R. (2014). A functional insulator screen identifies NURF and dREAM components to be required for enhancer-blocking. PLoS One 9, e107765. 10.1371/journal.pone.0107765.

Theofel, I., Bartkuhn, M., Hundertmark, T., Boettger, T., Gärtner, S.M., Leser, K., Awe, S., Schipper, M., Renkawitz-Pohl, R., and Rathke, C. (2014). tBRD-1 selectively controls gene activity in the Drosophila testis and interacts with two new members of the bromodomain and extra-terminal (BET) family. PLoS One 9, e108267. 10.1371/journal.pone.0108267.

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Publications - 2nd Funding Period (2014-2018)

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